1Department of Health (2004) . Health Survey for England. London: National Statistics.
2Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS & Marks JS (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289, 76–79.
3Samuelson G (2000) Dietary habits and nutritional status in adolescents over Europe. An overview of current studies in the Nordic countries. Eur J Clin Nutr 54, S21–S28.
4Berteus-Forslund H, Torgerson JS, Sjostrom L & Lindroos AK (2005) Snacking frequency in relation to energy intake and food choices in obese men and women compared to a reference population. Int J Obes Relat Metab Disord 29, 711–719.
5Woods SC (2004) Gastrointestinal Satiety Signals I. An overview of gastrointestinal signals that influence food intake. Am J Physiol Gastrointest Liver Physiol 286, G7–G13.
6Stanley S, Wynne K & Bloom S (2004) Gastrointestinal Satiety Signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide. Am J Physiol Gastrointest Liver Physiol 286, G693–G697.
7Moran TH & Kinzig KP (2004) Gastrointestinal Satiety Signals II. Cholecystokinin. Am J Physiol Gastrointest Liver Physiol 286, G183–G188.
8Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H & Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656–660.
9Sugino T, Yamaura J, Yamagishi M, et al. (2002) A transient surge of ghrelin secretion before feeding is modified by different feeding regimens in sheep. Biochem Biophys Res Commun 298, 785–788.
10Flanagan DE, Evans ML, Monsod TP, Rife F, Heptulla RA, Tamborlane WV & Sherwin RS (2003) The influence of insulin on circulating ghrelin. Am J Physiol Endocrinol Metab 284, E313–E316.
11Murdolo G, Lucidi P, Di Loreto C, et al. (2003) Insulin is required for prandial ghrelin suppression in humans. Diabetes 52, 2923–2927.
12Saad MF, Bernaba B, Hwu CM, Jinagouda S, Fahmi S, Kogosov E & Boyadjian R (2002) Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 87, 3997–4000.
13Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E & Heiman ML (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes 50, 707–709.
14McLaughlin T, Abbasi F, Lamendola C, Frayo RS & Cummings DE (2004) Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls. J Clin Endocrinol Metab 89, 1630–1635.
15British Nutrition Foundation (2004) . British Nutrition Foundation National Diet Survey. London: National Statistics.
16Bertelsen J, Christiansen C, Thomsen C, Poulsen PL, Vestergaard S, Steinov A, Rasmussen LH, Rasmussen O & Hermansen K (1993) Effect of meal frequency on blood glucose, insulin, and free fatty acids in NIDDM subjects. Diabetes Care 16, 4–7.
17Farshchi HR, Taylor MA & Macdonald IA (2004) Regular meal frequency creates more appropriate insulin sensitivity and lipid profiles compared with irregular meal frequency in healthy lean women. Eur J Clin Nutr 58, 1071–1077.
18Murphy MC, Chapman C, Lovegrove JA, Isherwood SG, Morgan LM, Wright JW & Williams CM (1996) Meal frequency; does it determine postprandial lipaemia? Eur J Clin Nutr 50, 491–497.
19Farshchi HR, Taylor MA & Macdonald IA (2005) Beneficial metabolic effects of regular meal frequency on dietary thermogenesis, insulin sensitivity, and fasting lipid profiles in healthy obese women. Am J Clin Nutr 81, 16–24.
20Arnold L, Mann JI & Ball MJ (1997) Metabolic effects of alterations in meal frequency in type 2 diabetes. Diabetes Care 20, 1651–1654.
21Iwao S, Mori K & Sato Y (1996) Effects of meal frequency on body composition during weight control in boxers. Scand J Med Sci Sports 6, 265–272.
22Jenkins DJ, Wolever TM, Vuksan V, et al. (1989) Nibbling versus gorging: metabolic advantages of increased meal frequency. N Engl J Med 321, 929–934.
23Veldhuis JD & Johnson ML (1986) Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. Am J Physiol 250, E486–E493.
24Veldhuis JD, Johnson ML & Seneta E (1991) Analysis of the copulsatility of anterior pituitary hormones. J Clin Endocrinol Metab 73, 569–576.
25Meneilly GS, Veldhuis JD & Elahi D (2006) Pulsatile insulin secretion in elderly patients with diabetes. Diabetes Res Clin Pract 73, 218–220.
26Box GJ, Jenkins GM & Reinsel G (1994) Time Series Analysis: Forecasting & Control, 3rd ed.London: Prentice Hall.
27Carroll D (1977) Cardiac perception and cardiac control. A review. Biofeedback Self Regul 2, 349–369.
28Mohlig M, Spranger J, Otto B, Ristow M, Tschop M & Pfeiffer AF (2002) Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans. J Endocrinol Invest 25, RC36–RC38.
29Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE & Weigle DS (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50, 1714–1719.
30Peino R, Baldelli R, Rodriguez-Garcia J, et al. (2000) Ghrelin-induced growth hormone secretion in humans. Eur J Endocrinol 143, R11–R14.
31Lucidi P, Murdolo G, Di Loreto C, De Cicco A, Parlanti N, Fanelli C, Santeusanio F, Bolli GB & De Feo P (2002) Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia. Diabetes 51, 2911–2914.
32McCowen KC, Maykel JA, Bistrian BR & Ling PR (2002) Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents. J Endocrinol 175, R7–R11.
33Anderwald C, Brabant G, Bernroider E, Horn R, Brehm A, Waldhausl W & Roden M (2003) Insulin-dependent modulation of plasma ghrelin and leptin concentrations is less pronounced in type 2 diabetic patients. Diabetes 52, 1792–1798.
34van der Lely AJ, Tschop M, Heiman ML & Ghigo E (2004) Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25, 426–457.
35Barazzoni R, Bosutti A, Stebel M, et al. (2005) Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle. Am J Physiol Endocrinol Metab 288, E228–E235.
36Wortley KE, Anderson KD, Garcia K, et al. (2004) Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci U S A 101, 8227–8232.
37Jenkins DJ, Wolever TM, Ocana AM, et al. (1990) Metabolic effects of reducing rate of glucose ingestion by single bolus versus continuous sipping. Diabetes 39, 775–781.
38Meier U & Gressner AM (2004) Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 50, 1511–1525.
39Seoane LM, Lopez M, Tovar S, Casanueva FF, Senaris R & Dieguez C (2003) Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. Endocrinology 144, 544–551.
40Callahan HS, Cummings DE, Pepe MS, Breen PA, Matthys CC & Weigle DS (2004) Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans. J Clin Endocrinol Metab 89, 1319–1324.
41Murakami N, Hayashida T, Kuroiwa T, Nakahara K, Ida T, Mondal MS, Nakazato M, Kojima M & Kangawa K (2002) Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats. J Endocrinol 174, 283–288.
42Hotta M, Ohwada R, Katakami H, Shibasaki T, Hizuka N & Takano K (2004) Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa. J Clin Endocrinol Metab 89, 5707–5712.
43Thompson NM, Gill DA, Davies R, Loveridge N, Houston PA, Robinson IC & Wells T (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 145, 234–242.
44Koutkia P, Canavan B, Breu J, Johnson ML & Grinspoon SK (2004) Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men. Am J Physiol Endocrinol Metab 287, E506–E512.
45Paik HS & Yearick ES (1978) The influence of dietary fat and meal frequency on lipoprotein lipase and hormone-sensitive lipase in rat adipose tissue. J Nutr 108, 1798–1805.
46Toschke AM, Kuchenhoff H, Koletzko B & von Kries R (2005) Meal frequency and childhood obesity. Obes Res 13, 1932–1938.
47Hampl JS, Heaton CL & Taylor CA (2003) Snacking patterns influence energy and nutrient intakes but not body mass index. J Hum Nutr Diet 16, 3–11.
48Drummond S, Crombie N & Kirk T (1996) A critique of the effects of snacking on body weight status. Eur J Clin Nutr 50, 779–783.
49Gatenby SJ (1997) Eating frequency: methodological and dietary aspects. Br J Nutr 77, Suppl. 1, S7–S20.
50LeBlanc J, Mercier I & Nadeau A (1993) Components of postprandial thermogenesis in relation to meal frequency in humans. Can J Physiol Pharmacol 71, 879–883.
51de Bont AJ, Romsos DR, Tsai AC, Waterman RA & Leveille GA (1975) Influence of alterations in meal frequency on lipogenesis and body fat content in the rat. Proc Soc Exp Biol Med 149, 849–854.
52Molon-Noblot S, Keenan KP, Coleman JB, Hoe CM & Laroque P (2001) The effects of ad libitum overfeeding and moderate and marked dietary restriction on age-related spontaneous pancreatic islet pathology in Sprague-Dawley rats. Toxicol Pathol 29, 353–362.
53Garrow JS, Durrant M, Blaza S, Wilkins D, Royston P & Sunkin S (1981) The effect of meal frequency and protein concentration on the composition of the weight lost by obese subjects. Br J Nutr 45, 5–15.
54Verboeket-van de Venne WP & Westerterp KR (1993) Frequency of feeding, weight reduction and energy metabolism. Int J Obes Relat Metab Disord 17, 31–36.