Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 7
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Kirkegaard, Ellen Svensson, My Strandhave, Charlotte Schmidt, Erik Berg Jørgensen, Kaj Anker and Christensen, Jeppe Hagstrup 2012. Marine n-3 fatty acids, atrial fibrillation and QT interval in haemodialysis patients. British Journal of Nutrition, Vol. 107, Issue. 06, p. 903.


    Oikonomou, E. Chrysohoou, C. Tsiachris, D. Vogiatzi, G. Gialafos, E. Marinos, G. Tsitsinakis, G. Dimitriadis, K. Tousoulis, D. Pitsavos, C. and Stefanadis, C. 2011. Gender variation of exercise-induced anti-arrhythmic protection: the Ikaria Study. QJM, Vol. 104, Issue. 12, p. 1035.


    Bays, Harold E Tighe, Ann P Sadovsky, Richard and Davidson, Michael H 2008. Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications. Expert Review of Cardiovascular Therapy, Vol. 6, Issue. 3, p. 391.


    Busstra, M.C Geelen, A Feskens, E.J Hartog, R.J.M and Veer, P. van 't 2008. Design and Development of Digital Learning Material for Applied Data Analysis. The American Statistician, Vol. 62, Issue. 4, p. 329.


    Tziomalos, Konstantinos Athyros, Vasilios G. Karagiannis, Asterios and Mikhailidis, Dimitri P. 2008. Omega-3 fatty acids: How can they be used in secondary prevention?. Current Atherosclerosis Reports, Vol. 10, Issue. 6, p. 510.


    Tuncay, Erkan Seymen, A. Aytac Tanriverdi, Evrim Yaras, Nazmi Tandogan, Berivan Ulusu, N. Nuray and Turan, Belma 2007. Gender related differential effects of Omega-3E treatment on diabetes-induced left ventricular dysfunction. Molecular and Cellular Biochemistry, Vol. 304, Issue. 1-2, p. 255.


    Mozaffarian, Dariush Prineas, Ronald J. Stein, Phyllis K. and Siscovick, David S. 2006. Dietary Fish and n-3 Fatty Acid Intake and Cardiac Electrocardiographic Parameters in Humans. Journal of the American College of Cardiology, Vol. 48, Issue. 3, p. 478.


    ×

Effect of n-3 fatty acids from fish on electrocardiographic characteristics in patients with frequent premature ventricular complexes

  • Anouk Geelen (a1), Peter L. Zock (a1), Ingeborg A. Brouwer (a1), Martijn B. Katan (a1), Jan A. Kors (a2), Henk J. Ritsema van Eck (a2) and Evert G. Schouten (a1)
  • DOI: http://dx.doi.org/10.1079/BJN20051429
  • Published online: 01 March 2007
Abstract

n-3 Fatty acids may protect against heart disease mortality by preventing fatal arrhythmias. Underlying effects on cardiac electrophysiology may be demonstrable in the standard electrocardiogram (ECG) and provide insight into the mechanism. Therefore, we investigated the effect of dietary n-3 fatty acids on heart-rate-corrected QT interval, T-loop width, spatial QRS-T angle and spatial U-wave amplitude in patients with frequent premature ventricular complexes. Seventy-four patients received either capsules providing 1·5 g n-3 fatty acids daily or placebo for approximately 14 weeks. ECG were recorded before and after intervention. None of the ECG characteristics was significantly affected by treatment. The present results do not provide additional support for the hypothesis that n-3 fatty acids prevent cardiac arrhythmia through generic electrophysiologic effects on heart cell membranes. However, we cannot exclude effects of n-3 fatty acids on clinical relevant endpoints that are not easily detected by prior changes in the ECG.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effect of n-3 fatty acids from fish on electrocardiographic characteristics in patients with frequent premature ventricular complexes
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Effect of n-3 fatty acids from fish on electrocardiographic characteristics in patients with frequent premature ventricular complexes
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Effect of n-3 fatty acids from fish on electrocardiographic characteristics in patients with frequent premature ventricular complexes
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Anouk Geelen, fax +31 317 483342, email anouk.geelen@wur.nl
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

CM Albert , H Campos , MJ Stampfer , PM Ridker , JE Manson , WC Willett & J Ma (2002) Blood levels of long-chain n -3 fatty acids and the risk of sudden death. N Engl J Med 346, 11131118.

GE Billman , JX Kang & A Leaf (1997) Prevention of ischemia-induced cardiac sudden death by n -3 polyunsaturated fatty acids in dogs. Lipids 32, 11611168.

IA Brouwer , PL Zock , EF Wever , RN Hauer , AJ Camm , D Bocker , P Otto-Terlouw , MB Katan & EG Schouten (2003) Rationale and design of a randomised controlled clinical trial on supplemental intake of n -3 fatty acids and incidence of cardiac arrhythmia: SOFA. Eur J Clin Nutr 57, 13231330.

ML Burr , WP Ashfield , FDJ Dunstan , AM Fehily , P Breay , T Ashton , PC Zotos , NAA Haboubi & PC Elwood (2003) Lack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clin Nutr 57, 193200.

JG Cleland , N Freemantle , G Kaye , M Nasir , P Velavan , K Lalukota , T Mudawi , R Shelton , AL Clark & AP Coletta (2004) Clinical trials update from the American Heart Association meeting: Omega-3 fatty acids and arrhythmia risk in patients with an implantable defibrillator, ACTIV in CHF, VALIANT, the Hanover autologous bone marrow transplantation study, SPORTIF V, ORBIT and PAD and DEFINITE. Eur J Heart Fail 6, 109115.

MC de-Bruyne AW Hoes , JA Kors , A Hofman , JH van-Bemmel & DE Grobbee (1999) Prolonged QT interval predicts cardiac and all-cause mortality in the elderly. The Rotterdam Study. Eur Heart J 20, 278284.

JM Dekker , EG Schouten , P Klootwijk , J Pool & D Kromhout (1994) Association between QT interval and coronary heart disease in middle-aged and elderly men. The Zutphen Study. Circulation 90, 779785.

GISSI-Prevenzione Investigators (1999) Dietary supplementation with n -3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto miocardico. Lancet 354, 447455.

I Kardys , JA Kors , I van der Meer , A Hofman , DA van der Kuip & JC Witteman (2003) Spatial QRS-T angle predicts cardiac death in a general population. Eur Heart J 24, 13571364.

JA Kors , G van-Herpen & JH van-Bemmel (1999) QT dispersion as an attribute of T-loop morphology. Circulation 99, 14581463.

R Marchioli , F Barzi , E Bomba , (2002) Early protection against sudden death by n -3 polyunsaturated fatty acids after myocardial infarction–time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico (GISSI)-Prevenzione. Circulation 105, 18971903.

HJ Ritsema van Eck (2004) Fiducial segment averaging to improve cardiac time interval estimates. J Electrocardiol 35, Suppl. 8993.

EG Schouten , JM Dekker , P Meppelink , FJ Kok , JP Vandenbroucke & J Pool (1991) QT interval prolongation predicts cardiovascular mortality in an apparently healthy population. Circulation 84, 15161523.

M Trusz-Gluza , K Szydlo , P Kukla , I Wozniak-Skowerska , A Filipecki , E Peszek & E Wojcik (2002) Postextrasystolic repolarization abnormalities in ST-U segment in patients with ventricular arrhythmias. Ann Noninvasive Electrocardiol 7, 1721.

PL Zock , RP Mensink , J Harryvan , JH de-Vries & MB Katan (1997) Fatty acids in serum cholesteryl esters as quantitative biomarkers of dietary intake in humans. Am J Epidemiol 145, 11141122.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: