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Effect of potato on acid–base and mineral homeostasis in rats fed a high-sodium chloride diet

  • Agnés Narcy (a1), Laetitia Robert (a1), Andrzej Mazur (a1), Christian Demigné (a1) and Christian Rémésy (a1)...
Abstract

Excessive dietary NaCl in association with a paucity of plant foods, major sources of K alkaline salts, is a common feature in Western eating habits which may lead to acid–base disorders and to Ca and Mg wasting. In this context, to evaluate the effects of potato, rich in potassium citrate, on acid–base homeostasis and mineral retention, Wistar rats were fed wheat starch (WS) or cooked potato (CP) diets with a low (0·5 %) or a high (2 %) NaCl content during 3 weeks. The replacement of WS by CP in the diets resulted in a significant urinary alkalinisation (pH from 5·5 to 7·3) parallel to a rise in citrate and K excretion. Urinary Ca and Mg elimination represented respectively 17 and 62% of the daily absorbed mineral in rats fed the high-salt WS diet compared with 5 and 28% in rats fed the high-salt CP diet. The total SCFA concentration in the caecum was 3-fold higher in rats fed the CP diets compared with rats fed the WS diets, and it led to a significant rise in Ca and Mg intestinal absorption (Ca from 39 to 56 %; Mg from 37 to 60 %). The present model of low-grade metabolic acidosis indicates that CP may be effective in alkalinising urine, enhancing citrate excretion and ameliorating Ca and Mg balance.

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Corresponding author
*Corresponding author: Dr Christian Rémésy, fax +33 4 73 62 46 38, email remesy@clermont.inra.fr
References
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Ambuhl, PM, Zajicek, HK, Wang, H, Puttaparthi, K & Levi, MRegulation of renal phosphate transport by acute and chronic metabolic acidosis in the rat. Kidney Int 1998 53, 12881298.
Antoniou, LD, Eisner, GM, Slotkoff, LM & Lilienfield, LSRelationship between sodium and calcium transport in the kidney. J Lab Clin Med 1969 74, 410420.
Appel, LJ, Moore, TJ, Obarzanek, Eet al.. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 1997 336, 11171124.
Aruga, S, Wehrli, S, Kaissling, B, Moe, OW, Preisig, PA, Pajor, AM & Alpern, RJChronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidney. Kidney Int 2000 58, 206215.
Barzel, USAnion effects on calcium metabolism. J Bone Miner Res 1997 12, 298299.
Brennan, S, Hering-Smith, K & Hamm, LLEffect of pH on citrate reabsorption in the proximal convoluted tubule. Am J Physiol 1988 255, F301F306.
Brunette, MG, Mailloux, J & Lajeunesse, DCalcium transport through the luminal membrane of the distal tubule. I. Interrelationship with sodium. Kidney Int 1992 41, 281288.
Buclin, T, Cosma, M, , , Appenzeller, M, Jacquet, AF, Decosterd, LA, Biollaz, J & Burckhardt, PDiet acids and alkalis influence calcium retention in bone. Osteoporos Int 2001 12, 493499.
Chan, EL & Swaminathan, RThe effect of high protein and high salt intake for 4 months on calcium and hydroxyproline excretion in normal and oophorectomized rats. J Lab Clin Med 1994 124, 3741.
Cohen, AJ & Roe, FJReview of risk factors for osteoporosis with particular reference to a possible aetiological role of dietary salt. Food Chem Toxicol 2000 38, 237253.
Coudray, C, Demigne, C & Rayssiguier, YEffects of dietary fibers on magnesium absorption in animals and humans. J Nutr 2003 133, 14.
Creedon, A & Cashman, KDThe effect of high salt and high protein intake on calcium metabolism, bone composition and bone resorption in the rat. Br J Nutr 2000 84, 4956.
Dai, LJ, Friedman, PA & Quamme, GAAcid-base changes alter Mg2+ uptake in mouse distal convoluted tubule cells. Am J Physiol 1997 272, F759F766.
Dai, LJ, Ritchie, G, Kerstan, D, Kang, HS, Cole, DE & Quamme, GAMagnesium transport in the renal distal convoluted tubule. Physiol Rev 2001 81, 5184.
Eaton, SB, Eaton, SB III & Konner, MJPaleolithic nutrition revisited: a twelve-year retrospective on its nature and implications. Eur J Clin Nutr 1997 51, 207216.
Eaton, SB, Eaton, SB III, Konner, MJ & Shostak, MAn evolutionary perspective enhances understanding of human nutritional requirements. J Nutr 1996 126, 17321740.
Frassetto, LA, Morris, RC Jr & Sebastian, AEffect of age on blood acid-base composition in adult humans: role of age-related renal functional decline. Am J Physiol 1996 271, F1114F1122.
Frassetto, L, Morris, RC Jr, Sellmeyer, DE, Todd, K & Sebastian, ADiet, evolution and aging – the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Eur J Nutr 2001 40, 200213.
Frassetto, LA, Nash, E, Morris, RC Jr & Sebastian, AComparative effects of potassium chloride and bicarbonate on thiazideinduced reduction in urinary calcium excretion. Kidney Int 2000 58, 748752.
Ginty, F, Flynn, A & Cashman, KDThe effect of dietary sodium intake on biochemical markers of bone metabolism in young women. Br J Nutr 1998 79, 343350.
Goulding, A & Gold, EEffects of dietary sodium chloride loading on parathyroid function, 1,25-dihydroxyvitamin D, calcium balance, and bone metabolism in female rats during chronic prednisolone administration. Endocrinology 1986 119, 21482154.
Harvey, JA, Zobitz, MM & Pak, CYCalcium citrate: reduced propensity for the crystallization of calcium oxalate in urine resulting from induced hypercalciuria of calcium supplementation. J Clin Endocrinol Metab 1985 61, 12231225.
Itoh, R & Suyama, YSodium excretion in relation to calcium and hydroxyproline excretion in a healthy Japanese population. Am J Clin Nutr 1996 63, 735740.
Kurtz, TW & Morris, RC JrDietary chloride as a determinant of disordered calcium metabolism in salt-dependent hypertension. Life Sci 1985 36, 921929.
Lemann>, JRelationship between urinary calcium and net acid excretion as determined by dietary protein and potassium: a review. Nephron 1999 81, Suppl. 1, 1825.
Lemann, J Jr, Gray, RW & Pleuss, JAPotassium bicarbonate, but not sodium bicarbonate, reduces urinary calcium excretion and improves calcium balance in healthy men. Kidney Int 1989 35, 688695.
Lemann, J Jr, Pleuss, JA, Gray, RW & Hoffmann, RGPotassium administration reduces and potassium deprivation increases urinary calcium excretion in healthy adults [corrected]. Kidney Int 1991 39, 973983.
Lietz, G, Avenell, A & Robins, SPShort-term effects of dietary sodium intake on bone metabolism in postmenopausal women measured using urinary deoxypyridinoline excretion. Br J Nutr 1997 78, 7382.
Lutz, T & Scharrer, EEffect of short-chain fatty acids on calcium absorption by the rat colon. Exp Physiol 1991 76, 615618.
Macdonald, HM, New, SA, Fraser, WD, Campbell, MK & Reid, DMLow dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women. Am J Clin Nutr 2005 81, 923933.
Macdonald, HM, New, SA, Golden, MH, Campbell, MK & Reid, DMNutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids. Am J Clin Nutr 2004 79, 155165.
Marangella, M, Di Stefano, M, Casalis, S, Berutti, S, D'Amelio, P & Isaia, GCEffects of potassium citrate supplementation on bone metabolism. Calcif Tissue Int 2004 74, 330335.
Massey, LK & Whiting, SJDietary salt, urinary calcium, and bone loss. J Bone Miner Res 1996 11, 731736.
Mathers, JC & Dawson, LDLarge bowel fermentation in rats eating processed potatoes. Br J Nutr 1991 66, 313329.
Matkovic, V, Ilich, JZ, Andon, MB, Hsieh, LC, Tzagournis, MA, Lagger, BJ & Goel, PKUrinary calcium, sodium, and bone mass of young females. Am J Clin Nutr 1995 62, 417425.
Maurer, M, Riesen, W, Muser, J, Hulter, HN & Krapf, RNeutralization of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humans. Am J Physiol 2003 284, F32F40.
Melnick, JZ, Preisig, PA, Moe, OW, Srere, P & Alpern, RJRenal cortical mitochondrial aconitase is regulated in hypo- and hypercitraturia. Kidney Int 1998 54, 160165.
Melnick, JZ, Srere, PA, Elshourbagy, NA, Moe, OW, Preisig, PA & Alpern, RJAdenosine triphosphate citrate lyase mediates hypocitraturia in rats. J Clin Invest 1996 98, 23812387.
Meschi, T, Maggiore, U, Fiaccadori, E, Schianchi, T, Bosi, S, Adorni, G, Ridolo, E, Guerra, A, Allegri, F, Novarini, A & Borghi, LThe effect of fruits and vegetables on urinary stone risk factors. Kidney Int 2004 66, 24022410.
Morris, RC Jr, Schmidlin, O, Tanaka, M, Forman, A, Frassetto, L & Sebastian, ADiffering effects of supplemental KCl and KHCO3: pathophysiological and clinical implications. Semin Nephrol 1999 19, 487493.
Nellans, HN & Goldsmith, RSTransepithelial calcium transport by rat cecum: high-efficiency absorptive site. Am J Physiol 1981 240, G424G431.
New, SAIntake of fruit and vegetables: implications for bone health. Proc Nutr Soc 2003 62, 889899.
New, SA, Bolton-Smith, C, Grubb, DA & Reid, DMNutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr 1997 65, 18311839.
Pajor, AMSodium-coupled transporters for Krebs cycle intermediates. Annu Rev Physiol 1999 61, 663682.
Prynne, CJ, Ginty, F, Paul, AA, Bolton-Smith, C, Stear, SJ, Jones, SC & Prentice, ADietary acid-base balance and intake of bone-related nutrients in Cambridge teenagers. Eur J Clin Nutr 2004 58, 1558.
Remer, T & Manz, FPotential renal acid load of foods and its influence on urine pH. J Am Diet Assoc 1995 95, 791–47.
Remesy, C & Demigne, CDetermination of volatile fatty acids in plasma after ethanolic extraction. Biochem J 1974 141, 8591.
Ruano-Ravina, A, Figueiras, A, Dosil-Diaz, O, Barreiro-Carracedo, A & Barros-Dios, JMA population-based case-control study on fruit and vegetable intake and lung cancer: a paradox effect?. Nutr Cancer 2002 43, 4751.
Sabboh, H, Horcajada, MN, Coxam, V, Tressol, JC, Besson, C, Rémésy, C & Demigné, CEffect of potassium salts in rats adapted to an acidogenic high-sulfur amino acid diet. Br J Nutr 2005 94, 17.
Sakhaee, K, Alpern, R, Jacobson, HR & Pak, CYContrasting effects of various potassium salts on renal citrate excretion. J Clin Endocrinol Metab 1991 72, 396400.
Sebastian, A, Frassetto, LA, Sellmeyer, DE, Merriam, RL & Morris, RC JrEstimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors. Am J Clin Nutr 2002 76, 13081316.
Sebastian, A, Harris, ST, Ottaway, JH, Todd, KM & Morris, RC JrImproved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med 1994 330, 17761781.
Sellmeyer, D, Schloetter, M & Sebastian, APotassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet. J Clin Endocrinol Metab 2002 87, 20082012.
Shortt, C & Flynn, ASodium-calcium inter-relationships with specific reference to osteoporosis. Nutr Res Rev 1990 3, 101115.
Shortt, C & Flynn, AEffect of dietary lactose on salt-mediated changes in mineral metabolism and bone composition in the rat. Br J Nutr 1991 66, 7381.
Simpson, DPCitrate excretion: a window on renal metabolism. Am J Physiol 1983 244, F223F234.
Trinidad, P, Wolever, T & Thompson, LInteractive effects of calcium and short chain fatty acids on absorption in the distal colon of man. Nutr Res Rev 1993 13, 417425.
Tucker, KL, Hannan, MT, Chen, H, Cupples, LA, Wilson, PWF & Kiel, DPPotassium, magnesium and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 1999 69, 727736.
Vormann, J & Daniel, HThe role of nutrition in human acidbase homeostasis. Eur J Nutr 2001 40, 187188.
Whiting, SJ & Cole, DEEffect of dietary anion composition on acid-induced hypercalciuria in the adult rat. J Nutr 1986 116, 388394.
Wiederkehr, M & Krapf, RMetabolic and endocrine effects of metabolic acidosis in humans. Swiss Med Wkly 2001 131, 127132.
Yeh, BI, Sun, TJ, Lee, JZ, Chen, HH & Huang, CLMechanism and molecular determinant for regulation of rabbit transient receptor potential type 5 (TRPV5) channel by extracellular pH. J Biol Chem 2003 278, 5104451052.
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