Skip to main content
×
Home
    • Aa
    • Aa

The effect of test meal monounsaturated fatty acid: saturated fatty acid ratio on postprandial lipid metabolism

  • Helen M. Roche (a1), Antonis Zampelas (a2), Kim G. Jackson (a3), Christine M. Williams (a3) and Michael J. Gibney (a1)...
Abstract

Epidemiological evidence shows that a diet high in monounsaturated fatty acids (MUFA) but low in saturated fatty acids (SFA) is associated with reduced risk of CHD. The hypocholesterolaemic effect of MUFA is known but there has been little research on the effect of test meal MUFA and SFA composition on postprandial lipid metabolism. The present study investigated the effect of meals containing different proportions of MUFA and SFA on postprandial triacylglycerol and non-esterified fatty acid (NEFA) metabolism. Thirty healthy male volunteers consumed three meals containing equal amounts of fat (40g), but different proportions of MUFA (12, 17 and 24% energy) in random order. Postprandial plasma triacylglycerol, apolipoprotein B-48, cholesterol, HDL-cholesterol, glucose and insulin concentrations and lipoprotein lipase (EC 3.1.1.34) activity were not significantly different following the three meals which varied in their levels of SFA and MUFA. There was a significant difference in the postprandial NEFA response between meals. The incremental area under the curve of postprandial plasma NEFA concentrations was significantly (P = 0·03) lower following the high-MUFA meal. Regression analysis showed that the non-significant difference in fasting NEFA concentrations was the most important factor determining difference between meals, and that the test meal MUFA content had only a minor effect. In conclusion, varying the levels of MUFA and SFA in test meals has little or no effect on postprandial lipid metabolism.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The effect of test meal monounsaturated fatty acid: saturated fatty acid ratio on postprandial lipid metabolism
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      The effect of test meal monounsaturated fatty acid: saturated fatty acid ratio on postprandial lipid metabolism
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      The effect of test meal monounsaturated fatty acid: saturated fatty acid ratio on postprandial lipid metabolism
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Helen M. Roche, fax +353 1 454 2043, email hmroche@tcd.ie
References
Hide All
Binnert C, Pachiaudi C, Beylot M, Croset M, Cohen R, Riou JP & Laville M (1996) Metabolic fate of an oral long-chain triglyceride load in humans. American Journal of Physiology 270, E445E450.
Byrne CD, Brindle NPJ, Wang TWM & Hales CN (1991) Interaction of non-esterified fatty acid and insulin in control of triacylglycerol secretion by Hep G2 cells. Biochemical Journal 280, 99104.
Cohen JC & Schall R (1988) Reassessing the effects of simple carbohydrates on the serum triglyceride responses to fat meals. American Journal of Clinical Nutrition 48, 10311034.
Coifferier E, Paris R & Lecerf J (1987) Effects of dietary saturated and polyunsaturated fat on lipoprotein lipase and hepatic triglyceride lipase activity. Comparative Biochemistry and Physiology 88B, 187192.
Coppack SW, Jensen MD & Miles JM (1994) In vivo regulation of lipolysis in humans. Journal of Lipid Research 35, 177193.
De Bruin TWA, Brouwer CB, van Linde-Sibenius M, Jansen H & Erkelens DW (1993) Different postprandial metabolism of olive oil and soybean oil: a possible mechanism of the high-density lipoprotein conserving effect of olive oil. American Journal of Clinical Nutrition 58, 477483.
Fielding BA, Callow J, Owen RM, Samara JS, Matthews DR & Frayn KN (1996) Postprandial lipaemia: the origin of an early peak studied by specific fatty acid intake during sequential meals. American Journal of Clinical Nutrition 63, 3641.
Frayn KN, Shadid S, Hamlani R, Humphreys SM, Clark ML, Fielding BA, Boland O & Coppack SW (1994) Regulation of fatty acid movement in human adipose tissue in the post-absorptive-to-postprandial transition. American Journal of Physiology 266, E308E317.
Frayn KN, Wiliams CM & Amer P (1996) Are increased plasma non-esterified fatty acid concentrations a risk marker for coronary heart disease and other chronic diseases? Clinical Science 90, 243253.
Gregory J, Foster K, Tyler H & Wiseman M (1990) The Dietary and Nutritional Survey of British Adults. London: H.M. Stationery Office.
Groot PHE, van Stiphout WAHJ, Krauss XH, Jansen H, van Tol A, van Ramnhorst E, Chin-On S, Hofman A, Cresswell SR & Havekes L (1991) Postprandial lipoprotein metabolism in normolipidemic men with and without coronary heart disease. Arteriosclerosis and Thrombosis 11, 653662.
Grundy SM & Mok HYI (1976) Chylomicron clearance in normal and hyperlipidemic men. Metabolism 25, 12251239.
Jeppsen J, Chen Y-DI, Zhou M-Y, Wang T & Reaven GM (1995) Effect of variations in oral fat and carbohydrate: effects of fructose. American Journal of Clinical Nutrition 62, 787791.
Kafatos A & Mamalakis G (1993) Changing patterns of fat intake in Crete. European Journal of Clinical Nutrition 47, S21S24.
Karpe F, Steiner G, Uffelman K, Olivecrona T & Hamsten A (1994) Postprandial lipoproteins and progression of coronary atherosclerosis. Atherosclerosis 106, 8397.
Keys A, Menotti A, Karvonen MJ, Aravanis C, Blackburn H, Buzina R, Djordjevic BS, Doutas AS, Fidanza I, Keys MH, Kromhout D, Nedeljkovic S, Punsar S, Seccareccia F & Toshima H (1986) The diet and 15-year death rate in the seven countries study. American Journal of Epidemiology 124, 903915.
Lovegrove JA, Isherwood SG, Jackson KG, Williams CM & Gould BJ (1996) Quantitation of apolipoprotein B-48 in triacylglycerol-rich lipoproteins by a specific enzyme-linked immunoabsorbent assay. Biochimica et Biophysica Acta 1301, 221229.
Matthews JNS, Altman DG, Campbell MJ & Royson P (1990) Analysis of serial measurements in medical research. British Medical Journal 300, 230235.
Mensink RP (1992) Dietary monounsaturated fatty acids and serum lipoprotein levels in healthy subjects. Atherosclerosis 110, 6568.
Mensink RP & Katan MB (1989) Effect of a diet enriched with monounsaturated or polyunsaturated fatty acids on levels of low-density lipoprotein cholesterol in healthy women and men. New England Journal of Medicine 321, 436441.
Nilsson-Ehle P & Schotz MC (1976) A stable radioactive substrate emulsion for assay of lipoprotein lipase. Journal of Lipid Research 17, 536541.
Patsch JR, Miesenbock G, Hopferwieser T, Muhlberger V, Knapp E, Dunn JK, Gotto AM & Patsch W (1993) Relation of triglyceride metabolism and coronary artery disease. Arteriosclerosis and Thrombosis 12, 13361345.
Peel AS, Zampelas A, Williams CM & Gould BJ (1993) A novel antiserum specific to apolipoprotein B-48: application in the investigation of postprandial lipidaemia in humans. Clinical Science 53, 521524.
Roche HM & Gibney MJ (1995) Postprandial triacylglycerolae-mia–nutritional implications. Progress in Lipid Research 34, 249266.
Roche HM & Gibney MJ (1996) Postprandial triacylglycerolae-mia: the effect of low-fat dietary treatment with and without fish oil supplementation. European Journal of Clinical Nutrition 50, 249266.
Schneeman BO, Kotite L, Todd KM & Havel RJ (1993) Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans. Proceedings of the National Academy of Sciences USA 90, 20692073.
Shishehbor F (1997) Nutritional factors affecting postprandial lipaemia. PhD Thesis, University of Dublin.
Snedecor GW & Cochran WG (1989) Analysis of variance. In Statistical Methods, 8th ed., pp. 217246. Ames, IA: Iowa State University Press.
Stampfer MJ, Krauss RM, Ma J, Blanche PJ, Holl LG, Sacks FM & Hennekens CH (1996) A prospective study of triglyceride level, low-density liporotein particle diameter, and risk of myocardial infarction. Journal of the American Medical Association 276, 882888.
Weintraub MS, Zechner R, Brown A, Eisenberg S & Breslow JL (1988) Dietary polyunsaturated fats of the ω-6 and ω-3 series reduce postprandial lipoprotein levels. Journal of Clinical Investigation 82, 18841893.
Zampelas A, Peel AS, Gould BJ, Wright J & Williams CM (1994) Polyunsaturated fatty acids of the n-6 and n-3 series: effects on postprandial lipid and apolipoprotein levels in healthy men. European Journal of Clinical Nutrition 48, 842848.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 3
Total number of PDF views: 58 *
Loading metrics...

Abstract views

Total abstract views: 77 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 22nd October 2017. This data will be updated every 24 hours.