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Effects of dietary n-3 polyunsaturated fatty acids from plant and marine origin on platelet aggregation in healthy elderly subjects

  • A. G. C. L Wensing (a1), R. P. Mensink (a1) and G. Hornstra (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114599001361
  • Published online: 01 March 2007
Abstract

In the present intervention study we compared the effects of α-linolenic acid with those of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on platelet aggregation in vitro and ex vivo in healthy non-institutionalized elderly subjects. We also compared the effects of α-linolenic acid on platelet aggregation in elderly subjects with those in younger volunteers. During a run-in period of 3 weeks all subjects (thirty-eight elderly (> 60 years) and twelve younger volunteers (< 35 years)) received a diet rich in oleic acid. For the next 6 weeks the elderly subjects received a diet rich in oleic acid (n 11), α-linolenic acid (n 14) (6·8 g/d) or EPA/DHA (n 13) (1·05 g EPA plus 0·55 g DHA). The younger subjects were given a diet rich in α-linolenic acid. The diets did not affect ADP- or collagen-induced platelet aggregation in vitro in either platelet-rich plasma or whole blood. The ex vivo platelet aggregation as measured with filtragometry was significantly decreased in the elderly group that received EPA/DHA compared with the α-linolenic acid (P = 0·006) and the oleic acid (P = 0·005) diet groups. Effects of α-linolenic acid were not age-dependent. Our results suggest that α-linolenic acid and EPA/DHA do not change in vitro platelet aggregation. Compared with oleic acid, EPA/DHA, but not α-linolenic acid, favourably affects ex vivo platelet aggregation in healthy elderly subjects.

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Corresponding author
*Corresponding author: Dr Ronald Mensink, fax +31 43 367 0976, email R.Mensink@HB.Unimaas.nl
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R Abbate , S Favilla , M Boddi , G Costanzo & D Prisco (1986) Factors influencing platelet aggregation in whole blood. American Journal of Clinical Pathology 86, 9196.

EG Bligh & WJ Dyer (1959) A rapid method for total lipid extraction and purification. Canadian Journal of Biochemistry and Physiology 37, 911917.

G Debry & X Pelletier (1991) Physiological importance of ?-3/?-6 polyunsaturated fatty acids in man. An overview of still unresolved and controversial questions. Experienta 47, 172178.

G Hornstra (1989) The significance of fish and fish-oil enriched food for prevention and therapy of ischaemic cardiovascular disease. In The Role of Fats in Human Nutrition, pp. 151235 [A Vergroesen and M Crawford , editors]. San Diego, CA: Academic Press.

JE Kinsella , KS Broughton & JW Whelan (1990 a) Dietary unsaturated fatty acids: interactions and possible needs in relation to eicosanoid synthesis. Journal of Nutritional Biochemistry 1, 123141.

TW Meade , MV Vickers , SG Thompson , Y Stirling , AP Haines & GJ Miller (1985) Epidemiological characteristics of platelet aggregability. British Medical Journal 290, 428432.

E Vericel , M Croset , P Sedivy , P Courpron , M Dechavanne & M Lagarde (1988) Platelets and ageing. 1-Aggregation, arachidonate metabolism and antioxidant status. Thrombosis Research 49, 331342.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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