Skip to main content
×
Home
    • Aa
    • Aa

Effects of double-blind controlled calcium supplementation on calcium absorption in chinese children measured with stable isotopes (42Ca and 44Ca)

  • Warren T. K. Lee (a1), Sophie S. F. Leung (a1), Y. C. Xu (a2), S. H. Wang (a2), W. P. Zeng (a3), Joseph Lau (a4) and Susan J. Fairweather-Tait (a5)...
Abstract

A double-blind controlled Ca supplementation trial was conducted for 6 months in thirty-four 7-year-old Chinese children from Hongkong and Jiangmen, China. The children were randomly allocated to the study group (n 17) or control group (n 17), and a CaCO3 tablet (300 mg Ca) or a placebo tablet was taken daily. True fractional Ca absorption (TFCA) was evaluated before and after the trial using stable isotopes: 8 mg44Ca mixed in 100 g chocolate milk was given after an intravenous injection of 0·75 mg 42Ca. There was no significant difference in baseline TFCA between the study group (60·6 (SD 11·4)%) and the controls (58·2 (SD 9.0)% P = 0·55). Serum 25-hydroxycholecalciferol levels were comparable between the two groups (P = 0·71). After 6 months, TFCA of the study group (55·6 (SD 12·7)%) was significantly lower than that of the controls (64·3 (SD 10·7)% P = 0·015). By comparing the individual changes in TFCA after the trial between the two groups there was a non-significant reduction in TFCA (5·03 (SD 12·4)% P = 0·11, Wilcoxon signed-rank test) in the study group (60·6–55·6%), whereas a significant increase in TFCA (6·17(SD 7·7)% P = 0·004, Wilcoxon signed-rank test) was observed in the controls (58·2–64·3%). The differential in TFCA between the two groups after 6 months was significantly different (P = 0·001), and remained significant after adjustment for baseline dietary intakes, weight and height by multiple-regression analysis (P = 0·003). If the mechanism of TFCA from chocolate milk in response to the treatment effects is similar to that from the total diet, then our results suggest that children with adequate vitamin D status can adapt to a change in Ca intake by adjusting the efficiency of TFCA. In corollary, children on habitually-low Ca diets have a higher TFCA than the counterparts with higher Ca diets.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effects of double-blind controlled calcium supplementation on calcium absorption in chinese children measured with stable isotopes (42Ca and 44Ca)
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Effects of double-blind controlled calcium supplementation on calcium absorption in chinese children measured with stable isotopes (42Ca and 44Ca)
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Effects of double-blind controlled calcium supplementation on calcium absorption in chinese children measured with stable isotopes (42Ca and 44Ca)
      Available formats
      ×
Copyright
References
Hide All
Begum A. & Pereira S. M. (1969). Calcium balance studies on children accustomed to low calcium intakes. British Journal of Nutrition 23, 905911.
Bingham S. A. (1987). The dietary assessment of individuals; methods, accuracy, new techniques and recommendations. Nutrition Abstracts and Reviews 57, 705742.
Burke B. S. (1947). The dietary history as a tool in research. Journal of the American Dietetic Association 23, 10411046.
Chan E. P. L., Lau E., Shek C. C., MacDonald D., Woo J., hung P. C. & Swaminathan R. (1992). Age-related changes in bone density, serum parathyroid hormone, calcium absorption and other indices of bone metabolism in Chinese women. Clinical Endocrinology 36, 375381.
Chen C. (1986). The national nutrition survey in China, 1982; summary results (1986). Food and Nutrition 12, 5860.
Church C. F. & Church H. N. (1975). Food Values of Portions Commonly Used. Philadelphia: J. B. Lippincott co.
Department of Health (1972). Food Composition Table for Use in South East Asia. Washington DC: US Department of Health, Education and Welfare.
Eyberg C. J., Pettifor J. M. & Moodley G. (1986). Dietary calcium intake in rural black South African children. The relationship between calcium intake and calcium nutritional status. Human Nutrition: Clinical Nutrition 40C, 6974.
Fairweather-Tait S. J., Johnson A., Eagles J., Ganatra S., Kennedy H. & Gurr M. I. (1989). Studies on calcium absorption from milk using double-label stable isotope technique. British Journal of Nutrition 62, 379388.
Food and, Agriculture Organization/World, Health Organization Expert Group (1962). Calcium requirements. FAO Nutrition Meetings Report Series no. 230. Rome: FAO.
Grindulis H., Scott P. H. & Belton N. R. (1986). Combined deficiency of iron and vitamin D in Asian toddlers. Archives of Disease in Childhood 61, 843848.
Heaney R. P., Saville P. D. & Recker R. R. (1975). Calcium absorption as a function of calcium intake. Journal of Laboratory Clinical Medicine 85, 881887.
Hegsted D. M., Moscoso I., Carlos Collazos C. H. (1952). A study of the minimum calcium requirements of adult. Journal of Nutrition 48, 181201.
Heumann K. G. (1988). Isotope dilution mass spectrometry. In Inorganic Mass Spectrometry, pp. 301376 [Adams F., Gijbels R., van Grieken R., editors]. New York: J. Wiley & Sons.
Hillman L. S., Tack E., Covell D. G., Vieira N. E. & Yergey A. L. (1988). Measurement of true calcium absorption in premature infants using intravenous 46Ca and oral 44Ca. Pediatric Research 23, 589594.
Institute of Health (1980). Food Composition Table. Chinese Academy of Medical Sciences. Beijing: Chinese People's Health Publishing Co.
Jain M. G. (1989). Diet history: questionnaire and interview techniques used in some retrospective studies of cancer. Journal of the American Dietetic Association 89, 16471652.
Johnston C. C., Miller J. Z., Slemenda C. W., Reister T. K., Hui S., Christian J. C. & Peacock M. (1992). Calcium supplementation and increases in bone mineral density in children. New England Journal of Medicine 327, 8287.
Lee W. T. K., Leung S. S. F., Fairweather-Tait S., Leung D. M. Y., Tsang H. S. Y., Eagles J., Fox T., Wang S. H., Xu Y. C, Zeng W. P., Lau J. & Masarei J. R. L. (1994). True fractional calcium absorption in Chinese children measured with stable isotopes (42Ca and 44Ca). British Journal of Nutrition 72, 883898.
Lee W. T. K., Leung S. S. F., Lui S. S. H. & Lau J. (1993 a). Relationship between long-term calcium intake and bone mineral content of children aged from birth to 5 years. British Journal of Nutrition 70, 235248.
Lee W. T. K., Leung S. S. F., Ng M. Y., Wang S. H., Xu Y. C., Zeng W. P. & Lau J. (1993 b). Bone mineral content of two populations of Chinese children with different calcium intakes. Bone and Mineral 23, 195206.
Legius E., Proesmans W., Eggermont E., Vandamme-Lombaerts R., Bouillon R. & Smer M. (1989). Rickets due to dietary calcium deficiency. European Journal of Pediatrics 148, 784785.
Leung S. S. F. & Lui S. S. H. (1990). Nutritive value of Hongkong Chinese weaning diet. Nutrition Research 10, 707715.
Malm O. J. (1958). Calcium requirement and adaptation in adult men. Scandinavian Journal of Clinical Laboratory Investigation 10, Suppl. 36, 108199.
Matkovic V., Fontana D., Tominac C., Goel P & Chesnut C. H. III (1990). Factors that influence peak bone mass formation: a study of calcium balance and the inheritance of bone mass in adolescent females. American Journal of Clinical Nutrition 52, 878888.
Miller J. Z., Smith D. L., Flora L., Slemenda C. & Jiang X. (1988). Calcium absorption from calcium carbonate and a new form of calcium (CCM) in healthy male and female adolescents. American Journal of Clinical Nutrition 48, 12911294.
Nicholls L. & Nimalasuriya A. (1939). Adaptation to a low calcium intake in reference to the calcium requirements of a tropical population. Journal of Nutrition 18, 563577.
Nordin B. E. C. (editor) (1976). Plasma calcium and plasma magnesium homeostasis. In Calcium, Phosphate and Magnesim Metabolism, pp. 186216. Edinburgh: Churchill Livingstone.
Nordin B. E. C. & Marshall D. H. (1988). Dietary requirements for calcium. In Human Biology, pp. 447471 [Nordin B. E. C., editor]. London: Springer-Verlag.
Norman A. W. (1990). Intestinal calcium absorption: a vitamin D-hormone-mediated adaptive response. American Journal of Clinical Nutrition 51, 290300.
Norman D. A., Fordtran J. S., Brinkley J., Zerwekh J. E., Nicar M. J., Strowig S. M. & Pak C. Y. C. (1981). Jejunal and ileal adaptation to alternations in dietary calcium. Journal of Clinical Investigation 67, 15991603.
Paul A. A. & Southgate D. A. T. (1978). McCance and Widdowson's The Composition of Foods, 4th ed. London: H.M. Stationery office.
Pettifor J. M., Ross P., Moodley G. & Shuenyane E. (1979). Calcium deficiency in rural black children in South Africa - a comparison between rural and urban communities. American Journal of Clinical Nutrition 32, 24772483.
Statistical Package for Social Sciences (1990). Base Manual Version 4.0. Chicago, Ill: SPSS Inc. Tung, T. C., Hug, P. C. & Li, H. C. (1961). Composition of foods used in Taiwan. Journal of the Formosan Medical Association 60, 9731005.
Watt B. K. & Merrill H. L. (1983). Composition of Foods. Agriculture Handbook no. 8. Washington DC: US Department of Agriculture.
Woo J., Swaminathan R., Pang C. P., Mak Y. T. & MacDonald D. (1990). A comparison of biochemical indices of bone turnover in elderly institutionalised and free-living subjects. Bone and Mineral 8, 3138.
Yergey A. L., Vieira N. E. & Covell D. G. (1987). Direct measurement of dietary functional absorption using calcium isotopic tracers. Biochemical and Environmental Mass Spectrometry 14, 603607.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 30 *
Loading metrics...

Abstract views

Total abstract views: 40 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 23rd October 2017. This data will be updated every 24 hours.