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Effects of high-protein diets on body weight, glycaemic control, blood lipids and blood pressure in type 2 diabetes: meta-analysis of randomised controlled trials

  • Jia-Yi Dong (a1), Zeng-Li Zhang (a2), Pei-Yu Wang (a3) and Li-Qiang Qin (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114513002055
  • Published online: 05 July 2013
Abstract

High-protein diets are popular for weight management, but the health effects of such diets in diabetic persons are inconclusive. The aim of the present meta-analysis was to examine the effects of high-protein diets on body weight and metabolic risk factors in patients with type 2 diabetes. We searched the PubMed and Cochrane Library databases for relevant randomised trials up to August 2012. Either a fixed- or a random-effects model was used to combine the net changes in each outcome from baseline to the end of the intervention. Overall, nine trials including a total of 418 diabetic patients met our inclusion criteria. The study duration ranged from 4 to 24 weeks. The actual intake of dietary protein ranged from 25 to 32 % of total energy in the intervention groups and from 15 to 20 % in the control groups. Compared with the control diets, high-protein diets resulted in more weight loss (pooled mean difference: − 2·08, 95 % CI − 3·25, − 0·90 kg). High-protein diets significantly decreased glycated Hb A1C (HbA1C) levels by 0·52 (95 % CI − 0·90, − 0·14) %, but did not affect the fasting blood glucose levels. There were no differences in lipid profiles. The pooled net changes in systolic and diastolic blood pressure were − 3·13 (95 % CI − 6·58, 0·32) mmHg and − 1·86 (95 % CI − 4·26, 0·56) mmHg, respectively. However, two studies reported a large influence on weight loss and HbA1C levels, respectively. In summary, high-protein diets (within 6 months) may have some beneficial effects on weight loss, HbA1C levels and blood pressure in patients with type 2 diabetes. However, further investigations are still required to draw a conclusion.

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*Corresponding author: Dr L.-Q. Qin, fax +86 512 65880050, email qinliqiang@suda.edu.cn
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3S Wild , G Roglic , A Green , et al. (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27, 10471053.

5MK Serdula , AH Mokdad , DF Williamson , et al. (1999) Prevalence of attempting weight loss and strategies for controlling weight. JAMA 282, 13531358.

6A Avenell , J Broom , TJ Brown , et al. (2004) Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement. Health Technol Assess 8, iiiiv, 1–182.

7JD Latner & M Schwartz (1999) The effects of a high-carbohydrate, high-protein or balanced lunch upon later food intake and hunger ratings. Appetite 33, 119128.

9GL Blackburn , JC Phillips & S Morreale (2001) Physician's guide to popular low-carbohydrate weight-loss diets. Cleve Clin J Med 68, 761, 765766, 768–769, 773–764.

10M Hession , C Rolland , U Kulkarni , et al. (2009) Systematic review of randomized controlled trials of low-carbohydrate vs. low-fat/low-calorie diets in the management of obesity and its comorbidities. Obes Rev 10, 3650.

11N Santesso , EA Akl , M Bianchi , et al. (2012) Effects of higher- versus lower-protein diets on health outcomes: a systematic review and meta-analysis. Eur J Clin Nutr 66, 780788.

12B Parker , M Noakes , N Luscombe , et al. (2002) Effect of a high-protein, high-monounsaturated fat weight loss diet on glycemic control and lipid levels in type 2 diabetes. Diabetes Care 25, 425430.

14MC Gannon & FQ Nuttall (2004) Effect of a high-protein, low-carbohydrate diet on blood glucose control in people with type 2 diabetes. Diabetes 53, 23752382.

15KR Sargrad , C Homko , M Mozzoli , et al. (2005) Effect of high protein vs high carbohydrate intake on insulin sensitivity, body weight, hemoglobin A1c, and blood pressure in patients with type 2 diabetes mellitus. J Am Diet Assoc 105, 573580.

16ME Daly , R Paisey , BA Millward , et al. (2006) Short-term effects of severe dietary carbohydrate-restriction advice in type 2 diabetes – a randomized controlled trial. Diabet Med 23, 1520.

17EC Westman , WS Yancy Jr, JC Mavropoulos , et al. (2008) The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus. Nutr Metab (Lond) 5, 36.

18E Papakonstantinou , D Triantafillidou , DB Panagiotakos , et al. (2010) A high-protein low-fat diet is more effective in improving blood pressure and triglycerides in calorie-restricted obese individuals with newly diagnosed type 2 diabetes. Eur J Clin Nutr 64, 595602.

19TP Wycherley , M Noakes , PM Clifton , et al. (2010) A high-protein diet with resistance exercise training improves weight loss and body composition in overweight and obese patients with type 2 diabetes. Diabetes Care 33, 969976.

20J Khoo , C Piantadosi , R Duncan , et al. (2011) Comparing effects of a low-energy diet and a high-protein low-fat diet on sexual and endothelial function, urinary tract symptoms, and inflammation in obese diabetic men. J Sex Med 8, 28682875.

22D Moher , A Liberati , J Tetzlaff , et al. (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8, 336341.

23D Follmann , P Elliott , I Suh , et al. (1992) Variance imputation for overviews of clinical trials with continuous response. J Clin Epidemiol 45, 769773.

24JP Higgins & SG Thompson (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21, 15391558.

25JP Higgins , SG Thompson , JJ Deeks , et al. (2003) Measuring inconsistency in meta-analyses. BMJ 327, 557560.

26M Egger , G Davey Smith , M Schneider , et al. (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315, 629634.

27UK Prospective Diabetes Study (UKPDS) Group (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352, 854865.

28SP Whelton , A Chin , X Xin , et al. (2002) Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann Intern Med 136, 493503.

29TL Halton , WC Willett , S Liu , et al. (2006) Low-carbohydrate-diet score and the risk of coronary heart disease in women. N Engl J Med 355, 19912002.

30L de Koning , TT Fung , X Liao , et al. (2011) Low-carbohydrate diet scores and risk of type 2 diabetes in men. Am J Clin Nutr 93, 844850.

32D Aune , G Ursin & MB Veierod (2009) Meat consumption and the risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies. Diabetologia 52, 22772287.

33A Pan , Q Sun , AM Bernstein , et al. (2011) Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis. Am J Clin Nutr 94, 10881096.

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British Journal of Nutrition
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