Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 31
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Araujo, Quintino Reis De Gattward, James Nascimento Almoosawi, Suzana Parada Costa Silva, Maria das Graças Conceição Dantas, Paulo Alfredo De Santana and Araujo Júnior, Quintino Reis De 2016. Cocoa and Human Health: From Head to Foot—A Review. Critical Reviews in Food Science and Nutrition, Vol. 56, Issue. 1, p. 1.


    Ghodrati, Fariba Mahmoodi, Minoo Shahidi, Siamak and Ghadimipoure, Hamid Reza 2016. Morphological Effects of Hydroalcoholic Zingiber Officinalis Extract in the Murine Hippocampus of Male Rat Offspring. Avicenna Journal of Neuro Psych Physiology, Vol. In Press, Issue. In Press,


    Moreira, Afonso Diógenes, Maria José de Mendonça, Alexandre Lunet, Nuno and Barros, Henrique 2016. Chocolate Consumption is Associated with a Lower Risk of Cognitive Decline. Journal of Alzheimer's Disease, Vol. 53, Issue. 1, p. 85.


    Pérez-Hernández, Jesús Zaldívar-Machorro, Víctor Javier Villanueva-Porras, David Vega-Ávila, Elisa and Chavarría, Anahí 2016. A Potential Alternative against Neurodegenerative Diseases: Phytodrugs. Oxidative Medicine and Cellular Longevity, Vol. 2016, p. 1.


    Visioli, Francesco and Burgos-Ramos, Emma 2016. Selected Micronutrients in Cognitive Decline Prevention and Therapy. Molecular Neurobiology, Vol. 53, Issue. 6, p. 4083.


    Badrie, Neela Bekele, Frances Sikora, Elzbieta and Sikora, Marek 2015. Cocoa Agronomy, Quality, Nutritional, and Health Aspects. Critical Reviews in Food Science and Nutrition, Vol. 55, Issue. 5, p. 620.


    Carito, Valentina Ceccanti, Mauro Chaldakov, George Tarani, Luigi De Nicolò, Sara Ciafrè, Stefania Tirassa, Paola and Fiore, Marco 2015. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease.


    Hasanein, Parisa and Mahtaj, Azam Kazemian 2015. Ameliorative effect of rosmarinic acid on scopolamine-induced memory impairment in rats. Neuroscience Letters, Vol. 585, p. 23.


    Hosseini, Abdolkarim and Mirazi, Naser 2015. Alteration of pentylenetetrazole-induced seizure threshold by chronic administration of ginger (Zingiber officinale) extract in male mice. Pharmaceutical Biology, Vol. 53, Issue. 5, p. 752.


    Rendeiro, Catarina Rhodes, Justin S. and Spencer, Jeremy P.E. 2015. The mechanisms of action of flavonoids in the brain: Direct versus indirect effects. Neurochemistry International, Vol. 89, p. 126.


    2015. Herbal Bioactives and Food Fortification.


    Farhat, Grace Drummond, Sandra Fyfe, Lorna and Al-Dujaili, E. A. S. 2014. Dark Chocolate: An Obesity Paradox or a Culprit for Weight Gain?. Phytotherapy Research, Vol. 28, Issue. 6, p. 791.


    Hosseini, Abdolkarim and Mirazi, Naser 2014. Acute administration of ginger (Zingiber officinale rhizomes) extract on timed intravenous pentylenetetrazol infusion seizure model in mice. Epilepsy Research, Vol. 108, Issue. 3, p. 411.


    Kim, Jiyoung Kim, Jaekyoon Shim, Jaesung Lee, Chang Yong Lee, Ki Won and Lee, Hyong Joo 2014. Cocoa Phytochemicals: Recent Advances in Molecular Mechanisms on Health. Critical Reviews in Food Science and Nutrition, Vol. 54, Issue. 11, p. 1458.


    Papadimitriou, Alexandros Peixoto, Elisa B.M.I. Silva, Kamila C. Lopes de Faria, Jacqueline M. and Lopes de Faria, José B. 2014. Increase in AMPK brought about by cocoa is renoprotective in experimental diabetes mellitus by reducing NOX4/TGFβ-1 signaling. The Journal of Nutritional Biochemistry, Vol. 25, Issue. 7, p. 773.


    Si, Hongwei and Liu, Dongmin 2014. Dietary antiaging phytochemicals and mechanisms associated with prolonged survival. The Journal of Nutritional Biochemistry, Vol. 25, Issue. 6, p. 581.


    Haskell, Crystal F. and Watson, Anthony W. 2013. Bioactives in Fruit.


    Jayasena, T. Poljak, A. Smythe, G. Braidy, N. Münch, G. and Sachdev, P. 2013. The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease. Ageing Research Reviews, Vol. 12, Issue. 4, p. 867.


    Ortega, Francisco B. 2013. The intriguing association among chocolate consumption, country's economy and Nobel Laureates. Clinical Nutrition, Vol. 32, Issue. 5, p. 874.


    Sokolov, Alexander N. Pavlova, Marina A. Klosterhalfen, Sibylle and Enck, Paul 2013. Chocolate and the brain: Neurobiological impact of cocoa flavanols on cognition and behavior. Neuroscience & Biobehavioral Reviews, Vol. 37, Issue. 10, p. 2445.


    ×

Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats

  • Jean-François Bisson (a1), Amine Nejdi (a1), Pascale Rozan (a1), Sophie Hidalgo (a1), Robert Lalonde (a2) and Michaël Messaoudi (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114507886375
  • Published online: 01 July 2008
Abstract

Numerous studies have indicated that increased vulnerability to oxidative stress may be the main factor involved in functional declines during normal and pathological ageing, and that antioxidant agents, such as polyphenols, may improve or prevent these deficits. We examined whether 1-year administration of a cocoa polyphenolic extract (Acticoa powder), orally delivered at the dose of 24 mg/kg per d between 15 and 27 months of age, affects the onset of age-related cognitive deficits, urinary free dopamine levels and lifespan in old Wistar-Unilever rats. Acticoa powder improved cognitive performances in light extinction and water maze paradigms, increased lifespan and preserved high urinary free dopamine levels. These results suggest that Acticoa powder may be beneficial in retarding age-related brain impairments, including cognitive deficits in normal ageing and perhaps neurodegenerative diseases. Further studies are required to elucidate the mechanisms of cocoa polyphenols in neuroprotection and to explore their effects in man.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Michaël Messaoudi, fax +33 383 446 441, email etap@etap-lab.com
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1HK Biesalski (2000) The role of antioxidants in nutritional support. Nutrition 16, 593596.

2A Huber , G Stuchbury , A Burkle , J Burnell & G Munch (2006) Neuroprotective therapies for Alzheimer's disease. Curr Pharm Des 12, 705717.

3T Egashira , F Takayama & Y Yamanaka (1996) Effects of bifemelane on muscarinic receptors and choline acetyltransferase in the brains of aged rats following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries. Jpn J Pharmacol 72, 5765.

5MS Levine & C Cepeda (1998) Dopamine modulation of responses mediated by excitatory amino acids in the neostriatum. Adv Pharmacol 42, 724729.

6MG Hertog , EJM Feskens , PC Hollman , MB Martijn & D Kromhout (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. Lancet 342, 10071011.

7MG Hertog , D Kromhout , C Aravanis , (1995) Flavonoid intake and long-term risk of coronary heart disease and cancer in the Seven Countries Studies. Arch Intern Med 155, 381386.

8KA Steinmetz & JD Potter (1991) Vegetables, fruit and cancer. 1. Epidemiology. Cancer Causes Control 2, 325357.

9SO Keli , MG Hertog , EJ Feskens & D Kromhout (1996) Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med 156, 637642.

12GE Adamson , SA Lazarus , AE Mitchel , (1999) HPLC method for the quantification of procyanidins in cocoa and chocolate samples and correlation to total antioxidant capacity. J Agric Food Chem 47, 773781.

13SA Lazarus , JF Hammerstone & HH Schmitz (1999) Chocolate contains additional flavanoids not found in tea. Lancet 354, 1825.

14M Natsume , N Osakabe , M Yamagishi , T Takizawa , T Nakamura , H Miyatake , T Hanato & T Yoshida (2000) Analyses of polyphenols in cacao liquor, cocoa, and chocolate by normal phase HPLC. Biosci Biotechnol Biochem 64, 25812587.

15JF Hammerstone , SA Lazarus , AE Mitchell , R Rucker & HH Schmitz (1999) Identification of procyanidins in cocoa (Theobroma cacao) and chocolate using high-performance liquid chromatography/mass spectrometry. J Agric Food Chem 47, 490496.

17GE Arteel & H Sies (1999) Protection against peroxynitrite in cocoa polyphenols oligomers. FEBS Lett 462, 167170.

19K Kondo , R Hirano , A Matsumoto , O Igarashi & H Itakura (1996) Inhibition of LDL oxidation by cocoa. Lancet 348, 1514.

21SB Lotito & CG Fraga (2000) Catechins delay lipid oxidation and alpha-tocopherol and beta-carotene depletion following ascorbate depletion in human plasma. Proc Soc Exp Biol Med 225, 3238.

22Y Miura , T Chiba , S Miura , I Tomita , K Umegaki , M Ikeda & T Tomita (2000) Green Tea polyphenols (flavan 3-ols) prevent oxidative modification of low densitylipoproteins – an ex vivo study in humans. J Nutr Biochem 11, 216222.

25T Pan , J Jankovic & WD Le (2003) Potential therapeutic properties of green tea polyphenols in Parkinson's disease. Drugs Aging 20, 711721.

26H Schroeter , JR Williams , R Matin , L Iverson & CA Rice-Evans (2000) Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein. Free Radic Biol Med 29, 12221233.

27HK Kim , M Kim , S Kim , M Kim & JH Chung (2004) Effects of green tea polyphenol on cognitive and acetylcholinesterase activities. Biosci Biotechnol Biochem 68, 19771979.

28S Mandel , O Weinreb , T Amit & MBH Youdim (2004) Cell signalling pathways in the neuroprotective actions of the green tea polyphenols ( − )-epigallocatechin-3-gallate: implications for neurodegenerative diseases. J Neurochem 88, 15551569.

30M Messaoudi , A Tricoire , R Lalonde , F Canini & A Minn (1996) Effects of MPTP on lever-pressing for light extinction in rats. Eur J Pharmacol 299, 1720.

31M Messaoudi , D Desor , V Grasmuck , M Joyeux , A Langlois & FJ Roman (1999) Behavioral evaluation of visceral pain in a rat model of colonic inflammation. Neuroreport 10, 11371141.

32R Morris (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11, 4760.

36EL Kaplan & P Meier (1958) Non-parametric estimation from incomplete observations. J Am Stat Assoc 53, 457481.

37R Lalonde & R Badescu (1995) Exploratory drive, frontal lobe function and adipsia in aging. Gerontology 41, 134144.

38GS Rai , C Shovlin & KA Wesnes (1991) A double-blind placebo controlled study of ginkgo biloba extract (‘tanakan’) in elderly outpatients with mild moderate memory impairment. Curr Med Res Opin 12, 350355.

39J Kleijnen & P Knipschild (1992) Ginkgo biloba for cerebral insufficiency. Br J Clin Pharmacol 34, 352358.

40Y Oyama , PA Fuchs , N Katayama & K Noda (1994) Myricetin and quercetin, the flavonoid constituents of Ginkgo biloba extract, greatly reduce oxidative metabolism in both resting and Ca2+-loaded brain neurons. Brain Res 635, 125129.

41S Kanowski , WM Herrmann , K Stephan , W Wierich & R Horr (1996) Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 29, 4756.

43T Moriguchi , H Saito & N Nishiyama (1997) Anti-aging effect of aged garlic extract in the inbred brain atrophy mouse model. Clin Exp Pharmacol Physiol 24, 235242.

44N Nishiyama , T Morigushy & H Saito (1997) Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse. Exp Gerontol 32, 149160.

45G Cao , E Sofic & RL Prior (1997) Antioxidant and prooxidant behaviour of flavonoids: structure–activity relationships. Free Radic Biol Med 22, 749760.

46G Casadesus , B Shukitt-Hale , HM Stellwagen , X Zhu , HG Lee , MA Smith & J Joseph (2004) Modulation of hippocampal plasticity and cognitive behaviour by short-term blueberry supplementation in aged rats. Nutr Neurosci 7, 309316.

47FC Lau , L Shukitt & JA Joseph (2005) The beneficial effects of fruits polyphenols on brain aging. Neurobiol Aging 26, Suppl. 1, 128132.

48Y Matsuoka , Y Kitamura , T Tsukahara , K Terai , I Tooyama , H Kimura & T Taniguchi (1995) Neuroprotective effects of NBQX on hypoxia-induced neuronal damage in rat hippocampus. Neuroreport 6, 22052208.

49S Lee , S Suh & S Kim (2000) Protective effects of the green tea polyphenol ( − )-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci Lett 287, 191194.

50K Ishige , D Shubert & Y Sagara (2001) Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 30, 433446.

51TJ Crowley , MM Hoehn , CO Rutledge , MA Stallings , RK Heaton , S Sundell & D Stilson (1978) Dopamine excretion and vulnerability to drug-induced Parkinsonism in schizophrenic patients. Arch Gen Psychiatry 35, 97104.

53T Pan , J Fei , XD Zhou , J Jankovic & WD Le (2003) Effects of green tea polyphenols on dopamine uptake and on MMP+-induced dopamine neuron injury. Life Sci 72, 10731083.

54Y Levites , O Weinreb , G Maor , MB Youdim & S Mandel (2001) Green tea polyphenol ( − )-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration. J Neurochem 78, 10731082.

55LD Mercer , BL Kelly , MK Horne & PM Beart (2005) Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. Biochem Pharmacol 69, 339345.

56N Osakabe , M Yamagishi , C Sanbongi , M Natsume , T Takizawa & T Osawa (1998) The antioxidative substances in cacao liquor. J Nutr Sci Vitaminol 44, 313321.

57VL Cropley , M Fujita , RB Innis & PJ Nathan (2006) Molecular imaging of the dopaminergic system and its association with human cognitive function. Biol Psychiatry 59, 898907.

58A Lieberman (2006) Depression in Parkinson's disease – a review. Acta Neurol Scand 113, 18.

60V Seutin (2005) Dopaminergic neurones: much more than dopamine? Br J Pharmacol 146, 167169.

61SK Shook , EA Franz , CI Higginson , VL Wheelock & KA Sigvardt (2005) Dopamine dependency of cognitive switching and response repetition effects in Parkinson's patients. Neuropsychologia 43, 19901999.

63P Rozan , S Hidalgo , A Nejdi , JF Bisson , R Lalonde & M Messaoudi (2007) Preventive antioxidant effects of cocoa polyphenolic extract on free radical production and cognitive performances after heat exposure in Wistar rats. J Food Sci 72, S203S206.

65KW Lee , YJ Kim , HJ Lee & CY Lee (2003) Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J Agric Food Chem 51, 72927295.

66C Heiss , A Dejam , T Kleinbongard , P Schewe , H Sies & M Kelm (2003) Vascular effects of cocoa rich in flavan-3-ols. JAMA 290, 10301031.

68H Schroeter , C Heiss , J Balzer , P Kleinbongard , CL Keen , NK Hollenberg , H Sies , C Kwik-Uribe , HH Schmitz & M Kelm (2006) ( − )-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A 103, 10241029.

69DA Pearson , HH Schmitz , SA Lazarus & CL Keen (2001) Inhibition of in vitro low-density lipoprotein oxidation by oligomeric procyanidins present in chocolate and cocoas. Methods Enzymol 335, 350360.

72TK Mao , JJ Powell , J Van de Water , CL Keen , HH Schmitz , JF Hammerstone & ME Gershwin (2000) The effect of cocoa procyanidins on the transcription and secretion of interleukin-1β in peripheral blood mononuclear cells. Life Sci 66, 13771386.

73C Sanbongi , N Suzuki & T Sakane (1997) Polyphenols in chocolate, which have antioxidant activity, modulate immune functions in humans in vitro. Cell Immunol 177, 129136.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: