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British Journal of Nutrition British Journal of Nutrition

Article contents

Effects of milk fermented byLactobacillusgasseri SBT2055 on adipocyte size in rats

Published online by Cambridge University Press:  01 May 2008

Masao Sato ,
Kazunori Uzu ,
Takeshi Yoshida ,
Essam M. Hamad ,
Hiroshi Kawakami ,
Hiroaki Matsuyama ,
Ibrahim A. Abd El-Gawad  and
Katsumi Imaizumi
Masao Sato
Affiliation:
Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan
Kazunori Uzu
Affiliation:
Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan
Takeshi Yoshida
Affiliation:
Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan
Essam M. Hamad
Affiliation:
Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan Dairy Science & Technology Department, Faculty of Agriculture, Cairo University, Giza, 12613, Egypt
Hiroshi Kawakami
Affiliation:
Technology & Research Institute, Snow Brand Milk Products Co. Ltd., Saitama, 350-1165, Japan
Hiroaki Matsuyama
Affiliation:
Technology & Research Institute, Snow Brand Milk Products Co. Ltd., Saitama, 350-1165, Japan
Ibrahim A. Abd El-Gawad
Affiliation:
Dairy Science & Technology Department, Faculty of Agriculture, Cairo University, Giza, 12613, Egypt
Katsumi Imaizumi*
Affiliation:
Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan
*
*Corresponding author: Dr Katsumi Imaizumi, fax +81 92 642 3003, email imaizumi@agr.kyushu-u.ac.jp
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Abstract

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Despite adequate scientific evidence of the potential benefits of probiotics to human health or disease prevention, their contribution to the growth of adipose tissue remains to be established. Four-week-old male Sprague-Dawley rats were fed a diet containing skim milk (control diet) or skim milk fermented by Lactobacillus gasseri SBT2055 (LGSP diet) for 4 weeks. Their body weight gain, adipose tissue weight, adipocyte size distribution profile, blood and hepatic lipids, and serum leptin, glucose and adiponectin levels were determined. There was a significant reduction in average adipocyte size in mesenteric white adipose tissue (P = 0·004). Moreover, the rats fed the LGSP diet displayed greater numbers of small adipocytes from mesenteric and retroperitoneal adipose tissues than did those on the control diet. Whereas adiponectin concentrations did not differ between the groups, serum leptin concentrations were decreased to 32 % in the LGSP diet group compared with the control group. Concentrations of serum glucose and lipids, and liver lipids, except for the liver TAG level, were similar in the two groups. These results indicate a possible role for a fermented milk product in the regulation of adipose tissue growth.

Keywords

Lactobacillus gasseriProbioticsLeptinAdipocyte size
Type
Full Papers
Information
British Journal of Nutrition , Volume 99 , Issue 5 , May 2008 , pp. 1013 - 1017
Copyright
Copyright © The Authors 2007

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