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Egg consumption as part of an energy-restricted high-protein diet improves blood lipid and blood glucose profiles in individuals with type 2 diabetes

  • Karma L. Pearce (a1) (a2) (a3), Peter M. Clifton (a1) and Manny Noakes (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114510003983
  • Published online: 07 December 2010
Abstract

The role of dietary cholesterol in people with diabetes has been little studied. We investigated the effect of a hypoenergetic high-protein high-cholesterol (HPHchol) diet compared to a similar amount of animal protein (high-protein low-cholesterol, HPLchol) on plasma lipids, glycaemic control and cardiovascular risk markers in individuals with type 2 diabetes. A total of sixty-five participants with type 2 diabetes or impaired glucose tolerance (age 54·4 (sd 8·2) years; BMI 34·1 (sd 4·8) kg/m2; LDL-cholesterol (LDL-C) 2·67 (sd 0·10) mmol/l) were randomised to either HPHchol or HPLchol. Both hypoenergetic dietary interventions (6–7 MJ; 1·4–1·7 Mcal) and total carbohydrate:protein:fat ratio of 40:30:30 % were similar but differed in cholesterol content (HPHchol, 590 mg cholesterol; HPLchol, 213 mg cholesterol). HPHchol participants consumed two eggs per d, whereas HPHchol participants replaced the eggs with 100 g of lean animal protein. After 12 weeks, weight loss was 6·0 (sd 0·4) kg (P < 0·001). LDL-C and homocysteine remained unchanged. All the subjects reduced total cholesterol ( − 0·3 (sd 0·1) mmol/l, P < 0·001), TAG ( − 0·4 (sd 0·1) mmol/l, P < 0·001), non-HDL-cholesterol (HDL-C, − 0·4 (sd 0·1) mmol/l, P < 0·001), apo-B ( − 0·04 (sd 0·02) mmol/l, P < 0·01), HbA1c ( − 0·6 (sd 0·1) %, P < 0·001), fasting blood glucose ( − 0·5 (sd 0·2) mmol/l, P < 0·01), fasting insulin ( − 1·7 (sd 0·7) mIU/l, P < 0·01), systolic blood pressure ( − 7·6 (sd 1·7) mmHg, P < 0·001) and diastolic blood pressure ( − 4·6 (sd 1·0) mmHg; P < 0·001). Significance was not altered by diet, sex, medication or amount of weight loss. HDL-C increased on HPHchol (+0·02 (sd 0·02) mmol/l) and decreased on HPLchol ( − 0·07 (sd 0·03) mmol/l, P < 0·05). Plasma folate and lutein increased more on HPHchol (P < 0·05). These results suggest that a high-protein energy-restricted diet high in cholesterol from eggs improved glycaemic and lipid profiles, blood pressure and apo-B in individuals with type 2 diabetes.

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*Corresponding author: K. L. Pearce, fax +61 8 8302 2389, email karma.pearce@unisa.edu.au
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2SM Haffner (1998) Epidemiology of type 2 diabetes: risk factors. Diabetes Care 21, Suppl. 3, C3C6.

3JB Marks & P Raskin (2000) Cardiovascular risk in diabetes: a brief review. J Diabetes Complications 14, 108115.

5NH Baba , S Sawaya , N Torbay , (1999) High protein vs high carbohydrate hypoenergetic diet for the treatment of obese hyperinsulinemic subjects. Int J Obes Relat Metab Disord 23, 12021206.

7PM Piatti , F Monti , I Fermo , (1994) Hypocaloric high-protein diet improves glucose oxidation and spares lean body mass: comparison to hypocaloric high-carbohydrate diet. Metabolism 43, 14811487.

8AR Skov , S Toubro , B Ronn , (1999) Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity. Int J Obes Relat Metab Disord 23, 528536.

9FB Hu , MJ Stampfer , EB Rimm , (1999) A prospective study of egg consumption and risk of cardiovascular disease in men and women. JAMA 281, 13871394.

12GM Reaven (2001) Insulin resistance, dietary cholesterol, and cholesterol concentration in postmenopausal women. Metabolism 50, 594597.

13G Romano , MK Tilly-Kiesi , L Patti , (1998) Effects of dietary cholesterol on plasma lipoproteins and their subclasses in IDDM patients. Diabetologia 41, 193200.

14LR Tannock , KD O'Brien , RH Knopp , (2005) Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects. Circulation 111, 30583062.

18TM Wallace , JC Levy & DR Matthews (2004) Use and abuse of HOMA modeling. Diabetes Care 27, 14871495.

20F Khachik , GR Beecher , MB Goli , (1992) Separation and identification of carotenoids and their oxidation products in the extracts of human plasma. Anal Chem 64, 21112122.

21PM Clifton , M Noakes , D Ross , (2004) High dietary intake of phytosterol esters decreases carotenoids and increases plasma plant sterol levels with no additional cholesterol lowering. J Lipid Res 45, 14931499.

23B Parker , M Noakes , N Luscombe , (2002) Effect of a high-protein, high-monounsaturated fat weight loss diet on glycemic control and lipid levels in type 2 diabetes. Diabetes Care 25, 425430.

24WE Boden (2000) High-density lipoprotein cholesterol as an independent risk factor in cardiovascular disease: assessing the data from Framingham to the Veterans Affairs High-Density Lipoprotein Intervention Trial. Am J Cardiol 86, 19L22L.

26Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285, 24862497.

29DK Spady & JM Dietschy (1988) Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster. J Clin Invest 81, 300309.

30RH Knopp , B Retzlaff , B Fish , (2003) Effects of insulin resistance and obesity on lipoproteins and sensitivity to egg feeding. Arterioscler Thromb Vasc Biol 23, 14371443.

31KL Herron , IE Lofgren , X Adiconis , (2006) Associations between plasma lipid parameters and APOC3 and APOA4 genotypes in a healthy population are independent of dietary cholesterol intake. Atherosclerosis 184, 113120.

33KL Herron , S Vega-Lopez , K Conde , (2002) Pre-menopausal women, classified as hypo- or hyper-responders, do not alter their LDL/HDL ratio following a high dietary cholesterol challenge. J Am Coll Nutr 21, 250258.

34MA Austin (1991) Plasma triglyceride and coronary heart disease. Arterioscler Thromb Vasc Biol 11, 214.

35WM Verschuren , DR Jacobs , BP Bloemberg , (1995) Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven countries study. JAMA 274, 131136.

36N Sattar , K Williams , AD Sniderman , (2004) Comparison of the associations of apolipoprotein B and non-high-density lipoprotein cholesterol with other cardiovascular risk factors in patients with the metabolic syndrome in the Insulin Resistance Atherosclerosis Study. Circulation 110, 26872693.

37TE Strandberg , K Pyorala , TJ Cook , (2004) Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S). Lancet 364, 771777.

38AD Sniderman , CD Furberg & A Keech (2003) Apoproteins versus lipids as indices of coronary risk and as targets for statin therapy. Lancet 361, 777780.

39S Linn , R Fulwood , M Carroll , (1991) Serum total cholesterol: HDL cholesterol ratios in US white and black adults by selected demographic and socioeconomic variables (HANES II). Am J Public Health 81, 10381043.

41AG Bostom , DR Gagnon , LA Cupples , (1994) A prospective investigation of elevated lipoprotein (a) detected by electrophoresis and cardiovascular disease in women. The Framingham Heart Study. Circulation 90, 16881695.

42AG Bostom , LA Cupples , JL Jenner , (1996) Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger. A prospective study. JAMA 276, 544548.

43RR Wing , R Koeske , LH Epstein , (1987) Long-term effects of modest weight loss in type II diabetic patients. Arch Intern Med 147, 17491753.

44H Ginsberg , J Plutzky & BE Sobel (1999) A review of metabolic and cardiovascular effects of oral antidiabetic agents: beyond glucose-level lowering. J Cardiovasc Risk 6, 337346.

45J Stamler , O Vaccaro , JD Neaton , (1993) Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 16, 434444.

46WS Yancy Jr, M Foy , AM Chalecki , (2005) A low-carbohydrate, ketogenic diet to treat type 2 diabetes. Nutr Metab (Lond) 2, 34.

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