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B Berraondo , A Marti , JS Duncan , P Trayhurn & JA Martinez (2000) Up-regulation of muscle UCP2 gene expression by a new β3-adrenoceptor agonist, trecadrine, in obese (cafeteria) rodents, but down-regulation in lean animals. Int J Obes Relat Metab Disord 24, 156–163.
LM Browning (2003) n-3 Polyunsaturated fatty acids, inflammation and obesity-related disease. Proc Nutr Soc 62, 447–453.
PC Calder (2001) Omega 3 polyunsaturated fatty acids, inflammation and immunity. World Rev Nutr Diet 88, 109–116.
J Campion & JA Martinez (2004) Ketoconazole, an antifungal agent, protects against adiposity induced by a cafeteria diet. Horm Metab Res 36, 485–491.
C Chambrier , JP Bastard , J Rieusset , E Chevillotte , D Bonnefont-Rousselot , P Therond , B Hainque , JP Riou , M Laville & H Vidal (2002) Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor γ. Obes Res 10, 518–525.
TP Combs , UB Pajvani , AH Berg , (2004) A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 145, 367–383.
P Dandona , A Aljada & A Bandyopadhyay (2004) Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 25, 4–7.
UN Das (2001) Is obesity an inflammatory condition? Nutrition 17, 953–966.
P Flachs , V Mohamed-Ali , O Horakova , M Rossmeisl , MJ Hosseinzadeh-Attar , M Hensler , J Ruzickova & J Kopecky (2006) Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. Diabetologia 49, 1–4.
PJ Havel (2004) Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 53, Suppl. 1, S143–S151.
GS Hotamisligil (1999) The role of TNFα and TNF receptors in obesity and insulin resistance. J Intern Med 245, 621–625.
GS Hotamisligil , NS Shargill & BM Spiegelman (1993) Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259, 87–91.
K Hotta , T Funahashi , NL Bodkin , HK Ortmeyer , Y Arita , BC Hansen & Y Matsuzawa (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50, 1126–1133.
K Kawaguchi , T Sugiyama , H Hibasami & N Toyoda (2003) PPAR-γ, TNF-α messenger RNA levels and lipase activity in the pregnant and lactating rat. Life Sci 72, 1655–1663.
N Kubota , Y Terauchi , T Yamauchi , (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277, 25863–25866.
M Kumada , S Kihara , S Sumitsuji , (2003) Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 23, 85–89.
M Kusunoki , K Tsutsumi , T Hara , (2003) Ethyl icosapentate (omega-3 fatty acid) causes accumulation of lipids in skeletal muscle but suppresses insulin resistance in OLETF rats. Otsuka Long-Evans Tokushima Fatty. Metabolism 52, 30–34.
IP Lopez , A Marti , FI Milagro , L Zulet Md Mde , MJ Moreno-Aliaga , JA Martinez & C De Miguel (2003) DNA microarray analysis of genes differentially expressed in diet-induced (cafeteria) obese rats. Obes Res 11, 188–194.
IP Lopez , FI Milagro , A Marti , MJ Moreno-Aliaga , JA Martinez & C De Miguel (2004) Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display. Biochem Biophys Res Commun 318, 234–239.
IP Lopez , FI Milagro , A Marti , MJ Moreno-Aliaga , JA Martinez & C De Miguel (2005) High-fat feeding period affects gene expression in rat white adipose tissue. Mol Cell Biochem 275, 109–115.
J Margareto , M Aguado , JA Oses-Prieto , I Rivero , A Monge , I Aldana , A Marti & JA Martinez (2000) A new NPY-antagonist strongly stimulates apoptosis and lipolysis on white adipocytes in an obesity model. Life Sci 68, 99–107.
J Margareto , J Gomez-Ambrosi , A Marti & JA Martinez (2001) Time-dependent effects of a high-energy-yielding diet on the regulation of specific white adipose tissue genes. Biochem Biophys Res Commun 283, 6–11.
J Margareto , I Rivero , A Monge , I Aldana , A Marti & JA Martinez (2002) Changes in UCP2, PPARγ2, and c/EBPα gene expression induced by a neuropeptide Y (NPY) related receptor antagonist in overweight rats. Nutr Neurosci 5, 13–17.
MJ Moreno-Aliaga , O Lamas , A Marti & JA Martinez (2002) Effects of a β3-adrenergic agonist on glucose uptake and leptin expression and secretion in cultured adipocytes from lean and overweight (cafeteria) rats. Biochem Biophys Res Commun 291, 1201–1207.
TA Mori & LJ Beilin (2004) Omega-3 fatty acids and inflammation. Curr Atheroscler Rep 6, 461–467.
Y Mori , Y Murakawa , S Katoh , S Hata , J Yokoyama , N Tajima , Y Ikeda , H Nobukata , T Ishikawa & Y Shibutani (1997) Influence of highly purified eicosapentaenoic acid ethyl ester on insulin resistance in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus. Metabolism 46, 1458–1464.
Y Mori , Y Murakawa , J Yokoyama , N Tajima , Y Ikeda , H Nobukata , T Ishikawa & Y Shibutani (1999) Effect of highly purified eicosapentaenoic acid ethyl ester on insulin resistance and hypertension in Dahl salt-sensitive rats. Metabolism 48, 1089–1095.
CL Morin , RH Eckel , T Marcel & MJ Pagliassotti (1997) High fat diets elevate adipose tissue-derived tumor necrosis factor-α activity. Endocrinology 138, 4665–4671.
M Murata , H Kaji , Y Takahashi , K Iida , I Mizuno , Y Okimura , H Abe & K Chihara (2000) Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro. Biochem Biophys Res Commun 270, 343–348.
C Nelson-Dooley , MA Della-Fera , M Hamrick & CA Baile (2005) Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes. Curr Med Chem 12, 2215–2225.
H Nobukata , T Ishikawa , M Obata & Y Shibutani (2000) Long-term administration of highly purified eicosapentaenoic acid ethyl ester prevents diabetes and abnormalities of blood coagulation in male WBN/Kob rats. Metabolism 49, 912–919.
CC Parrish , DA Pathy & A Angel (1990) Dietary fish oils limit adipose tissue hypertrophy in rats. Metabolism 39, 217–219.
N Perez-Echarri , P Perez-Matute , JA Martinez , A Marti & MJ Moreno-Aliaga (2005) Serum and gene expression levels of leptin and adiponectin in rats susceptible or resistant to diet-induced obesity. J Physiol Biochem 61, 333–342.
P Perez-Matute , A Marti , JA Martinez & MJ Moreno-Aliaga (2003) Effects of arachidonic acid on leptin secretion and expression in primary cultured rat adipocytes. J Physiol Biochem 59, 201–208.
MP Portillo , E Simon , MA Garcia-Calonge & AS Del Barrio (1999) Effect of high-fat diet on lypolisis in isolated adipocytes from visceral and subcutaneous WAT. Eur J Nutr 38, 177–182.
EJ Ramos , Y Xu , I Romanova , F Middleton , C Chen , R Quinn , A Inui , U Das & MM Meguid (2003) Is obesity an inflammatory disease? Surgery 134, 329–335.
C Ruxton (2004) Health benefits of omega-3 fatty acids. Nurs Stand 18, 38–42.
J Ruzickova , M Rossmeisl , T Prazak , P Flachs , J Sponarova , M Veck , E Tvrzicka , M Bryhn & J Kopecky (2004) Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue. Lipids 39, 1177–1185.
AP Simopoulos (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmecother 56, 365–379.
N Stefan , JC Bunt , AD Salbe , T Funahashi , Y Matsuzawa & PA Tataranni (2002) Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab 87, 4652–4656.
P Trayhurn & IS Wood (2005) Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 33, 1078–1081.
KE Wellen & GS Hotamisligil (2003) Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112, 1785–1788.
Y Zhao , S Joshi-Barve , S Barve & LH Chen (2004) Eicosapentaenoic acid prevents LPS-induced TNF-α expression by preventing NF-κB activation. J Am Coll Nutr 23, 71–78.