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    Coop, R.L. and Kyriazakis, I. 1999. Nutrition–parasite interaction. Veterinary Parasitology, Vol. 84, Issue. 3-4, p. 187.


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Elevation of feed intake in parasite-infected lambs by central administration of a cholecystokinin receptor antagonist

  • Robyn A. Dynes* (a1), Dennis P. Poppi (a1), Graham K. Barrell (a1) and Andrew R. Sykes (a1)
  • DOI: http://dx.doi.org/10.1079/BJN19980008
  • Published online: 01 March 2007
Abstract

The role of cholecystokinin (CCK) in modulating feed intake depression in parasite-infected lambs was investigated using CCK receptor antagonists (L364–718 and loxiglumide). Four experiments were carried out using ewe lambs infected with 4000 Trichostrongylus colubriformis larvae/d or non-infected controls (n 8, live weight 25 kg). Animals were fed daily on a nutritionally complete pelleted diet and had free access to water. In the first experiment, infected and non-infected animals were injected subcutaneously with CCK antagonist (100 μg L364–718) or carrier alone as a single dose. In the second experiment, CCK antagonist (loxiglumide: 0, 5, 10 or 20mg/kg live weight) was injected into a jugular vein immediately before feeding. In the third experiment, animals were infused continuously with the CCK antagonist (loxiglumide; 10mg/kg per h) for 10 min before feeding and for the first 2 h of feeding. In the final experiment, lambs were fitted with an indwelling cerebral ventricular cannula and infused with a CCK antagonist (loxiglumide, 162μg/min), CCK agonist (CCK-8, 2.5 pmol/min), loxiglumide plus CCK-8 or sterile saline solution alone via the cannula for 30 min before feeding and for the first 60 min of feeding. In all the experiments short-term feed intake was recorded at 10 and 15 min intervals for the first and second hours of feeding respectively, then at hourly intervals for the remainder of the 8 h recording period. Peripheral injection with L364–718 or loxiglumide did not elevate feed intake in either the infected or non-infected animals. However, feed intake was increased (P < 0.05) in the short term by central infusion of loxiglumide, this effect being greater in the infected animals and apparently due to an elevation in intake during the second hour of feeding. CCK-8 depressed short term feed intake only in the infected animals (P < 0.05). Total daily feed consumption was not influenced by any of the pharmacological agents. The results indicate an involvement of central CCK receptors in regulation of feed intake depression following gastrointestinal parasitism of sheep and the possibility of a similar role in non-infected sheep. They do not support the singular importance of a peripheral action of CCK in determining satiety.

Cholecystokinin: Loxiglumide: Feed intake: Gastrointestinal parasites

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Corresponding author
*Corresponding author:Dr R. A. Dynes, fax +61 8 9387 8991, email r.dynes@ccmar.csiro.au
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BA Baldwin , C de la Riva & VP Gerskowitch (1994) Effect of a novel CCK-A receptor antagonist (2-NAP) on the reduction in food intake produced by CCK in pigs. Physiology and Behavior 55, 175179.

RSL Chang & VJ Lotti (1986) Biochemical and pharmacological characterisation of an extremely potent and selective nonpeptide cholecystokinin antagonist. Proceedings of the National Academy of Sciences USA 83, 49234926.

E Corrazziari , R Ricci , D Biliotti , I Bontempi , A De Medici , N Pallotta & A Torsoli (1990) Oral administration of loxiglumide CCK antagonist inhibits postprandial gall bladder contraction without affecting gastric emptying. Digestive Diseases and Sciences 35, 5054.

MA Della-Fera & CA Baile (1979) Cholecystokinin octapeptide: continuous picomole injections into the cerebral ventricles suppress feeding. Science 206, 471473.

MA Della-Fera & CA Baile (1981) Cholecystokinin antibody injected into cerebral ventricles stimulated feeding in sheep. Science 212, 687689.

DAH Farningham , JG Mercer & CB Lawrence (1993) Satiety signals in sheep: involvement of CCK, propionate, and vagal CCK binding sites. Physiology and Behavior 54, 437442.

JM Forbes (1980) A model of the short-term control of feeding. Appetite 1, 2141.

BG Hoebel (1985) Integrative peptides. Brain Research Bulletin 14, 525528.

F Makovec , M Bani , R Cereda , R Chiste , L Revel , LC Rovati , I Setnikar & LA Rovati (1986) Protective effect of CR 1409 on experimental pancreatitis in rats and mice. Peptides 7, 11591164.

JE Morley , AS Levin & J Knelp (1981) Muscimol induced feeding: a model to study the hypothalamic regulation of appetite. Life Science 29, 12131218.

RF Parrott (1993) Peripheral and central effects of CCK receptor agonists on operant feeding in pigs. Physiology and Behavior 53, 367372.

DV Rayner & S Miller (1993) Voluntary intake and gastric emptying in pigs: effects of fat and a CCK inhibitor. Physiology and Behavior 54, 917922.

AC Scallett , MA Della-Fera & CA Baile (1985) Satiety, hunger and regional brain content of cholecystokinin and metenkephalin in sheep. Peptides 6, 937.

JW Steel , LEA Symons & WO Jones (1980) Effects of level of larval intake on the productivity and physiology and metabolic responses of lambs infected with Trichostrongylus colubriformis. Australian Journal of Agricultural Research 31, 821828.

LEA Symons & DR Hennessy (1981) Cholecystokinin and anorexia in sheep infected by the intestinal nematode. Trichostrongylus colubriformis. International Journal of Parasitology 11, 5558.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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