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Evidence for the existence of adaptive thermogenesis during weight loss

Published online by Cambridge University Press:  09 March 2007

Eric Doucet
Affiliation:
Division of Kinesiology, Laval University, Ste-Foy, Québec G1K 7P4, Canada Department of Food Science and Nutrition, Laval University, Ste-Foy, Québec, G1K 7P4, Canada
Sylvie St-Pierre
Affiliation:
Division of Kinesiology, Laval University, Ste-Foy, Québec G1K 7P4, Canada
Natalie Alméras
Affiliation:
Department of Food Science and Nutrition, Laval University, Ste-Foy, Québec, G1K 7P4, Canada
Jean-Pierre Després
Affiliation:
Department of Food Science and Nutrition, Laval University, Ste-Foy, Québec, G1K 7P4, Canada
Claude Bouchard
Affiliation:
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
Angelo Tremblay*
Affiliation:
Division of Kinesiology, Laval University, Ste-Foy, Québec G1K 7P4, Canada
*
*Corresponding author: Dr Angelo Tremblay, fax +1 418 656 2441, email angelo.tremblay@kin.msp.ulaval.ca
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Abstract

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The present study was performed to further investigate the adaptive component of thermogenesis that appears during prolonged energy restriction. Fifteen obese men and twenty obese women underwent a 15-week weight-loss programme. During this programme, body weight and composition as well as resting energy expenditure (REE) were measured at baseline, after 2 and 8 weeks of energy restriction (-2929 kJ/d) and drug therapy (or placebo), and finally 2–4 weeks after the end of the 15-week drug therapy and energy restriction intervention, when subjects were weight stable. Regression equations were established in a control population of the same age. These equations were then used to predict REE in obese men and women at baseline, after 2 and 8 weeks, as well as after the completion of the programme. In both men and women body weight and fat mass were significantly reduced (P < 0.05 in all cases) while fat-free mass remained unchanged throughout the programme. At baseline, REE predicted from the regression equation was not significantly different from the measured REE in men, while in women the measured REE was 13 % greater than predicted. After 2 weeks of energy restriction, measured REE had fallen by 469 and 635 kJ/d more than predicted and this difference reached 963 and 614 kJ/d by week 8 of treatment in men and women respectively. Once body-weight stability was recovered at the end of the programme, changes in REE remained below predicted changes in men (-622 kJ/d). However, in women changes in predicted and measured REE were no longer different at this time, even if the women were maintaining a reduced body weight. In summary, the present results confirm the existence of adaptive thermogenesis and give objective measurements of this component during weight loss in obese men and women, while they also emphasize that in women this component seems to be essentially explained by the energy restriction.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2001

References

Arone, LJ, Mackintosh, R, Rosenbaum, M, Leibel, RL & Hirsch, J (1995) Autonomic nervous system activity in weight gain and weight loss. American Journal of Physiology 269, R222R225.Google Scholar
Association Diabète Québec (1993) Plan d'alimentation avec le système d'échanges (Food exchange system). Montréal, Canada: Groupe Litho Graphique.Google Scholar
Astrup, A, Buemann, B, Western, P, Toubro, S, Raben, A & Christensen, NJ (1994) Obesity as an adaptation to a high-fat diet: evidence from a cross-sectional study. American Journal of Clinical Nutrition 59, 350355.CrossRefGoogle ScholarPubMed
Behnke, AR & Wilmore, JT (1974) Evaluation and Regulation of Body Build and Composition, pp. 2037. Englewood Cliffs, NJ: Prentice-Hall.Google Scholar
Dionne, I, Després, J-P, Bouchard, C & Tremblay, A (1999) Gender difference in the effect of body composition on energy metabolism. International Journal of Obesity 23, 312319.CrossRefGoogle ScholarPubMed
Doucet, E, St Pierre, S, Almeras, N, Mauriege, P, Richard, D & Tremblay, A (2000) Changes in energy expenditure and substrate oxidation resulting from weight loss in obese men and women: is there an important contribution of leptin? Journal of Clinical Endocrinology and Metabolism 85, 15501556.Google ScholarPubMed
Dulloo, AG, Jacquet, J & Girardier, L (1997) Poststarvation hyperphagia and body fat overshooting in humans: a role for feedback signals from lean and fat tissues. American Journal of Clinical Nutrition 65, 717723.CrossRefGoogle ScholarPubMed
Ferraro, R, Lillioja, S, Fontvieille, A-M, Rising, R, Bogardus, C & Ravussin, E (1992) Lower sedentary metabolic rate in women compared with men. Journal of Clinical Investigation 90, 780784.CrossRefGoogle ScholarPubMed
Geldszus, R, Mayr, B, Horn, R, Geisthovel, F, von zur Muhlen, A & Brabant, G (1996) Serum leptin and weight reduction in female obesity. European Journal of Endocrinology 135, 659662.CrossRefGoogle ScholarPubMed
Keys, A, Brozek, J, Henschel, A, Mickelsen, O & Taylor, HL 1950 The biology of human starvation. Minneapolis: University of Minneapolis Press.CrossRefGoogle Scholar
Khan, MA, Herzog, CA, St Peter, JV, Hartley, GG, Madlon-Kay, R, Dick, CD, Asinger, RW & Vessey, JT (1998) The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite-suppressant drugs. New England Journal of Medicine 10, 713718.CrossRefGoogle Scholar
Lafreniere, F, Lambert, J, Rasio, E & Serri, O (1993) Effects of dexfenfluramine treatment on body weight and postprandial thermogenesis in obese subjects. A double-blind placebo-controlled study. International Journal of Obesity 17, 2530.Google Scholar
Leibel, RL & Hirsch, J (1984) Diminished energy requirements in reduced–obese patients. Metabolism 33, 164169.CrossRefGoogle ScholarPubMed
Leibel, RL, Rosenbaum, M & Hirsch, J (1995) Changes in energy expenditure resulting from altered body weight. New England Journal of Medicine 332, 621628.Google Scholar
Levine, AS & Billington, CJ (1998) Do circulating leptin concentrations reflect body adiposity or energy flux? American Journal of Clinical Nutrition 68, 761762.CrossRefGoogle ScholarPubMed
Meneely, EA & Kaltreider, NL (1949) Volume of the lung determined by helium dilution. Journal of Clinical Investigation 28, 129139.CrossRefGoogle ScholarPubMed
Pasman, WJ, Saris, WH & Westerterp-Plantenga, MS (1999) Predictors of weight maintenance. Obesity Research 7, 4350.Google Scholar
Prentice, AM, Goldberg, GR, Jebb, SA, Black, AE, Murgatroyd, PR & Diaz, EO (1991) Physiological responses to slimming. Proceedings of the Nutrition Society 50, 441458.CrossRefGoogle ScholarPubMed
Prud'homme, D, Langlais, M, Samson, MP, Gallagher, P, Turcotte, J, Tremblay, A and Després, J-P (1999) Lack of major cardiac valvular abnormalities in asymptomatic obese men and women following a 3-month fenfluramine or dexfenfluramine treatment. International Journal of Obesity 23, S175.Google Scholar
Ravussin, E, Lillioja, S, Anderson, TE, Christin, L & Bogardus, C (1986) Determinants of 24-hour energy expenditure in man. Journal of Clinical Investigation 78, 15681578.Google Scholar
Ravussin, E, Lillioja, S, Knowler, WC, Christin, L, Freymond, D, Abbott, WGH, Boyce, V, Howard, BV & Bogardus, C (1988) Reduced rate of energy expenditure as a risk factor for body-weight gain. New England Journal of Medicine 318, 467472.Google Scholar
Recasens, MA, Barenys, M, Sola, R, Blanch, S, Masana, L & Salas-Salvado, J (1995) Effect of dexfenfluramine on energy expenditure in obese patients on a very-low-calorie diet. International Journal of Obesity 19, 162168.Google ScholarPubMed
Rosenbaum, M, Hirsch, J, Murphy, E & Leibel, RL (2000) Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function. American Journal of Clinical Nutrition 71, 14211432.Google Scholar
Saris, WH (1995) Effects of energy restriction and exercise on the sympathetic nervous system. International Journal of Obesity 19, Suppl. 7, S17S23.Google ScholarPubMed
Scalfi, L, D'Arrigo, E, Carandente, V, Coltorti, A & Contaldo, F (1993) The acute effect of dexfenfluramine on resting metabolic rate and postprandial thermogenesis in obese subjects: a double-blind placebo-controlled study. International Journal of Obesity 17, 9196.Google ScholarPubMed
Schutz, Y, Tremblay, A, Weinsier, RL & Nelson, KM (1992) Role of fat oxidation in the long-term stabilization of body weight in obese women. American Journal of Clinical Nutrition 55, 670674.Google Scholar
Siri, WE (1956) The gross composition of the body. Advances in Biology of Medicine and Physiology 4, 239280.Google Scholar
Snitker, S, Pratley, RE, Nicolson, M, Tataranni, PA & Ravussin, E (1997) Relationship between muscle sympathetic nervous activity and plasma leptin concentration. Obesity Research 5, 338340.CrossRefGoogle ScholarPubMed
Stallone, DD & Levitsky, DA (1994) Chronic fenfluramine treatment: effects on body weight, food intake and energy expenditure. International Journal of Obesity 18, 679685.Google ScholarPubMed
Tremblay, A, Despres, JP, Theriault, G, Fournier, G & Bouchard, C (1992) Overfeeding and energy expenditure in humans. American Journal of Clinical Nutrition 56, 857862.CrossRefGoogle ScholarPubMed
Van Gaal, LF, Vansant, GA, Steijaert, MC & De Leeuw, IH (1995) Effects of dexfenfluramine on resting metabolic rate and thermogenesis in premenopausal obese women during therapeutic weight reduction. Metabolism 44, 4245.CrossRefGoogle ScholarPubMed
van Gemert, WG, Westerterp, KR, Greve, JW & Soeters, PB (1998) Reduction of sleeping metabolic rate after vertical banded gastroplasty. International Journal of Obesity 22, 343348.CrossRefGoogle ScholarPubMed
Wadden, TA, Considine, RV, Foster, GD, Anderson, DA, Sarwer, DB & Caro, JS (1998) Short- and long-term changes in serum leptin dieting obese women: effects of caloric restriction and weight loss. Journal of Clinical Endocrinology and Metabolism 83, 214218.Google Scholar
Wadden, TA, Foster, GD, Stunkard, AJ & Conill, AM (1996) Effects of weight cycling on the resting energy expenditure and body composition of obese women. International Journal of Eating Disorders 19, 512.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Wales, JK (1980) The effect of fenfluramine on weight loss during restricted dietary regimes. International Journal of Obesity 4, 127132.Google ScholarPubMed
Weir, JB (1949) New methods for calculating metabolic rate with special reference to protein metabolism. Journal of Physiology 109, 19.CrossRefGoogle ScholarPubMed
Weissman, NJ, Tighe, JFJ, Gottdiener, JS & Gwynne, JT (1998) An assessment of heart-valve abnormalities in obese patients taking dexfenfluramine, sustained-release dexfenfluramine, or placebo. Sustained-Release Dexfenfluramine Study Group. New England Journal of Medicine 10, 725732.CrossRefGoogle Scholar
Westerterp, KR, Meijer, GA, Schoffelen, P & Janssen, EM (1994) Body mass, body composition and sleeping metabolic rate before, during and after endurance training. European Journal of Applied Physiology 69, 203208.CrossRefGoogle ScholarPubMed
Weyer, C, Walford, RL, Harper, IT, Milner, M, MacCallum, T, Tataranni, PA & Ravussin, E (2000) Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment. American Journal of Clincal Nutrition 72, 946953.Google Scholar
Wisse, BE, Campfield, LA, Marliss, EB, Morais, JA, Tenenbaum, R & Gougeon, R (1999) Effect of prolonged moderate and severe energy restriction and refeeding on plasma leptin concentrations in obese women. American Journal of Clinical Nutrition 70, 321330.CrossRefGoogle ScholarPubMed