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Evidence of unmetabolised folic acid in cord blood of newborn and serum of 4-day-old infants

  • Mary R. Sweeney (a1) (a2), Joseph McPartlin (a1), Donald G. Weir (a1), Sean Daly (a3), Kristina Pentieva (a4), Leslie Daly (a2) and John M. Scott (a5)
  • DOI: http://dx.doi.org/10.1079/BJN20051572
  • Published online: 01 March 2007
Abstract

Oral folic acid above certain threshold doses results in unmetabolised folic acid in serum. This raises a number of public health safety issues, principally the potential to mask pernicious anaemia; more recently the theoretical potential for high-dose folic acid to promote cancer has been highlighted. In this paper we set out to examine the appearance of unmetabolised folic acid both in cord blood from newborn full-term and premature infants and serum from 4-d-old infants post-formula feeding. Blood was collected from the umbilical cord of eleven infants in the delivery room immediately after birth. A follow-up serum sample (n 9) was collected 4d later from infants post-formula feeding. We detected unmetabolised folic acid in cord blood from all infants at birth. In addition, unmetabolised folic acid was present in serum of seven infants post-formula feeding, six of which had increased from birth. Our results imply that infants in Ireland, which does not yet have mandatory fortification, could potentially have circulatory unmetabolised folic acid at the time of birth. We do not know if the presence of folic acid in cord blood will have any adverse consequences. However, if theoretical safety concerns are borne out by future research, the likelihood is that the longer the exposure the more likely the potential for harm. This would also be the case in infants exposed to unmetabolised folic acid as a result of formula feeding.

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Corresponding author
*Corresponding author: Dr Mary R. Sweeney, fax +353 1 7167407, email maryrose.sweeney@ucd.ie
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M Lucock & Z Yates (2005) Folic acid – vitamin and panacea or genetic time bomb? Nat Rev Genet 6, 235240.

A Molloy & JM Scott (1997) Microbiological assay for serum, plasma and red cell folate using cryopreserved microtitre plate method. Methods Enzymol 281, 4353.

MR Sweeney , J McPartlin , DG Weir & JM Scott (2003) Measurements of subnanomolar concentrations of unmetabolised folic acid in serum. J Chromotogr B 788, 187191.

T Tamura (1998) Determination of food folates. Nutr Biochem 9, 285293.

JR Thompson , P Fitzgerald , ML Willoghby & BK Amstrong (2001) Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study. Lancet 358, 19351940.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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