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    Eckel, Robert H. 2015. Intestinal Lipoprotein Secretion: Incretin-Based Physiology and Pharmacology Beyond Glucose: Figure 1. Diabetes, Vol. 64, Issue. 7, p. 2338.


    Maillot, François Baulieu, Françoise Guilloteau, Denis Boirie, Yves Garrigue, Marie-Ange Hoinard, Claude and Couet, Charles 2008. Gut emptying affects dietary fat contribution to postprandial lipemia following sequential meals in healthy subjects. Nutrition, Vol. 24, Issue. 7-8, p. 682.


    Maillot, F Garrigue, MA Pinault, M Objois, M Théret, V Lamisse, F Hoinard, C Antoine, JM Lairon, D and Couet, C 2005. Changes in plasma triacylglycerol concentrations after sequential lunch and dinner in healthy subjects. Diabetes & Metabolism, Vol. 31, Issue. 1, p. 69.


    Carstensen, Marius Thomsen, Claus and Hermansen, Kjeld 2003. Incremental area under response curve more accurately describes the triglyceride response to an oral fat load in both healthy and type 2 diabetic subjects. Metabolism, Vol. 52, Issue. 8, p. 1034.


    Orth, Matthias Wahl, Sabine Hanisch, Monika Friedrich, Isolde Wieland, Heinrich and Luley, Claus 1996. Clearance of postprandial lipoproteins in normolipemics: role of the apolipoprotein E phenotype. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 1303, Issue. 1, p. 22.


    TSETSONIS, NATASSA V. and HARDMAN, ADRIANNE E. 1996. Reduction in postprandial lipemia after walking: influence of exercise intensity. Medicine &amp Science in Sports &amp Exercise, Vol. 28, Issue. 10, p. 1235.


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Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal

  • Jennifer L. Potts (a1), Sandy M. Humphreys (a1), Simon W. Coppack (a1), Rachel M. Fisher (a1), Geoffrey F. Gibbons (a2) and Keith N. Fray (a1)
  • DOI: http://dx.doi.org/10.1079/BJN19940013
  • Published online: 09 March 2007
Abstract

The changes in lipoprotein metabolism which follow the ingestion of a large fat load have been well described. The hypothesis was tested that similar changes in lipoprotein metabolism would occur after a relatively normal meal. Plasma and lipoprotein triacylglycerol, cholesterol and apolipoprotein concentrations were determined in twenty subjects (ten female) given a mixed meal containing approximately one-third of the daily intake of major nutrients in the typical Western diet. Fasting plasma triacylglycerol concentrations (range 0.38–2.70 mm/l) and the postprandial rise in plasma triacylglycerol varied considerably between subjects and were significantly associated (P < 0.01). The rise in plasma triacylglycerol corresponded to marked increases in the triacylglycerol concentration of the triacylglycerol-rich lipoproteins (TRL; chylomicrons and very-low-density lipoproteins). TRL cholesterol also increased after the meal. An increase in high-density-lipoprotein (HDL)-triacylglycerol following the meal was accompanied by a decrease in HDL-cholesterol concentration, presumably due to the action of the cholesteryl-ester transfer protein. The increases in HDL-triacylglycerol and in TRL- cholesterol were correlated with the postprandial rise in triacylglycerol in the TRL (P < 0.01). We conclude that potentially adverse changes occur in both triacylglycerol-rich and high-density lipoproteins following a typical mixed meal, as they do after large fat loads. The changes are exaggerated in those subjects with greater fasting plasma triacylglycerol concentrations.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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