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Fruit polyphenols, immunity and inflammation

  • Javier González-Gallego (a1), M. Victoria García-Mediavilla (a1), Sonia Sánchez-Campos (a1) and María J. Tuñón (a1)
Abstract

Flavonoids are a large class of naturally occurring compounds widely present in fruits, vegetables and beverages derived from plants. These molecules have been reported to possess a wide range of activities in the prevention of common diseases, including CHD, cancer, neurodegenerative diseases, gastrointestinal disorders and others. The effects appear to be related to the various biological/pharmacological activities of flavonoids. A large number of publications suggest immunomodulatory and anti-inflammatory properties of these compounds. However, almost all studies are in vitro studies with limited research on animal models and scarce data from human studies. The majority of in vitro research has been carried out with single flavonoids, generally aglycones, at rather supraphysiological concentrations. Few studies have investigated the anti-inflammatory effects of physiologically attainable flavonoid concentrations in healthy subjects, and more epidemiological studies and prospective randomised trials are still required. This review summarises evidence for the effects of fruit and tea flavonoids and their metabolites in inflammation and immunity. Mechanisms of effect are discussed, including those on enzyme function and regulation of gene and protein expression. Animal work is included, and evidence from epidemiological studies and human intervention trials is reviewed. Biological relevance and functional benefits of the reported effects, such as resistance to infection or exercise performance, are also discussed.

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Corresponding author
*Corresponding author: M. J. Tuñón, fax +34 987 291267, email mjtung@unileon.es
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1K Robards & M Antolovich (1997) Analytical biochemistry of fruit flavonoids, a review. Analyst 122, 436.

2SK Katiyar (2003) Skin photoprotection by green tea: antioxidant and immunomodulatory effects. Curr Drug Targets Immune Endocr Metabol Disord 3, 234242.

4MJ Tuñón , MV García-Mediavilla , S Sánchez-Campos , (2009) Potential of flavonoids as anti-inflammatory agents: modulation of inflammatory gene expression and signal transduction pathways. Curr Drug Metab 10, 256271.

5YC Liang , YT Huang , SH Tsai , (1999) Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis 20, 19451952.

6SC Shen , WR Lee , HY Lin , (2002) In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. Eur J Pharmacol 446, 187194.

8S Ahmed , A Rahman , A Hasnain , (2002) Green tea polyphenol epigallocatechin 3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radic Biol Med 33, 10971105.

9GM Raso , R Meli , G Di Carlo , (2001) Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci 68, 921931.

10WJ Jung & M Sung (2004) Effects of major dietary antioxidants on inflammatory markers of RAW 264·7 macrophages. Biofactors 21, 131137.

11JY Kim , S Park , KJ Yun , (2008) Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264·7 macrophages. Eur J Pharmacol 584, 175184.

12N Lin , T Sato , Y Takayama , (2003) Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem Pharmacol 65, 20652071.

13DX Hou , D Luo , S Tanigawa , (2007) Prodelphinidin B-4 3′-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway. Biochem Pharmacol 74, 742751.

14M Mutoh , M Takahashi , K Fukuda , (2000) Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. Carcinogenesis 21, 959963.

15MV García-Mediavilla , I Crespo , PS Collado , (2007) Anti-inflammatory effect of the flavones quercetin and kaempferol in Chang Liver cells involves inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway. Eur J Pharmacol 557, 221229.

16CY Chen , WH Peng , KD Tsai , (2007) Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci 81, 16021614.

17HK Kang , D Ecklund , M Liu , (2009) Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. Arthritis Res Ther 11, R59.

18HP Kim , KH Son , HW Chang , (2004) Anti-inflammatory plant flavonoids and cellular action mechanisms. Pharm Sci 96, 229245.

19A Moreira , C Fraga , M Alonso , (2004) Quercetin prevents oxidative stress and NF-kappaB activation in gastric mucosa of portal hypertensive rats. Biochem Pharmacol 68, 19391946.

20J Tieppo , MJ Cuevas , R Vercelino , (2009) Prevention of hepatopulmonary syndrome by quercetin administration in cirrhotic rats. J Nutr 139, 13391346.

21T Hirano , S Higa , J Arimitsu , (2004) Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. Int Arch Allergy Immunol 134, 135140.

22TL Wadsworth & DR Koop (1999) Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264·7 macrophages. Biochem Pharmacol 57, 941949.

23IB Kim , DY Kim , SJ Lee , (2006) Inhibition of IL-8 production by green tea polyphenols in human nasal fibroblasts and A549 epithelial cells. Biol Pharm Bull 29, 11201125.

24HH Park , S Lee , HY Son , (2008) Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch Pharm Res 31, 13031311.

25YJ Kim , SE Choi , MW Lee , (2008) Taxifolin glycoside inhibits dendritic cell responses stimulated by lipopolysaccharide and lipoteichoic acid. J Pharm Pharmacol 60, 14651472.

26Z Sternberg , K Chadka , A Lieberman , (2008) Quercetin and interferon-beta modulate immune response(s) in peripheral blood mononuclear cell isolated from multiple sclerosis patients. J Neuroimmunol 205, 142147.

27CY Li , JL Suen , BL Chiang , (2006) Morin promotes the production of Th2 cytokine by modulating bone marrow-derived dendritic cells. Am J Chin Med 34, 667684.

28JS Lee , SG Kim , KH Kim , (2007) Silibilin polarizes Th1/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells. J Cell Physiol 210, 385397.

29M Comalada , I Ballester , E Bailón , (2006) Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. Biochem Pharmacol 72, 10101021.

30S Crouvezier , B Powell , D Keir , (2005) The effects of phenolic components of tea on the production of pro- and anti-inflammatory cytokines by human leukocytes in vitro. Cytokine 13, 280286.

31J Wang , Q Zhang , S Jin , (2008) Genistein modulate immune responses in collage-induced reumathoid arthiritis model. Maturitas 59, 405412.

32S Yano , D Umeda , T Yamashita , (2007) Dietary flavones suppress IgE and Th2 cytokines in OVA-immunized BALB/c mice. Eur J Nutr 46, 257263.

33HJ Park , CM Lee , ID Jung , (2009) Quercetin regulates Th1/Th2 balance in a murine model of asthma. Int Immunopharmacol 9, 261267.

34CS Yu , KC Lai , JS Yang , (2010) Quercetin inhibited murine leukemia WEHI-3 cells in vivo and promoted immune response. Phytother Res 24, 163168.

35JP Lin , JS Yang , CC Lu , (2009) Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune responses in vivo. Leuk Res 33, 823828.

36K Min , WK Yoon , SK Kim , (2007) Immunosuppressive effects of silibilin in experimental autoimmune encephalomyelitis. Arch Pharm Res 30, 12651272.


39JS Kang , YD Yoon , MH Han , (2006) Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. Mol Pharmacol 69, 941949.

40Z Nowakowska (2007) A review of anti-infective and anti-inflammatory chalcones. Eur J Med Chem 42, 125137.

41SB Lotito & B Frei (2006) Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion alpha-induced adhesion molecule expression in human aortic endothelial cells. J Biol Chem 281, 3710237110.

42HY Ahn , Y Xu & ST Davidge (2008) Epigallocatechin-3-O-gallate inhibits TNFα-induced monocyte chemotactic protein-1 production from vascular endothelial cells. Life Sci 82, 964968.

44J Kowalski , A Samojedny , M Paul , (2006) Apigenin inhibit release and gene expression of monocyte chemoattractant protein 1 (MCP-1) in J774·2 macrophages. Wiad Lek 59, 634638.

45K Muraoka , K Shimizu , X Sun , (2002) Flavonoids exert diverse inhibitory effects on the activation of NF-kappaB. Transplant Proc 34, 13351340.

46CA Musonda & JK Chipman (1998) Quercetin inhibits hydrogen peroxide (H2O2)-induced NF-kappaB DNA binding activity and DNA damage in HepG2 cells. Carcinogenesis 19, 15831589.

47M Comalada , D Camuesco , S Sierra , (2005) In vivo quercitrin anti-inflammatory effect involves releases of quercetin, which inhibits inflammation through down-regulation of NF-kappaB pathway. Eur J Immunol 35, 584592.

48MP Nair , S Mahajan , JL Reynolds , (2006) The flavonoid quercetin inhibits proinflammatory cytokine (Tumor necrosis factor alpha) gene expression in normal peripheral mononuclear cells via modulation of the NF-κB system. Clin Vac Immunol 13, 319328.

49AG Erlejman , G Jaggers , CG Fraga , (2008) TNFα-induced NF-κB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells. Arch Biochem Biophys 476, 186195.

50V Sivaramakrishnan & S Niranjali Devaraj (2009) Morin regulates the expression of NF-κB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chem Biol Interact 180, 353359.

51SY Choi , JH Hwang , HC Ko , (2007) Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-κB and ROS production in LPS-activated RAW264·7 cells. J Ethnopharmacol 113, 149155.


53L Xu , L Zhang , AM Bertucci , (2008) Apigenin a dietary flavonoid sensitizes human T cells for activation-induced cell death by inhibiting PKB/Akt and NF-κB activation pathway. Immunol Lett 121, 7483.

54GK Rangan , Y Wang & DC Harris (2002) Dietary quercetin augments activator protein-1 and does not reduce nuclear factor-kappa B in the renal cortex of rats with established chronic glomerular disease. Nephron 90, 313319.

55S Jang , KW Kelley & RW Johnson (2008) Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. Proc Natl Acad Sci U S A 105, 75347539.

56M Hamlinen , R Nieminen , P Vuorela , (2007) Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavones, rhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with the inhibitory effects on iNOS expression and NO production in activated macrophages. Mediators Inflamm 2007, 4567345683.

57F Cai , CR Li , JL Wu , (2006) Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1. Mediators Inflamm 2006, 30490.

59L Ma , HQ Gao , BY Li , (2007) Grape seed proanthocyanidin extracts inhibit vascular cell adhesion molecule expression induced by advanced glycation end products through activation of peroxisome proliferators-activated receptor gamma. J Cardiovasc Pharmacol 49, 293298.

60TL Wadsworth & DR Koop (2001) Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide. Chem Biol Interact 137, 4358.

61B Ying , T Yang , X Song , (2009) Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways. Mol Biol Rep 36, 18251832.

62A Xagorar , C Roussos & A Papapetropoulos (2002) Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin. Br J Pharmacol 136, 10581064.

64DJ O'Byrne , S Devaraj , SM Grundy , (2002) Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin Nutr 76, 13671374.

65J García-Alonso , G Ros , ML Vidal-Guevara , (2006) Acute intake of phenolic-rich juice improves antioxidant status in healthy subjects. Nutr Res 26, 330339.

66D Heber , NP Seeram , H Wyatt , (2007) Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. J Agric Food Chem 55, 1005010054.

67GS Jensen , X Wu , KM Patterson , (2008) In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study. J Agric Food Chem 56, 83268333.

69J Salas-Salvadó , A Garcia-Arellano , R Estruch , (2008) PREDIMED Investigators. Components of the Mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease. Eur J Clin Nutr 62, 651659.

70EM Holt , LM Steffen , A Moran , (2009) Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents. J Am Diet Assoc 109, 414421.


76D De Bacquer , E Clays , J Delanghe , (2006) Epidemiological evidence for an association between habitual tea consumption and markers of chronic inflammation. Atherosclerosis 189, 428435.

77A Steptoe , EL Gibson , R Vuononvirta , (2007) The effects of chronic tea intake on platelet activation and inflammation: a double-blind placebo controlled trial. Atherosclerosis 193, 277282.

78C Schoen , A Schulz , J Schweikart , (2009) Regulatory effects of a fermented food concentrate on immune function parameters in healthy volunteers. Nutrition 25, 499505.

79ME Widlansky , SJ Duffy , NM Hamburg , (2005) Effect of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease. Free Radic Biol Med 38, 499506.

80R Freese , O Vaarala , AM Turpeinen , (2004) No difference in platelet activation and inflammation markers after diets rich or poor in vegetables, berries and apple in healthy subjects. Eur J Nutr 43, 175182.

81MP De Maat , H Pijl , C Kluft , (2000) Consumption of black and green tea had no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals. Eur J Clin Nutr 54, 757763.

82SU Mertens-Talcott , P Jilma-Stohlawetz , J Rios , (2006) Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum L.) polyphenols after ingestion of a standardized extract in healthy human volunteers. J Agric Food Chem 54, 89568961.

83AW Boots , LC Wilms , EL Swennen , (2008) In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers. Nutrition 24, 703710.

84P Knekt , J Kumpulainen , R Järvinen , (2002) Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 76, 560568.

85R Barros , A Moreira , J Fonseca , (2008) Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control. Allergy 63, 917923.

86V Garcia , IC Arts , JA Sterne , (2005) Dietary intake of flavonoids and asthma in adults. Eur Resp J 26, 449452.

87RR Watson , S Zibadi , H Rafatpanah , (2008) Oral administration of the purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma. Nutr Res 28, 166171.

90L Gil , L Lewis , G Martínez , (2005) Effect of increase of dietary micronutrient intake on oxidative stress indicators in HIV/AIDS patients. Int J Vitam Nutr Res 75, 1927.

91DA Shoskes , SI Zeitlin , A Shahed , (1999) Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 54, 960963.

93SC Bae , WJ Jung , EJ Lee , (2009) Effects of antioxidant supplement intervention on the level of plasma inflammatory molecules and disease severity of reumatoid arthritis patients. J Am Coll Nutr 28, 5662.

94Y Song , JE Manson , JE Buring , (2005) Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis. J Am Coll Nutr 24, 376384.

95OH Ryu , J Lee , KW Lee , (2006) Effects of green tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes patients. Diabetes Res Clin Pract 71, 34563458.

96Y Fukino , M Shimbo , N Aoki , (2005) Randomized controlled trial for and effect of green tea consumption on insulin resistance and inflammation markers. J Nutr Sci Vitaminol 51, 335342.

97P Kar , D Laight , HK Rooprai , (2009) Effects of grape seed extract in type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med 26, 526531.

98LH Yao , YM Jiang , J Shi , (2004) Flavonoids in food and their health benefits. Plant Foods Hum Nutr 59, 113122.

99MG Hertog , EJ Feskens , PC Hollman , (1994) Dietary flavonoids and cancer risk in the Zutphen Elderly Study. Nutr Cancer 22, 175184.

100RA Goldbohm , MG Hertog , HA Brants , (1996) Consumption of black tea and cancer risk: a prospective cohort study. J Natl Cancer Inst 88, 93100.

101Y Tsubono , Y Nishino , S Komatsu , (2001) Green tea and the risk of gastric cancer in Japan. N Eng J Med 344, 632636.

102K Imai , K Suga & K Nakachi (1997) Cancer-preventive effects of drinking green tea among a Japanese population. Prev Med 26, 769775.

103JV Higdon & B Frei (2003) Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sci Nutr 43, 89143.

104P Knekt , R Järvinen , R Seppänen , (1997) Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 146, 223230.

105M Rossi , W Garavello , R Talamini , (2007) Flavonoids and risk of squamous cell esophageal cancer. Int J Cancer 120, 15601564.

106C Bosetti , M Rossi , JK McLaughlin , (2007) Flavonoids and the risk of renal cell carcinoma. Cancer Epidemiol Biomarkers Prev 16, 98101.

107M Rossi , E Negri , R Talamini , (2006) Flavonoids and colorectal cancer in Italy. Cancer Epidemiol Biomarkers Prev 15, 15551558.

108A Rietveld & S Wiseman (2003) Antioxidant effects of tea: evidence from human clinical trials. J Nutr 133, 3285S3292S.

109LA Kresty , WL Frankel , CD Hammond , (2006) Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients. Nutr Cancer 54, 148156.

110SR Mallery , JC Zwick , P Pei , (2008) Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions. Cancer Res 68, 49454957.

111CA Elmets , D Singh , K Tubesing , (2001) Cutaneous photoprotection from ultraviolet injury by green tea polyphenols. J Am Acad Dermatol 44, 425432.

112A Jatoi , N Ellison , PA Burch , (2003) A phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma. Cancer 97, 14421446.

113AJ Pantuck , JT Leppert , N Zomorodian , (2006) Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res 12, 40184026.

114H Luo , L Tang , M Tang , (2006) Phase II chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. Carcinogenesis 27, 262268.

115RJ Williams , JP Spencer & C Rice-Evans (2004) Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 36, 838849.

116T Vassilakopoulos , MH Karatza , P Katsaounou , (2003) Antioxidants attenuate the plasma cytokine response to exercise in humans. J Appl Physiol 94, 10251032.

117SL Williams , NA Strobel , LA Lexis , (2006) Antioxidant requirements of endurance athletes: implications for health. Nutr Rev 64, 93108.

118TA Watson , R Callister , RD Taylor , (2005) Antioxidant restriction and oxidative stress in short-duration exhaustive exercise. Med Sci Sports Exerc 37, 6371.

120J Morillas-Ruiz , P Zafrilla , M Almar , (2005) The effects of an antioxidant-supplemented beverage on exercise-induced oxidative stress: results from a placebo-controlled double-blind study in cyclists. Eur J Appl Physiol 95, 543549.

121RJ Bloomer , AH Goldfarb & MJ McKenzie (2006) Oxidative stress response to aerobic exercise: comparison of antioxidant supplements. Med Sci Sports Exerc 38, 10981105.

122AH Goldfarb , MJ McKenzie & R Bloomer (2007) Gender comparisons of exercise-induced oxidative stress: influence of antioxidant supplementation. Appl Physiol Nutr Metab 32, 11241131.

123VS Panza , E Wazlawik , G Ricardo Schütz , (2008) Consumption of green tea favorably affects oxidative stress markers in weight-trained men. Nutrition 24, 433442.

124JC Quindry , SR McAnulty , MB Hudson , (2008) Oral quercetin supplementation and blood oxidative capacity in response to ultramarathon competition. Int J Sport Nutr Exerc Metab 18, 601616.

125T Phillips , AC Childs , DM Dreon , (2003) A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. Med Sci Sports Exerc 35, 20322037.

126DC Nieman , DA Henson , JM Davis , (2007) Quercetin ingestion does not alter cytokine changes in athletes competing in the Western States Endurance Run. J Interferon Cytokine Res 27, 10031011.

127SR McAnulty , LS McAnulty , DC Nieman , (2008) Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation. Appl Physiol Nutr Metab 33, 254262.

128DC Nieman , DA Henson , JM Davis , (2007) Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA. J Appl Physiol 103, 17281735.

129DC Nieman , DA Henson , SJ Gross , (2007) Quercetin reduces illness but not immune perturbations after intensive exercise. Med Sci Sports Exerc 39, 15611569.

130D Henson , D Nieman , JM Davis , (2008) Post-160-km race illness rates and decreases in granulocyte respiratory burst and salivary IgA output are not countered by quercetin ingestion. Int J Sports Med 29, 856863.

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