Adibi, SA (1997) The oligopeptide transporter (Pept-1) in human intestine: biology and function. Gastroenterology 113, 332–340.
Ahima, RS & Flier, JS (2000) Leptin. Annu Rev Physiol 62, 413–437.
Ariyasu, H, Takaya, K, Tagami, T, et al. (2001) Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 86, 4753–4758.
Attoub, S, Levasseur, S, Buyse, M, et al. (1999) Physiological role of cholecystokinin B/gastrin receptor in leptin secretion. Endocrinology 140, 4406–4410.
Bado, A, Levasseur, S, Attoub, S, et al. (1998) The stomach is a source of leptin. Nature 394, 790–793.
Barrachina, MD, Martinez, V, Wang, L, Wei, JY & Tache, Y (1997) Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 94, 10455–10460.
Batterham, RL, Cowley, MA, Small, CJ, et al. (2002) Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418, 650–654.
Berthoud, HR & Powley, TL (1992) Vagal afferent innervation of the rat fundic stomach: morphological characterization of the gastric tension receptor. J Comp Neurol 319, 261–276.
Boden, G, Chen, X, Mozzoli, M & Ryan, I (1996) Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab 81, 3419–3423.
Buyse, M, Berlioz, F, Guilmeau, S, et al. (2001 a) PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine. J Clin Invest 108, 1483–1494.
Buyse, M, Ovesjo, ML, Goiot, H, et al. (2001 b) Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve. Eur J Neurosci 14, 64–72.
Campfield, LA & Smith, FJ (1990) Transient declines in blood glucose signal meal initiation. Int J Obes 14, Suppl. 3, 15–31.
Campfield, LA & Smith, FJ (2003) Blood glucose dynamics and control of meal initiation: a pattern detection and recognition theory. Physiol Rev 83, 25–58.
Campfield, LA, Smith, FJ, Rosenbaum, M & Hirsch, J (1996) Human eating: evidence for a physiological basis using a modified paradigm. Neurosci Biobehav Rev 20, 133–137.
Casabiell, X, Pineiro, V, Tome, MA, Peino, R, Dieguez, C & Casanueva, FF (1997) Presence of leptin in colostrum and/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake. J Clin Endocrinol Metab 82, 4270–4273.
Cinti, S, de Matteis, R, Ceresi, E, et al. (2001) Leptin in the human stomach. Gut 49, 155.
Cinti, S, de Matteis, R, Pico, C, et al. (2000) Secretory granules of endocrine and chief cells of human stomach mucosa contain leptin. Int J Obes Relat Metab Disord 24, 789–793.
Considine, RV, Sinha, MK, Heiman, ML, et al. (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334, 292–295.
Corp, ES, McQuade, J, Moran, TH & Smith, GP (1993) Characterization of type A and type B CCK receptor binding sites in rat vagus nerve. Brain Res 623, 161–166.
Crawley, JN (1999) The role of galanin in feeding behavior. Neuropeptides 33, 369–375.
Cummings, DE, Purnell, JQ, Frayo, RS, Schmidova, K, Wisse, BE & Weigle, DS (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50, 1714–1719.
Date, Y, Kojima, M, Hosoda, H, et al. (2000) Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141, 4255–4261.
Frederich, RC, Lollmann, B, Hamann, A, et al. (1995) Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest 96, 1658–1663.
Gibbs, J, Young, RC & Smith, GP (1973) Cholecystokinin decreases food intake in rats. J Comp Physiol Psychol 84, 488–495.
Gundlach, AL, Burazin, TC & Larm, JA (2001) Distribution, regulation and role of hypothalamic galanin systems: renewed interest in a pleiotropic peptide family. Clin Exp Pharmacol Physiol 28, 100–105.
Hampton, LL, Ladenheim, EE, Akeson, M, et al. (1998) Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice. Proc Natl Acad Sci USA 95, 3188–3192.
Hardie, LJ, Rayner, DV, Holmes, S & Trayhurn, P (1996) Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem Biophys Res Commun 223, 660–665.
Himms-Hagen, J (1999) Physiological roles of the leptin endocrine system: differences between mice and humans. Crit Rev Clin Lab Sci 36, 575–655.
Kamegai, J, Tamura, H, Shimizu, T, Ishii, S, Sugihara, H & Wakabayashi, I (2001) Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes 50, 2438–2443.
Kojima, M, Hosoda, H, Date, Y, Nakazato, M, Matsuo, H & Kangawa, K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656–660.
Kolaczynski, JW, Considine, RV, Ohannesian, J, et al. (1996 a) Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves. Diabetes 45, 1511–1515.
Kolaczynski, JW, Ohannesian, JP, Considine, RV, Marco, CC & Caro, JF (1996 b) Response of leptin to short-term and prolonged overfeeding in humans. J Clin Endocrinol Metab 81, 4162–4165.
Kopin, AS, Mathes, WF, McBride, EW, et al. (1999) The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J Clin Invest 103, 383–391.
Lee, HM, Wang, G, Englander, EW, Kojima, M & Greeley, GH Jr (2002) Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 143, 185–190.
Lewin, MJ & Bado, A (2001) Gastric leptin. Microsc Res Tech 53, 372–376.
Lostao, MP, Urdaneta, E, Martinez-Anso, E, Barber, A & Martinez, JA (1998) Presence of leptin receptors in rat small intestine and leptin effect on sugar absorption. FEBS Lett 423, 302–306.
Maffei, M, Halaas, J, Ravussin, E, et al. (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1, 1155–1161.
Masuzaki, H, Ogawa, Y, Sagawa, N, et al. (1997) Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3, 1029–1033.
Moran, TH (2000) Cholecystokinin and satiety: current perspectives. Nutrition 16, 858–865.
Morton, NM, Emilsson, V, Liu, YL & Cawthorne, MA (1998) Leptin action in intestinal cells. J Biol Chem 273, 26194–26201.
Ohki-Hamazaki, H, Sakai, Y, Kamata, K, et al. (1999) Functional properties of two bombesin-like peptide receptors revealed by the analysis of mice lacking neuromedin B receptor. J Neurosci 19, 948–954.
Oliver, P, Picó, C, De Matteis, R, Cinti, S & Palou, A (2002) Perinatal expression of leptin in rat stomach. Dev Dyn 223, 148–154.
Palou, A, Serra, F, Bonet, ML & Picó, C (2000) Obesity: molecular bases of a multifactorial problem. Eur J Nutr 39, 127–144.
Phillips, RJ & Powley, TL (1996) Gastric volume rather than nutrient content inhibits food intake. Am J Physiol 271, R766–R769.
Picó, C, Sanchez, J, Oliver, P & Palou, A (2002) Leptin production by the stomach is up-regulated in obese (fa/fa) Zucker rats. Obes Res 10, 932–938.
Qu, D, Ludwig, DS, Gammeltoft, S, et al. (1996) A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380, 243–247.
Rentsch, J & Chiesi, M (1996) Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Lett 379, 55–59.
Sahu, A (1998) Leptin decreases food intake induced by melanin-concentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat. Endocrinology 139, 4739–4742.
Sakurai, T, Amemiya, A, Ishii, M, et al. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573–585.
Saladin, R, De Vos, P, Guerre-Millo, M, et al. (1995) Transient increase in obese gene expression after food intake or insulin administration. Nature 377, 527–529.
Scrocchi, LA, Brown, TJ, MacLusky, N, et al. (1996) Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med 2, 1254–1258.
Shintani, M, Ogawa, Y, Ebihara, K, et al. (2001) Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50, 227–232.
Sobhani, I, Bado, A, Vissuzaine, C, et al. (2000) Leptin secretion and leptin receptor in the human stomach. Gut 47, 178–183.
Sobhani, I, Buyse, M, Goiot, H, et al. (2002) Vagal stimulation rapidly increases leptin secretion in human stomach. Gastroenterology 122, 259–263.
Stanley, BG, Kyrkouli, SE, Lampert, S & Leibowitz, SF (1986) Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7, 1189–1192.
Tartaglia, LA, Dembski, M, Weng, X, et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263–1271.
Tschop, M, Smiley, DL & Heiman, ML (2000) Ghrelin induces adiposity in rodents. Nature 407, 908–913.
Wang, G, Lee, HM, Englander, E & Greeley, GH (2002) Ghrelin – not just another stomach hormone. Regul Pept 105, 75–81.
Wang, J, Liu, R, Hawkins, M, Barzilai, N & Rossetti, L (1998) A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393, 684–688.
Wang, MY, Zhou, YT, Newgard, CB & Unger, RH (1996) A novel leptin receptor isoform in rat. FEBS Lett 392, 87–90.
Wang, YH, Tache, Y, Sheibel, AB, Go, VL & Wei, JY (1997) Two types of leptin-responsive gastric vagal afferent terminals: an in vitro single-unit study in rats. Am J Physiol 273, R833–R837.
West, DB, Fey, D & Woods, SC (1984) Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am J Physiol 246, R776–R787.
Woods, SC, Schwartz, MW, Baskin, DG & Seeley, RJ (2000) Food intake and the regulation of body weight. Annu Rev Psychol 51, 255–277.
Woods, SC, Seeley, RJ, Porte, D Jr & Schwartz, MW (1998) Signals that regulate food intake and energy homeostasis. Science 280, 1378–1383.
Wren, AM, Seal, LJ, Cohen, MA, et al. (2001 a) Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86, 5992.
Wren, AM, Small, CJ & Abbott, CR (2001 b) Ghrelin causes hyperphagia and obesity in rats. Diabetes 50, 2540–2547.
Yuan, CS, Attele, AS, Wu, JA, Zhang, L & Shi, ZQ (1999) Peripheral gastric leptin modulates brain stem neuronal activity in neonates. Am J Physiol 277, G626–G630.
Yuan, CS, Dey, L, Xie, JT & Aung, HH (2002) Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity. J Pharmacol Exp Ther 301, 488–493.
Zhang, Y, Proenca, R, Maffei, M, Barone, M, Leopold, L & Friedman, JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432.