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Immunobiology of gestational zinc deficiency

  • Nele Wellinghausen (a1)
  • DOI: http://dx.doi.org/10.1049/BJN2000298
  • Published online: 01 March 2007
Abstract

The trace element zinc is an essential micronutrient for the proper functioning of the immune system. Zinc deficiency leads to impaired function of the unspecific and specific immune response and consequently to an increased susceptibility to bacterial, viral and fungal infections. Immunological defects are not only seen in pronounced but even in marginal and moderate zinc deficiency. Lack of zinc is especially harmful for the development of the immune system, which stresses the importance of a balanced zinc level during pregnancy. However, gestational zinc deficiency due to an imbalance between intake and increased requirements is a common problem world-wide. In animals, gestational zinc deficiency results in reduced thymic and spleen size and depressed active and passive immunity in the infant. For example, depressed immunoglobulin levels, altered antibody repertoire, reduced proliferative response of lymphocytes and diminished neutrophil functions have been reported. Interestingly, immune defects caused by prenatal zinc deficiency, such as depressed antibody levels and lymphocyte proliferation, may even persist in subsequent generations and are not reversible by postnatal zinc administration. Since gestational zinc deficiency is a common problem throughout all cultures and socioeconomic levels, it might have immense consequences for the health status of the population. Based on a summary of the immunobiology of zinc, this article reviews the significance of zinc deficiency during pregnancy and the effect of gestational zinc deficiency on passive and active immunity in the infant. It provides a rational basis for both immunological laboratory investigations and field studies, such as large community-based zinc supplementation trials in pregnant women.

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Copyright
Corresponding author
Corresponding author: Dr Nele Wellinghausen, fax +49 731 502 3473, email nele.wellinghausen@medizin.uni-ulm.de
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RS Bedwal & A Bahuguna (1994) Zinc, copper and selenium in reproduction. Experientia 50, 626640.

RS Beach , ME Gershwin & LS Hurley (1982 b) Gestational zinc deprivation in mice: persistence of immunodeficiency for three generations. Science 218, 469471.

K Chandra (1984) Excessive intake of zinc impairs immune response. Journal of the American Medical Association 252, 14431446.

PS Dowd , J Kelleher & PJ Guillou (1986) T-lymphocyte subsets and interleukin-2 production in zinc-deficient rats. British Journal of Nutrition 55, 5969.

AE Favier (1992) The role of zinc in reproduction. Biological Trace Element Research 32, 363382.

RL Goldenberg , T Tamura , Y Neggers , RL Copper , KE Johnston , MB DuBard & JC Hauth (1995) The effect of zinc supplementation on pregnancy outcome. Journal of the American Medical Association 274, 463468.

RA Good (1981) Nutrition and immunity. Journal of Clinical Immunology 1, 311.

JW Hadden (1992) Thymic endocrinology. International Journal of Immunopharmacology 14, 345352.

S Jameson (1993) Zinc status in pregnancy: the effect of zinc therapy on perinatal mortality, prematurity, and placental ablation. Annals of the New York Academy of Science 678, 178192.

CL Keen & ME Gershwin (1990) Zinc deficiency and immune function. Annual Reviews of Nutrition 10, 415431.

H Kirchner & H Rühl (1970) Stimulation of human peripheral lymphocytes by Zn2+in vitro. Experimental Cell Research 61, 229230.

M Merialdi , LE Caulfield , N Zavaleta , A Figueroa & JA DiPietro (1999) Adding zinc to prenatal iron and folate tablets improves fetal neurobehavioral development. American Journal of Obstetrics and Gynecology 180, 483490.

W Mertz (1995) Risk assessment of essential trace elements: new approaches to assessing recommended dietary allowances and safety limits. Nutrition Review 53, 179185.

E Mocchegiani , L Santarelli , M Muzziolo & N Fabris (1995) Reversibility of the thymic involution and of age-related peripheral immune dysfunction by zinc supplementation in old mice. International Journal of Immunopharmacology 17, 703718.

KH Neldner & KM Hambidge (1975) Zinc therapy in acrodermatitis enteropathica. New England Journal of Medicine 292, 879882.

M Salas & H Kirchner (1987) Induction of interferon-γ in human leukocyte cultures stimulated by Zn2+. Clinical Immunology and Immunopathology 45, 139142.

S Sazawal , RE Black , MK Bhan , N Bhandari , A Sinha & S Jalla (1995) Zinc supplementation in young children with acute diarrhea in India. New England Journal of Medicine 333, 839844.

KG Vruwink , LS Hurley , ME Gershwin & CL Keen (1988) Gestational zinc deficiency amplifies the regulation of metallothionein induction in adult mice. Proceedings of the Society for Experimental Biology and Medicine 188, 3034.

CT Walsh , HH Sandstead , AS Prasad , PM Newberne & PJ Fraker (1994) Zinc: health effects and research priorities for the 1990s. Environmental and health perspectives 102, 546.

N Wellinghausen , H Kirchner & L Rink (1997 a) The immunobiology of zinc. Immunology Today 18, 519521.

N Wellinghausen , M Martin & L Rink (1997 b) Zinc inhibits interleukin 1-dependent T-cell stimulation. European Journal of Immunology 27, 25292535.

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British Journal of Nutrition
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