Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 42
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Assefa, Senait Ahles, Kathleen Bigelow, Simone Curtis, J. Thomas and Köhler, Gerwald A. 2015. Lactobacilli with probiotic potential in the prairie vole (Microtus ochrogaster). Gut Pathogens, Vol. 7, Issue. 1,


    Sayın, F. Kübra 2015. THE EFFECT OF PICKLING ON TOTAL PHENOLIC CONTENTS AND ANTIOXIDANT ACTIVITY OF 10 VEGETABLES. Journal of Food and Health Science,


    Killer, J. Havlik, J. Vlkova, E. Rada, V. Pechar, R. Benada, O. Kope ny, J. Kofro ova, O. and Sechovcova, H. 2014. Lactobacillus rodentium sp. nov., from the digestive tract of wild rodents. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol. 64, Issue. Pt 5, p. 1526.


    Miura, Toshinaga Kozai, Yusuke Kawamata, Ryota Wakao, Hiromi Sakurai, Takashi and Kashima, Isamu 2014. Inhibitory effect of a fermented soy product from lactic acid bacteria (PS-B1) on deterioration of bone mass and quality in ovariectomized mice. Oral Radiology, Vol. 30, Issue. 1, p. 45.


    Shafi, Afshan Farooq, Umar Akram, Kashif Hayat, Zafar and Murtaza, Mian Anjum 2014. Prevention and Control of Diseases by Use of Pro- and Prebiotics (Synbiotics). Food Reviews International, Vol. 30, Issue. 4, p. 291.


    Swain, Manas Ranjan Anandharaj, Marimuthu Ray, Ramesh Chandra and Parveen Rani, Rizwana 2014. Fermented Fruits and Vegetables of Asia: A Potential Source of Probiotics. Biotechnology Research International, Vol. 2014, p. 1.


    Wang, J. Ji, H.F. Hou, C.L. Wang, S.X. Zhang, D.Y. Liu, H. Shan, D.C. and Wang, Y.M. 2014. Effects of Lactobacillus johnsonii XS4 supplementation on reproductive performance, gut environment, and blood biochemical and immunological index in lactating sows. Livestock Science, Vol. 164, p. 96.


    Arora, Tulika Singh, Satvinder and Sharma, Raj Kumar 2013. Probiotics: Interaction with gut microbiome and antiobesity potential. Nutrition, Vol. 29, Issue. 4, p. 591.


    Hawrelak, Jason 2013. Textbook of Natural Medicine.


    Kim, S.-W. Suda, W. Kim, S. Oshima, K. Fukuda, S. Ohno, H. Morita, H. and Hattori, M. 2013. Robustness of Gut Microbiota of Healthy Adults in Response to Probiotic Intervention Revealed by High-Throughput Pyrosequencing. DNA Research, Vol. 20, Issue. 3, p. 241.


    Lahti, Leo Salonen, Anne Kekkonen, Riina A. Salojärvi, Jarkko Jalanka-Tuovinen, Jonna Palva, Airi Orešič, Matej and de Vos, Willem M. 2013. Associations between the human intestinal microbiota,Lactobacillus rhamnosusGG and serum lipids indicated by integrated analysis of high-throughput profiling data. PeerJ, Vol. 1, p. e32.


    Sikorska, Hanna and Smoragiewicz, Wanda 2013. Role of probiotics in the prevention and treatment of meticillin-resistant Staphylococcus aureus infections. International Journal of Antimicrobial Agents, Vol. 42, Issue. 6, p. 475.


    TAKEDA, Shiro FUJIMOTO, Ryoji TAKENOYAMA, Shin-ichi TAKESHITA, Masahiko KIKUCHI, Yukiharu TSEND-AYUSH, Chuluunbat DASHNYAM, Bumbein MUGURUMA, Michio and KAWAHARA, Satoshi 2013. Application of Probiotics from Mongolian Dairy Products to Fermented Dairy Products and Its Effects on Human Defecation. Food Science and Technology Research, Vol. 19, Issue. 2, p. 245.


    Tulk, Hilary M F Blonski, Diane C Murch, Lauren A Duncan, Alison M and Wright, Amanda J 2013. Daily consumption of a synbiotic yogurt decreases energy intake but does not improve gastrointestinal transit time: a double-blind, randomized, crossover study in healthy adults. Nutrition Journal, Vol. 12, Issue. 1,


    Wakai, Taketo Shinoda, Tadashi Uchida, Naoto Hattori, Masahira Nakamura, Yasunori Beresford, Tom Ross, R. Paul and Yamamoto, Naoyuki 2013. Comparative analysis of proteolytic enzymes need for processing of antihypertensive peptides between Lactobacillus helveticus CM4 and DPC4571. Journal of Bioscience and Bioengineering, Vol. 115, Issue. 3, p. 246.


    Bel-Rhlid, Rachid Pagé-Zoerkler, Nicole Fumeaux, René Ho-Dac, Thang Chuat, Jean-Yves Sauvageat, Jean Luc and Raab, Thomas 2012. Hydrolysis of Chicoric and Caftaric Acids with Esterases and Lactobacillus johnsonii in Vitro and in a Gastrointestinal Model. Journal of Agricultural and Food Chemistry, Vol. 60, Issue. 36, p. 9236.


    Chaluvadi, S. Hotchkiss Jr., A.T. Call, J.E. Luchansky, J.B. Phillips, J.G. Liu, LS. and Yam, K.L. 2012. Protection of probiotic bacteria in a synbiotic matrix following aerobic storage at 4 °C. Beneficial Microbes, Vol. 3, Issue. 3, p. 175.


    Chaluvadi, S. Hotchkiss Jr., A.T. Call, J.E. Luchansky, J.B. Phillips, J.G. Liu, LS. and Yam, K.L. 2012. Protection of probiotic bacteria in a synbiotic matrix following aerobic storage at 4 °C. Beneficial Microbes, Vol. 3, Issue. 3, p. 175.


    ISOBE, Hirokazu NISHIYAMA, Akihito TAKANO, Tomomi HIGUCHI, Wataru NAKAGAWA, Saori TANEIKE, Ikue FUKUSHIMA, Yoichi and YAMAMOTO, Tatsuo 2012. Reduction of OverallHelicobacter pyloriColonization Levels in the Stomach of Mongolian Gerbil byLactobacillus johnsoniiLa1 (LC1) and Itsin VitroActivities againstH. pyloriMotility and Adherence. Bioscience, Biotechnology, and Biochemistry, Vol. 76, Issue. 4, p. 850.


    Roessler, A. Forssten, S.D. Glei, M. Ouwehand, A.C. and Jahreis, G. 2012. The effect of probiotics on faecal microbiota and genotoxic activity of faecal water in patients with atopic dermatitis: A randomized, placebo-controlled study. Clinical Nutrition, Vol. 31, Issue. 1, p. 22.


    ×

Improvement of the human intestinal flora by ingestion of the probiotic strain Lactobacillus johnsoniiLa1

  • Toshihiko Yamano (a1), Hisakazu Iino (a2), Mamiko Takada (a2), Stephanie Blum (a3), Florence Rochat (a3) and Yoichi Fukushima (a1)
  • DOI: http://dx.doi.org/10.1079/BJN20051507
  • Published online: 08 March 2007
Abstract

To exert beneficial effects for the host, for example, improving the intestinal microflora, a probiotic must reach the intestine as a viable strain. These properties must be demonstrated by in vitro as well as in vivo methods. However, only a few well-designed human clinical studies have shown these properties. Lactobacillus johnsonii La1 has been shown to give many beneficial effects for the host, but it is unclear whether a viable strain of L. johnsonii La1 has the effect of improving host intestinal microflora. In the present study, a randomised double-blind placebo-controlled cross-over trial was conducted to elucidate the effect of L. johnsonii La1 on human intestinal microflora. Twenty-two young healthy Japanese women were randomly divided into two groups, and either received fermented milk with L. johnsonii La1 or a fermented milk without L. johnsonii La1 (placebo) daily for 21d. Consumption of the fermented milk: (a) increased total Bifidobacterium and Lactobacillus, and decreased lecithinase-positive Clostridium in the faeces; (b) increased the faecal lactic acid concentrations; (c) decreased the faecal pH; (d) increased the defecation frequency. These changes were stronger than those observed with the placebo. L. johnsonii La1 was identified in all subjects only after the consumption of the fermented milk. These results suggest that L. johnsonii La1 can contribute to improve intestinal microflora with probiotic properties.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Improvement of the human intestinal flora by ingestion of the probiotic strain Lactobacillus johnsoniiLa1
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Improvement of the human intestinal flora by ingestion of the probiotic strain Lactobacillus johnsoniiLa1
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Improvement of the human intestinal flora by ingestion of the probiotic strain Lactobacillus johnsoniiLa1
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Yoichi Fukushima, fax +81 3 5769 6290, email Yoichi.Fukushima@jp.nestle.com
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

R Benner , A van Oudenaren , JJ Haaijman , J Slingerland-Teunissen BS Wostmann & W Hijmans Regulation of the ‘spontaneous’ (background) immunoglobulin synthesis. Int Arch Allergy Appl Immunol 1981 66, 404415.

MF Bernet , D Brassart , JR Neeser & AL Servin Lactobacillus acidophilusLA 1 binds to cultured human intestinal cell lines and inhibits cell attachment and cell invasion by enterovirulent bacteria. Gut 1994 35, 483489.

S Blum , R Reniero , EJ Schiffrin , al et Adhesion studies for probiotics: need for validation and refinement. Trends Food Sci Technol 1999 10, 405410.

JJ Cebra , SB Periwal , G Lee , F Lee & KE Shroff Development and maintenance of the gut-associated lymphoid tissue (GALT): the roles of enteric bacteria and viruses. Dev Immunol 1998 6, 1318.

WP Charteris , PM Kelly , L Morelli , & JK Collins Development and application of an in vitro methodology to determine the transit tolerance of potentially probiotic Lactobacillus and Bifidobacterium in the upper human gastrointestinal tract. J Appl Microbiol 1998 84, 759768.

JK Collins , G Thornton & GO Sullivan Selection of probiotics strains for human application. Int Dairy J 1998 8, 487490.

A Donnet-Huges , F Rochat , P Serrant , JM Aeschlimann & EJ Shiffrin Modulation of nonspecific mechanisms of defense by lactic acid bacteria: effective dose. J Dairy Sci 1999 82, 863869.

R Dubos , RW Schaedler , R Costello & P Hoet Indigenous, normal and autochthonous flora of the gastrointestinal tract. J Exp Med 1965 122, 6776.

T Eklund The antimicrobial effect of dissociated and undissociated sorbic acid at different pH levels. J Appl Bacteriol 1983 54, 383389.

CP Felley , I Corthesy-Theulaz , JL Rivero , al et Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man. Eur J Gastroenterol Hepatol 2001 13, 2529.

Y Fukushima , Y Kawata , H Hara , A Terada & T Mitsuoka Effect of probiotic formula on intestinal immunoglobulin A production in healthy children. Int J Food Microbiol 1998 42, 3944.

Y Fukushima , H Li Shou-Tou Hara , A Terada & T Mitsuoka Effect of follow-up formula containing bifidobacteria (NAN BF) on fecal flora and fecal metabolites in healthy children. Biosci Microflora 1997 16, 6572.

SE Gilliland ML Speck , GF Jr Nauyok & FG Giesbrecht Influence of consuming fermented milk containing Lactobacillus acidophilus on fecal flora of healthy males. J Dairy Sci 1978 61, 110.

B Goldin , S Gorbach , M Saxelin , S Barakat , L Gualtieri & S Salminen Survival of Lactobacillus GG in human gastrointestinal tract. Dig Dis Sci 1992 37, 121128.

PK Gopal , J Prasad , J Smart & HS Gill In vitro adherence properties of Lactobacillus rhamnosus DR20 and Bifidobacterium lactis DR10 strains and their antagonistic activity against an enterotoxigenic Escherichia coli. Int J Food Microbiol 2001 67, 207216.

D Haller , S Blum , C Bode , WP Hammes & EJ Shiffrin Activation of human peripheral blood mononuclear cells by nonpathogenic bacteria in vitro: evidence of NK cells as primary targets. Infect Immun 2000a 68, 752759.

D Haller , C Bode , WP Hammes , A Pfeifer ,EJ Schiffrin ,S Blum (2000 b) Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures. Gut 47, 7987.

N Ibnou-Zekri , S Blum , EJ Schiffrin , T von der Weid Divergent patterns of colonization and immune response elicited from two intestinal Lactobacillus strains that display similar properties. in vitro. Infect Immun (2003) 71 428436.

A Imaoka , S Matsumoto , H Setoyama , Y Okada , Y Umesaki Proliferative recruitment of intestinal intraepithelial lymphocytes after microbial colonization of germ-free mice. Eur J Immunol (1996) 26 945948.

ML Johansson , M Quednau , G Molin , S Ahrne Randomly amplified polymorphic DNA (RAPD) for rapid typing of Lactobacillus plantrum strains. Lett Appl Microbiol (1995) 21 155159.

JL Johnson , CF Phelps , CS Cummins , J London , F Gasser Taxonomy of Lactobacillus acidophilus group. Int J Syst Bacteriol (1980) 30 5368.

G Kiessling , J Schneider , G Jahreis Long-term consumption of fermented dairy products over 6 months increases HDL cholesterol. Eur J Clin Nutr (2002) 56 843849.

YK Lee , S Salminen The coming age of probiotics. Trends Food Sci Technol (1995) 6 241245.

A Lidbeck , CE Nord Lactobacilli and the normal human anaerobic microflora. Clin Infect Dis (1993) 16 S181S187.

H Link-Amster , F Rochat , KY Saudan , O Mignot , JM Aeschlimann Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake. FEMS Immunol Med Microbiol (1994) 10 5564.

ML Marin , JH Lee , J Murtha , Z Ustunol , JJ Pestka Differential cytokine production in clonal macrophage and T-cell lines cultured with bifidobacteria. J Dairy Sci (1997) 80 27132720.

p Matzinger An innate sense of danger. Semin Immunol (1998) 10 399415.

P Michetti , G Dorta , PH Wiesel Effect of whey-based culture supernatant of Lactobacillus acidophilus (johnsonii) La1 on Helicobacter pylori infection in humans. Digestion (1999) 60 203209.

F Nagao , M Nakayama , T Muto & K Okumura Effects of fermented milk drink containing Lactobacillus casei strain Shirota on the immune system in healthy human subjects. Biosci Biotechnol Biochem 2000 64 27062708

JR Neeser , D Granato , M Rouvet , A Servin , S Teneberg & EA Karlsson Lactobacillus johnsonii La1 shares carbohydrate-binding specificities with several enteropathogenic bacteria. Glycobiology 2000 10 11931199

J Prasad , H Gill , J Smart & PK Gopal Selection and characterization of Lactobacillus and Bifidobacterium strains for use as probiotics source. Int Dairy J 1998 8 9931002

S Salminen , M Laine , A Von Wright , J Vuopio-Varkila , T Korhonen & T Mattila-Sandholm Development of selection criteria for probiotics strains to assess their potential in functional foods. A Nordic and European approach. Biosci Microflora 1996 15 6167

EJ Schiffrin , F Rochat , H Link-Amster , JM Aeschlimann & A Donnet-Huighes Immunomodulation of human blood cells following the ingestion of lactic acid bacteria. J Dairy Sci 1995 78 491497

Q Shu , JS Zhou , KJ Rutherfurd , MJ Birtles J Prasad , PK Gopal & HS Gill 1999) Probiotic lactic acid bacteria (Lactobacillus acidophilus HN017, Lactobacillus rhamnosus HN001and Bifidobacterium lactis HN019) have no effects on the health of mice. Int Dairy J 1999 9 831836

EM Tuomola , AC Ouwehand & SJ Salminen The effect of probiotic bacteria on the adhesion of pathogens to human intestinal mucus. FEMS Immunol Med Microbiol 1999 26 137142

M Ventura & R Zink Specific identification and molecular typing analysis of Lactobacillus johnsonii by using PCR-based method and pulsed field gel electrophoresis FEMS MicrobiolLett 2002 217 141154

T Yaeshima , S Takahashi , N Matsumoto , N Ishibashi , H Hayasawa & H Iino Effect of yogurt containing Bifidobacterium BB536 on the intestinal environment, fecal characteristics and defecation frequency: a comparison with standard yogurt. Biosci Microflora 1997 16 7377

T Yokokura , T Yajima & S Hashimoto Effect of organic acid on gastrointestinal motility of rat in vitro. Life Sci 1977 21 5962

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: