1USDA (2010) .
2Deutsche Gesellschaft für Ernährung e. V. Bonn (2008) Ernährungsbericht 2008 (Nutrition Report 2008). .
3Anderson, KJ, Teuber, SS, Gobeille, A, et al. (2001) Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation. J Nutr 131, 2837–2842.
4Alasalvar, C & Shahidi, F (2009) Tree Nuts – Composition, Phytochemicals and Health Effects. Boca Raton, FL: CRC Press.
5Nash, SD & Westpfal, M (2005) Cardiovascular benefits of nuts. Am J Cardiol 95, 963–965.
6Hu, FB, Stampfer, MJ, Manson, JE, et al. (1998) Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study. BMJ 317, 1341–1345.
7Marangoni, F, Colombo, C, Martiello, A, et al. (2007) Levels of the n-3 fatty acid eicosapentaenoic acid in addition to those of alpha linolenic acid are significantly raised in blood lipids by the intake of four walnuts a day in humans. Nutr Metab Cardiovasc Dis 17, 457–461.
8Griel, AE, Cao, Y, Bagshaw, DD, et al. (2008) A macadamia nut-rich diet reduces total and LDL-cholesterol in mildly hypercholesterolemic men and women. J Nutr 138, 761–767.
9Garg, ML, Blake, RJ, Wills, RB, et al. (2007) Macadamia nut consumption modulates favourably risk factors for coronary artery disease in hypercholesterolemic subjects. Lipids 42, 583–587.
10Torabian, S, Haddad, E, Cordero-Macintyre, Z, et al. (2010) Long-term walnut supplementation without dietary advice induces favorable serum lipid changes in free-living individuals. Eur J Clin Nutr 64, 274–279.
11Banel, DK & Hu, FB (2009) Effects of walnut consumption on blood lipids and other cardiovascular risk factors: a meta-analysis and systematic review. Am J Clin Nutr 90, 56–63.
12Garcia-Lorda, P, Megias, RI & Salas-Salvado, J (2003) Nut consumption, body weight and insulin resistance. Eur J Clin Nutr 57, Suppl. 1, S8–S11.
13Rajaram, S & Sabate, J (2006) Nuts, body weight and insulin resistance. Br J Nutr 96, Suppl. 2, S79–S86.
14Rainey, C & Nyguist, L (1997) Nuts – nutrition and health benefits of daily use. Nutrition Today 32, 157–163.
15Alasalvar, C, Karamac, M, Kosinska, A, et al. (2009) Antioxidant activity of hazelnut skin phenolics. J Agric Food Chem 57, 4645–4650.
16Dujardin, U (2007) Nüsse in der gesunden Ernährung (Nuts in healthy diet). Ernährungsumschau 9, 554–556.
17Coates, AM & Howe, PR (2007) Edible nuts and metabolic health. Curr Opin Lipidol 18, 25–30.
18Gray, J (2006) Dietary Fibre – Definition, Analysis, Physiology & Health, pp. 22–23. Brussels: International Life Sciences Institute Europe.
19Cummings, JH (2001) The effect of dietary fiber on fecal weight and composition. In CRC Handbook of Dietary Fiber in Human Nutrition, vol. 3, p. 183–252 [Spiller, GA, editor]. Boca Raton, FL: CRC Press.
20Bingham, SA, Day, NE, Luben, R, et al. (2003) Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet 361, 1496–1501.
21Davis, PA & Iwahashi, CK (2001) Whole almonds and almond fractions reduce aberrant crypt foci in a rat model of colon carcinogenesis. Cancer Lett 165, 27–33.
22Jenab, M, Ferrari, P, Slimani, N, et al. (2004) Association of nut and seed intake with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev 13, 1595–1603.
23Cummings, JH, Pomare, EW, Branch, WJ, et al. (1987) Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 28, 1221–1227.
24Beyer-Sehlmeyer, G, Glei, M, Hartmann, E, et al. (2003) Butyrate is only one of several growth inhibitors produced during gut flora-mediated fermentation of dietary fibre sources. Br J Nutr 90, 1057–1070.
25Borowicki, A, Stein, K, Scharlau, D, et al. (2010) Fermented wheat aleurone inhibits growth and induces apoptosis in human HT29 colon adenocarcinoma cells. Br J Nutr 103, 360–369.
26Pool-Zobel, BL & Sauer, J (2007) Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans. J Nutr 137, 2580S–2584S.
27Sauer, J, Richter, KK & Pool-Zobel, BL (2007) Physiological concentrations of butyrate favorably modulate genes of oxidative and metabolic stress in primary human colon cells. J Nutr Biochem 18, 736–745.
28Gibson, GR & Roberfroid, MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125, 1401–1412.
29Mandalari, G, Nueno-Palop, C, Bisignano, G, et al. (2008) Potential prebiotic properties of almond (Amygdalus communis L.) seeds. Appl Environ Microbiol 74, 4264–4270.
30Gibson, GR, Probert, HM, Loo, JV, et al. (2004) Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 17, 259–275.
31Bernet, MF, Brassart, D, Neeser, JR, et al. (1993) Adhesion of human bifidobacterial strains to cultured human intestinal epithelial cells and inhibition of enteropathogen-cell interactions. Appl Environ Microbiol 59, 4121–4128.
32Gibson, GR & Wang, X (1994) Regulatory effects of bifidobacteria on the growth of other colonic bacteria. J Appl Bacteriol 77, 412–420.
33Glei, M, Habermann, N, Osswald, K, et al. (2005) Assessment of DNA damage and its modulation by dietary and genetic factors in smokers using the Comet assay: a biomarker model. Biomarkers 10, 203–217.
34Rafter, J, Govers, M, Martel, P, et al. (2004) PASSCLAIM – diet-related cancer. Eur J Nutr 43, Suppl. 2, II47–II84.
35Rafter, J, Bennett, M, Caderni, G, et al. (2007) Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr 85, 488–496.
36Garcia, M, Jemal, A, Ward, EM, et al. (2007) Global cancer facts & figures. Am Cancer Soc 404, 320–3333.
37Barry, JL, Hoebler, C, Macfarlane, GT, et al. (1995) Estimation of the fermentability of dietary fibre in vitro: a European interlaboratory study. Br J Nutr 74, 303–322.
38Glei, M, Hofmann, T, Kuster, K, et al. (2006) Both wheat (Triticum aestivum) bran arabinoxylans and gut flora-mediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxide. J Agric Food Chem 54, 2088–2095.
39Borowicki, A, Stein, K, Scharlau, D, et al. (2010) Fermentation supernatants of wheat (Triticum aestivum L.) aleurone beneficially modulate cancer progression in human colon cells. J Agric Food Chem 58, 2001–2007.
40Stein, K, Borowicki, A, Scharlau, D, et al. (2010) Fermented wheat aleurone induces enzymes involved in detoxification of carcinogens and in antioxidative defence in human colon cells. Br J Nutr 104, 1101–1111.
41Stein, K, Borowicki, A, Scharlau, D, et al. (2011) Modification of an in vitro model simulating the whole digestive process to investigate cellular endpoints of chemoprevention. Br J Nutr 105, 678–687.
42Klein, A, Friedrich, U, Vogelsang, H, et al. (2008) Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults. Eur J Clin Nutr 62, 584–593.
43Burkard, I, von Eckardstein, A & Rentsch, KM (2005) Differentiated quantification of human bile acids in serum by high-performance liquid chromatography–tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 826, 147–159.
44Birringer, M (2010) Analysis of vitamin E metabolites in biological specimen. Mol Nutr Food Res 54, 588–598.
45Muller, L, Theile, K & Bohm, V (2010) In vitro antioxidant activity of tocopherols and tocotrienols and comparison of vitamin E concentration and lipophilic antioxidant capacity in human plasma. Mol Nutr Food Res 54, 731–742.
46Miller, NJ, Sampson, J, Candeias, LP, et al. (1996) Antioxidant activities of carotenes and xanthophylls. FEBS Lett 384, 240–242.
47Liua, D, Shi, J, Ibarra, AC, et al. (2008) The scavenging capacity and synergistic effects of lycopene, vitamin E, vitamin C, and beta-carotene mixtures on the DPPH free radical. LWT – Food Sci Technol 41, 1344–1349.
48Re, R, Pellegrini, N, Proteggente, A, et al. (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26, 1231–1237.
49Klenow, S, Pool-Zobel, BL & Glei, M (2009) Influence of inorganic and organic iron compounds on parameters of cell growth and survival in human colon cells. Toxicol In vitro 23, 400–407.
50Tice, RR, Agurell, E, Anderson, D, et al. (2000) Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35, 206–221.
51Collins, AR (2004) The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol 26, 249–261.
52Glei, M, Matuschek, M, Steiner, C, et al. (2003) Initial in vitro toxicity testing of functional foods rich in catechins and anthocyanins in human cells. Toxicol In vitro 17, 723–729.
53Nash, SD & Nash, DT (2008) Nuts as part of a healthy cardiovascular diet. Curr Atheroscler Rep 10, 529–535.
54Bundesministerium für Ernährung, Landwirtschaft und Verbraucherschutz (2008) Nationale Verzehrsstudie II (National Nutritional Survey II). .
55Hamer, HM, Jonkers, D, Venema, K, et al. (2008) Review Article: the role of butyrate on colonic function. Aliment Pharmacol Ther 27, 104–119.
56McIntyre, A, Gibson, PR & Young, GP (1993) Butyrate production from dietary fibre and protection against large bowel cancer in a rat model. Gut 34, 386–391.
57Tong, JL, Ran, ZH, Shen, J, et al. (2008) Association between fecal bile acids and colorectal cancer: a meta-analysis of observational studies. Yonsei Med J 49, 792–803.
58Zampa, A, Silvi, S, Fabiani, R, et al. (2004) Effects of different digestible carbohydrates on bile acid metabolism and SCFA production by human gut micro-flora grown in an in vitro semi-continuous culture. Anaerobe 10, 19–26.
59Byers, T & Perry, G (1992) Dietary carotenes, vitamin C, and vitamin E as protective antioxidants in human cancers. Annu Rev Nutr 12, 139–159.
60Bolling, BW, McKay, DL & Blumberg, JB (2010) The phytochemical composition and antioxidant actions of tree nuts. Asia Pac J Clin Nutr 19, 117–123.
61Chen, CY & Blumberg, JB (2008) Phytochemical composition of nuts. Asia Pac J Clin Nutr 17, Suppl. 1, 329–332.
62Fjaeraa, C & Nanberg, E (2009) Effect of ellagic acid on proliferation, cell adhesion and apoptosis in SH-SY5Y human neuroblastoma cells. Biomed Pharmacother 63, 254–261.
63Blottiere, HM, Buecher, B, Galmiche, JP, et al. (2003) Molecular analysis of the effect of short-chain fatty acids on intestinal cell proliferation. Proc Nutr Soc 62, 101–106.
64Borowicki, A, Michelmann, A, Stein, K, et al. (2011) Fermented wheat aleurone enriched with probiotic strains LGG and Bb12 modulates markers of tumor progression in human colon cells. Nutr Cancer 63, 151–160.
65Pellegrini, N, Serafini, M, Salvatore, S, et al. (2006) Total antioxidant capacity of spices, dried fruits, nuts, pulses, cereals and sweets consumed in Italy assessed by three different in vitro assays. Mol Nutr Food Res 50, 1030–1038.
66Martinez, ML, Labuckas, DO, Lamarque, AL, et al. (2010) Walnut (Juglans regia L.): genetic resources, chemistry, by-products. J Sci Food Agric 90, 1959–1967.
67Rosignoli, P, Fabiani, R, De Bartolomeo, A, et al. (2001) Protective activity of butyrate on hydrogen peroxide-induced DNA damage in isolated human colonocytes and HT29 tumour cells. Carcinogenesis 22, 1675–1680.