Blok WL, Deslypere J-P, Demacker PNM, van der Ven-Jongekrijg J, Hectors MPC, van der Meer JMW & Katan MB (1997) Pro- and anti-inflammatory cytokines in healthy volunteers fed various doses of fish oil for 1 year. Eur J Clin Invest 27, 1003–1008.
British Nutrition Foundation (1992) Report of the Task Force on Unsaturated Fatty Acids: Nutritional and Physiological Significance. London: Chapman & Hall.
British Nutrition Foundation (1999) Briefing Paper: n-3 Fatty Acids and Health. London: British Nutrition Foundation.
Burdge GC, Jones AE & Wootton SA (2002) Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men. Br J Nutr 88, 355–363.
Burdge GC & Wootton SA (2002) Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr 88, 411–420.
Calder PC (2001 a) Polyunsaturated fatty acids, inflammation and immunity. Lipids 36, 1007–1024.
Calder PC (2001 b) n-3 Polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 21, 309–341.
Calder PC (2002) Dietary modification of inflammation with lipids. Proc Nutr Soc 61, 345–358.
Calder PC (2003) n-3 Polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids 38, 342–352.
Caughey GE, Mantzioris E, Gibson RA, Cleland LG & James MJ (1996) The effect on human tumour factor α and interleukin 1β production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr 63, 116–122.
De Luca P, Rossetti RG, Alavian C, Karim P & Zurier RB (1999) Effects of gammalinolenic acid on interleukin-1 beta and tumor necrosis factor-alpha secretion by stimulated human peripheral blood monocytes: studies in vitro and in vivo. J Invest Med 47, 246–250.
Gibney MJ & Hunter B (1993) The effects of short term and long term supplementation with fish oil on the incorporation of n-3 polyunsaturated fatty acids into cells of the immune system in healthy volunteers. Eur J Clin Nutr 47, 255–259.
Healy DA, Wallace FA, Miles EA, Calder PC & Newsholme P (2000) Effect of low to moderate amounts of dietary fish oil on neutrophil lipid composition and function. Lipids 35, 763–768.
Huang YS, Smith RS, Redden PR, Cantrill RC & Horrobin DF (1991) Modification of liver fatty-acid metabolism in mice by n-3 and n-6 delta-6-desaturase substrates and products. Biochim Biophys Acta 1082, 319–327.
Ishihara K, Komatsu W, Saito H & Shinohara K (2002) Comparison of the effects of dietary alpha-linolenic, stearidonic, and eicosapentaenoic acids on production of inflammatory mediators in mice. Lipids 37, 481–486.
James MJ, Ursin VM & Cleland LG (2003) Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. Am J Clin Nutr 77, 1140–1145.
Johnson MM, Swan DD, Surette ME, Stegner J, Chilton T, Fonteh AN & Chilton FH (1997) Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. J Nutr 127, 1435–1444.
Kelley DS, Branch LB, Love JE, Taylor PC, Rivera YM & Iacono JM (1991) Dietary alpha-linolenic acid and immunocompetance in humans. Am J Clin Nutr 53, 40–46.
Kew K, Banerjee T, Minihane AM, Finnegan YE, Muggli R, Albers R, Williams CR & Calder PC (2003) Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. Am J Clin Nutr 77, 1287–1295.
Mann DR, Akinbami MA, Gould KG & Ansari AA (2000) Seasonal variation in cytokine expression and cell-mediated immunity in male rhesus monkeys. Cell Immunol 200, 105–115.
Meydani SN, Lichtenstein AH, Cornwall S, Meydani M, Goldin BR, Rasmussen H, Dinarello CA & Schaefer EJ (1993) Immunologic effects of national cholesterol education step-2 diets with and without fish-derived n-3 fatty acid enrichment. J Clin Invest 92, 105–113.
Nelson RJ & Demas GE (1996) Seasonal changes in immune function. Q Rev Biol 71, 511–548.
Rossetti RG, Seiler CM, De Luca P, Laposata M & Zurier RB (1997) Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. J Leukoc Biol 62, 438–443.
Schmidt EB, Varming K, Moller JM, Bulow Pederson I, Madsen P & Dyerberg J (1996) No effect of very low dose n-3 fatty acids on monocyte function in healthy humans. Scand J Clin Invest 56, 87–92.
Thies F, Miles EA, Nebe-von-Caron G, Powell JR, Hurst TL, Newsholme EA & Calder PC (2001 a) Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy humans. Lipids 36, 1183–1193.
Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA & Calder PC (2001 b) Dietary supplementation with gamma linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. J Nutr 131, 1918–1927.
Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA & Calder PC (2001 c) Dietary supplementation with eicosapentaenoic acid, but not with other long chain n 3 or n 6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. Am J Clin Nutr 73, 539–548.
Trebble T, Arden NK, Stroud MA, Wotton SA, Burge GC, Miles EA, Ballinger AB, Thompdon RL & Calder PC (2003 a) Inhibition of tumour necrosis factor-α and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation. Br J Nutr 90, 405–412.
Trebble TM, Wootton SA, Miles EA, Mullee M, Arden NK, Ballinger AB, Stroud MA, Burdge GC & Calder PC (2003 b) Prostaglandin E2 production and T-cell function following dietary fish oil: response to antioxidant co-supplementation. Am J Clin Nutr 78, 376–382.
Wallace FA, Miles EA & Calder PC (2003) Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy humans. Br J Nutr 89, 679–689.
Yamazaki K, Fujikawa M, Hamazaki T, Yano S & Shono T (1992) Comparison of the conversion rates of alpha-linolenic acid (18–3(n-3)) and stearidonic acid (18–4(n-3)) to longer polyunsaturated fatty-acids in rats. Biochim Biophys Acta 1123, 18–26.
Yaqoob P, Pala HS, Cortina-Borja M, Newsholme EA & Calder PC (2000) Encapsulated fish oil enriched in α-tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions. Eur J Clin Invest 30, 260–274.