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The intake of flavonoids and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study

  • Jaakko Mursu (a1), Tarja Nurmi (a1), Tomi-Pekka Tuomainen (a1), Anu Ruusunen (a1), Jukka T. Salonen (a1) (a2) and Sari Voutilainen (a1)...
Abstract

The role of flavonoids in CVD is still unclear. In this cross-sectional study we assessed the relation between the intakes of twenty-six flavonoids from five subclasses: flavonols, flavones, flavanones, flavan-3-ols and anthocyanidins, and the mean common carotid artery intima-media thickness (CCA-IMT). The study population consisted of 1380 middle-aged eastern Finnish men for whom the mean CCA-IMT examinations were carried out as a part of the prospective population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). The mean intake of flavonoids was 128·5 (sd 206·7) mg/d and the mean CCA-IMT was 0·78 (sd 0·17) mm. In the lowest quartile of total flavonoid intake the non-adjusted mean CCA-IMT was 0·79 (sd 0·19) mm, while the mean CCA-IMT was 0·76 (sd 0·15) in the highest quartile (P < 0·001). After adjustment for age, variables related to CCA-IMT measurement, history of atherosclerosis, smoking, BMI, diabetes, systolic blood pressure, serum HDL- and LDL-cholesterol, VO2 max, and intakes of alcohol, SFA, folate, vitamins C and E, the total flavonoid intake was inversely associated with the mean CCA-IMT (P = 0·018). Out of different flavonoid subclasses, flavan-3-ols were inversely associated with CCA-IMT (P = 0·025) after statistical adjustment. There was a trend for an inverse association between intake of flavonols and mean CCA-IMT (P = 0·055). We conclude that high intake of flavonoids is associated with decreased carotid atherosclerosis in middle-aged Finnish men.

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Corresponding author
*Corresponding author: Jaakko Mursu, Ph.D., fax +358 17 162936, email jaakko.mursu@uku.fi
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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