Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 82
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Czadek, Paulina 2016. Chemoprevention of colorectal cancer. Polish Annals of Medicine, Vol. 23, Issue. 1, p. 75.


    Lavermicocca, P. Dekker, M. Russo, F. Valerio, F. Di Venere, D. and Sisto, A. 2016. Probiotics, Prebiotics, and Synbiotics.


    Li, Juan-Mei and Nie, Shao-Ping 2016. The functional and nutritional aspects of hydrocolloids in foods. Food Hydrocolloids, Vol. 53, p. 46.


    Park, Chan Joo Lee, Hyun-Ah and Han, Ji-Sook 2016. Jicama (<i>Pachyrhizus erosus</i>) extract increases insulin sensitivity and regulates hepatic glucose in C57BL/Ksj-db/db mice. Journal of Clinical Biochemistry and Nutrition, Vol. 58, Issue. 1, p. 56.


    Shoaib, Muhammad Shehzad, Aamir Omar, Mukama Rakha, Allah Raza, Husnain Sharif, Hafiz Rizwan Shakeel, Azam Ansari, Anum and Niazi, Sobia 2016. Inulin: Properties, health benefits and food applications. Carbohydrate Polymers, Vol. 147, p. 444.


    Zannini, Emanuele Waters, Deborah M. Coffey, Aidan and Arendt, Elke K. 2016. Production, properties, and industrial food application of lactic acid bacteria-derived exopolysaccharides. Applied Microbiology and Biotechnology, Vol. 100, Issue. 3, p. 1121.


    da Silva Almeida, Ana Paula Avi, Camilla Martins Barbisan, Luís Fernando de Moura, Nelci Antunes Caetano, Brunno Felipe Ramos Romualdo, Guilherme Ribeiro and Sivieri, Kátia 2015. Yacon (Smallanthus sonchifolius) and Lactobacillus acidophilus CRL 1014 reduce the early phases of colon carcinogenesis in male Wistar rats. Food Research International, Vol. 74, p. 48.


    de Falco, Bruna Incerti, Guido Amato, Mariana and Lanzotti, Virginia 2015. Artichoke: botanical, agronomical, phytochemical, and pharmacological overview. Phytochemistry Reviews, Vol. 14, Issue. 6, p. 993.


    Liu, Jun Willför, Stefan and Xu, Chunlin 2015. A review of bioactive plant polysaccharides: Biological activities, functionalization, and biomedical applications. Bioactive Carbohydrates and Dietary Fibre, Vol. 5, Issue. 1, p. 31.


    Machado, Mariana T.C. Eça, Kaliana S. Vieira, Gláucia S. Menegalli, Florencia C. Martínez, Julian and Hubinger, Miriam D. 2015. Prebiotic oligosaccharides from artichoke industrial waste: evaluation of different extraction methods. Industrial Crops and Products, Vol. 76, p. 141.


    Mensink, Maarten A. Frijlink, Henderik W. van der Voort Maarschalk, Kees and Hinrichs, Wouter L.J. 2015. Inulin, a flexible oligosaccharide. II: Review of its pharmaceutical applications. Carbohydrate Polymers, Vol. 134, p. 418.


    Nobre, Clarisse Cerqueira, Miguel Ângelo Rodrigues, Lígia Raquel Vicente, António Augusto and Teixeira, José António 2015. Industrial Biorefineries & White Biotechnology.


    Shah, Nagendra 2015. Health Benefits of Fermented Foods and Beverages.


    Steiner, J. Procopio, S. and Becker, T. 2015. Brewer’s spent grain: source of value-added polysaccharides for the food industry in reference to the health claims. European Food Research and Technology, Vol. 241, Issue. 3, p. 303.


    Tuohy, Kieran M. Brown, Duncan T. Klinder, Annett Costabile, Adele and Fava, Francesca 2015. Diet-Microbe Interactions in the Gut.


    Verbeke, Kristin A. Boobis, Alan R. Chiodini, Alessandro Edwards, Christine A. Franck, Anne Kleerebezem, Michiel Nauta, Arjen Raes, Jeroen van Tol, Eric A. F. and Tuohy, Kieran M. 2015. Towards microbial fermentation metabolites as markers for health benefits of prebiotics. Nutrition Research Reviews, Vol. 28, Issue. 01, p. 42.


    Cheong, Kit-Leong Li, Jing Zhao, Jing and Li, Shao-Ping 2014. A simple analysis of fructooligosaccharides in two medicinal plants by high-performance thin-layer chromatography. Journal of Planar Chromatography – Modern TLC, Vol. 27, Issue. 4, p. 245.


    Coleman, Katie L. Miah, Emma M. Morris, Gordon A. and Morris, Cecile 2014. Impact of health claims in prebiotic-enriched breads on purchase intent, emotional response and product liking. International Journal of Food Sciences and Nutrition, Vol. 65, Issue. 2, p. 164.


    Faltermaier, Andrea Waters, Deborah Becker, Thomas Arendt, Elke and Gastl, Martina 2014. Common wheat (Triticum aestivumL.) and its use as a brewing cereal - a review. Journal of the Institute of Brewing, Vol. 120, Issue. 1, p. 1.


    Li, Jing Hu, Dejun Zong, Wanrong Lv, Guangping Zhao, Jing and Li, Shaoping 2014. Determination of Inulin-type Fructooligosaccharides in Edible Plants by High-Performance Liquid Chromatography with Charged Aerosol Detector. Journal of Agricultural and Food Chemistry, Vol. 62, Issue. 31, p. 7707.


    ×

Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data

  • Beatrice L. Pool-Zobel (a1)
  • DOI: http://dx.doi.org/10.1079/BJN20041349
  • Published online: 01 March 2007
Abstract

Inulin-type fructans (β(2,1)fructans) extracted from chicory roots (Cichorium intybus) are prebiotic food ingredients, which in the gut lumen are fermented to lactic acid and SCFA. Research in experimental animal models revealed that inulin-type fructans have anticarcinogenic properties. A number of studies report the effects of inulin-type fructans on chemically induced pre-neoplastic lesions (ACF) or tumours in the colon of rats and mice. In twelve studies, there were twenty-nine individual treatment groups of which twenty-four measured aberrant crypt foci (ACF) and five measured tumours. There was a significant reduction of ACF in twenty-one of the twenty-four treatment groups and of tumour incidence in five of the five treatment groups. Higher beneficial effects were achieved by synbiotics (mixtures of probiotics and prebiotics), long-chain inulin-type fructans compared to short-chain derivatives, and feeding high-fat Western style diets. Inulin-type fructans reduced tumour incidence in APCMin mice in two of four studies and reduced growth and metastasising properties of implanted tumour cells in mice (four studies). The effects have been reported to be associated with gut flora-mediated fermentation and production of butyrate. In human cells, inulin-derived fermentation products inhibited cell growth, modulated differentiation and reduced metastasis activities. In conclusion, evidence has been accumulated that shows that inulin-type fructans and corresponding fermentation products reduced the risks for colon cancer. The involved mechanisms included the reduction of exposure to risk factors and suppression of tumour cell survival. Thus, this specific type of dietary fibre exerted both blocking agent and suppressing agent types of chemopreventive activities.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Professor Beatrice L. Pool-Zobel, fax +49 3641 949672, email, b8pobe@uni-jena.de
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

DS Alberts , ME Martinez & DJ Roe (2000) The Phoenix Colon Cancer Prevention Physicians' Network. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. N Engl J Med 342, 11561162.

BN Ames & LS Gold (1990) Too many rodent carcinogens: mitogenesis increases mutagenesis. Science 249, 970971.

SA Bingham , NE Day & R Luen (2003) Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet 361, 14961501.

RP Bird (1987) Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett 37, 147151.

F Bolognani , CJ Rumney , JT Coutts , BL Pool-Zobel & IR Rowland (2001) Effect of lactobacilli, bifidobacteria and inulin on the formation of aberrant crypt foci in rats. Eur J Nutr 40, 293300.

C Bonithon-Kopp , O Kronborg & A Giacosa (2000) Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. Lancet 356, 13001306.

G Caderni , C Luceri , C DeFilippo , M Salvadori , A Giannini , L Tessitore & P Dolara (2001) Slow-release pellets of sodium butyrate do not modify azoxymethane (AOM)-induced intestinal carcinogenesis in F344 rats. Carcinogenesis 22, 525527.

CW Compher , WL Frankel , J Tazelaar , JA Lawson , S McKinney , S Segall , BP Kinosian , NN Williams & JL Rombeau (1999) Wheat bran decreases aberrant crypt foci, preserves normal proliferation, and increases intraluminal butyrate levels in experimental colon cancer. J Parenter Enteral Nutr 23, 269277.

C DeFilippo , G Caderni , M Bazzicalupo , C Briani , A Giannini , M Fazi & P Dolara (1998) Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats. Br J Cancer 77, 21482151 Abstr.

MN Ebert , G Beyer-Sehlmeyer , UM Liegibel , T Kautenburger , TW Becker , BL Pool-Zobel (2001) Butyrate-induces glutathione S-transferase in human colon cells and protects from genetic damage by 4-hydroxynonenal. Nutr Cancer 41, 156164.

MN Ebert , A Klinder , A Schäferhenrich , WHM Peters , W Sendt , J Scheele , BL Pool-Zobel (2003) Expression of glutathione S-transferases (GST) in human colon cells and inducibility of GSTM2 by butyrate. Carcinogenesis 24, 16371644.

A Fazeli , RG Steen , SL Dickinson , D Bautista , WF Dietrich , RT Bronson , RS Bresalier , ES Sander , J Costa & RA Weinberg (1997) Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas. Proc Natl Acad Sci USA 94, 1019910204.

ER Fearon & B Vogelstein (1990) A genetic model for colorectal tumorigenesis. Cell 61, 759767.

AP Femia , C Luceri , P Dolara , A Giannini , A Biggeri , M Salvadori , Y Clune , KJ Collins , M Paglierani & G Caderni (2002) Antitumourigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis 23, 19531960.

LR Ferguson & PJ Harris (2003) The dietary fibre debate: more food for thought – commentary. Lancet 361, 14871488.

LR Ferguson , RR Chavan & PJ Harris (2001) Changing concepts of dietary fiber: implications for carcinogenesis. Nutr Cancer 39, 155169.

R Fodde , R Smits & H Clevers (2001) APC signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer 1, 5567.

CS Fuchs , E Giovannucci , GA Colditz , DJ Hunter , MJ Stampfer , B Rosner , FE Speizer & WC Willett (1999) Dietary fiber and the risk of colo-rectal cancer and adenoma in women. N Engl J Med 340, 169176.

PR Gibson , O Rosella , AJ Wilson , JM Mariadason , K Rickard , K Byron & DH Barkla (1999) Colonic epithelial cell activation and the paradoxical effects of butyrate. Carcinogenesis 20, 539544.

A Hague , AM Manning , KA Hanlon , LI Huschtscha , D Hart & C Paraskeva (1993) Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. Int J Cancer 55, 498505.

A Hague , B Singh & C Paraskeva (1997) Butyrate acts as a survival factor for colonic epithelial cells: further fuel for the in vivo versus in vitro debate. Gastroenterology 112, 10361040.

PJ Harris & LR Ferguson (1993) Dietary fibre: its composition and role in protection against colorectal cancer. Mutat Res 290, 97110.

H Hidaka , T Eida , T Takizawa , T Tokunaga & Y Tashiro (1986) Effects of fructooligosaccharides on intestinal flora and human health. Bifidobacteria Microflora 5, 3750.

R Hughes & IR Rowland (2001) Stimulation of apoptosis by two prebiotic chicory fructans in the rat colon. Carcinogenesis 22, 4347.

IT Johnson (1995) Butyrate and markers of neoplastic change in the colon. Eur J Cancer Prev 4, 365371.

A Klinder , A Förster , G Caderni , AP Femia , BL Pool-Zobel ((2004a)) Fecal water genotoxicity is predictive of tumor-preventive activities by inulin-like oligofructoses, probiotics ( Lactobacillus rhamnosus and Bifidobacterium lactis ) and their synbiotic combination. Nutr Cancer 49, 144155.

H Kobayashi , ME Tan & SE Fleming (2003) Sodium butyrate inhibits cell growth and stimulates p21 wap/CIPI protein in human colonic adenocarcinoma cells independently of p53 status. Nutr Cancer 46, 202211.

TMCM Kok , JMS van Maanen (2000) Evaluation of fecal mutagenicity and colorectal cancer risk. Mutat Res 463, 53101.

M Koo & AV Rao (1991) Long-term effect of bifidobacteria and Neosugar on precursor lesions of colonic cancer in CF1 mice. Nutr Cancer 16, 249257.

B Levin (2003) Potential pitfalls in the use of surrogate endpoints in colorectal adenoma chemoprevention. JNCI Cancer Spectr 95, 697.

JR Lupton (1995) Butyrate and colonic cytokinetics: differences between in vitro and in vivo studies. Eur J Cancer Prev 4, 373378.

A McIntyre , PR Gibson & GP Young (1993) Butyrate production from dietary fibre and protection against large bowel cancer in a rat model. Gut 34, 386391.

JM Mariadason , A Velchich , AJ Wilson , LH Augenlicht & PR Gibson (2001) Resistance to butyrate-induced cell differentiation and apoptosis during spontaneous Caco-2 cell differentiation. Gastroenterology 120, 889899.

M Mutanen , AM Pajari & SI Oikarinen (2000) Beef induces and rye bran prevents the formation of intestinal polyps in Apc Min mice: relation to β-catenin and PKC isozymes. Carcinogenesis 21, 11671173.

K Osswald , TW Becker , M Grimm , G Jahreis , BL Pool-Zobel (2000) Inter- and intra-individual variation of faecal water – genotoxicity in human colon cells. Mutat Res 472, 5970.

AM Pajari , J Rajakangas , E Päivärinta , VM Kosma , J Rafter & M Mutanen (2003) Promotion of intestinal tumour formation by inulin is associated with an accumulation of β-catenin in MIN mice. Int J Cancer 106, 653660.

MA Pereira , LH Barnes , VL Rassman , GV Kelloff & VE Steele (1994) Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents. Carcinogenesis 15, 10491054.

P Perrin , F Pierre , Y Patry , M Champ , M Berreur , G Pradal , P Bornet , K Meflah & J Menenteau (2001) Only fibres promoting a stable butyrate producing colonic ecosystem decrease the rate of aberrant crypt foci in rats. Gut 48, 5361.

U Peters , R Sinha & N Chaterjee (2003) Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme. Lancet 361, 14011405.

P Pietinen , N Malila , M Virtanen , TJ Hartman , JA Tangrea , D Albanes & J Virtamo (1999) Diet and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes Control 10, 387396.

BL Pool-Zobel , C Neudecker , I Domizlaff , S Ji , U Schillinger , CJ Rumney , M Moretti , M Villarini , G Scassellati-Sforzolini & IR Rowland (1996) Lactobacillus - and Bifidobacterium -mediated antigenotoxicity in colon cells of rats: prevention of carcinogen-induced damage in vivo and elucidation of involved mechanisms. Nutr Cancer 26, 365380.

BL Pool-Zobel , J Van Loo , IR Rowland & MB Roberfroid (2002) Experimental evidences on the potential of prebiotic fructans to reduce the risk of colon cancer. Br J Nutr 87, S273S281.

JD Potter (1999) Colorectal cancer: molecules and populations. J Natl Cancer Inst 91, 916932.

M Poulson , AM Mølck & BL Jacobsen (2002) Different effects of short- and long-chained fructans on large intestinal physiology and carcinogen-induced aberrant crypt foci in rats. Nutr Cancer 42, 194205.

CV Rao , D Chou , B Simi , H Ku & BS Reddy (1998) Prevention of colonic aberrant crypt foci and modulation of large bowel microbial activity by dietary coffee fiber, inulin and pectin. Carcinogenesis 19, 18151819.

BS Reddy , R Hamid & CV Rao (1997) Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition. Carcinogenesis 18, 13711374.

IR Rowland , CA Bearne , R Fischer , BL Pool-Zobel (1996) The effect of lactulose on DNA damage induced by 1,2-dimethylhydrazine in the colon of human-flora-associated rats. Nutr Cancer 26, 3847.

IR Rowland , CJ Rumney , JT Coutts & LC Lievense (1998) Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis 19, 281285.

A Schatzkin , E Lanza & D Corle (2000) The Polyp Prevention Trial Study Group. Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. N Engl J Med 342, 11491155.

HS Taper & MB Roberfroid (2000b) Nontoxic potentiation of cancer chemotherapy by dietary oligofructose or inulin. Nutr Cancer 38, 15.

HS Taper & MB Roberfroid (2002) Inulin/oligofructose and anticancer therapy. Br J Nutr 87, S283S286.

OT Terpstra , M van Blankenstein , J Dees & GAM Eilers (1987) Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer. Gastroenterology 92, 704708.

P Terry , E Giovannucci , KB Michels , L Bergvist , H Hansen , L Holmberb & A Wolk (2001) Fruit, vegetables, dietary fiber, and risk of colorectal cancer. J Natl Cancer Inst 93, 525533.

MJ Thun , SJ Henley & C Patrono (2002) Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst 94, 252266.

J Van Loo (1995) On the presence of inulin and oligofructose as natural ingredients in the Western diet. Crit Rev Food Sci Nutr 35, 525552.

M Venturi , RJ Hambly , B Glinghammer , JJ Rafter & IR Rowland (1997) Genotoxic activity in human faecal water and the role of bile acids: a study using the alkaline comet assay. Carcinogenesis 18, 23532359.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: