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Iron metabolism in copper-deficient rats

Published online by Cambridge University Press:  26 July 2012

H. R. Marston ,
Shirley H. Allen  and
S. L. Swaby
H. R. Marston
Affiliation:
Division of Nutritional Biochemistry, Commonwealth Scientific and Industrial Research Organization, University of Adelaide, South Austral. 5000, Australia
Shirley H. Allen
Affiliation:
Division of Nutritional Biochemistry, Commonwealth Scientific and Industrial Research Organization, University of Adelaide, South Austral. 5000, Australia
S. L. Swaby
Affiliation:
Division of Nutritional Biochemistry, Commonwealth Scientific and Industrial Research Organization, University of Adelaide, South Austral. 5000, Australia
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Abstract

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1. The effects of ingestion of diets deficient in both copper and iron on storage of these elements and on the red cell indices have been studied in rats.

2. Injection of Cu into rats whose stores of Cu had been virtually exhausted resulted in a temporary increase in the concentration of plasma Fe and depletion of the Fe stored in the liver. Storage of Fe in the spleen seemed to be affected somewhat differently from that in the liver.

3. Fe injected into Cu-deficient rats was transported to storage sites but, although the plasma Fe concentration was presumably transiently increased thereby, there was no lasting effect.

4. The hypotheses that Cu mediates in the release of Fe from ferritin and that of Osaki, Johnson & Frieden (1966) that caeruloplasmin promotes the rate of Fe-saturation of apotransferrin are discussed.

Type
Research Article
Information
British Journal of Nutrition , Volume 25 , Issue 1 , January 1971 , pp. 15 - 30
Copyright
Copyright © The Nutrition Society 1971

References

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