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Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice

  • Maqsood M. Elahi (a1), Felino R. Cagampang (a1), Dhea Mukhtar (a1), Frederick W. Anthony (a1), Sunil K. Ohri (a2) and Mark A. Hanson (a1)
  • DOI:
  • Published online: 10 February 2009

In rodents, adverse prenatal nutrition, such as a maternal diet rich in fat during pregnancy, enhances susceptibility of the offspring to hypertension, type 2 diabetes and other features of the human metabolic syndrome in adulthood. However, previous experimental studies were confined to short-term modifications of the maternal diet during pregnancy and/or lactation periods, a situation uncommon in humans. Moreover in humans, the offspring may also consume a high-fat diet, which may take them beyond the range to which their development has adapted them to respond healthily. We examined in C57 mice the effects on offspring of feeding their mothers a high-fat (HF) or standard chow (C) diet from weaning through pregnancy and lactation, and whether there are additive phenotypic effects of feeding the offspring an HF diet from weaning to adulthood (dam–offspring dietary group HF-HF). This group was compared with offspring from HF-fed dams fed a C diet from weaning to adulthood (HF-C) and offspring from C-fed mothers fed the C or HF diet (C-C and HF-C, respectively). HF-HF, HF-C and C-HF adult female offspring were heavier, fatter, and had raised serum cholesterol and blood pressure compared with C-C female offspring. We observed a similar trend in male offspring except for the HF-C group which was not heavier or fatter than male C-C offspring. Histology showed lipid vacuoles within hepatocytes in the HF-HF, HF-C and C-HF but not the CC offspring. Serum C-reactive protein was elevated in female (C-HF and HF-HF) but not in male offspring. Elevated blood pressure in the HF-C and C-HF groups was attenuated in the HF-HF group in males but not in females. These findings indicate that long-term consumption of an HF diet by the mother predisposes her offspring to developing a metabolic syndrome-like phenotype in adult life, although cardiovascular effects of an HF diet are related to sex specificity in the HF-HF group.

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*Corresponding author: Professor Mark A. Hanson, fax +44 238 0785255, email
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1P Bateson , D Barker , T Clutton-Brock , (2004) Developmental plasticity and human health. Nature 430, 419421.

2DC Benyshek , JF Martin & CS Johnston (2001) A reconsideration of the origins of the type 2 diabetes epidemic among Native Americans and the implications for intervention policy. Med Anthropol 20, 2564.

3PD Gluckman & MA Hanson (2004) Living with the past: evolution, development, and patterns of disease. Science 305, 17331736.

4CW Kuzawa , LS Adair , JL Avila , (2003) Atherogenic lipid profiles in Filipino adolescents with low body mass index and low dietary fat intake. Am J Hum Biol 15, 688696.

9MC Franco , RM Arruda , AP Dantas , (2002) Intrauterine undernutrition: expression and activity of the endothelial nitric oxide synthase in male and female adult offspring. Cardiovasc Res 56, 145153.

10T Ozaki , H Nishina , MA Hanson , (2001) Dietary restriction in pregnant rats causes gender-related hypertension and vascular dysfunction in offspring. J Physiol 530, 141152.

12SA Bayol , BH Simbi & NC Stickland (2005) A maternal cafeteria diet during gestation and lactation promotes adiposity and impairs skeletal muscle development and metabolism in rat offspring at weaning. J Physiol 567, 951961.

13I Khan , V Dekou , M Hanson , (2004) Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring. Circulation 110, 10971102.

14IY Khan , PD Taylor , V Dekou , (2003) Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension 41, 168175.

16SC Langley-Evans , AG Clamp , RF Grimble , (1996) Influence of dietary fats upon systolic blood pressure in the rat. Int J Food Sci Nutr 47, 417425.

17E Zambrano , CJ Bautista , M Deas , (2006) A low maternal protein diet during pregnancy and lactation has sex- and window of exposure-specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat. J Physiol 571, 221230.

18IY Khan , V Dekou , G Douglas , (2005) A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring. Am J Physiol Regul Integr Comp Physiol 288, R127R133.

19J Zhang , C Wang , PL Terroni , (2005) High-unsaturated-fat, high-protein, and low-carbohydrate diet during pregnancy and lactation modulates hepatic lipid metabolism in female adult offspring. Am J Physiol Regul Integr Comp Physiol 288, R112R118.

20M Van Heek , DS Compton , CF France , (1997) Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 99, 385390.

21JH Krege , JB Hodgin , JR Hagaman , (1995) A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension 25, 11111115.

22J Danesh , JG Wheeler , GM Hirschfield , (2004) C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 350, 13871397.

23SC Langley-Evans (1996) Intrauterine programming of hypertension in the rat: nutrient interactions. Comp Biochem Physiol A Physiol 114, 327333.

24W Oh , NL Gelardi & CJ Cha (1988) Maternal hyperglycemia in pregnant rats: its effect on growth and carbohydrate metabolism in the offspring. Metabolism 37, 11461151.

25MM Elahi , FR Cagampang , FW Anthony , (2008) Statin treatment in hypercholesterolemic pregnant mice reduces cardiovascular risk factors in their offspring. Hypertension 51, 939944.

26F Guo & KL Jen (1995) High-fat feeding during pregnancy and lactation affects offspring metabolism in rats. Physiol Behav 57, 681686.

27E Koukkou , P Ghosh , C Lowy , (1998) Offspring of normal and diabetic rats fed saturated fat in pregnancy demonstrate vascular dysfunction. Circulation 98, 28992904.

28AE Reid (2001) Nonalcoholic steatohepatitis. Gastroenterology 121, 710723.

29R Shiri-Sverdlov , K Wouters , PJ van Gorp , (2006) Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates. J Hepatol 44, 732741.

30M Tous , N Ferre , J Camps , (2005) Feeding apolipoprotein E-knockout mice with cholesterol and fat enriched diets may be a model of non-alcoholic steatohepatitis. Mol Cell Biochem 268, 5358.

31P Libby (2002) Inflammation in atherosclerosis. Nature 420, 868874.

38PM Ridker , M Cushman , MJ Stampfer , (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336, 973979.

35W Khovidhunkit , MS Kim , RA Memon , (2004) Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res 45, 11691196.

36PM Ridker , CH Hennekens , N Rifai , (1999) Hormone replacement therapy and increased plasma concentration of C-reactive protein. Circulation 100, 713716.

37M Visser , LM Bouter , GM McQuillan , (1999) Elevated C-reactive protein levels in overweight and obese adults. JAMA 282, 21312135.

34PM Ridker , CH Hennekens , JE Buring , (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342, 836843.

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