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Long-term vitamin C supplementation has no markedly favourable effect on serum lipids in middle-aged Japanese subjects

  • Mi Kyung Kim (a1) (a2), Satoshi Sasaki (a1) (a3), Shizuka Sasazuki (a1), Shunji Okubo (a4), Masato Hayashi (a4) and Shoichiro Tsugane (a1)
  • DOI: http://dx.doi.org/10.1079/BJN20031024
  • Published online: 01 March 2007
Abstract

Antioxidant vitamins have been reported to be associated with an improvement in blood lipid profiles, but results are not consistent. The present study was designed to determine whether long-term vitamin C supplementation could alter serum lipid concentrations in subjects who completed a 5-year population-based double-blind intervention trial. A total of 439 Japanese subjects with atrophic gastritis initially participated in the trial using vitamin C and β-carotene to prevent gastric cancer. Before and upon early termination of β-carotene supplementation, 134 subjects dropped out of the trial; finally, 161 subjects assigned to the high-dose group (500 mg vitamin C/d) and 144 subjects assigned to the low-dose group (50 mg vitamin C/d) were studied. No favourable effect of vitamin C supplementation on serum concentrations of total cholesterol, HDL- and LDL-cholesterol, and triacylglycerol was observed, although high-dose vitamin C supplementation increased serum vitamin C concentrations substantially. Among women, the mean change in serum triacylglycerol decreased (−0·12 mmol/l, 95 % CI −0·32, 0·09) in the high-dose group, but increased (+0·12 mmol/l, 95 % CI 0·03, 0·22) in the low-dose group. In addition, the mean change in serum triacylglycerol among women with hypertriacylglycerolaemia was statistically significant (−1·21, 95 % CI −2·38, −0·05) after high-dose vitamin C supplementation. The 5-year vitamin C supplementation had no markedly favourable effects on the serum lipid and lipoprotein profile. However, our present results do not preclude the possibility that vitamin C supplementation may decrease triacylglycerol concentrations among women with hypertriacylglycerolaemia.

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Corresponding author
*Corresponding author: Dr Shoichiro Tsugane, fax +81 4 7134 6862, email stsugane@east.ncc.go.jp
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JE Buring & JM Gaziano (1997) Antioxidant vitamins and cardiovascular disease. In Preventive Nutrition, 171180 [A Bendich and RJ Deckelbaum , editors]. New Jersey: Humana Press.

PB Geil , JW Anderson & NJ Gustafson (1995) Women and men with hypercholesterolemia respond similarly to an American Heart Association step 1 diet. J Am Diet Assoc 95, 436441.

AM Gotto (2003) Antioxidants, statins, and atherosclerosis. J Am Coll Cardiol 41, 12051210.

Heart Protection Study Collaborative Group (2002) MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360, 2333.

PF Jacques , SI Sulsky , GE Perrone , J Jenner & EJ Schaefer (1995) Effect of vitamin C supplementation on lipoprotein cholesterol, apolipoprotein, and triacylglycerol concentrations. Ann Epidemiol 5, 5259.

KJ Joshipura , FB Hu , JE Manson , et al. (2001) The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 134, 11061114.

MK Kim , S Sasaki , S Sasazuki , et al. (2002) Lack of long-term effect of vitamin C supplementation on blood pressure. Hypertension 40, 797803.

MK Kim , S Sasazuki , S Sasaki , et al. (2003) Effect of five-year supplementation of vitamin C on serum vitamin C concentration and consumption of vegetables and fruits in middle-aged Japanese: a randomized controlled trial. J Am Coll Nutr 22, 208216.

M Levine , C Corny-Cantilena , Y Wang , et al. (1996) Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci 93, 37043709.

K Nyyssonen , MT Parviainen , R Salonen , J Tuomilehto & JT Salonen (1997) Vitamin C deficiency and risk of myocardial infarction: prospective population study of men from eastern Finland. Br Med J 314, 634638.

GS Omenn , GE Goodman , MD Thornquist , et al. (1996) Effect of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334, 11501155.

TR Pedersen , AG Olsson , O Fargeman , et al. (1998) Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S). Circulation 97, 14531460.

NR Sahyoun , PF Jacques & RM Russell (1996) Carotenoids, vitamin C and E, and mortality in an elderly population. Am J Epidemiol 144, 485495.

RM Salonen , K Nyyssonen , J Kaikkonen , et al. (2003) Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the antioxidant supplementation in atherosclerosis prevention (ASAP) study. Circulation 107, 947953.

JA Simon , ES Hudes & WS Browner (1998) Serum ascorbic acid and cardiovascular disease prevalence in U.S. adults. Epidemiology 9, 316321.

JA Simon & ES Hudes (1999) Serum ascorbic acid and cardiovascular disease prevalence in U.S. adults: the Third National Health and Nutrition Examination Survey (NHANES III). Ann Epidemiol 9, 358365.

GH Tofler , JJ Stec , I Stubbe , et al. (2000) The effect of vitamin C supplementation on coagularity and lipid level in healthy male subjects. Thromb Res 100, 3541.

Y Tsubono , S Okubo , M Hayashi , T Kakizoe & S Tsugane (1997) A randomized controlled trial for chemoprevention of gastric cancer in high-risk Japanese population; study design, feasibility and protocol modification. Jpn J Cancer Res 88, 344349.

Y Tsubono , S Takamori , M Kobayashi , et al. (1995) A data-based approach for designing a semiquantitative food frequency questionnaire for a population-based prospective study in Japan. J Epidemiol 6, 4553.

CE Walden , BM Retzlaff , BL Buck , BS McCann & RH Knopp (1997) Lipoprotein lipid response to the National Cholesterol Education Program step II diet by hypercholesterolemic and combined hyperlipidemic women and men. Arterioscler Thromb Vasc Biol 17, 375382.

AJ Waring , IM Drake , CJ Schorah , et al. (1996) Ascorbic acid and total vitamin C concentrations in plasma, gastric juice, and gastrointestinal mucosa: effects of gastritis and oral supplementation. Gut 38, 171176.

V Zannoni , M Lynch , S Goldstein & P Sato (1974) A rapid micromethod for the determination of ascorbic acid in plasma and tissues. Biochem Med 11, 4148.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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