Skip to main content
×
Home
    • Aa
    • Aa

Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice

  • Maqsood M. Elahi (a1), Felino R. Cagampang (a1), Dhea Mukhtar (a1), Frederick W. Anthony (a1), Sunil K. Ohri (a2) and Mark A. Hanson (a1)...
Abstract

In rodents, adverse prenatal nutrition, such as a maternal diet rich in fat during pregnancy, enhances susceptibility of the offspring to hypertension, type 2 diabetes and other features of the human metabolic syndrome in adulthood. However, previous experimental studies were confined to short-term modifications of the maternal diet during pregnancy and/or lactation periods, a situation uncommon in humans. Moreover in humans, the offspring may also consume a high-fat diet, which may take them beyond the range to which their development has adapted them to respond healthily. We examined in C57 mice the effects on offspring of feeding their mothers a high-fat (HF) or standard chow (C) diet from weaning through pregnancy and lactation, and whether there are additive phenotypic effects of feeding the offspring an HF diet from weaning to adulthood (dam–offspring dietary group HF-HF). This group was compared with offspring from HF-fed dams fed a C diet from weaning to adulthood (HF-C) and offspring from C-fed mothers fed the C or HF diet (C-C and HF-C, respectively). HF-HF, HF-C and C-HF adult female offspring were heavier, fatter, and had raised serum cholesterol and blood pressure compared with C-C female offspring. We observed a similar trend in male offspring except for the HF-C group which was not heavier or fatter than male C-C offspring. Histology showed lipid vacuoles within hepatocytes in the HF-HF, HF-C and C-HF but not the CC offspring. Serum C-reactive protein was elevated in female (C-HF and HF-HF) but not in male offspring. Elevated blood pressure in the HF-C and C-HF groups was attenuated in the HF-HF group in males but not in females. These findings indicate that long-term consumption of an HF diet by the mother predisposes her offspring to developing a metabolic syndrome-like phenotype in adult life, although cardiovascular effects of an HF diet are related to sex specificity in the HF-HF group.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Professor Mark A. Hanson, fax +44 238 0785255, email m.hanson@soton.ac.uk
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1 P Bateson , D Barker , T Clutton-Brock , (2004) Developmental plasticity and human health. Nature 430, 419421.

2 DC Benyshek , JF Martin & CS Johnston (2001) A reconsideration of the origins of the type 2 diabetes epidemic among Native Americans and the implications for intervention policy. Med Anthropol 20, 2564.

3 PD Gluckman & MA Hanson (2004) Living with the past: evolution, development, and patterns of disease. Science 305, 17331736.

4 CW Kuzawa , LS Adair , JL Avila , (2003) Atherogenic lipid profiles in Filipino adolescents with low body mass index and low dietary fat intake. Am J Hum Biol 15, 688696.

9 MC Franco , RM Arruda , AP Dantas , (2002) Intrauterine undernutrition: expression and activity of the endothelial nitric oxide synthase in male and female adult offspring. Cardiovasc Res 56, 145153.

10 T Ozaki , H Nishina , MA Hanson , (2001) Dietary restriction in pregnant rats causes gender-related hypertension and vascular dysfunction in offspring. J Physiol 530, 141152.

12 SA Bayol , BH Simbi & NC Stickland (2005) A maternal cafeteria diet during gestation and lactation promotes adiposity and impairs skeletal muscle development and metabolism in rat offspring at weaning. J Physiol 567, 951961.

13 I Khan , V Dekou , M Hanson , (2004) Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring. Circulation 110, 10971102.

14 IY Khan , PD Taylor , V Dekou , (2003) Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension 41, 168175.

16 SC Langley-Evans , AG Clamp , RF Grimble , (1996) Influence of dietary fats upon systolic blood pressure in the rat. Int J Food Sci Nutr 47, 417425.

17 E Zambrano , CJ Bautista , M Deas , (2006) A low maternal protein diet during pregnancy and lactation has sex- and window of exposure-specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat. J Physiol 571, 221230.

18 IY Khan , V Dekou , G Douglas , (2005) A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring. Am J Physiol Regul Integr Comp Physiol 288, R127R133.

19 J Zhang , C Wang , PL Terroni , (2005) High-unsaturated-fat, high-protein, and low-carbohydrate diet during pregnancy and lactation modulates hepatic lipid metabolism in female adult offspring. Am J Physiol Regul Integr Comp Physiol 288, R112R118.

20 M Van Heek , DS Compton , CF France , (1997) Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 99, 385390.

21 JH Krege , JB Hodgin , JR Hagaman , (1995) A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension 25, 11111115.

22 J Danesh , JG Wheeler , GM Hirschfield , (2004) C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 350, 13871397.

23 SC Langley-Evans (1996) Intrauterine programming of hypertension in the rat: nutrient interactions. Comp Biochem Physiol A Physiol 114, 327333.

24 W Oh , NL Gelardi & CJ Cha (1988) Maternal hyperglycemia in pregnant rats: its effect on growth and carbohydrate metabolism in the offspring. Metabolism 37, 11461151.

25 MM Elahi , FR Cagampang , FW Anthony , (2008) Statin treatment in hypercholesterolemic pregnant mice reduces cardiovascular risk factors in their offspring. Hypertension 51, 939944.

26 F Guo & KL Jen (1995) High-fat feeding during pregnancy and lactation affects offspring metabolism in rats. Physiol Behav 57, 681686.

27 E Koukkou , P Ghosh , C Lowy , (1998) Offspring of normal and diabetic rats fed saturated fat in pregnancy demonstrate vascular dysfunction. Circulation 98, 28992904.

28 AE Reid (2001) Nonalcoholic steatohepatitis. Gastroenterology 121, 710723.

29 R Shiri-Sverdlov , K Wouters , PJ van Gorp , (2006) Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates. J Hepatol 44, 732741.

30 M Tous , N Ferre , J Camps , (2005) Feeding apolipoprotein E-knockout mice with cholesterol and fat enriched diets may be a model of non-alcoholic steatohepatitis. Mol Cell Biochem 268, 5358.

31 P Libby (2002) Inflammation in atherosclerosis. Nature 420, 868874.

38 PM Ridker , M Cushman , MJ Stampfer , (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336, 973979.

35 W Khovidhunkit , MS Kim , RA Memon , (2004) Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res 45, 11691196.

36 PM Ridker , CH Hennekens , N Rifai , (1999) Hormone replacement therapy and increased plasma concentration of C-reactive protein. Circulation 100, 713716.

37 M Visser , LM Bouter , GM McQuillan , (1999) Elevated C-reactive protein levels in overweight and obese adults. JAMA 282, 21312135.

34 PM Ridker , CH Hennekens , JE Buring , (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342, 836843.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 33
Total number of PDF views: 158 *
Loading metrics...

Abstract views

Total abstract views: 342 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 28th May 2017. This data will be updated every 24 hours.