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Low-carbohydrate diets impair flow-mediated dilatation: evidence from a systematic review and meta-analysis

  • Lukas Schwingshackl (a1) and Georg Hoffmann (a1)
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1Bueno NB, de Melo IS, de Oliveira SL, et al. (2013) Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials. Br J Nutr (Epublication ahead of print version 7 May 2013).
2Inaba Y, Chen JA & Bergmann SR (2010) Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis. Int J Cardiovasc Imaging 26, 631640.
3Hu T, Mills KT, Yao L, et al. (2012) Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors: a meta-analysis of randomized controlled clinical trials. Am J Epidemiol 176, Suppl. 7, S44S54.
4Buscemi S, Verga S, Tranchina MR, et al. (2009) Effects of hypocaloric very-low-carbohydrate diet vs. Mediterranean diet on endothelial function in obese women. Eur J Clin Invest 39, 339347.
5de Roos NM, Bots ML, Siebelink E, et al. (2001) Flow-mediated vasodilation is not impaired when HDL-cholesterol is lowered by substituting carbohydrates for monounsaturated fat. Br J Nutr 86, 181188.
6Phillips SA, Jurva JW, Syed AQ, et al. (2008) Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity. Hypertension 51, 376382.
7Varady KA, Bhutani S, Klempel MC, et al. (2011) Improvements in vascular health by a low-fat diet, but not a high-fat diet, are mediated by changes in adipocyte biology. Nutr J 10, 8.
8Volek JS, Ballard KD, Silvestre R, et al. (2009) Effects of dietary carbohydrate restriction versus low-fat diet on flow-mediated dilation. Metabolism 58, 17691777.
9Wycherley TP, Brinkworth GD, Keogh JB, et al. (2010) Long-term effects of weight loss with a very low carbohydrate and low fat diet on vascular function in overweight and obese patients. J Intern Med 267, 452461.
10Noto H, Goto A, Tsujimoto T, et al. (2013) Low-carbohydrate diets and all-cause mortality: a systematic review and meta-analysis of observational studies. PLOS ONE 8, e55030.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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