Hostname: page-component-8448b6f56d-42gr6 Total loading time: 0 Render date: 2024-04-19T02:45:06.980Z Has data issue: false hasContentIssue false
  • English
  • Français

Low-iodine diet for the production of severe I deficiency in marmosets (Callithrix jacchus jacchus)

Published online by Cambridge University Press:  09 March 2007

M. T. Mano ,
B. J. Potter ,
G. B. Belling  and
B. S. Hetzel
M. T. Mano
Affiliation:
Division of Human Nutrition, CSIRO Australia, Kintore Avenue, Adelaide, South Australia 5000, Australia
B. J. Potter
Affiliation:
Division of Human Nutrition, CSIRO Australia, Kintore Avenue, Adelaide, South Australia 5000, Australia
G. B. Belling
Affiliation:
Division of Human Nutrition, CSIRO Australia, Kintore Avenue, Adelaide, South Australia 5000, Australia
B. S. Hetzel
Affiliation:
Division of Human Nutrition, CSIRO Australia, Kintore Avenue, Adelaide, South Australia 5000, Australia
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. A low-iodine diet consisting of maize, peas (Pisum sativum), torula yeast, meat meal, maize oil and added vitamins, minerals and amino acids was given to eight pairs of adult, common cotton-eared marmosets (Caliithrix jacchus jacchus). Eight control pairs were given the same diet to which potassium iodate was added. Both groups also received low-I apple and deionized water.

2. The diet provided adequate nutrition, as confirmed by the maintenance of body-weight and good health.

3. In the I-deficient marmosets the concentration of plasma thyroxine was decreased from 140.1 nmol/l to 22.4 nmol/l and thyroid-stimulating hormone increased significantly from 1.8 ng/ml to 9.0 ng/ml compared with control marmosets, thereby indicating severe I deficiency.

4. Compared with newborn offspring from control marmosets, the thyroid glands from the I-deficient offspring showed (a) an increase in weight, (b) a decrease in I content and (c), on histological examination, hyperplasia, hypertrophy and a total absence of colloid material in the follicles.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 2 , September 1985 , pp. 367 - 372
Copyright
Copyright © The Nutrition Society 1985

References

REFERENCES

Belling, G. B. (1982). Determination of Iodine, pp. 1–14. Adelaide: CSIRO Division of Human Nutrition.Google Scholar
Foss, O. P., Hankes, L. V. & van Slyke, D. D. (1960). Clinica Chimica Acta 5, 301–326.CrossRefGoogle Scholar
Grist, S. M. (1973). Journal of the Institute of Animal Technicians 27, 1–7.Google Scholar
Hearn, J. P., Lunn, S. F., Burden, F. J. & Pilcher, M. M. (1975). Laboratory Animals 9, 135–137.CrossRefGoogle Scholar
Hetzel, B. S. (1983). Lancet ii, 1126–1129.CrossRefGoogle Scholar
King, G. J. (1978). British Journal of Nutrition 40, 55–62.CrossRefGoogle Scholar
McIntosh, G. H., Jones, G. B., Howard, D. H., Belling, G. B., Potter, B. J. & Hetzel, B. S. (1980). Australian Journal of Biological Sciences 33, 205–211.CrossRefGoogle Scholar
McIntosh, G. H. & Looker, J. W. (1982). Laboratory Animal Science 32, 677–679.Google Scholar
Patel, Y. C., Burger, H. G. & Hudson, B. (1971). Journal of Clinical Endocrinology 33, 768–774.CrossRefGoogle Scholar
Phillips, I. R. & Grist, S. M. (1975). Laboratory Animals 9, 57–60.CrossRefGoogle Scholar
Poswillo, D. E., Hamilton, W. J. & Sopher, D. (1972). Nature 239, 460–462.CrossRefGoogle Scholar
Potter, B. J., Jones, G. B., Buckley, R. A., Belling, G. B., McIntosh, G. H. & Hetzel, B. S. (1980). Australian Journal of Biological Sciences 33, 53–61.CrossRefGoogle Scholar
Potter, B. J., Mano, M. T., Belling, G. B., McIntosh, G. H., Hua, C., Cragg, B. G., Marshall, J., Wellby, M. L. & Hetzel, B. S. (1982). Neuropathology and Applied Neurobiology 8, 303–313.CrossRefGoogle Scholar
Shimwell, M., Warrington, B. F. & Fowler, J. S. L. (1979). Laboratory Animals 13, 139–142.CrossRefGoogle Scholar
Wirth, H. & Buselmaier, W. (1982). Laboratory Animals 16, 175–181.CrossRefGoogle Scholar