1 Flegal KM, Carroll MD, Ogden CL, et al. (2010) Prevalence and trends in obesity among US adults. 1999–2008. JAMA 303, 235–241.
2 Popkin BM (2001) The nutrition transition and obesity in the developing world. J Nutr 31, 871S–873S.
3 American Heart Association (2010) .
4 American Heart Association. .
5 Mathieu P, Lemieux I & Després JP (2010) Obesity, inflammation, and cardiovascular risk. Clin Pharmacol Ther 87, 407–416.
6 Siri-Tarino PW, Sun Q, Hu FB, et al. (2010) Saturated fat, carbohydrate, and cardiovascular disease. Am J Clin Nutr 91, 502–509.
7 Hanna-Moussa A, Gardner MJ, Kurukulasuriya LR, et al. (2009) Dysglycemia/prediabetes and cardiovascular risk factors. Rev Cardiovasc Med 10, 202–208.
8 Robinson E & Grieve DJ (2009) Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease. Pharmacol Ther 122, 246–263.
9 Wang YX (2010) PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res 20, 124–137.
10 Latruffe N & Vamecq J (1997) Peroxisome proliferators and peroxisome proliferator activated receptors as regulators of lipid metabolism. Biochimie 79, 81–94.
11 Kalaitzidis RG, Sarafidis PA & Bakris GL (2009) Effects of thiazolidinediones beyond glycaemic control. Curr Pharm Des 15, 529–536.
12 Roberts WC (1989) Safety of fenofibrate – US and worldwide experience. Cardiology 76, 169–179.
13 Ullah MF & Khan MW (2008) Food as medicine: potential therapeutic tendencies of plant derived polyphenolic compounds. Asian Pac J Cancer Prev 9, 187–195.
14 Jew S, AbuMweis SS & Jones PJ (2009) Evolution of the human diet: linking our ancestral diet to modern functional foods as a means of chronic disease prevention. J Med Food 12, 925–934.
15 Jayaprakasam B, Vareed SK, Olson LK, et al. (2005) Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. J Agric Food Chem 53, 28–31.
16 Ware WR (2009) Nutrition and the prevention and treatment of cancer: association of cytochrome P450 CYP1B1 with the role of fruit and fruit extracts. Integr Cancer Ther 8, 22–28.
17 Wu H, Dai Q, Shrubsole MJ, et al. (2009) Fruit and vegetable intakes are associated with lower risk of colorectal adenomas. J Nutr 139, 340–344.
18 Iriti M & Faoro F (2006) Grape phytochemicals: a bouquet of old and new nutraceuticals for human health. Med Hypotheses 67, 833–838.
20 Ojewole JA (2005) Antiinflammatory, analgesic and hypoglycemic effects of Mangifera indica Linn. (Anacardiaceae) stem-bark aqueous extract. Methods Find Exp Clin Pharmacol 27, 547–554.
21 Muruganandan S, Srinivasan K, Gupta S, et al. (2005) Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats. J Ethnopharmacol 97, 497–501.
22 Aderibigbe AO, Emudianughe TS & Lawal BAS (2001) Evaluation of the antidiabetic action of Mangifera indica in mice. Phytother Res 15, 456–458.
23 Aderibigbe AO, Emudianughe TS & Lawal BAS (1999) Antihyperglycaemic effect of Mangifera indica in rat. Phytother Res 13, 504–507.
24 Percival SS, Talcott ST, Chin ST, et al. (2006) Neoplastic transformation of BALB/3T3 cells and cell cycle of HL-60 cells are inhibited by mango (Mangifera indica L.) juice and mango juice extracts. J Nutr 136, 1300–1304.
25 Wilkinson AS, Monteith GR, Shaw PN, et al. (2008) Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem 56, 3037–3042.
26 Reeves PG, Nielsen FH & Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc Writing Committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 1939–1951.
27 Molnar J, Yu S, Mzhavia N, et al. (2005) Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice. Circ Res 96, 1178–1184.
28 Manthey J & Perkins-Veazie P (2009) Influences of harvest date and location on the levels of beta-carotene, ascorbic acid, total phenols, the in vitro antioxidant capacity, and phenolic profiles of five commercial varieties of mango (Mangifera indica L.). J Agric Food Chem 57, 10825–10830.
29 Lucas EA, Juma S, Stoecker BJ, et al. (2000) Prune suppresses ovariectomy-induced hypercholesterolemia in rats. J Nutr Biochem 11, 255–259.
30 Prior RL, Wu X, Gu L, et al. (2008) Whole berries versus berry anthocyanins: interactions with dietary fat levels in the C57BL/6J mouse model of obesity. J Agric Food Chem 56, 647–653.
31 Dulebohn RV, Yi W, Srivastava A, et al. (2008) Effects of blueberry (Vaccinium ashei) on DNA damage, lipid peroxidation, and phase II enzyme activities in rats. J Agric Food Chem 56, 11700–11706.
32 Bobek P, Ginter E, Jurcovicova M, et al. (1990) Effect of dehydrated apple products on the serum and liver lipids in Syrian hamsters. Nahrung 34, 783–789.
33 Chao L, Marcus-Samuels B, Mason MM, et al. (2000) Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones. J Clin Invest 106, 1221–1228.
34 Guerre-Millo M, Gervois P, Raspé E, et al. (2000) Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem 275, 16638–16642.
35 Tai MM (1994) A mathematical model for the determination of total area under glucose tolerance and other metabolic curves. Diabetes Care 17, 152–154.
36 Matthews DR, Hosker JP, Rudenski AS, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412–419.
37 Lee S, Muniyappa R, Yan X, et al. (2008) Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice. Am J Physiol Endocrinol Metab 294, E261–E270.
38 Valasek MA, Clarke SL & Repa JJ (2007) Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse. J Lipid Res 48, 2725–2735.
39 Prior RL, Wilkes S, Rogers T, et al. (2010) Purified blueberry anthocyanins and blueberry juice alter development of obesity in mice fed an obesogenic high-fat diet. J Agric Food Chem 58, 3970–3976.
40 Fukumitsu S, Aida K, Ueno N, et al. (2008) Flaxseed lignin attenuates high-fat diet-induced fat accumulation and induces adiponectin expression in mice. Br J Nutr 100, 669–676.
41 Yoon M, Jeong S, Nicol CJ, et al. (2002) Fenofibrate regulates obesity and lipid metabolism with sexual dimorphism. Exp Mol Med 34, 481–488.
42 Mancini FP, Lanni A, Sabatino L, et al. (2001) Fenofibrate prevents and reduced body weight gain and adiposity in diet-induced obese rats. FEBS Lett 491, 154–158.
43 Nagai Y, Nishio Y, Nakamura T, et al. (2002) Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha. Am J Physiol Endocrinol Metab 282, E1180–E1190.
44 Kuda O, Jelenik T, Jilkova Z, et al. (2009) n-3 fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet. Diabetologia 52, 941–951.
45 Caldwell J (1989) The biochemical pharmacology of fenofibrate. Cardiology 76, 33–41.
46 Walker GE, Marzullo P, Verti B, et al. (2008) Subcutaneous abdominal adipose tissue subcompartments: potential role in rosiglitazone effects. Obesity (Silver Spring) 16, 1983–1991.
47 Larsen TM, Toubro S & Astrup A (2003) PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy? Int J Obes Relat Metab Disord 27, 147–161.
48 Contractor Z, Hussain F & Jabbar A (1999) Postprandial glucose response to mango, banana and sapota. J Pak Med Assoc 49, 215–216.
49 Roongpisuthipong C, Banphotkasem S, Komindr S, et al. (1991) Postprandial glucose and insulin responses to various tropical fruits of equivalent carbohydrate content in non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 14, 123–131.
50 Parmar H & Kar A (2007) Antidiabetic potential of Citrus sinensis and Punica granatum peel extracts in alloxan-treated male mice. Biofactors 31, 17–24.
51 Xie W, Nie Y, Du L, et al. (2007) Preventive effects of fenofibrate on insulin resistance, hyperglycaemia, visceral fat accumulation in NIH mice induced by small-dose streptozotocin and lard. Pharmacol Res 55, 392–399.
52 Srivastava RA (2009) Fenofibrate ameliorates diabetic and dyslipidemic profiles in KKAy mice partly via down-regulation of 11beta-HSD1, PEPCK and DGAT2. Comparison of PPARalpha, PPARgamma, and liver × receptor agonists. Eur J Pharmacol 607, 258–263.
53 Arai T, Kim HJ, Chiba H, et al. (2009) Interaction of fenofibrate and fish oil in relation to lipid metabolism in mice. J Atheroscler Thromb 16, 283–291.
54 Declercq V, Yeganeh B, Moshtaghi-Kashanian GR, et al. (2005) Paradoxical effects of fenofibrate and nicotinic acid in apo E-deficient mice. J Cardiovasc Pharmacol 46, 18–24.
55 Mancini FP, Lanni A, Sabatino L, et al. (2001) Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats. FEBS Lett 491, 154–158.