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Mediterranean alcohol-drinking pattern and mortality in the SUN (Seguimiento Universidad de Navarra) Project: a prospective cohort study

  • Alfredo Gea (a1), Maira Bes-Rastrollo (a1) (a2), Estefania Toledo (a1) (a2), Martin Garcia-Lopez (a3), Juan J. Beunza (a1) (a4), Ramon Estruch (a2) (a5) and Miguel A. Martinez-Gonzalez (a1) (a2)...
Abstract

Moderate alcohol intake has been related to lower mortality. However, alcohol use includes other dimensions beyond the amount of alcohol consumed. These aspects have not been sufficiently studied as a comprehensive entity. We aimed to test the relationship between an overall alcohol-drinking pattern and all-cause mortality. In a Mediterranean cohort study, we followed 18 394 Spanish participants up to 12 years. A validated 136-item FFQ was used to assess baseline alcohol intake. We developed a score assessing simultaneously seven aspects of alcohol consumption to capture the conformity to a traditional Mediterranean alcohol-drinking pattern (MADP). It positively scored moderate alcohol intake, alcohol intake spread out over the week, low spirit consumption, wine preference, red wine consumption, wine consumed during meals and avoidance of binge drinking. During the follow-up, 206 deaths were identified. For each 2-point increment in a 0–9 score of adherence to the MADP, we observed a 25 % relative risk reduction in mortality (95 % CI 11, 38 %). Within each category of alcohol intake, a higher adherence to the MADP was associated with lower mortality. Abstainers (excluded from the calculations of the MADP) exhibited higher mortality (hazard ratio 1·82, 95 % CI 1·14, 2·90) than participants highly adherent to the MADP. In conclusion, better adherence to an overall healthy alcohol-drinking pattern was associated with reduced mortality when compared with abstention or departure from this pattern. This reduction goes beyond the inverse association usually observed for moderate alcohol drinking. Even moderate drinkers can benefit from the advice to follow a traditional MADP.

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Corresponding author
* Corresponding author: Professor M. A. Martinez-Gonzalez, email mamartinez@unav.es
References
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2 M Jin , S Cai , J Guo , et al. (2013) Alcohol drinking and all cancer mortality: a meta-analysis. Ann Oncol 24, 807816.

3 A Di Castelnuovo , S Costanzo , V Bagnardi , et al. (2006) Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies. Arch Intern Med 166, 24372445.

7 EB Rimm , P Williams , K Fosher , et al. (1999) Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ 319, 15231528.

8 R Estruch , E Sacanella , E Badia , et al. (2004) Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers. Atherosclerosis 175, 117123.

9 F Facchini , YD Chen & GM Reaven (1994) Light-to-moderate alcohol intake is associated with enhanced insulin sensitivity. Diabetes Care 17, 115119.

11 JL Valencia-Martin , I Galan & F Rodriguez-Artalejo (2007) Binge drinking in Madrid, Spain. Alcohol Clin Exp Res 31, 17231730.

12 M Seguí-Gómez , C de la Fuente , Z Vázquez , et al. (2006) Cohort profile: the ’Seguimiento Universidad de Navarra’ (SUN) study. Int J Epidemiol 35, 14171422.

15 S Renaud & M de Lorgeril (1992) Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339, 15231526.

18 MA Martínez-González , C López-Fontana , JJ Varo , et al. (2005) Validation of the Spanish version of the physical activity questionnaire used in the Nurses' Health Study and the Health Professionals' Follow-up Study. Public Health Nutr 8, 920927.

19 A Trichopoulou , C Bamia & D Trichopoulos (2009) Anatomy of health effects of Mediterranean diet: Greek EPIC prospective cohort study. BMJ 338, b2337.

20 JS Tolstrup , MK Jensen , A Tjønneland , et al. (2004) Drinking pattern and mortality in middle-aged men and women. Addiction 99, 323330.

21 L Baglietto , DR English , JL Hopper , et al. (2006) Average volume of alcohol consumed, type of beverage, drinking pattern and the risk of death from all causes. Alcohol Alcohol 41, 664671.

23 KJ Mukamal , KM Conigrave , MA Mittleman , et al. (2003) Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med 348, 109118.

26 SC Renaud , R Guéguen , G Siest , et al. (1999) Wine, beer, and mortality in middle-aged men from eastern France. Arch Intern Med 159, 18651870.

27 LR Harriss , DR English , JL Hopper , et al. (2007) Alcohol consumption and cardiovascular mortality accounting for possible misclassification of intake: 11-year follow-up of the Melbourne Collaborative Cohort Study. Addiction 102, 15741585.

28 AL Klatsky , GD Friedman , MA Armstrong , et al. (2003) Wine, liquor, beer, and mortality. Am J Epidemiol 158, 585595.

30 H Theobald , LO Bygren , J Carstensen , et al. (2000) A moderate intake of wine is associated with reduced total mortality and reduced mortality from cardiovascular disease. J Stud Alcohol 61, 652656.

31 MT Streppel , MC Ocké , HC Boshuizen , et al. (2009) Long-term wine consumption is related to cardiovascular mortality and life expectancy independently of moderate alcohol intake: the Zutphen Study. J Epidemiol Community Health 63, 534540.

32 NR Nielsen , P Schnohr , G Jensen , et al. (2004) Is the relationship between type of alcohol and mortality influenced by socio-economic status? J Intern Med 255, 280288.

34 TE Strandberg , AY Strandberg , VV Salomaa , et al. (2007) Alcoholic beverage preference, 29-year mortality, and quality of life in men in old age. J Gerontol A Biol Sci Med Sci 62, 213218.

37 S Arranz , G Chiva-Blanch , P Valderas-Martinez , et al. (2012) Wine, beer, alcohol and polyphenols on cardiovascular disease and cancer. Nutrients 4, 759781.

38 TO Kiviniemi , A Saraste , JO Toikka , et al. (2007) A moderate dose of red wine, but not de-alcoholized red wine increases coronary flow reserve. Atherosclerosis 195, e176e181.

40 CR Pace-Asciak , S Hahn , EP Diamandis , et al. (1995) The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 235, 207219.

45 MK Jensen , AT Andersen , TI Sørensen , et al. (2002) Alcoholic beverage preference and risk of becoming a heavy drinker. Epidemiology 13, 127132.

46 T Norström (1998) Effects on criminal violence of different beverage types and private and public drinking. Addiction 93, 689699.

47 J Kauhanen , GA Kaplan , DE Goldberg , et al. (1997) Beer binging and mortality: results from the Kuopio ischaemic heart disease risk factor study, a prospective population based study. BMJ 315, 846851.

48 S Graff-Iversen , MD Jansen , DA Hoff , et al. (2013) Divergent associations of drinking frequency and binge consumption of alcohol with mortality within the same cohort. J Epidemiol Community Health 67, 350357.

49 RP Murray , JE Connett , SL Tyas , et al. (2002) Alcohol volume, drinking pattern, and cardiovascular disease morbidity and mortality: is there a U-shaped function? Am J Epidemiol 155, 242248.

50 KJ Mukamal , M Maclure , JE Muller , et al. (2005) Binge drinking and mortality after acute myocardial infarction. Circulation 112, 38393845.

51 M Roerecke , TK Greenfield , WC Kerr , et al. (2011) Heavy drinking occasions in relation to ischaemic heart disease mortality – an 11–22 year follow-up of the 1984 and 1995 US National Alcohol Surveys. Int J Epidemiol 40, 14011410.

52 S Malyutina , M Bobak , S Kurilovitch , et al. (2002) Relation between heavy and binge drinking and all-cause and cardiovascular mortality in Novosibirsk, Russia: a prospective cohort study. Lancet 360, 14481454.

53 LS Mørch , D Johansen , E Løkkegaard , et al. (2008) Drinking pattern and mortality in Danish nurses. Eur J Clin Nutr 62, 817822.

56 HW Gruchow , RG Hoffmann , AJ Anderson , et al. (1982) Effects of drinking patterns on the relationship between alcohol an coronary occlusion. Atherosclerosis 43, 393404.

57 S Kiechl , J Willeit , G Rungger , et al. (1998) Alcohol consumption and atherosclerosis: what is the relation? prospective results from the Bruneck Study. Stroke 29, 900907.

59 K Standerwick , C Davies , L Tucker , et al. (2007) Binge drinking, sexual behaviour and sexually transmitted infection in the UK. Int J STD AIDS 18, 810813.

61 KA Hätönen , J Virtamo , JG Eriksson , et al. (2012) Modifying effects of alcohol on the postprandial glucose and insulin responses in healthy subjects. Am J Clin Nutr 96, 4449.

62 M Foppa , FD Fuchs , L Preissler , et al. (2002) Red wine with the noon meal lowers post-meal blood pressure: a randomized trial in centrally obese, hypertensive patients. J Stud Alcohol 63, 247251.

64 M Trevisan , E Schisterman , A Mennotti , et al. (2001) Drinking pattern and mortality: the Italian Risk Factor and Life Expectancy pooling project. Ann Epidemiol 11, 312319.

66 FB Hu (2002) Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol 13, 39.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
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