Skip to main content
×
Home
    • Aa
    • Aa

Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?

  • Cristovao F. Lima (a1), Marisa F. Azevedo (a1), Rita Araujo (a1), Manuel Fernandes-Ferreira (a1) and Cristina Pereira-Wilson (a1)...
Abstract

Common sage (Salvia officinalis L.) is among the plants that are claimed to be beneficial to diabetic patients, and previous studies have suggested that some of its extracts have hypoglycaemic effects in normal and diabetic animals. In the present study, we aimed to verify the antidiabetic effects of an infusion (tea) of common sage, which is the most common form of this plant consumed. Replacing water with sage tea for 14d lowered the fasting plasma glucose level in normal mice but had no effect on glucose clearance in response to an intraperitoneal glucose tolerance test. This indicated effects on gluconeogenesis at the level of the liver. Primary cultures of hepatocytes from healthy, sage-tea-drinking rats showed, after stimulation, a high glucose uptake capacity and decreased gluconeogenesis in response to glucagon. Essential oil from sage further increased hepatocyte sensitivity to insulin and inhibited gluconeogenesis. Overall, these effects resemble those of the pharmaceutical drug metformin, a known inhibitor of gluconeogenesis used in the treatment and prevention of type 2 diabetes mellitus. In primary cultures of rat hepatocytes isolated from streptozotocin (STZ)-induced diabetic rats, none of these activities was observed. The present results seem to indicate that sage tea does not possess antidiabetic effects at this level. However, its effects on fasting glucose levels in normal animals and its metformin-like effects on rat hepatocytes suggest that sage may be useful as a food supplement in the prevention of type 2 diabetes mellitus by lowering the plasma glucose of individuals at risk.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Cristina Pereira-Wilson, fax +351 253678980, email cpereira@bio.uminho.pt
References
Hide All
Alarcon-Aguilar FJ, Roman-Ramos R, Flores-Saenz JL & Aguirre-Garcia F Investigation on the hypoglycaemic effects of extracts of four Mexican medicinal plants in normal and alloxan-diabetic mice. Phytother Res (2002) 16, 383386.
Amatruda JM, Salhanick AI & Chang CL Hepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action. Diabetes Care 7, (1984Suppl. 1, 4753
Baricevic D & Bartol T The biological/pharmacological activity of the Salvia genus InSage – the Genus Salvia, pp. 143184 [Kintzios SE, editor]. Amsterdam: Harwood Academic Publishers. (2000)
Cheng JT, Liu IM, Chi TC, Su HC & Chang CG Metforminlike effects of Quei Fu Di Huang Wan, a Chinese herbal mixture, on streptozotocin-induced diabetic rat. Horm Metab Res (2001) 33, 727732.
Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A& Laakso M Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet (2002) 359, 20722077.
Costacou T & Mayer-Davis EJ Nutrition and prevention of type 2 diabetes. Annu Rev Nutr (2003) 23, 147170.
Day C Traditional plant treatments for diabetes mellitus: pharmaceutical foods. Br J Nutr (1998) 80, 56.
Dunbar JC, Schultz S, Houser F & Walker J Regulation of the hepatic response to glucagon – role of insulin, growth-hormone and cortisol. Horm Res (1989) 31, 244249.
Eidi M, Eidi A & Zamanizadeh H Effect of Salvia officinalis L. leaves on serum glucose and insulin in healthy and streptozotocininduced diabetic rats. J Ethnopharmacol (2005) 100, 310313.
Giannouli AL, Kintzios SE Essential oils of Salvia spp: examples of intraspecific and seasonal variation. InSage – the Genus Salvia, pp.6980 [Kintzios SE, editor]. Amsterdam: Harwood Academic Publishers. (2000)
Guarino MP, Afonso RA, Raimundo N, Raposo JF & Macedo MP Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action. Am J Physiol Gastrointest Liver Physiol (2003) 284, G588G594.
Han YM, Oh H, Na M, Kim BS, Oh WK, Kim BY, Jeong DG, Ryu SE, Sok DE & Ahn JS PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza. Biol Pharm Bull (2005) 28, 17951797.
HussinAH & Skett P Lack of effect of insulin in hepatocytes isolated from streptozotocin-diabetic male-rats. Biochem Pharmacol (1988) 37, 16831686.
Jermendy G Can type 2 diabetes mellitus be considered preventable?. Diabetes Res Clin Pract 68, Suppl. 1, (2005) S73S81.
Klover PJ & Mooney RA Hepatocytes: critical for glucose hom36eostasis. Int J Biochem Cell Biol (2004) 36, 753758.
Lai LC Prevention of type 2 diabetes. Malays J Pathol (2002) 24,7176.
Large V & Beylot M Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin. Diabetes (1999) 48, 12511257.
Li WL, Zheng HC, Bukuru J & De Kimpe N Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol (2004) 92, 121.
Lima CF, Andrade PB, Seabra RM, Fernandes-Ferreira M & Pereira-Wilson C The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats. J Ethnopharmacol (2005) 97, 383389.
Lima CF, Carvalho F, Fernandes E, Bastos ML, Santos-Gomes PC, Fernandes-Ferreira M & Pereira-Wilson C Evaluation of toxic/protective effects of the essential oil of Salvia officinalis on freshly isolated rat hepatocytes. Toxicol in Vitro (2004) 18, 457465.
Moldeus P, Hogberg J & Orrenius S Isolation and use of liver cells. Methods Enzymol (1978) 52, 6071.
National Institutes of Health Principles of Laboratory Animal Care. Bethesda, MD: National Institutes of Health. (1985)
Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y & Sato Y Gosha-jinki-gan (a herbal complex) corrects abnormal insulin signaling. Evid Based ComplementAlternat Med (2004) 1, 269276.
Roden M & Bernroider E Hepatic glucose metabolism in humans – its role in health and disease. Best Pract Res Clin Endocrinol Metab (2003) 17, 365383.
Salhanick AI, Konowitz P & Amatruda JM Potentiation of insulin action by a sulfonylurea in primary cultures of hepatocytes from normal and diabetic rats. Diabetes (1983) 32, 206212.
Saxena A & Vikram NK Role of selected Indian plants in management of type 2 diabetes: a review. J Altern Complement Med 2004) 10, 369378.
Schernthaner G Progress in the prevention of type 2 diabetes. Wien Klin Wochenschr (2003) 115, 745757.
Simpson RW, Shaw JE & Zimmet PZ The prevention of type 2 diabetes – lifestyle change or pharmacotherapy? A challenge for the 21st century. Diabetes Res Clin Pract (2003) 59, 165180.
Sreenan S, Sturis J, Pugh W, Burant CF & Polonsky KS Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin and troglitazone. Am J Physiol (1996) 271, E742E747.
Stoeckli R & Keller U Nutritional fats and the risk of type 2 diabetes and cancer. Physiol Behav (2004) 83, 611615.
Williams G & Pickup JC Handbook of Diabetes,3rd ed. Malden: Blackwell Publishing. (2004)
Yeh GY, Eisenberg DM, Kaptchuk TJ & Phillips RS Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care (2003) 26, 12771294.
Yuan L, Ziegler R, Hamann A Inhibition of phosphoenolpyruvate carboxykinase gene expression by metformin in cultured hepatocytes. Chin Med J (Engl) (2002) 115, 18431848.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 2
Total number of PDF views: 277 *
Loading metrics...

Abstract views

Total abstract views: 470 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 23rd October 2017. This data will be updated every 24 hours.