Skip to main content
×
Home

Micronutrient interactions: effects on absorption and bioavailability

  • Brittmarie Sandström (a1)
Abstract

A potential risk of interactions between micronutrients affecting absorption and bioavailability has to be considered in any supplementation or fortification strategy. At levels of essential micronutrients present in foods, most micronutrients appear to utilise specific absorptive mechanisms and not be vulnerable to interactions. In aqueous solutions and at higher intake levels competition between elements with similar chemical characteristics and uptake by non-regulated processes can take place. These interactions have clearly been demonstrated in experimental absorption studies and to some extent have been confirmed in supplementation studies. Negative effects of iron supplementation on indices of zinc and copper status and of zinc supplementation on iron and copper status have been reported. In contrast, the negative effect of calcium on iron absorption has not been confirmed in long-term supplementation studies. Ascorbic acid has a strong iron absorption promoting potential and in iron deficient populations ascorbic acid supplementation improves iron status. Thus, ascorbic acid supplements or an increased intake of ascorbic acid rich foods could have important public health implications, especially in populations subsisting on a mainly plant food based diet. The effect of poor status of a given micronutrient on absorption and utilisation of other micronutrients should also be considered while developing strategies to improve micronutrient status in a population. Awareness of these interactions, combined with a balanced evaluation of the dietary intake of the population with regard to absorption promoting and inhibiting substances and the risk for multiple deficiencies, could lead to more effective strategies to improve micronutrient status.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Micronutrient interactions: effects on absorption and bioavailability
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Micronutrient interactions: effects on absorption and bioavailability
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Micronutrient interactions: effects on absorption and bioavailability
      Available formats
      ×
Copyright
Corresponding author
Corresponding author: Dr Brittmarie Sandström, fax +45 35 28 24 83, email bsa@kvl.dk
References
Hide All
Breskin MW, Worthington-Roberts BS, Knopp RH, Brown Z, Plovie B, Karle Mottet N & Mills JL (1983) First trimester serum zinc concentrations in human pregnancy. American Journal of Clinical Nutrition 38, 943953.
Broun ER, Greist A, Tricot G & Hoffman R (1990) Excessive zinc ingestion. Journal of the American Medical Association 264, 14411443.
Cook JD, Watson SS, Simpson KM, Lipschitz DA & Skikne BS (1984) The effect of high ascorbic acid supplementation on body iron stores. Blood 64, 721726.
Davidsson L, Almgren A, Sandström B & Hurrell RF (1995) Zinc absorption in adult humans: the effect of iron fortification. British Journal of Nutrition 74, 417425.
Dawson EB, Albers J & McGanity WJ (1989) Serum zinc changes due to iron supplementation in teenage pregnancy. American Journal of Clinical Nutrition 50, 848852.
Fairweather-Tait SJ, Powers HJ, Minski MJ, Whitehead J & Downes R (1992) Riboflavin deficiency and iron absorption in adult Gambian men. Annals of Nutrition & Metabolism 36, 3440.
Finley EB & Cerklewski FL (1983) Influence of ascorbic acid supplementation on copper status in young adult men. American Journal of Clinical Nutrition 37, 553556.
Fischer PWF, Giroux A & L'Abbé MR (1984) Effect of zinc supplementation on copper status in adult man. American Journal of Clinical Nutrition 40, 743746.
Garcia-Casal MN, Larysse M, Solano L, Baron MA, Arguello F, Llovera D, Ramirez J, Leets I & Tropper E (1998) Vitamin A and beta-carotene can improve nonheme iron absorption from rice, wheat and corn by humans. Journal of Nutrition 128, 646650.
Hallberg L, Brune M & Rossander L (1986) Effect of ascorbic acid on iron absorption from different types of meal. Studies with ascorbic-acid-rich foods and synthetic ascorbic acid given in different amounts with different meals. Human Nutrition: Clinical Nutrition 40, 97113.
Hallberg L, Brune M, Erlandsson M, Sandberg A-S & Rossander-Hultén L (1991) Calcium: effect of different amounts on nonheme- and heme-iron absorption in humans. American Journal of Clinical Nutrition 53, 112119.
Hallberg L, Rossander-Hultén L, Brune M & Gleerup A (1993) Inhibition of haem-iron absorption in man by calcium. British Journal of Nutrition 69, 533540.
Hambidge KM, Krebs NF, Jacobs MA, Favier A, Guyette L & Ikle DN (1983) Zinc nutritional status during pregnancy: a longitudinal study. American Journal of Clinical Nutrition 37, 429442.
Hambidge KM, Krebs NF, Sibley L & English J (1987) Acute effects of iron therapy on zinc status during pregnancy. Obstetrics & Gynaecology 70, 593596.
Hoogenraad TU, Dekker AW & Van Den Hamer CJA (1985) Copper responsive anemia, induced by oral zinc therapy in a patient with acrodermatitis enteropathica. The Science of the Total Environment 42, 3743.
Ilich-Ernst JZ, McKenna AA, Badenhop NE, Clairmont AC, Andon MB, Nahhas RW, Goel P & Matkovic V (1998) Iron status, menarche, and calcium supplementation in adolescent girls. American Journal of Clinical Nutrition 68, 880887.
Jacob RA, Skala JH, Omaye ST & Turnlund JR (1987) Effect of varying ascorbic acid intakes on copper absorption and ceruloplasmin levels in young men. Journal of Nutrition 117, 21092115.
Kalkwarf HJ & Harrast SD (1998) Effects of calcium supplementation and lactation on iron status. American Journal of Clinical Nutrition 67, 12441249.
Kauwell GPA, Bailey LB, Gregory JFI, Bowling DW & Cousins RJ (1995) Zinc status is not adversely affected by folic acid supplementation and zinc intake does not impair folate utilization in human subjects. Journal of Nutrition 125, 6672.
Levander OA (1987) A global view of human selenium nutrition. Annual Review of Nutrition 7, 227250.
Lönnerdal B, Cederblad Å, Davidsson L & Sandström B (1984) The effect of individual components of soy formula and cows' milk formula on zinc bioavailability. American Journal of Clinical Nutrition 40, 10641070.
Mao X & Yao G (1992) Effect of vitamin C supplementations on iron deficiency anemia in Chinese children. Biomedical Environmental Science 5, 125129.
Mena I, Horiuchi K, Burke K & Cotzias GC (1969) Chronic manganese poisoning. Individual susceptibility and absorption of iron. Neurology 19, 10001006.
Milne DB (1989) Effects of folic acid supplements on zinc-65 absorption and retention. The Journal of Trace Elements in Experimental Medicine 2, 297304.
Minihane AM & Fairweather-Tait SJ (1998) Effect of calcium supplementation on daily nonheme-iron absorption and long-term iron status. American Journal of Clinical Nutrition 68, 96102.
Munoz EC, Rosado JL, Lopez P, Furr HC & Allen LH (2000) Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers. American Journal of Clinical Nutrition 71, 789794.
Oberleas D, Muhrer ME & O'Dell BL (1966) Dietary metal-complexing agents and zinc availability in the rat. Journal of Nutrition 90, 5662.
O'Brien KO, Zavaleta N, Caulfield LE, Yang D-X & Abrams SA (1999) Influence of prenatal iron and zinc supplements on supplemental iron absorption, red blood cell iron incorporation, and iron status in pregnant Peruvian women. American Journal of Clinical Nutrition 69, 509515.
Petterson DS, Sandström B & Cederblad Å (1994) Absorption of zinc from lupin (Lupinus angustifolius)-based foods. British Journal of Nutrition 72, 865871.
Power HM, Heese HD, Beatty DW, Hughes J & Dempster WS (1991) Iron fortification of infant milk formula: the effects on iron status and immune function. Annals of Tropical Paediatrics 11, 5766.
Powers HJ (1995) Riboflavin-iron interactions with particular emphasis on the gastrointestinal tract. Proceedings of the Nutrition Society 54, 509517.
Robinson MF, Thomson CD & Huemmer PK (1985) Effect of a megadose of ascorbic acid, a meal and orange juice on the absorption of selenium as sodium selenite. The New Zealand Medical Journal 98, 627629.
Rossander-Hultén L, Brune M, Sandström B, Lönnerdal B & Hallberg L (1991) Competitive inhibition of iron absorption by manganese and zinc in humans. American Journal of Clinical Nutrition 54, 152156.
Sandström B, Davidsson L, Cederblad Å & Lönnerdal B (1985) Oral iron, dietary ligands and zinc absorption. Journal of Nutrition 115, 411414.
Sandström B & Cederblad Å (1987) Effect of ascorbic acid on the absorption of zinc and calcium in man. International Journal of Vitamin & Nutrition Research 57, 8790.
Seshadri S, Shah A & Bhade S (1985) Haematologic response to anaemic preschool children to ascorbic acid supplementation. Human Nutrition: Applied Nutrition 39, 151154.
Sharma DC & Mathur R (1995) Correction of anaemia and iron deficiency in vegetarians by administration of ascorbic acid. Indian Journal of Physiological Pharmacology 39, 403406.
Sheldon WL, Aspillaga MO, Smith PA & Lind T (1985) The effects of oral iron supplementation on zinc and magnesium levels during pregnancy. British Journal of Obstretics and Gynaecology 92, 892898.
Shingwekar AG, Mohanram M & Reddy V (1979) Effect of zinc supplementation on plasma levels of vitamin A and retinol-binding protein in malnourished children. Clinica Chimica Acta 93, 97100.
Sokoll LJ & Dawson-Hughes B (1992) Calcium supplementation and plasma ferritin concentrations in premenopausal women. American Journal of Clinical Nutrition 56, 10451048.
Spencer H, Kramer L, Norris C & Osis D (1984) Effect of calcium and phosphorus on zinc metabolism in man. American Journal of Clinical Nutrition 40, 12131218.
Tamura T, Goldenberg RL, Freeberg LE, Cliver SP, Cutter GR & Hoffman HJ (1992) Maternal serum folate and zinc concentrations and their relationships to pregnancy outcome. American Journal of Clinical Nutrition 56, 365370.
Turnlund JR, Wada L, King JC, Keyes WR & Acord LL (1988) Copper absorption in young men fed adequate and low zinc diets. Biological Trace Element Research 17, 3141.
Wright RO, Shannon MW, Wright RJ & Hu H (2000) Association between iron deficiency and low-level lead poisoning in an urban primary care clinic. American Journal of Public Health 89, 10491053.
Yadrick MK, Kenney MA & Winterfeldt EA (1989) Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. American Journal of Clinical Nutrition 49, 145150.
Yan L, Prentice A, Dibba B, Jarjou LMA, Stirling DM & Fairweather-Tait S (1996) The effect of long-term calcium supplementation on indices of iron, zinc and magnesium status in lactating Gambian women. British Journal of Nutrition 76, 821831.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 4
Total number of PDF views: 1479 *
Loading metrics...

Abstract views

Total abstract views: 1624 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 22nd November 2017. This data will be updated every 24 hours.