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Micronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohort

  • Eduardo Villamor (a1) (a2), Constanza Marín (a2) (a3), Mercedes Mora-Plazas (a3) and Henry Oliveros (a2)
Abstract

Childhood intake of animal foods is associated with age at first menstrual period (menarche). It is unknown whether the micronutrients present in these foods could explain this association. Our objective was to investigate the associations of micronutrient status biomarkers in middle childhood with age at menarche. We quantified circulating Hb, ferritin, mean corpuscular volume, Zn, vitamin B12, erythrocyte folate and retinol in 1464 pre-menarcheal girls aged 5–12 years in Bogotá, Colombia, and followed them for a median 5·7 years for the occurrence and date of menarche. We estimated median age at menarche and hazard ratios (HR) with 95 % CI by levels of each biomarker with use of Kaplan–Meier survival probabilities and Cox regression, respectively. Median age at menarche was 12·4 years. Middle childhood Hb was inversely related to age at menarche whereas plasma ferritin was positively associated with this outcome in a linear manner. HR of menarche for every 1 sd of Hb (11 g/l) and ferritin (23·2 µg/l) were 1·11 (95 % CI 1·04, 1·18; P=0·001) and 0·94 (95 % CI 0·88, 0·99; P=0·02), respectively, after adjustment for baseline age, C-reactive protein concentration, maternal age at menarche and parity and socioeconomic status. The association with ferritin was stronger in girls aged 9–10 years at baseline. Additional adjustment for baseline height- and BMI-for-age did not change the results. We conclude that higher Fe status in middle childhood is related to later age at menarche whereas Hb concentrations are inversely associated with age at onset of menses.

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Corresponding author
* Corresponding author: E. Villamor, fax +1 734 936 7283, email villamor@umich.edu
References
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1. Hsieh, CC, Trichopoulos, D, Katsouyanni, K, et al. (1990) Age at menarche, age at menopause, height and obesity as risk factors for breast cancer: associations and interactions in an international case-control study. Int J Cancer 46, 796800.
2. Dossus, L, Allen, N, Kaaks, R, et al. (2010) Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 127, 442451.
3. Canoy, D, Beral, V, Balkwill, A, et al. (2015) Age at menarche and risks of coronary heart and other vascular diseases in a large UK cohort. Circulation 131, 237244.
4. Charalampopoulos, D, McLoughlin, A, Elks, CE, et al. (2014) Age at menarche and risks of all-cause and cardiovascular death: a systematic review and meta-analysis. Am J Epidemiol 180, 2940.
5. Morris, DH, Jones, ME, Schoemaker, MJ, et al. (2011) Familial concordance for age at menarche: analyses from the Breakthrough Generations Study. Paediatr Perinat Epidemiol 25, 306311.
6. Villamor, E & Jansen, EC (2016) Nutritional determinants of the timing of puberty. Annu Rev Public Health 37, 3346.
7. Jansen, EC, Marín, C, Mora-Plazas, M, et al. (2016) Higher childhood red meat intake frequency is associated with earlier age at menarche. J Nutr 146, 792798.
8. Frisch, RE (2002) Female Fertility and the Body Fat Connection, Women in Culture and Society. Chicago, IL: University of Chicago Press.
9. Kissinger, D & Sanchez, A (1987) The association of dietary factors with age at menarche. Nutr Res 7, 471479.
10. Moisan, J, Meyer, F & Gingras, S (1990) Diet and age at menarche. Cancer Causes Control 1, 149154.
11. Maclure, M, Travis, LB, Willett, W, et al. (1991) A prospective cohort study of nutrient intake and age at menarche. Am J Clin Nutr 54, 649656.
12. Rogers, IS, Northstone, K, Dunger, DB, et al. (2010) Diet throughout childhood and age at menarche in a contemporary cohort of British girls. Public Health Nutr 13, 20522063.
13. Arsenault, JE, Mora-Plazas, M, Forero, Y, et al. (2009) Provision of a school snack is associated with vitamin B-12 status, linear growth, and morbidity in children from Bogota, Colombia. J Nutr 139, 17441750.
14. Harrison, GG, Stormer, A, Herman, DR, et al. (2003) Development of a Spanish-language version of the US household food security survey module. J Nutr 133, 11921197.
15. Makino, T & Takahara, K (1981) Direct determination of plasma copper and zinc in infants by atomic absorption with discrete nebulization. Clin Chem 27, 14451447.
16. World Health Organization (2007) Assessing the Iron Status of Populations: Including Literature Reviews: Report of a Joint World Health Organization/Centers for Disease Control and Prevention Technical Consultation on the Assessment of Iron Status at the Population Level, Geneva, Switzerland, 6–8 April 2004, 2nd ed. Geneva: WHO.
17. Zimmermann, MB & Hurrell, RF (2007) Nutritional iron deficiency. Lancet 370, 511520.
18. Villamor, E, Mora-Plazas, M, Forero, Y, et al. (2008) Vitamin B-12 status is associated with socioeconomic level and adherence to an animal food dietary pattern in Colombian school children. J Nutr 138, 13911398.
19. Allen, LH (2009) How common is vitamin B-12 deficiency? Am J Clin Nutr 89, 693S696S.
20. de Pee, S & Dary, O (2002) Biochemical indicators of vitamin A deficiency: serum retinol and serum retinol binding protein. J Nutr 132, 2895S2901S.
21. de Onis, M, Onyango, AW, Borghi, E, et al. (2007) Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 85, 660667.
22. Lin, DY & Wei, LJ (1989) The robust inference for the proportional hazards model. J Amer Statist Assoc 84, 10741078.
23. Schaefer, EJ (1997) Analysis of Incomplete Multivariable Data. New York: Chapman and Hill.
24. Li, SJ, Paik, HY & Joung, H (2006) Dietary patterns are associated with sexual maturation in Korean children. Br J Nutr 95, 817823.
25. Berkey, CS, Gardner, JD, Frazier, AL, et al. (2000) Relation of childhood diet and body size to menarche and adolescent growth in girls. Am J Epidemiol 152, 446452.
26. Gunther, AL, Karaolis-Danckert, N, Kroke, A, et al. (2010) Dietary protein intake throughout childhood is associated with the timing of puberty. J Nutr 140, 565571.
27. Wiley, AS (2011) Milk intake and total dairy consumption: associations with early menarche in NHANES 1999-2004. PLoS ONE 6, e14685.
28. Ramezani Tehrani, F, Mirmiran, P, Gholami, R, et al. (2014) Factors influencing menarcheal age: results from the cohort of Tehran lipid and glucose study. Int J Endocrinol Metab 12, e16130.
29. Trujillo, S & Valenzuela, C (1986) [Correlations between the age of menarche and hematological variables in girls of the northern area of Santiago]. Rev Chil Pediatr 57, 1821.
30. Instituto Colombiano de Bienestar Familiar (2006) Encuesta Nacional de la Situación Nutricional en Colombia, 2005. Bogota: ICBF.
31. Gao, Y, Li, Z, Gabrielsen, JS, et al. (2015) Adipocyte iron regulates leptin and food intake. J Clin Invest 125, 36813691.
32. Matkovic, V, Ilich, JZ, Skugor, M, et al. (1997) Leptin is inversely related to age at menarche in human females. J Clin Endocrinol Metab 82, 32393245.
33. Elias, CF (2012) Leptin action in pubertal development: recent advances and unanswered questions. Trends Endocrinol Metab 23, 915.
34. Margolis, HS, Hardison, HH, Bender, TR, et al. (1981) Iron deficiency in children: the relationship between pretreatment laboratory tests and subsequent hemoglobin response to iron therapy. Am J Clin Nutr 34, 21582168.
35. Arsenault, JE, Mora-Plazas, M, Forero, Y, et al. (2009) Hemoglobin concentration is inversely associated with erythrocyte folate concentrations in Colombian school-age children, especially among children with low vitamin B12 status. Eur J Clin Nutr 63, 842849.
36. Xie, LK & Yang, SH (2016) Brain globins in physiology and pathology. Med Gas Res 6, 154163.
37. Dassen, H, Kamps, R, Punyadeera, C, et al. (2008) Haemoglobin expression in human endometrium. Hum Reprod 23, 635641.
38. James-Todd, T, Tehranifar, P, Rich-Edwards, J, et al. (2010) The impact of socioeconomic status across early life on age at menarche among a racially diverse population of girls. Ann Epidemiol 20, 836842.
39. Jansen, EC, Herran, OF & Villamor, E (2015) Trends and correlates of age at menarche in Colombia: results from a nationally representative survey. Econ Hum Biol 19, 138144.
40. Morris, DH, Jones, ME, Schoemaker, MJ, et al. (2010) Determinants of age at menarche in the UK: analyses from the Breakthrough Generations Study. Br J Cancer 103, 17601764.
41. Villamor, E, Chavarro, JE & Caro, LE (2009) Growing up under generalized violence: an ecological study of homicide rates and secular trends in age at menarche in Colombia, 1940s–1980s. Econ Hum Biol 7, 238245.
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