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n-3 PUFA status in school children is associated with beneficial lipid profile, reduced physical activity and increased blood pressure in boys

  • Camilla T. Damsgaard (a1), Ken D. Stark (a2), Mads F. Hjorth (a1), Anja Biltoft-Jensen (a3), Arne Astrup (a1), Kim F. Michaelsen (a1) and Lotte Lauritzen (a1)...
Abstract

Dietary n-3 long-chain PUFA (LC-PUFA) improve dyslipidaemia and hypertension and may affect insulin resistance and adiposity. Increasing numbers of children show signs of the metabolic syndrome (MetS), but few studies have investigated the association with n-3 LC-PUFA status. We examined the relationship between fasting whole-blood EPA or DHA (w/w% of the total fatty acids, FA%) and markers of the MetS (anthropometry, blood pressure, plasma lipids and glucose homeostasis) cross-sectionally in seventy-three 8–11-year-old Danish children from the OPUS School Meal Pilot Study (OPUS is an acronym of the project ‘Optimal well-being, development and health for Danish children through a healthy New Nordic Diet’ and is supported by a grant from the Nordea Foundation). Also, we explored the potential mediating effects of physical activity and energy intake. Girls had higher body fat percentage (BF%), diastolic blood pressure, heart rate, plasma TAG, insulin, homeostasis model assessment-insulin resistance and glycosylated Hb than boys. Sexes did not differ in fish or macronutrient intake or whole-blood fatty acids. After adjustment for sex, age and total whole-blood fatty acid concentration, BF% and HDL:TAG increased with whole-blood EPA (β>0·25, P< 0·05), and HDL increased 0·35 (sem 0·13) mmol/l per FA% EPA increase (β = 0·30, P= 0·008). Unexpectedly, DHA was positively associated with mean arterial pressure in boys (6·3 (sem 1·7) mmHg/FA% DHA increase, β = 0·62, P= 0·001) and reduced physical activity in both sexes ( − 44 (sem 19) counts/min per FA%, β = − 0·22, P= 0·024). The associations with blood pressure and HDL remained after adjustment for physical activity, BF% and energy intake. The present study confirmed the beneficial association between n-3 LC-PUFA status and lipid profile seen in adults, but showed unexpected relationships with physical activity, BF% and blood pressure. This is the third time we have observed such tendencies in Danish children.

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Corresponding author
*Corresponding author: C. T. Damsgaard, fax +45 2034 8104, email ctd@life.ku.dk
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1D Mozaffarian & JH Wu (2011) Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 58, 20472067.

2P Zimmet , G Alberti , F Kaufman , et al. (2007) The metabolic syndrome in children and adolescents. Lancet 369, 20592061.

3JC Eisenmann (2008) On the use of a continuous metabolic syndrome score in pediatric research. Cardiovasc Diabetol 7, 17.

4JA Morrison , LA Friedman , P Wang , et al. (2008) Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later. J Pediatr 152, 201206.

5GE Duncan , SM Li & XH Zhou (2004) Prevalence and trends of a metabolic syndrome phenotype among U.S. adolescents, 1999–2000. Diabetes Care 27, 24382443.

7MH Pedersen , C Molgaard , LI Hellgren , et al. (2010) Effects of fish oil supplementation on markers of the metabolic syndrome. J Pediatr 157, 395400.

8F Campbell , HO Dickinson , JA Critchley , et al. (2013) A systematic review of fish-oil supplements for the prevention and treatment of hypertension. Eur J Prev Cardiol 20, 107120.

9L Lauritzen , LB Harslof , LI Hellgren , et al. (2011) Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys. Br J Nutr 107, 697704.

10M Asserhoj , S Nehammer , J Matthiessen , et al. (2009) Maternal fish oil supplementation during lactation may adversely affect long-term blood pressure, energy intake, and physical activity of 7-year-old boys. J Nutr 139, 298304.

11MY Wei & TA Jacobson (2011) Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. Curr Atheroscler Rep 13, 474483.

13SG Trost , PD Loprinzi , R Moore , et al. (2011) Comparison of accelerometer cut points for predicting activity intensity in youth. Med Sci Sports Exerc 43, 13601368.

14TJ Cole , MC Bellizzi , KM Flegal , et al. (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320, 12401243.

15JM Armstrong , AH Metherel & KD Stark (2008) Direct microwave transesterification of fingertip prick blood samples for fatty acid determinations. Lipids 43, 187196.

16AH Metherel , AY Taha , H Izadi , et al. (2009) The application of ultrasound energy to increase lipid extraction throughput of solid matrix samples (flaxseed). Prostaglandins Leukot Essent Fatty Acids 81, 417423.

18WS Cutfield , CA Jefferies , WE Jackson , et al. (2003) Evaluation of HOMA and QUICKI as measures of insulin sensitivity in prepubertal children. Pediatr Diabetes 4, 119125.

20MH Davidson (2006) Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids. Am J Cardiol 98, 27i33i.

21JS Forsyth , P Willatts , C Agostoni , et al. (2003) Long chain polyunsaturated fatty acid supplementation in infant formula and blood pressure in later childhood: follow up of a randomised controlled trial. BMJ 326, 953957.

22B Drew Rockett , M Harris & S Raza Shaikh (2012) High dose of an n-3 polyunsaturated fatty acid diet lowers activity of C57BL/6 mice. Prostaglandins Leukot Essent Fatty Acids 86, 137140.

23W Tu , GJ Eckert , LA DiMeglio , et al. (2011) Intensified effect of adiposity on blood pressure in overweight and obese children. Hypertension 58, 818824.

24SP Whelton , A Chin , X Xin , et al. (2002) Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann Intern Med 136, 493503.

25MS Treuth , NF Butte , AL Adolph , et al. (2004) A longitudinal study of fitness and activity in girls predisposed to obesity. Med Sci Sports Exerc 36, 198204.

26E Kodas , L Galineau , S Bodard , et al. (2004) Serotoninergic neurotransmission is affected by n-3 polyunsaturated fatty acids in the rat. J Neurochem 89, 695702.

27T Takeuchi , Y Fukumoto & E Harada (2002) Influence of a dietary n-3 fatty acid deficiency on the cerebral catecholamine contents, EEG and learning ability in rat. Behav Brain Res 131, 193203.

28T Hamazaki , S Sawazaki , M Itomura , et al. (1996) The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study. J Clin Invest 97, 11291133.

29L Buydens-Branchey & M Branchey (2006) n-3 Polyunsaturated fatty acids decrease anxiety feelings in a population of substance abusers. J Clin Psychopharmacol 26, 661665.

32AH Metherel , JM Armstrong , AC Patterson , et al. (2009) Assessment of blood measures of n-3 polyunsaturated fatty acids with acute fish oil supplementation and washout in men and women. Prostaglandins Leukot Essent Fatty Acids 81, 2329.

33D Mozaffarian & JH Wu (2012) (n-3) Fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary? J Nutr 142, 614S625S.

34GC Burdge , A Sala-Vila , AL West , et al. (2007) The effect of altering the 20 : 5n-3 and 22 : 6n-3 content of a meal on the postprandial incorporation of n-3 polyunsaturated fatty acids into plasma triacylglycerol and non-esterified fatty acids in humans. Prostaglandins Leukot Essent Fatty Acids 77, 5965.

35LB Andersen , M Harro , LB Sardinha , et al. (2006) Physical activity and clustered cardiovascular risk in children: a cross-sectional study (The European Youth Heart Study). Lancet 368, 299304.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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