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Omega-3 long-chain polyunsaturated fatty acids supplementation on inflammatory biomakers: a systematic review of randomised clinical trials

  • Oscar D. Rangel-Huerta (a1), Concepcion M. Aguilera (a1), Maria D. Mesa (a1) and Angel Gil (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114512001559
  • Published online: 17 May 2012
Abstract

Inflammation is part of the normal host response to infection and injury. Eicosanoids, cytokines, chemokines, adhesion molecules and other inflammatory molecules are frequently produced during this process. Numerous studies in humans have documented the inflammation-limiting properties of omega-3 fatty acids, but only a few have been randomised clinical trials. The aim of this study was to perform a systematic search of randomised clinical trials on omega-3 fatty acids and inflammatory biomarkers in all subjects including healthy and ill persons up to February 2011 using PubMed and LILACS databases, defined by a specific equation using MeSH terms and limited to randomised clinical trials; there was no any a priori decision to include some diseases and not others. The quality of each publication was validated by using the JADAD scale and the CONSORT checklist. Inflammatory biomarkers were considered as primary outcomes. Twenty-six publications of the last 10 years were selected. Studies included healthy subjects and patients with cardiovascular disease and other chronic and acute diseases; all reported the number of subjects, type of study, type and doses of omega-3 fatty acids, main outcomes and major inflammatory biomarkers. Dietary omega-3 fatty acids are associated with plasma biomarker levels, reflecting lower levels of inflammation and endothelial activation in cardiovascular disease and other chronic and acute diseases, including chronic renal disease, sepsis and acute pancreatitis. However, further research is required before definitive recommendations can be made about the routine use of omega-3 fatty acids in critically ill patients or with neurodegenerative or chronic renal disease.

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*Corresponding author: A. Gil, fax +34 958 248960, email agil@ugr.es
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1M Romano (2008) Inflammation resolution: does the bone marrow have a say? Am J Hematol 83, 435436.

2PC Calder (2006) Polyunsaturated fatty acids and inflammation. Prostaglandins Leukot Essent Fatty Acids 75, 197202.

4H Seki , Y Tani & M Arita (2009) Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1. Prostaglandins Other Lipid Mediat 89, 126130.

6R Medzhitov (2008) Origin and physiological roles of inflammation. Nature 454, 428435.

7P Singer , H Shapiro , M Theilla , (2008) Anti-inflammatory properties of omega-3 fatty acids in critical illness: novel mechanisms and an integrative perspective. Intensive Care Med 34, 15801592.

8A Gil , C María Aguilera , M Gil-Campos & R Cañete (2007) Altered signalling and gene expression associated with the immune system and the inflammatory response in obesity. Br J Nutr 98, Suppl. 1, S121S126.

9S Basu (2010) Bioactive eicosanoids: Role of prostaglandin F2α and F2-isoprostanes in inflammation and oxidative stress related pathology. Mols Cells 30, 383391.

10CN Serhan , S Yacoubian & R Yang (2008) Anti-inflammatory and pro-resolving lipid mediators. Annu Rev Pathol 3, 279.

14C Galli & PC Calder (2009) Effects of fat and fatty acid intake on inflammatory and immune responses: a critical review. Ann Nutr Metab 55, 123139.

15JM Schwab & CN Serhan (2006) Lipoxins and new lipid mediators in the resolution of inflammation. Curr Opin Pharmacol 6, 414420.

16R Jadad , R Moore , D Carroll , (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17, 112.

17KF Schulz , DG Altman & D Moher (2010) CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. J Pharmacol Pharmacother 1, 100107.

18GK Pot , IA Brouwer , A Enneman , (2009) No effect of fish oil supplementation on serum inflammatory markers and their interrelationships: a randomized controlled trial in healthy, middle-aged individuals. Eur J Clin Nutr 63, 13531359.

19M Bouwens , Rest O van de , N Dellschaft , (2009) Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. Am J Clin Nutr 90, 415424.

20HM Yusof , E Miles & P Calder (2008) Influence of very long-chain n-3 fatty acids on plasma markers of inflammation in middle-aged men. Prostaglandins Leukot Essent Fatty Acids 78, 219228.

21R Schubert , R Kitz , C Beermann , (2007) Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults. Nutrition 23, 724730.

22S Fujioka , K Hamazaki , M Itomura , (2006) The effects of eicosapentaenoic acid-fortified food on inflammatory markers in healthy subjects–A randomized, placebo-controlled, double-blind study. J Nutr Sci Vitaminol 52, 261265.

24F Thies , E Miles , G Nebe-von-Caron , (2001) Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults. Lipids 36, 11831193.

25DC Nieman , D Henson , SR McAnulty , (2009) N-3 Polyunsaturated Fatty Acids Do Not Alter Immune and Inflammation Measures in Endurance Athletes. Int J Sport Nutr Exerc Metab 19, 536546.

28YT Zhao , L Shao , LL Teng , (2009) Effects of n-3 polyunsaturated fatty acid therapy on plasma inflammatory markers and N-terminal pro-brain natriuretic peptide in elderly patients with chronic heart failure. J Int Med Res 37, 18311841.

29HMF Tulk & LE Robinson (2009) Modifying the n-6/n-3 polyunsaturated fatty acid ratio of a high-saturated fat challenge does not acutely attenuate postprandial changes in inflammatory markers in men with metabolic syndrome. Metabolism 58, 17091716.

30LM Browning , JD Krebs , CS Moore , (2007) The impact of long chain n-3 polyunsaturated fatty acid supplementation on inflammation, insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotype. Diabetes Obes Metab 9, 7080.

31MM Engler , MB Engler & MJ Malloy (2005) Effect of docosahexaenoic acid on lipoprotein subclasses in hyperlipidemic children (the EARLY study). Am J Cardiol 95, 869871.

32T Mori , RJ Woodman , V Burke , (2003) Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects. Free Radic Biol Med 35, 772781.

33AC Skulas-Ray , PM Kris-Etherton , WS Harris , (2011) Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr 93, 243.

34RG Bowden , RL Wilson , E Deike , (2011) Fish oil supplementation lowers C-reactive protein levels independent of triglyceride reduction in patients with end-stage renal disease. Nutr Clin Pract 24, 508512.

35GB Perunicic-Pekovic , ZR Rasic , SI Pljesa , (2007) Effect of n-3 fatty acids on nutritional status and inflammatory markers in haemodialysis patients. Nephrology 12, 331336.

36Y Freund-Levi , E Hjorth , C Lindberg , (2009) Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease: the OmegAD study. Dement Geriatr Cogn Disord 27, 481490.

38VM Barbosa , Ea Miles , C Calhau , (2010) Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial. Crit Care 14, R5.

39K Mayer , S Meyer , M Reinholz-Muhly , (2003). Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans. J Immunol 171, 4837.

42DC Nieman , DA Henson , SJ Gross , (2007) Quercetin reduces illness but not immune perturbations after intensive exercise. Med Sci Sports Exerc 39, 15611569.

43H Bruunsgaard , M Pedersen & BK Pedersen (2001) Aging and proinflammatory cytokines. Curr Opin Hematol 8, 131136.

45LA Smith , GM Paszkiewicz , AD Hutson , (2010) Inflammatory response of lung macrophages and epithelial cells to tobacco smoke: a literature review of ex vivo investigations. Immunol Res 46, 94126.

47A Saifullah , BA Watkins , C Saha , (2007) Oral fish oil supplementation raises blood omega-3 levels and lowers C-reactive protein in haemodialysis patients–a pilot study. Nephrol Dial Transplant. 22, 35613567.

48JM Martin & RD Stapleton (2010) Omega-3 fatty acids in critical illness. Nutr Rev 68, 531541.

49G Bannenberg & CN Serhan (2010) Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochim Biophys Acta 1801, 12601273.

51PM Kris-Etherton (2000) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106, 27472757.

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