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Chiaverini, Christine Roger, Coralie Fontas, Eric Bourrat, Emmanuelle Bourdon-Lanoy, Eva Labrèze, Christine Mazereeuw, Juliette Vabres, Pierre Bodemer, Christine and Lacour, Jean-Philippe 2016. Oral epigallocatechin-3-gallate for treatment of dystrophic epidermolysis bullosa: a multicentre, randomized, crossover, double-blind, placebo-controlled clinical trial. Orphanet Journal of Rare Diseases, Vol. 11, Issue. 1,
Clarke, Kayleigh A. Dew, Tristan P. Watson, Rachel E.B. Farrar, Mark D. Osman, Joanne E. Nicolaou, Anna Rhodes, Lesley E. and Williamson, Gary 2016. Green tea catechins and their metabolites in human skin before and after exposure to ultraviolet radiation. The Journal of Nutritional Biochemistry, Vol. 27, p. 203.
Lamuela-Raventos, Rosa M and St Onge, Marie-Pierre 2016. Prebiotic Nut Compounds and Human Microbiota. Critical Reviews in Food Science and Nutrition, p. 00.
Shapovalova, Olga E. Levy, David Avnir, David and Vinogradov, Vladimir V. 2016. Protection of enzymes from photodegradation by entrapment within alumina. Colloids and Surfaces B: Biointerfaces, Vol. 146, p. 731.
Li, Yanjie Lei, Jincan and Liang, Dawei 2015. Identification of Fake Green Tea by Sensory Assessment and Electronic Tongue. Food Science and Technology Research, Vol. 21, Issue. 2, p. 207.
Lucas, R. M. Norval, M. Neale, R. E. Young, A. R. de Gruijl, F. R. Takizawa, Y. and van der Leun, J. C. 2015. The consequences for human health of stratospheric ozone depletion in association with other environmental factors. Photochem. Photobiol. Sci., Vol. 14, Issue. 1, p. 53.
Molinett, Sebastian Nuñez, Francisca Moya-León, María Alejandra and Zúñiga-Hernández, Jessica 2015. Chilean Strawberry Consumption Protects against LPS-Induced Liver Injury by Anti-Inflammatory and Antioxidant Capability in Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine, Vol. 2015, p. 1.
Nowak, Piotr Jan Zasowska-Nowak, Anna Bialasiewicz, Piotr de Graft-Johnson, Jeffrey Nowak, Dariusz and Nowicki, Michal 2015. Inhibitory effect of plant phenolics on fMLP-induced intracellular calcium rise and chemiluminescence of human polymorphonuclear leukocytes and their chemotactic activityin vitro. Pharmaceutical Biology, Vol. 53, Issue. 11, p. 1661.
Setkowicz, M. Mastalerz, L. Gielicz, A. Wojas-Pelc, A. and Sanak, M. 2015. Lack of association ofALOX12andALOX15Bpolymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid. British Journal of Dermatology, Vol. 172, Issue. 2, p. 337.
Tuong, William Kuo, Sandy and Sivamani, Raja K. 2015. Photoprotective effect of botanicals and vitamins: A systematic review of clinical trials. Journal of Dermatological Treatment, Vol. 26, Issue. 6, p. 558.
Pilkington, Suzanne M. Gibbs, Neil K. Friedmann, Peter S. and Rhodes, Lesley E. 2014. Nutritional abrogation of photoimmunosuppression:in vivoinvestigations. Photodermatology, Photoimmunology & Photomedicine, Vol. 30, Issue. 2-3, p. 112.
Green tea catechins (GTC) reduce UV radiation (UVR)-induced inflammation in experimental models, but human studies are scarce and their cutaneous bioavailability and mechanism of photoprotection are unknown. We aimed to examine oral GTC cutaneous uptake, ability to protect human skin against erythema induced by a UVR dose range and impact on potent cyclo-oxygenase- and lipoxygenase-produced mediators of UVR inflammation, PGE2 and 12-hydroxyeicosatetraenoic acid (12-HETE), respectively. In an open oral intervention study, sixteen healthy human subjects (phototype I/II) were given low-dose GTC (540 mg) with vitamin C (50 mg) daily for 12 weeks. Pre- and post-supplementation, the buttock skin was exposed to UVR and the resultant erythema quantified. Skin blister fluid and biopsies were taken from the unexposed and the UVR-exposed skin 24 h after a pro-inflammatory UVR challenge (three minimal erythema doses). Urine, skin tissue and fluid were analysed for catechin content and skin fluid for PGE2 and 12-HETE by liquid chromatography coupled to tandem MS. A total of fourteen completing subjects were supplement compliant (twelve female, median 42·5 years, range 29–59 years). Benzoic acid levels were increased in skin fluid post-supplementation (P= 0·03), and methylated gallic acid and several intact catechins and hydroxyphenyl-valerolactones were detected in the skin tissue and fluid. AUC analysis for UVR erythema revealed reduced response post-GTC (P= 0·037). Pre-supplementation, PGE2 and 12-HETE were UVR induced (P= 0·003, 0·0001). After GTC, UVR-induced 12-HETE reduced from mean 64 (sd 42) to 41 (sd 32) pg/μl (P= 0·01), while PGE2 was unaltered. Thus, GTC intake results in the incorporation of catechin metabolites into human skin associated with abrogated UVR-induced 12-HETE; this may contribute to protection against sunburn inflammation and potentially longer-term UVR-mediated damage.
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