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Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer

Published online by Cambridge University Press:  09 March 2007

Pamela J. Magee*
Northern Ireland Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, UK
Ian R. Rowland
Northern Ireland Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, UK
*Corresponding author: Dr Pamela J. Magee, fax +44 28 70324965, email
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The incidence of hormone-dependent cancers, such as those of the breast and prostate, is much lower in Eastern countries such as China and Japan in comparison with the Western world. Diet is believed to have a major effect on disease risk and one group of compounds, the phyto-oestrogens, which are consumed in large amounts in Asian populations, have been implicated in cancer protection. This view follows the finding that plasma and urinary levels of phyto-oestrogens are much higher in areas where cancer incidence is low in comparison with areas of high cancer incidence. The phyto-oestrogens are comprised of two main groups; the isoflavones and lignans. Of the isoflavones, genistein and daidzein have been the most widely studied. These compounds have been shown to possess anticancer properties; however their precise mechanism of action remains to be elucidated. In comparison, few studies have investigated the effects of lignans in breast and prostate cancer. In vitro studies have shown that genistein exerts biphasic effects on cancer cell growth, stimulating growth at low concentrations (<10μM) and inhibiting growth at high concentrations (>10μM), which suggests that low phyto-oestrogen levels may stimulate cancer growth in vivo. Plasma phyto-oestrogen concentrations of >10μM cannot be achieved by dietary intake and therefore the timing of exposure to phyto-oestrogens may be of the utmost importance in determining their chemopreventive effects. The present paper reviews the effects of phyto-oestrogens on breast and prostate cancer in vivo and in vitro and discusses possible mechanisms of action via which these compounds may exert their effects.

Review article
Copyright © The Nutrition Society 2004


Aaltomaa, S, Lipponen, P, Eskelinen, M, Ala-Opas, M & Kosma, V (1999) Prognostic value and expression of p21 (waf1/cip1) protein in prostate cancer. Prostate 39, 815.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
Adlercreutz, H (2002) Phyto-oestrogens and cancer. Lancet Oncol 3, 364373.CrossRefGoogle ScholarPubMed
Adlercreutz, H, Bannwart, C, Wahala, K, Makela, T, Brunow, G, Hase, TAroseemena, P, Kellis, J & Vickery, L (1993) Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens. J Steroid Biochem Mol Biol 44, 147153.CrossRefGoogle ScholarPubMed
Adlercreutz, H, Fotsis, T, Bannwart, C, Wahala, K, Makela, T, Brunow, G & Hase, T (1986) Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. J Steroid Biochem 25, 791797.CrossRefGoogle ScholarPubMed
Adlercreutz, H, Fotsis, THeikkinen, R, Dwyer, J, Woods, M, Goldin, B & Gorbach, S (1982) Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian women and in women with breast cancer. Lancet ii, 12951299.CrossRefGoogle Scholar
Adlercreutz, H, Goldin, BGorbach, S et al. , (1995) Soybean phytoestrogen intake and cancer risk. J Nutr 125, 757S770S.Google ScholarPubMed
Adlercreutz, H, Hamalainen, E, Gorbach, S & Goldin, B (1992) Dietary phyto-oestrogens and the menopause in Japan. Lancet 339, 1233.CrossRefGoogle ScholarPubMed
Adlercreutz, H, Hockerstedt, K, Bannwart, C, Bloigu, S, Hamalainen, E, Fotsis, T & Ollus, A (1987) Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of oestrogens and on sex hormone binding globulin (SHBG). J Steroid Biochem 27, 11351144.CrossRefGoogle Scholar
Adlercreutz, H, Hockerstedt, K, Bannwart, C, Hamalainen, E, Fotsis, T & Bloigu, S (1988) Association between dietary fiber, urinary excretion of lignans and isoflavonic phytoestrogens, and plasma non-protein bound sex hormones in relation to breast cancer. In Hormones and Cancer 3, Proceedings Progress in Cancer Research and Therapy, (35), 409412 [Bresciani, F, King, R, Lippman, M, Raynaud, J-P, editors]. New York: Raven Press.Google Scholar
Adlercreutz, H, Honjo, H, Higashi, A, Fotsis, T, Hamalainen, E, Hasegawa, T & Okada, H, (1991) Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming traditional Japanese diet. Am J Clin Nutr 54, 10931100.CrossRefGoogle ScholarPubMed
Adlercreutz, H, Markkanen, H & Watanabe, S (1993 b) Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 342, 12091210.CrossRefGoogle ScholarPubMed
Adlercreutz, H & Mazur, W (1997) Phyto-oestrogens and Western diseases. Ann Med 29, 95120.CrossRefGoogle ScholarPubMed
Akiyama, T, Ishida, J, Nakagawa, S, Ogawara, H, Watanabe, S, Itoh, N, Shibuya, M & Fukami, Y (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262, 55925595.Google ScholarPubMed
Allen, N, Appleby, P, Davey, G & Key, T (2001) Soy milk intake in relation to serum sex hormone levels in British men. Nutr Cancer 41, 4146.CrossRefGoogle ScholarPubMed
Baird, D, Umbach, D, Lansdell, L, Hughes, C, Setchell, KDRWeinberg, C, Haney, A, Wilcox, A & McLachlan, J (1995) Dietary intervention study to assess oestrogenicity of dietary soy among postmenopausal women. J Clin Endocrinol Metabol 80, 16851690.Google Scholar
Balabhadrapathruni, S, Thomas, T, Yurkow, E, Amenta, P & Thomas, T (2000) Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells. Oncol Rep 7, 312.Google ScholarPubMed
Balduyck, M, Zerimech, F, Gouyer, V et al. , (2000) Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells in vitro. Clin Exp Metastasis 18, 171178.CrossRefGoogle ScholarPubMed
Barkhem, T, Carlsson, B, Nilsson, Y, Enmark, E, Gustafsson, J & Nilsson, S (1998) Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. Mol Pharmacol 54, 105112.CrossRefGoogle ScholarPubMed
Barnes, S (1997) The chemopreventive properties of soy isoflavonoids in animal models of breast cancer. Breast Cancer Res Treat 46, 169179.CrossRefGoogle ScholarPubMed
Barnes, S (1998) Phytoestrogens and breast cancer. Baillieres Clin Endocrinol Metabol 12, 559579.CrossRefGoogle ScholarPubMed
Barnes, S, Grubbs, C, Setchell, KDR & Carlson, J (1990) Soybeans inhibit mammary tumours in models of breast cancer. In Mutagens and Carcinogens in the Diet, pp.239253 [Pariza, M, Aeschbacher, H, Felton, J, Sato, S, editors]. New York: Wiley-Liss.Google Scholar
Beatty, E, O'Reilly, J, England, T, McAnlis, G, Young, I, Geissler, C, Sanders, T & Wiseman, H (2000) Effect of dietary quercetin on oxidative DNA damage in healthy human subjects. Br J Nutr 84, 919925.Google ScholarPubMed
Bennetts, HW, Underwood, EJ & Shier, FL (1946) A specific breeding problem of sheep on subterranean clover pastures in Western Australia. Aust J Agricult Res 22, 131138.Google ScholarPubMed
Bergan, R, Kyle, E, Nguyen, P, Trepel, J & Neckers, L (1996) Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-1 integrin. Clin Exp Metastasis 14, 389398.CrossRefGoogle ScholarPubMed
Bingham, SA, Atkinson, C, Liggins, J, Bluck, L & Coward, A (1998) Phyto-oestrogens: where are we now?. Br J Nutr 79, 393406.CrossRefGoogle ScholarPubMed
Bowey, E, Adlercreutz, H & Rowland, I (2003) Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. Food Chem Toxicol 41, 631636.CrossRefGoogle ScholarPubMed
Burg, B, Selm-Miltenburg, A, Laat, S & Zoelen, E (1989) Direct effects of estrogen on c-fos and c-myc protooncogene expression and cellular proliferation in human breast cancer cells. Mol Cell Endocrinol 64, 223228.CrossRefGoogle ScholarPubMed
Bylund, A, Zhang, J, Bergh, A, Damber, J, Widmark, A, Johansson, A, Adlercreutz, H, Aman, P, Shepherd, M & Hallmans, G (2000) Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice. Prostate 42, 304314.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Cappelletti, V, Fioravanti, L, Miodini, PDi Fronzo, G (2000) Genistein blocks breast cancer cells in the G(2)M phase of the cell cycle. J Cell Biochem 79, 594600.3.0.CO;2-4>CrossRefGoogle Scholar
Carroll, K (1975) Experimental evidence of dietary factors and hormone-dependent cancers. Cancer Res, 35, 33743383.Google ScholarPubMed
Cassidy, A, Bingham, S & Setchell, K (1994) Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am J Clin Nutr 60, 333340.CrossRefGoogle Scholar
Cassidy, A, Bingham, S & Setchell, K (1995) Biological effects of isoflavones in young women: importance of the chemical composition of soybean products. Br J Nutr 74, 587601.CrossRefGoogle Scholar
Chan, J, Stampfer, M, Giovannucci, E, Gann, P, Ma, J, Wilkinson, P, Hennekens, C & Pollak, M (1998) Plasma insulin-like growth factor-1 and prostate cancer risk: a prospective study. Science 279, 563566.CrossRefGoogle ScholarPubMed
Choi, Y, Zhang, L, Lee, W & Park, K (1998) Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells. Int J Oncol 13, 391396.Google ScholarPubMed
Clinton, S & Giovannucci, E (1998) Diet, nutrition and prostate cancer. Annu Rev Nutr 18, 413440.CrossRefGoogle ScholarPubMed
Cohen, J, Kristal, A & Stanford, J (2000) Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 92, 6168.CrossRefGoogle ScholarPubMed
Constantinou, A, Kamath, N & Murley, J (1998) Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells. Eur J Cancer 34, 19271934.CrossRefGoogle ScholarPubMed
Constantinou, A, Mehta, R & Vaughan, A (1996) Inhibition of N-methyl-N-nitrosourea-induced mammary tumours in rats by the soybean isoflavones. Anticancer Res 16, 32933298.Google ScholarPubMed
Dabrosin, C, Chen, J, Wang, L & Thompson, LU (2002) Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett 185, 3137.CrossRefGoogle ScholarPubMed
Davis, J, Kucuk, O & Sarkar, F (1999) Genistein inhibits NF-kappa B activation in prostate cancer cells. Nutr Cancer 35, 167174.CrossRefGoogle ScholarPubMed
Davis, J, Muqim, N, Bhuiyan, M, Kucuk, O, Pienta, K & Sarkar, F (2000) Inhibition of prostate specific antigen expression by genistein in prostate cancer cells. Int J Oncol 16, 10911097.Google ScholarPubMed
Davis, J, Singh, B, Bhuiyan, M & Sarkar, F (1998) Genistein-induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells. Nutr Cancer 32, 123131.CrossRefGoogle ScholarPubMed
Demark-Wahnefried, W, Price, D, Polascik, T, Robertson, C, Anderson, E, Paulson, D, Walther, P, Gannon, M & Vollmer, R (2001) Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology 58, 4752.CrossRefGoogle ScholarPubMed
Duffy, M, Maguire, T, Hill, A, McDermott, E & O'Higgins, N (2000) Metalloproteinases: role in breast carcinogenesis, invasion and metastasis. Breast Cancer Res 2, 252257.CrossRefGoogle ScholarPubMed
Evans, B, Griffiths, K & Morton, M (1995) Inhibition of 5alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. J Endocrinol 147, 295302.CrossRefGoogle Scholar
Ewings, P & Bowie, C (1996) A case-control study of cancer of the prostate in Somerset and east Devon. Br J Cancer 74, 661666.CrossRefGoogle ScholarPubMed
Ferguson, D & Anderson, T (1981) Morphological evaluation of cell turnover in relation to the menstrual cycle in the "resting" human breast. Br J Cancer 44, 177181.CrossRefGoogle ScholarPubMed
Ferlay, J, Bray, F, Pisani, P & Parkin, D (2001) GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide. Lyon, France: IARCPress.Google Scholar
Fioravanti, L, Cappelletti, V, Miodini, P, Ronchi, E, Brivio, M & Di Fronzo, G (1998) Genistein in the control of breast cancer cell growth: insights into the mechanism of action in vitro. Cancer Lett 130, 143152.CrossRefGoogle ScholarPubMed
Fotsis, T, Pepper, M, Adlercreutz, H, Hase, T, Montesano, R & Schweigerer, L (1995) Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J Nutr 125, 790S797S.Google ScholarPubMed
Fotsis, T, Pepper, M, Montesano, R, Aktas, E, Breit, S, Schweigerer, L, Rasku, S, Wahala, K & Adlercreutz, H, (1998) Phytoestrogens and inhibition of angiogenesis. Bailliere's Clin Endocrinol Metabol 12, 649666.CrossRefGoogle ScholarPubMed
Frey, R, Li, J & Singletary, K (2001) Effects of genistein on cell proliferation and cell cycle arrest in nonneoplastic human mammary epithelial cells: involvement of Cdc2, p21waf/cip1, p27kip1 and Cdc25C expression. Biochem Pharmacol 61, 979989.CrossRefGoogle Scholar
Fritz, W, Coward, L, Wang, J & Lamartiniere, C (1998) Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenesis 19, 21512158.CrossRefGoogle ScholarPubMed
Fritz, W, Wang, J, Eltoum, I & Lamartiniere, C (2002) Dietary genistein down-regulates androgen and estrogen receptor expression in the rat prostate. Mol Cell Endocrinol 186, 8999.CrossRefGoogle ScholarPubMed
Gallo, D, Giacomelli, SCantelmo, F et al. , (2001) Chemoprevention of DMBA-induced mammary cancer in rats by dietary soy. Breast Cancer Res Treat 69, 153164.CrossRefGoogle ScholarPubMed
Geller, J, Sionit, L, Partido, C, Li, L, Tan, X, Youngkin, T, Nachtsheim, D & Hoffman, R (1998) Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture. Prostate 34 7579.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Giovannucci, E, Ascherio, A, Rimm, EB, Stampfer, MJ, Colditz, GA & Willett, WC, (1995) Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 87, 17671776.CrossRefGoogle ScholarPubMed
Goldin, B, Adlercreutz, H, Gorbach, S, Woods, M, Dweyer, J, Conlon, T, Bohn, E & Gershoff, S (1986) The relationship between estrogen levels and diets of Caucasian American and Oriental immigrant women. Am J Clin Nutr 44, 945953.CrossRefGoogle ScholarPubMed
Gotoh, T, Yamada, K, Yin, H, Ito, A, Kataoka, T & Dohi, K (1998) Chemoprevention of N-nitroso-N-methylurea-induced rat mammary carcinogenesis by soy foods or biochanin A. Jpn J Cancer Res 89, 137142.CrossRefGoogle ScholarPubMed
Graham, S, Haughey, B, Marshall, J, Priore, R, Byers, T, Rzepka, T, Mettlin, C & Pontes, J (1983) Diet in the epidemiology of carcinoma of the prostate gland. J Nat Cancer Inst 70, 687692.Google ScholarPubMed
Griffiths, K, Davies, P, Eaton, C, Harper, M, Turkes, A & Peeling, W (1991) Endocrine factors in the initiation, diagnosis and treatment of prostatic cancer. In Endocrine Dependent Tumours, pp. 83130 [Voight, K, Knabbe, C, editors]. New York: Raven Press.Google Scholar
Habito, R, Montalto, J, Leslie, E & Ball, M (2000) Effects of replacing meat with soybean in the diet on sex hormone concentrations in healthy adult males. Br J Nutr 84, 557563.CrossRefGoogle ScholarPubMed
Haggans, C, Travelli, E, Thomas, W, Martini, M & Slavin, J (2000) The effect of flaxseed and wheat bran consumption on urinary estrogen metabolites in premenopausal women. Cancer Epidemiol Biomarkers Prev 9, 719725.Google ScholarPubMed
Hakkak, R, Korourjan, S, Shelnutt, S, Lensing, S, Ronis, M & Badger, T (2000) Diets containing whey proteins or soy protein isolate protect against 7, 12-dimethylbenz[a]anthracene-induced mammary tumours in female rats.Cancer Epidemiol Biomarkers Prev 9, 113117.Google ScholarPubMed
Hargreaves, D, Potten, C, Harding, C, Shaw, L, Morton, M, Roberts, S, Howell, A & Bundred, N (1999) Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast. J Clin Endocrinol Metabol 84, 40174024.Google ScholarPubMed
Hayashi, A, Popovich, K, Kim, H & de Juan, E (1997) Role of protein tyrosine phosphorylation in rat corneal neovascularization. Graefes Arch Clin Exp Opthalmol 235, 460467.CrossRefGoogle ScholarPubMed
Hempstock, J, Kavanagh, J & George, N (1998) Growth inhibition of prostate cell lines in vitro by phyto-oestrogens. Br J Urol 82, 560563.CrossRefGoogle ScholarPubMed
Honma, Y, Okabe-Kado, J, Kasaukabe, T, Hozumi, M & Umezawa, K (1990) Inhibition of abl oncogene tyrosine kinase induces erythroid differentiation of human myelogenous leukemia K-562 cells. Jpn J Cancer Res 81, 11321136.CrossRefGoogle Scholar
Horn-Ross, P, John, E, Lee, M, Stewart, S, Koo, J, Sakoda, L, Shiau, A, Goldstein, J, Davis, P & Perez-Stable, E (2001) Phytoestrogen consumption and breast cancer risk in a multiethnic population: the Bay Area Breast Cancer Study. Am J Epidemiol 154, 434441.CrossRefGoogle Scholar
Hsieh, C, Santell, R, Haslam, S & Helferich, W (1998) Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res 58, 38333838.Google ScholarPubMed
Hsueh, A & Park, H (1990) Quality of dietary protein and chemical carcinogenesis in rats. Int News Fats Oils Related Materials 1, 303, Abstr.Google Scholar
Hu, Y, Dragowska, W, Wallis, A, Duronio, V & Mayer, L (2001) Cytotoxicity induced by manipulation of signal transduction pathways is associated with down-regulation of Bcl-2 but not Mcl-1 in MCF-7 human breast cancer. Breast Cancer Res Treat 70, 1120.CrossRefGoogle Scholar
Hulka, B & Moorman, P (2001) Breast cancer: hormones and other risk factors Maturitas 38, 103116.CrossRefGoogle ScholarPubMed
Hussain, M, Sarkar, F & Djuric, Z (2002) Soy isoflavones in the treatment of prostate cancer. J Nutr 132, 575S576S.Google Scholar
Jacobsen, B, Knutsen, S & Fraser, G (1998) Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States). Cancer Causes Control 9, 553557.CrossRefGoogle Scholar
Jones, JL, Daley, BJ, Enderson, BL, Zhou, JR & Karlstad, MD (2002) Genistein inhibits tamoxifen effects on cell proliferation and cell cycle arrest in T47D breast cancer cells. Am Surg 68, 575577.Google ScholarPubMed
Kato, K, Takahashi, S, Cui, L, Toda, T, Suzuki, S, Futakuchi, M, Sugiura, S & Shirai, T (2000) Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis. Jpn J Cancer Res 91, 786791.CrossRefGoogle ScholarPubMed
Key, T, Chen, J, Pike, M & Boreham, J (1990) Sex hormones in women in rural China and Britain. Br J Cancer 62, 631636.CrossRefGoogle ScholarPubMed
Key, T, Silcocks, P, Davey, G, Appleby, P & Bishop, D (1997) A case-control study of diet and prostate cancer. Br J Cancer 76, 678687.CrossRefGoogle ScholarPubMed
Kim, H, Peterson, T & Barnes, S (1998) Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways. Am J Clin Nutr 68, 1418S1425S.CrossRefGoogle ScholarPubMed
Kirk, C, Harris, R, Wood, D, Waring, R & Hughes, P (2001) Do dietary phytoestrogens influence susceptibility to hormone-dependent cancer by disrupting the metabolism of endogenous oestrogens?. Biochem Soc Trans 29, 209216.CrossRefGoogle Scholar
Kobayashi, T, Nakata, T & Kuzumaki, T (2002) Effect of flavonoids on cell cycle progression in prostate cancer cells, Cancer Lett 176, 1723.CrossRefGoogle ScholarPubMed
Kolonel, L, Nomura, A & Cooney, R (1999) Dietary fat and prostate cancer: current review. J Natl Cancer Inst 91, 414428.CrossRefGoogle Scholar
Kruse, F, Joussen, A, Fotsis, T, Schweigerer, L, Rohrschneider, K & Volcker, H (1997) Inhibition of neovascularization of the eye by dietary factors exemplified by isoflavonoids. Opthalmologe 94, 152156.CrossRefGoogle ScholarPubMed
Kuiper, G, Carlsson, B, Grandien, K, Enmark, E, Haggblad, J, Nilsson, S & Gustafsson, J (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138, 863870.CrossRefGoogle ScholarPubMed
Kuiper, G, Lemmen, J, Carlsson, B, Corton, J, Safe, S, van der Saag, P, van der Burg, B & Gustafsson, J, (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139, 42524263.CrossRefGoogle ScholarPubMed
Kumar, N, Cantor, A, Allen, K, Riccardi, D & Cox, C (2002) The specific role of isoflavones on estrogen metabolism in premenopausal women. Cancer 94 11661174.CrossRefGoogle ScholarPubMed
Kyle, E, Neckers, L, Takimoto, C, Curt, G & Bergan, R (1997) Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Mol Pharmacol 51, 193200.CrossRefGoogle ScholarPubMed
Lamartiniere, CA (2000) Protection against breast cancer with genistein: a component of soy. Am J Clin Nutr 71 Suppl.l1705S1707S.CrossRefGoogle ScholarPubMed
Lamartiniere, CA, Cotroneo, MS, Fritz, WA, Wang, J, Mentor-Marcel, R & Elgavish, A (2002) Genistein chemoprevention: timing and mechanisms of action in murine mammary and prostate. J Nutr 132, 552S558S.CrossRefGoogle ScholarPubMed
Lamartiniere, CA, Moore, JB, Brown, NM, Thompson, R, Hardin, MJ & Barnes, S (1995) Genistein suppresses mammary cancer in rats. Carcinogenesis 16, 28332840.CrossRefGoogle ScholarPubMed
Lamartiniere, CA, Murrill, WB, Manzolillo, PA, Zhang, JX, Barnes, S, Zhang, X, Wei, H & Brown, NM (1998) Genistein alters the ontogeny of mammary gland development and protects against chemically-induced mammary cancer in rats. Proc Soc Exp Biol Med 217, 358364.CrossRefGoogle ScholarPubMed
Lamartiniere, CA, Wang, J, Smith-Johnson, M & Eltoum, IE (2002) Daidzein: bioavailability, potential for reproductive toxicity, and breast cancer chemoprevention in female rats. Toxicol Sci 65, 228238.CrossRefGoogle ScholarPubMed
Lampe, JW, Karr, SC, Hutchins, AM & Slavin, JL (1998) Urinary equol excretion with a soy challenge: influence of habitual diet. Proc Soc Exp Biol Med 217, 335339.CrossRefGoogle ScholarPubMed
Landstrom, M, Zhang, J, Hallmans, G, Aman, P, Bergh, A, Damber, J, Mazur, W, Wahala, K & Adlercreutz, H (1998) Inhibitory effects of soy and rye diets on the development of Dunning R3327 prostate adenocarcinoma in rats. Prostate 36, 151161.3.0.CO;2-K>CrossRefGoogle ScholarPubMed
Le Bail, J, Champavier, Y, Chulia, A & Habrioux, G (2000) Effects of phytoestrogens on aromatase 3b and 17b-hydroxysteroid dehydrogenase activities and human breast cancer cells. Life Sci 66, 12811291.CrossRefGoogle Scholar
Lee, H, Gourley, L, Duffy, S, Esteve, J, Lee, J & Day, N (1991) Dietary effects on breast-cancer risk in Singapore. Lancet 337, 11971200.CrossRefGoogle ScholarPubMed
Lee, M, Wang, R, Hsing, A, Gu, F, Wang, T & Spitz, M (1998) Case-control study of diet and prostate cancer. Cancer Causes Control 9, 545552.CrossRefGoogle ScholarPubMed
Leung, L & Wang, T (2000) Bcl-2 is not reduced in the death of MCF-7 cells at low genistein concentration. J Nutr 130, 29222926.CrossRefGoogle Scholar
Li, Y & Sarkar, FH (2002) Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein. Cancer Lett 186, 157164.CrossRefGoogle ScholarPubMed
Li, Y, Upadhyay, S, Bhuiyan, M & Sarker, F (1999) Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein. Oncogene 18, 31663172.CrossRefGoogle ScholarPubMed
Lin, X, Switzer, BDemark-Wahnefried, W (2001) Effect of mammalian lignans on the growth of prostate cancer cell lines Anticancer Res 21, 39954000.Google ScholarPubMed
Lu, L, Anderson, K, Grady, J, Kohen, F & Nagamani, M (2000) Decreased ovarian hormones during a soya diet: implications for breast cancer prevention Cancer Res 60, 41124121.Google ScholarPubMed
McMichael-Phillips, D, Harding, C, Morton, M, Roberts, S, Howell, A, Potten, C, Bundred, N, (1998) Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast. Am J Clin Nutr 68, 1431S1435S.CrossRefGoogle ScholarPubMed
Maggiolini, M, Bonofiglio, D, Marsico, S, Panno, ML, Cenni, BPicard, D & Ando, S (2001) Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol Pharmacol 60, 595602.Google Scholar
Maggiolini, M, Vivacqua, A, Carpino, A, Bonofiglio, D, Fasanella, G, Salerno, M, Picard, D & Ando, S (2002) The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate cancer cells. Mol Pharmacol 62, 10271035.CrossRefGoogle Scholar
Makela, S, Poutanen, M, Lehtimaki, J, Kostian, M, Santti, R & Vihko, R (1995) Estrogen-specific 17beta-hydroxysteroid oxidoreductase type 1 (E.C as a possible target for the action of phytoestrogens. Proc Soc Exp Biol Med 208, 5159.CrossRefGoogle Scholar
Markovits, J, Linassier, C, Fosse, P, Couprie, J, Pierre, J, Jacquemin-Sablon, A, Saucier, J, Le Pecq, J & Larsen, A (1989) Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II Cancer Res 49, 51115117.Google ScholarPubMed
Maskarinec, G, Williams, A. Inouye, J, Stanczyk, F & Franke, A (2002) A randomized isoflavone intervention among premenopausal women. Cancer Epidemiol Biomarkers Prev 11, 195201.Google ScholarPubMed
Mentor-Marcel, R, Lamartiniere, C, Eltoum, I-E, Greenberg, N & Elgavish, A (2001) Genistein in the diet reduces the incidence of poorly differentiated prostatic adenocarcinoma in transgenic mice (TRAMP). Cancer Res 61, 67776782.Google Scholar
Messina, MJ (2003) Emerging evidence on the role of soy in reducing prostate cancer risk. Nutr Rev 61, 117131.CrossRefGoogle ScholarPubMed
Miksicek, RJ (1995) Estrogenic flavonoids: structural requirements for biological activity. Proc Soc Exp Biol Med 208, 4450.CrossRefGoogle ScholarPubMed
Mills, P, Beeson, W, Phillips, R & Fraser, G (1989) Cohort study of diet, lifestyle and prostate cancer in Adventist men. Cancer 64, 598604.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
Miodini, P, Fioravanti, L, Di Fronzo, G & Cappelletti, V (1999) The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function. Br J Cancer 80, 11501155.CrossRefGoogle ScholarPubMed
Mitchell, J, Cawood, E, Kinniburgh, D, Provan, A, Collins, A & Irvine, D (2001) Effect of a phytoestrogen food supplement on reproductive health in normal males. Clin Sci 100, 613618.CrossRefGoogle ScholarPubMed
Mitchell, J, Duthie, S & Collins, A, (2000) Effects of phytoestrogens on growth and DNA integrity in human prostate tumour cell lines: PC-3 and LNCaP. Nutr Cancer 38, 223228.CrossRefGoogle ScholarPubMed
Monti, E & Sinha, B (1994) Antiproliferative effect of genistein and adriamycin against estrogen-dependent and -independent human breast carcinoma cell lines. Anticancer Res 14, 12211226.Google ScholarPubMed
Morton, MS, Chan, PS, Cheng, C, Blacklock, N, Matos-Ferreira, A, branches-Monteiro, L, Correia, R, Lloyd, S & Griffiths, K (1997) Lignans and isoflavonoids in plasma and prostatic fluid in men: samples from Portugal Hong Kong and the United Kingdom. Prostate 32, 122128.3.0.CO;2-O>CrossRefGoogle ScholarPubMed
Morton, MS, Wilcox, G, Wahlqvist, ML & Griffiths, K (1994) Determination of lignans and isoflavonoids in human female plasma following dietary supplementation. J Endocrinol 142, 251259.CrossRefGoogle ScholarPubMed
Mousavi, Y & Adlercreutz, H (1992) Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. J Steroid Biochem Mol Biol 41, 615619.CrossRefGoogle ScholarPubMed
Mueller, S, Yeh, Y & Chen, W, (1992) Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells. J Cell Biol 119, 13091325.CrossRefGoogle ScholarPubMed
Murkies, A, Dalais, F, Briganti, E, Burger, H, Healy, D, Wahlqvist, M & Davis, S (2000) Phytoestrogens and breast cancer in postmenopausal women: a case control study. Menopause 7, 289296.CrossRefGoogle ScholarPubMed
Murrill, W, Brown, N, Zhang, J, Manzolillo, P, Barnes, S & Lamartiniere, C (1996) Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. Carcinogenesis 17, 14511457.CrossRefGoogle ScholarPubMed
Nagata, C, Inaba, S, Kawakami, N, Kakizoe, T & Shimizu, H (2000) Inverse association of soy product intake with serum androgen and estrogen concentrations in Japanese men. Nutr Cancer 36, 1418.CrossRefGoogle ScholarPubMed
Nagata, C, Takatsuka, N, Shimizu, H, Hayashi, H, Akamatsu, T & Murase, K (2001) Effect of soymilk consumption on serum estrogen and androgen concentrations in Japanese men. Cancer Epidemiol Biomarkers Prev 10, 179184.Google ScholarPubMed
Naik, H, Lehr, J & Pienta, K (1994) An in vitro and in vivo study of antitumour effects of genistein on hormone refractory prostate cancer. Anticancer Res 14, 26172619.Google Scholar
Nakao-Hayashi, J, Ito, H, Kanayasu, T, Morita, I & Murota, S (1992) Stimulatory effects of insulin and insulin-like growth factor 1 on migration and tube formation by vascular cells. Atherosclerosis 92, 141149.CrossRefGoogle Scholar
Nomoto, S, Arao, Y, Horiguchi, H, Ikeda, K & Kayama, F (2002) Oestrogen causes G2/M arrest and apoptosis in breast cancer cells MDA-MB-231. Oncol Rep 9, 773776.Google ScholarPubMed
Ohta, T, Nakatsugi, S, Watanabe, K, Kawamori, T, Ishikawa, F, Morotomi, M, Sugie, S, Toda, T, Sugimura, T & Wakabayashi, K (2000) Inhibitory effects of bifidobacterium-fermented soy milk on 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine-induced rat mammary carcinogenesis, with a partial contribution of its component isoflavones. Carcinogenesis 21, 937941.CrossRefGoogle ScholarPubMed
Onozawa, M, Kawamori, T, Baba, M, Fukuda, K, Toda, T, Sato, H, Ohtani, M, Akaza, H, Sugimura, T & Wakabayashi, K (1999) Effects of a soybean isoflavone mixture on carcinogenesis in prostate and seminal vesicles of F344 rats. Jpn J Cancer Res, 90, 393398.CrossRefGoogle ScholarPubMed
Pagliacci, M, Smacchia, M, Migliorati, G, Grignani, F, Riccardi, C & Nicoletti, I (1994) Growth-inhibitory effects of the natural phyto-oestrogen genistein in MCF-7 human breast cancer cells. Eur J Cancer 30A, 16751682.CrossRefGoogle ScholarPubMed
Peterson, G & Barnes, S (1991) Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene. Biochem Biophys Res Commun 179, 661667.CrossRefGoogle ScholarPubMed
Peterson, G & Barnes, S (1993) Genistein and bichanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate 22, 335345.CrossRefGoogle Scholar
Petrakis, N, Barnes, S, King, E, Lowenstein, J, Wiencke, J, Lee, M, Miike, R, Krik, M & Coward, L (1996) Stimulatory influence of soy protein isolate on breast secretion in pre and post menopausal women. Cancer Epidemiol Biomarkers Prev 5, 785794.Google Scholar
Phipps, W, Martini, M, Lampe, JW, Slavin, JL & Kurzer, M (1993) Effects of flaxseed ingestion on the menstrual cycle. J Clin Endocrinol Metabol 77, 12151219.Google Scholar
Pietinen, P, Stumpf, K, Mannisto, S, Kataja, V, Uusitupa, M & Adlercreutz, H (2001) Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland. Cancer Epidemiol Biomarkers Prev 10, 339344.Google ScholarPubMed
Polascik, T, Oesterling, J & Partin, A (1999) Prostate specific antigen: a decade of discovery - what we have learned and where we are going. J Urol 162, 293306.CrossRefGoogle ScholarPubMed
Polkowski, K & Mazurek, AP(2000) Biological properties of genistein. A review of in vitro and in vivo data. Acta Pol Pharm 57, 135155.Google ScholarPubMed
Pollard, M & Wolter, W (2000) Prevention of spontaneous prostate-related cancer in Lobund-Wistar rats by a soy protein isolate/isoflavone diet. Prostate 45, 101105.3.0.CO;2-P>CrossRefGoogle ScholarPubMed
Price, KR & Fenwick, GR (1985) Naturally occurring oestrogens in foods – a review. Food Add Contam 2, 73106.CrossRefGoogle ScholarPubMed
Prud'homme, J, Jolivet, A, Pichon, M, Savouret, J & Milgrom, E (1990) Monoclonal antibodies against native and denatured forms of estrogen-induced breast cancer protein (BCEI/p52) obtained by expression in Escherichia coli. Cancer Res 50, 23902396.Google Scholar
Reinli, K & Block, G (1996) Phytoestrogen content of foods – a compendium of literature values. Nutr Cancer 26, 123148.CrossRefGoogle Scholar
Rice, L, Samedi, V, Medrano, T, Sweeney, C, Baker, H, Stenstrom, A, Furman, J & Shiverick, K (2002) Mechanisms of the growth inhibitory effects of the isoflavonoid biochanin A on LNCaP cells and xenografts. Prostate 52, 201212.CrossRefGoogle ScholarPubMed
Rochefort, H (1998) Estrogens, cathepsin D and metastasis in breast and ovarian cancer: invasion or proliferation? (in French). C R Seances Soc Biol Fil 192, 241251.Google Scholar
Rokhlin, O & Cohen, M (1995) Differential sensitivity of human prostatic cancer cell lines to the effects of protein kinase and phosphate inhibitors. Cancer Lett 98, 103110.CrossRefGoogle Scholar
Rosenberg Zand, RS, Jenkins, DJ, Brown, TJ & Diamandis, EP (2002) Flavonoids can block PSA production by breast and prostate cancer cell lines. Clin Chim Acta 317, 1726.CrossRefGoogle ScholarPubMed
Rowland, I, Faughan, M, Hoey, L, Wahala, K, Williamson, G & Cassidy, A (2003) Bioavailability of phyto-oestrogens. BrJ Nutr 89, S45S58.Google ScholarPubMed
Rowland, I, Wiseman, H, Sanders, T, Adlercreutz, H & Bowey, E (1999) Metabolism of oestrogens and phytoestrogens: role of the gut microflora. Biochem Soc Trans 27, 304308.CrossRefGoogle ScholarPubMed
Rowland, I, Wiseman, H, Sanders, TABAdlercreutz, H & Bowey, EA (2000) Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr Cancer 36 2732.CrossRefGoogle ScholarPubMed
Santibanez, J, Navarro, A & Martinez, J (1997) Genistein inhibits proliferation and in vitro invasive potential of human prostatic cancer cell lines. Anticancer Res 17, 11991204.Google ScholarPubMed
Sathyamoorthy, N & Wang, T (1997) Differential effects of dietary phyto-oestrogens daidzein and equol on human breast cancer MCF-7 cells. Eur J Cancer 33, 23842389.CrossRefGoogle ScholarPubMed
Sathyamoorthy, N, Wang, T & Phang, J (1994) Stimulation of pS2 expression by diet-derived compounds. Cancer Res 54, 957961.Google ScholarPubMed
Schmitt, E, Dekant, W & Stopper, H (2001) Assaying the estrogenicity of phytoestrogens in cells of different estrogen sensitive tissues. Toxicol In Vitro 15, 433439.CrossRefGoogle ScholarPubMed
Scholar, E & Toews, M (1994) Inhibition of invasion of murine mammary carcinoma cells by the tyrosine kinase inhibitor genistein. Cancer Lett 87, 159162.CrossRefGoogle ScholarPubMed
Schuurmans, A, Bolt, J, Veldscholte, J & Mulder, E (1990) Stimulatory effects of antiandrogens on LNCaP human prostate tumor cell growth, EGF-receptor level and acid phosphatase secretion. J Steroid Biochem Mol Biol 37, 849853.CrossRefGoogle ScholarPubMed
Serraino, M & Thompson, LU (1992) The effect of flaxseed supplementation on the initiation and promotional stages of mammary tumorigenesis. Nutr Cancer 17, 153159.CrossRefGoogle ScholarPubMed
Setchell, KD, Gosselin, SJ, Welsh, MB, Johnston, JO, Balistreri, WF, Kramer, LW, Dresser, BL & Tarr, MJ (1987) Dietary estrogens – a probable cause of infertility and liver disease in captive cheetahs. Gastroenterology 93, 225233.CrossRefGoogle ScholarPubMed
Setchell, KD, Zimmer-Nechemias, L, Cai, J & Heubi, JE 1997) Exposure of infants to phyto-oestrogens from soy-based infant formula. Lancet 350, 2327.CrossRefGoogle ScholarPubMed
Setchell, KDR (2001) Soy isoflavones - benefits and risks from nature's selective estrogen receptor modulators (SERMs). J Am Coll Nutr 20, 354S362S.CrossRefGoogle Scholar
Setchell, KDR & Adlercreutz, H (1988) Mammalian lignans and phyto-oestrogens. Recent studies on their formation, metabolism and biological role in health and disease.In Role of the Gut Flora in Toxicity and Cancer 315345 [Rowland, IR, editor] London: Academic Press.CrossRefGoogle Scholar
Severson, R, Nomura, A, Grove, J & Stemmermann, G (1989) A prospective study of demographics, diet and prostate cancer among men of Japanese ancestry in Hawaii. Cancer Res 49, 18571860.Google ScholarPubMed
Shao, Z, Alpaugh, M, Fontana, J & Barsky, S (1998) Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by P21WAF1/CIP1 induction, G2/M arrest, and apoptosis. J Cell Biochem 69, 4454.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Shao, Z, Wu, J, Shen, Z & Barsky, S (1998) Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res 58, 48514857.Google ScholarPubMed
Shao, Z, Wu, J, Shen, Z & Barsky, S (1998) Genistein inhibits both constitutive and EGF-stimulated invasion in ER-negative human breast carcinoma cell lines. Anticancer Res 18, 14351440.Google ScholarPubMed
Sharma, O, Adlercreutz, H, Strandberg, J, Zirkin, B, Coffey, D & Ewing, L (1992) Soy of dietary source plays a preventive role against the pathogenesis of prostatitis in rats. J Steroid Biochem Mol Biol 43, 557564.CrossRefGoogle Scholar
Shen, J, Klein, R, Wei, Q, Guan, Y, Contois, J, Wang, T, Chang, S & Hursting, S (2000) Low-dose genistein induces cyclin-dependent kinase inhibitors and G1 cell-cycle arrest in human prostate cancer cells. Mol Carcinog 29, 92102.3.0.CO;2-Q>CrossRefGoogle ScholarPubMed
Shutt, DA (1976) The effects of plant oestrogens on animal reproduction. Endeavour 35, 110113.CrossRefGoogle ScholarPubMed
Sierens, J, Hartley, JA, Campbell, MJ, Leathem, AJ & Woodside, JV (2001) Effect of phytoestrogen and antioxidant supplementation on oxidative DNA damage assessed using the comet assay. Mutat Res 485, 169176.CrossRefGoogle ScholarPubMed
Signorello, LB, Brismar, K, Bergstrom, R, Andersson, SO, Wolk, A, Trichopoulos, D & Adami, HO (1999) Insulin-like growth factor-binding protein-1 and prostate cancer. J Natl Cancer Inst 91, 19651967.CrossRefGoogle ScholarPubMed
Stanford, JL, Just, JJ, Gibbs, M, Wicklund, KG, Neal, CL, Blumenstein, BA & Ostrander, EA (1997) Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk Cancer Res 57, 11941198.Google ScholarPubMed
Stattin, P, Adlercreutz, H & Tenkanen, L (2002) Circulating enterolactone and prostate cancer risk: a Nordic nested case-control study. Int J Cancer 99, 124129.CrossRefGoogle ScholarPubMed
Stephens, F (1997) Phytoestrogens and prostate cancer: possible preventive role. Med J Aust 167, 138140.Google ScholarPubMed
Strom, S, Yamamura, Y, Duphorne, C, Spitz, M, Babaian, R, Pillow, P & Hursting, S (1999) Phytoestrogen intake and prostate cancer: a case-control study using a new database. Nutr Cancer 33, 2025.CrossRefGoogle ScholarPubMed
Sun, X, Plouzek, C, Henry, J, Wang, T & Phang, J (1998) Increased UDP-glucuronosyltransferase activity and decreased prostate specific antigen production by biochanin A in prostate cancer cells. Cancer Res 58, 23792384.Google ScholarPubMed
Suzuki, K, Koike, H & Matsui, H (2002) Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC-3. Int J Cancer 99, 846852.CrossRefGoogle ScholarPubMed
Tham, D, Gardner, C & Haskell, W (1998) Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological and mechanistic evidence. J Clin Endocrinol Metabol 83, 22232235.Google ScholarPubMed
Thompson, LU, Robb, P, Serraino, M & Cheung, F (1991) Mammalian lignan production from various foods. Nutr Cancer 16, 4352.CrossRefGoogle ScholarPubMed
Thompson, LU & Serraino, M (1990) Lignans in flaxseed and breast and colon carcinogenesis Proc Flax Inst USA 3035.Google Scholar
Treolar, A, Boynton, R, Behn, B & Brown, B (1970) Variation of the human menstrual cycle throughout reproductive life. Int J Fertility 12, 77126.Google Scholar
Urban, D, Irwin, W, Kirk, M, Markiewicz, M, Myers, R, Smith, M, Weiss, H, Grizzle, W & Barnes, S (2001) The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen. J Urol 165, 294300.CrossRefGoogle ScholarPubMed
Wang, C & Kurzer, M (1997) Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells. Nutr Cancer 28, 236247.CrossRefGoogle ScholarPubMed
Wang, C, Makela, T, Hase, T, Adlercreutz, H & Kurzer, M (1994) Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes. J Steroid Biochem Mol Biol 50, 205212.CrossRefGoogle ScholarPubMed
Wang, T, Sathyamoorthy, N & Phang, J (1996) Molecular effects of genistein on estrogen receptor mediated pathways. Carcinogenesis 17, 271275.CrossRefGoogle ScholarPubMed
Weber, K, Setchell, K, Stocco, D & Lephart, E (2001) Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats. J Endocrinol 170, 591599.CrossRefGoogle ScholarPubMed
Wei, H, Frenkel, K, Bowen, R & Barnes, S (1993) Inhibition of tumour-promoter induced hydrogen peroxide formation by genistein in vitro and in vivo. Nutr Cancer 20, 112.CrossRefGoogle ScholarPubMed
Welshons, WV, Murphy, CS, Koch, R, Calaf, G & Jordan, VC (1987) Stimulation of breast cancer cells in vitro by the environmental estrogen enterolactone and the phytoestrogen equol. Breast Cancer Res Treat 10, 169175.CrossRefGoogle ScholarPubMed
Wiseman, H, O'Reilly, J, Adlercreutz, H, Mallet, A, Bowey, E, Rowland, I & Sanders, T (2000) Isoflavone phytoestrogens consumed in soy decrease F2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. Am J Clin Nutr 72, 395400.CrossRefGoogle ScholarPubMed
Wolk, A, Mantzoros, C, Andersson, S, Bergstrom, R, Signorello, L, Lagiou, P, Adami, H & Trichopoulos, D (1998) Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study. J Natl Cancer Inst 90, 911915.CrossRefGoogle ScholarPubMed
Wu, A, Ziegler, R, Horn-Ross, P, Nomura, A, West, D, Kolonel, LRosenthal, J & Hoover, RPike, M (1996) Tofu and risk of breast cancer in Asian-Americans. Cancer Epidemiol Biomarkers Prev 5, 901906.Google ScholarPubMed
Xu, X, Harris, K, Wang, H, Murphy, P & Hendrich, S (1995) Bioavailability of soybean isoflavones depends on gut microflora in women. J Nutr 125, 23072315.CrossRefGoogle ScholarPubMed
Xu, X, Wang, H, Murphy, P, Cook, L & Hendrich, S (1994) Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J Nutr 124, 825832.CrossRefGoogle ScholarPubMed
Yatani, R, Chigusa, I, Akazaki, K, Stemmermann, G, Welsh, R & Correa, P (1982) Geographic pathology of latent prostatic cancer. Int J Cancer 29, 611616.CrossRefGoogle Scholar
Yoshiji, H, Gomez, M, Shibuya, M & Thorgeirsson, U (1996) Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer. Cancer Res 56, 20132016.Google ScholarPubMed
Yuan, JM, Wang, QS, Ross, RK, Henderson, BE & Yu, MC (1995) Diet and risk of breast cancer in Shanghai and Tianjin, China. Br J Cancer 71, 13531358.CrossRefGoogle ScholarPubMed
Zaizen, Y, Higuchi, Y, Matsuo, N, Shirabe, K, Tokuda, H & Takeshita, M(2000) Antitumour effects of soybean hypocotyls and soybeans on the mammary tumour induction by N-methyl-n-nitrosourea in F344 rats. Anticancer Res 20, 14391444.Google Scholar
Zava, D & Duwe, G (1997) Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro. Nutr Cancer 27, 3140.CrossRefGoogle ScholarPubMed
Zhou, JR, Gugger, ET, Tanaka, T, Guo, Y, Blackburn, GL & Clinton, SK (1999) Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumour angiogenesis in mice. J Nutr 129, 16281635.CrossRefGoogle ScholarPubMed
Zhou, JR, Mukherjee, P, Gugger, ET, Tanaka, T, Blackburn, GL & Clinton, SK (1998) Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis and angiogenesis. Cancer Res 58, 52315238.Google ScholarPubMed
Ziegler, R, Hoover, R, Pike, M, Hidesheim, A, Nomura, A, West, D, Wu-Williams, A, Kolonel, L, Horn-Ross, P & Rosenthal, J (1993) Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst 85, 18191827.CrossRefGoogle ScholarPubMed