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Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer

  • Pamela J. Magee (a1) and Ian R. Rowland (a1)
Abstract

The incidence of hormone-dependent cancers, such as those of the breast and prostate, is much lower in Eastern countries such as China and Japan in comparison with the Western world. Diet is believed to have a major effect on disease risk and one group of compounds, the phyto-oestrogens, which are consumed in large amounts in Asian populations, have been implicated in cancer protection. This view follows the finding that plasma and urinary levels of phyto-oestrogens are much higher in areas where cancer incidence is low in comparison with areas of high cancer incidence. The phyto-oestrogens are comprised of two main groups; the isoflavones and lignans. Of the isoflavones, genistein and daidzein have been the most widely studied. These compounds have been shown to possess anticancer properties; however their precise mechanism of action remains to be elucidated. In comparison, few studies have investigated the effects of lignans in breast and prostate cancer. In vitro studies have shown that genistein exerts biphasic effects on cancer cell growth, stimulating growth at low concentrations (<10μM) and inhibiting growth at high concentrations (>10μM), which suggests that low phyto-oestrogen levels may stimulate cancer growth in vivo. Plasma phyto-oestrogen concentrations of >10μM cannot be achieved by dietary intake and therefore the timing of exposure to phyto-oestrogens may be of the utmost importance in determining their chemopreventive effects. The present paper reviews the effects of phyto-oestrogens on breast and prostate cancer in vivo and in vitro and discusses possible mechanisms of action via which these compounds may exert their effects.

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*Corresponding author: Dr Pamela J. Magee, fax +44 28 70324965, email pj.magee@ulster.ac.uk
References
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Aaltomaa, S, Lipponen, P, Eskelinen, M, Ala-Opas, M & Kosma, V (1999) Prognostic value and expression of p21 (waf1/cip1) protein in prostate cancer. Prostate 39, 815.
Adlercreutz, H (2002) Phyto-oestrogens and cancer. Lancet Oncol 3, 364373.
Adlercreutz, H, Bannwart, C, Wahala, K, Makela, T, Brunow, G, Hase, TAroseemena, P, Kellis, J & Vickery, L (1993) Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens. J Steroid Biochem Mol Biol 44, 147153.
Adlercreutz, H, Fotsis, T, Bannwart, C, Wahala, K, Makela, T, Brunow, G & Hase, T (1986) Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. J Steroid Biochem 25, 791797.
Adlercreutz, H, Fotsis, THeikkinen, R, Dwyer, J, Woods, M, Goldin, B & Gorbach, S (1982) Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian women and in women with breast cancer. Lancet ii, 12951299.
Adlercreutz, H, Goldin, BGorbach, S et al. , (1995) Soybean phytoestrogen intake and cancer risk. J Nutr 125, 757S770S.
Adlercreutz, H, Hamalainen, E, Gorbach, S & Goldin, B (1992) Dietary phyto-oestrogens and the menopause in Japan. Lancet 339, 1233.
Adlercreutz, H, Hockerstedt, K, Bannwart, C, Bloigu, S, Hamalainen, E, Fotsis, T & Ollus, A (1987) Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of oestrogens and on sex hormone binding globulin (SHBG). J Steroid Biochem 27, 11351144.
Adlercreutz, H, Hockerstedt, K, Bannwart, C, Hamalainen, E, Fotsis, T & Bloigu, S (1988) Association between dietary fiber, urinary excretion of lignans and isoflavonic phytoestrogens, and plasma non-protein bound sex hormones in relation to breast cancer. In Hormones and Cancer 3, Proceedings Progress in Cancer Research and Therapy, (35), 409412 [Bresciani, F, King, R, Lippman, M, Raynaud, J-P, editors]. New York: Raven Press.
Adlercreutz, H, Honjo, H, Higashi, A, Fotsis, T, Hamalainen, E, Hasegawa, T & Okada, H, (1991) Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming traditional Japanese diet. Am J Clin Nutr 54, 10931100.
Adlercreutz, H, Markkanen, H & Watanabe, S (1993 b) Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 342, 12091210.
Adlercreutz, H & Mazur, W (1997) Phyto-oestrogens and Western diseases. Ann Med 29, 95120.
Akiyama, T, Ishida, J, Nakagawa, S, Ogawara, H, Watanabe, S, Itoh, N, Shibuya, M & Fukami, Y (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262, 55925595.
Allen, N, Appleby, P, Davey, G & Key, T (2001) Soy milk intake in relation to serum sex hormone levels in British men. Nutr Cancer 41, 4146.
Baird, D, Umbach, D, Lansdell, L, Hughes, C, Setchell, KDRWeinberg, C, Haney, A, Wilcox, A & McLachlan, J (1995) Dietary intervention study to assess oestrogenicity of dietary soy among postmenopausal women. J Clin Endocrinol Metabol 80, 16851690.
Balabhadrapathruni, S, Thomas, T, Yurkow, E, Amenta, P & Thomas, T (2000) Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells. Oncol Rep 7, 312.
Balduyck, M, Zerimech, F, Gouyer, V et al. , (2000) Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells in vitro. Clin Exp Metastasis 18, 171178.
Barkhem, T, Carlsson, B, Nilsson, Y, Enmark, E, Gustafsson, J & Nilsson, S (1998) Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. Mol Pharmacol 54, 105112.
Barnes, S (1997) The chemopreventive properties of soy isoflavonoids in animal models of breast cancer. Breast Cancer Res Treat 46, 169179.
Barnes, S (1998) Phytoestrogens and breast cancer. Baillieres Clin Endocrinol Metabol 12, 559579.
Barnes, S, Grubbs, C, Setchell, KDR & Carlson, J (1990) Soybeans inhibit mammary tumours in models of breast cancer. In Mutagens and Carcinogens in the Diet, pp.239253 [Pariza, M, Aeschbacher, H, Felton, J, Sato, S, editors]. New York: Wiley-Liss.
Beatty, E, O'Reilly, J, England, T, McAnlis, G, Young, I, Geissler, C, Sanders, T & Wiseman, H (2000) Effect of dietary quercetin on oxidative DNA damage in healthy human subjects. Br J Nutr 84, 919925.
Bennetts, HW, Underwood, EJ & Shier, FL (1946) A specific breeding problem of sheep on subterranean clover pastures in Western Australia. Aust J Agricult Res 22, 131138.
Bergan, R, Kyle, E, Nguyen, P, Trepel, J & Neckers, L (1996) Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-1 integrin. Clin Exp Metastasis 14, 389398.
Bingham, SA, Atkinson, C, Liggins, J, Bluck, L & Coward, A (1998) Phyto-oestrogens: where are we now?. Br J Nutr 79, 393406.
Bowey, E, Adlercreutz, H & Rowland, I (2003) Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. Food Chem Toxicol 41, 631636.
Burg, B, Selm-Miltenburg, A, Laat, S & Zoelen, E (1989) Direct effects of estrogen on c-fos and c-myc protooncogene expression and cellular proliferation in human breast cancer cells. Mol Cell Endocrinol 64, 223228.
Bylund, A, Zhang, J, Bergh, A, Damber, J, Widmark, A, Johansson, A, Adlercreutz, H, Aman, P, Shepherd, M & Hallmans, G (2000) Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice. Prostate 42, 304314.
Cappelletti, V, Fioravanti, L, Miodini, PDi Fronzo, G (2000) Genistein blocks breast cancer cells in the G(2)M phase of the cell cycle. J Cell Biochem 79, 594600.
Carroll, K (1975) Experimental evidence of dietary factors and hormone-dependent cancers. Cancer Res, 35, 33743383.
Cassidy, A, Bingham, S & Setchell, K (1994) Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am J Clin Nutr 60, 333340.
Cassidy, A, Bingham, S & Setchell, K (1995) Biological effects of isoflavones in young women: importance of the chemical composition of soybean products. Br J Nutr 74, 587601.
Chan, J, Stampfer, M, Giovannucci, E, Gann, P, Ma, J, Wilkinson, P, Hennekens, C & Pollak, M (1998) Plasma insulin-like growth factor-1 and prostate cancer risk: a prospective study. Science 279, 563566.
Choi, Y, Zhang, L, Lee, W & Park, K (1998) Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells. Int J Oncol 13, 391396.
Clinton, S & Giovannucci, E (1998) Diet, nutrition and prostate cancer. Annu Rev Nutr 18, 413440.
Cohen, J, Kristal, A & Stanford, J (2000) Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 92, 6168.
Constantinou, A, Kamath, N & Murley, J (1998) Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells. Eur J Cancer 34, 19271934.
Constantinou, A, Mehta, R & Vaughan, A (1996) Inhibition of N-methyl-N-nitrosourea-induced mammary tumours in rats by the soybean isoflavones. Anticancer Res 16, 32933298.
Dabrosin, C, Chen, J, Wang, L & Thompson, LU (2002) Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett 185, 3137.
Davis, J, Kucuk, O & Sarkar, F (1999) Genistein inhibits NF-kappa B activation in prostate cancer cells. Nutr Cancer 35, 167174.
Davis, J, Muqim, N, Bhuiyan, M, Kucuk, O, Pienta, K & Sarkar, F (2000) Inhibition of prostate specific antigen expression by genistein in prostate cancer cells. Int J Oncol 16, 10911097.
Davis, J, Singh, B, Bhuiyan, M & Sarkar, F (1998) Genistein-induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells. Nutr Cancer 32, 123131.
Demark-Wahnefried, W, Price, D, Polascik, T, Robertson, C, Anderson, E, Paulson, D, Walther, P, Gannon, M & Vollmer, R (2001) Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology 58, 4752.
Duffy, M, Maguire, T, Hill, A, McDermott, E & O'Higgins, N (2000) Metalloproteinases: role in breast carcinogenesis, invasion and metastasis. Breast Cancer Res 2, 252257.
Evans, B, Griffiths, K & Morton, M (1995) Inhibition of 5alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. J Endocrinol 147, 295302.
Ewings, P & Bowie, C (1996) A case-control study of cancer of the prostate in Somerset and east Devon. Br J Cancer 74, 661666.
Ferguson, D & Anderson, T (1981) Morphological evaluation of cell turnover in relation to the menstrual cycle in the "resting" human breast. Br J Cancer 44, 177181.
Ferlay, J, Bray, F, Pisani, P & Parkin, D (2001) GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide. Lyon, France: IARCPress.
Fioravanti, L, Cappelletti, V, Miodini, P, Ronchi, E, Brivio, M & Di Fronzo, G (1998) Genistein in the control of breast cancer cell growth: insights into the mechanism of action in vitro. Cancer Lett 130, 143152.
Fotsis, T, Pepper, M, Adlercreutz, H, Hase, T, Montesano, R & Schweigerer, L (1995) Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J Nutr 125, 790S797S.
Fotsis, T, Pepper, M, Montesano, R, Aktas, E, Breit, S, Schweigerer, L, Rasku, S, Wahala, K & Adlercreutz, H, (1998) Phytoestrogens and inhibition of angiogenesis. Bailliere's Clin Endocrinol Metabol 12, 649666.
Frey, R, Li, J & Singletary, K (2001) Effects of genistein on cell proliferation and cell cycle arrest in nonneoplastic human mammary epithelial cells: involvement of Cdc2, p21waf/cip1, p27kip1 and Cdc25C expression. Biochem Pharmacol 61, 979989.
Fritz, W, Coward, L, Wang, J & Lamartiniere, C (1998) Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenesis 19, 21512158.
Fritz, W, Wang, J, Eltoum, I & Lamartiniere, C (2002) Dietary genistein down-regulates androgen and estrogen receptor expression in the rat prostate. Mol Cell Endocrinol 186, 8999.
Gallo, D, Giacomelli, SCantelmo, F et al. , (2001) Chemoprevention of DMBA-induced mammary cancer in rats by dietary soy. Breast Cancer Res Treat 69, 153164.
Geller, J, Sionit, L, Partido, C, Li, L, Tan, X, Youngkin, T, Nachtsheim, D & Hoffman, R (1998) Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture. Prostate 34 7579.
Giovannucci, E, Ascherio, A, Rimm, EB, Stampfer, MJ, Colditz, GA & Willett, WC, (1995) Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 87, 17671776.
Goldin, B, Adlercreutz, H, Gorbach, S, Woods, M, Dweyer, J, Conlon, T, Bohn, E & Gershoff, S (1986) The relationship between estrogen levels and diets of Caucasian American and Oriental immigrant women. Am J Clin Nutr 44, 945953.
Gotoh, T, Yamada, K, Yin, H, Ito, A, Kataoka, T & Dohi, K (1998) Chemoprevention of N-nitroso-N-methylurea-induced rat mammary carcinogenesis by soy foods or biochanin A. Jpn J Cancer Res 89, 137142.
Graham, S, Haughey, B, Marshall, J, Priore, R, Byers, T, Rzepka, T, Mettlin, C & Pontes, J (1983) Diet in the epidemiology of carcinoma of the prostate gland. J Nat Cancer Inst 70, 687692.
Griffiths, K, Davies, P, Eaton, C, Harper, M, Turkes, A & Peeling, W (1991) Endocrine factors in the initiation, diagnosis and treatment of prostatic cancer. In Endocrine Dependent Tumours, pp. 83130 [Voight, K, Knabbe, C, editors]. New York: Raven Press.
Habito, R, Montalto, J, Leslie, E & Ball, M (2000) Effects of replacing meat with soybean in the diet on sex hormone concentrations in healthy adult males. Br J Nutr 84, 557563.
Haggans, C, Travelli, E, Thomas, W, Martini, M & Slavin, J (2000) The effect of flaxseed and wheat bran consumption on urinary estrogen metabolites in premenopausal women. Cancer Epidemiol Biomarkers Prev 9, 719725.
Hakkak, R, Korourjan, S, Shelnutt, S, Lensing, S, Ronis, M & Badger, T (2000) Diets containing whey proteins or soy protein isolate protect against 7, 12-dimethylbenz[a]anthracene-induced mammary tumours in female rats.Cancer Epidemiol Biomarkers Prev 9, 113117.
Hargreaves, D, Potten, C, Harding, C, Shaw, L, Morton, M, Roberts, S, Howell, A & Bundred, N (1999) Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast. J Clin Endocrinol Metabol 84, 40174024.
Hayashi, A, Popovich, K, Kim, H & de Juan, E (1997) Role of protein tyrosine phosphorylation in rat corneal neovascularization. Graefes Arch Clin Exp Opthalmol 235, 460467.
Hempstock, J, Kavanagh, J & George, N (1998) Growth inhibition of prostate cell lines in vitro by phyto-oestrogens. Br J Urol 82, 560563.
Honma, Y, Okabe-Kado, J, Kasaukabe, T, Hozumi, M & Umezawa, K (1990) Inhibition of abl oncogene tyrosine kinase induces erythroid differentiation of human myelogenous leukemia K-562 cells. Jpn J Cancer Res 81, 11321136.
Horn-Ross, P, John, E, Lee, M, Stewart, S, Koo, J, Sakoda, L, Shiau, A, Goldstein, J, Davis, P & Perez-Stable, E (2001) Phytoestrogen consumption and breast cancer risk in a multiethnic population: the Bay Area Breast Cancer Study. Am J Epidemiol 154, 434441.
Hsieh, C, Santell, R, Haslam, S & Helferich, W (1998) Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res 58, 38333838.
Hsueh, A & Park, H (1990) Quality of dietary protein and chemical carcinogenesis in rats. Int News Fats Oils Related Materials 1, 303, Abstr.
Hu, Y, Dragowska, W, Wallis, A, Duronio, V & Mayer, L (2001) Cytotoxicity induced by manipulation of signal transduction pathways is associated with down-regulation of Bcl-2 but not Mcl-1 in MCF-7 human breast cancer. Breast Cancer Res Treat 70, 1120.
Hulka, B & Moorman, P (2001) Breast cancer: hormones and other risk factors Maturitas 38, 103116.
Hussain, M, Sarkar, F & Djuric, Z (2002) Soy isoflavones in the treatment of prostate cancer. J Nutr 132, 575S576S.
Jacobsen, B, Knutsen, S & Fraser, G (1998) Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States). Cancer Causes Control 9, 553557.
Jones, JL, Daley, BJ, Enderson, BL, Zhou, JR & Karlstad, MD (2002) Genistein inhibits tamoxifen effects on cell proliferation and cell cycle arrest in T47D breast cancer cells. Am Surg 68, 575577.
Kato, K, Takahashi, S, Cui, L, Toda, T, Suzuki, S, Futakuchi, M, Sugiura, S & Shirai, T (2000) Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis. Jpn J Cancer Res 91, 786791.
Key, T, Chen, J, Pike, M & Boreham, J (1990) Sex hormones in women in rural China and Britain. Br J Cancer 62, 631636.
Key, T, Silcocks, P, Davey, G, Appleby, P & Bishop, D (1997) A case-control study of diet and prostate cancer. Br J Cancer 76, 678687.
Kim, H, Peterson, T & Barnes, S (1998) Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways. Am J Clin Nutr 68, 1418S1425S.
Kirk, C, Harris, R, Wood, D, Waring, R & Hughes, P (2001) Do dietary phytoestrogens influence susceptibility to hormone-dependent cancer by disrupting the metabolism of endogenous oestrogens?. Biochem Soc Trans 29, 209216.
Kobayashi, T, Nakata, T & Kuzumaki, T (2002) Effect of flavonoids on cell cycle progression in prostate cancer cells, Cancer Lett 176, 1723.
Kolonel, L, Nomura, A & Cooney, R (1999) Dietary fat and prostate cancer: current review. J Natl Cancer Inst 91, 414428.
Kruse, F, Joussen, A, Fotsis, T, Schweigerer, L, Rohrschneider, K & Volcker, H (1997) Inhibition of neovascularization of the eye by dietary factors exemplified by isoflavonoids. Opthalmologe 94, 152156.
Kuiper, G, Carlsson, B, Grandien, K, Enmark, E, Haggblad, J, Nilsson, S & Gustafsson, J (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138, 863870.
Kuiper, G, Lemmen, J, Carlsson, B, Corton, J, Safe, S, van der Saag, P, van der Burg, B & Gustafsson, J, (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139, 42524263.
Kumar, N, Cantor, A, Allen, K, Riccardi, D & Cox, C (2002) The specific role of isoflavones on estrogen metabolism in premenopausal women. Cancer 94 11661174.
Kyle, E, Neckers, L, Takimoto, C, Curt, G & Bergan, R (1997) Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Mol Pharmacol 51, 193200.
Lamartiniere, CA (2000) Protection against breast cancer with genistein: a component of soy. Am J Clin Nutr 71 Suppl.l1705S1707S.
Lamartiniere, CA, Cotroneo, MS, Fritz, WA, Wang, J, Mentor-Marcel, R & Elgavish, A (2002) Genistein chemoprevention: timing and mechanisms of action in murine mammary and prostate. J Nutr 132, 552S558S.
Lamartiniere, CA, Moore, JB, Brown, NM, Thompson, R, Hardin, MJ & Barnes, S (1995) Genistein suppresses mammary cancer in rats. Carcinogenesis 16, 28332840.
Lamartiniere, CA, Murrill, WB, Manzolillo, PA, Zhang, JX, Barnes, S, Zhang, X, Wei, H & Brown, NM (1998) Genistein alters the ontogeny of mammary gland development and protects against chemically-induced mammary cancer in rats. Proc Soc Exp Biol Med 217, 358364.
Lamartiniere, CA, Wang, J, Smith-Johnson, M & Eltoum, IE (2002) Daidzein: bioavailability, potential for reproductive toxicity, and breast cancer chemoprevention in female rats. Toxicol Sci 65, 228238.
Lampe, JW, Karr, SC, Hutchins, AM & Slavin, JL (1998) Urinary equol excretion with a soy challenge: influence of habitual diet. Proc Soc Exp Biol Med 217, 335339.
Landstrom, M, Zhang, J, Hallmans, G, Aman, P, Bergh, A, Damber, J, Mazur, W, Wahala, K & Adlercreutz, H (1998) Inhibitory effects of soy and rye diets on the development of Dunning R3327 prostate adenocarcinoma in rats. Prostate 36, 151161.
Le Bail, J, Champavier, Y, Chulia, A & Habrioux, G (2000) Effects of phytoestrogens on aromatase 3b and 17b-hydroxysteroid dehydrogenase activities and human breast cancer cells. Life Sci 66, 12811291.
Lee, H, Gourley, L, Duffy, S, Esteve, J, Lee, J & Day, N (1991) Dietary effects on breast-cancer risk in Singapore. Lancet 337, 11971200.
Lee, M, Wang, R, Hsing, A, Gu, F, Wang, T & Spitz, M (1998) Case-control study of diet and prostate cancer. Cancer Causes Control 9, 545552.
Leung, L & Wang, T (2000) Bcl-2 is not reduced in the death of MCF-7 cells at low genistein concentration. J Nutr 130, 29222926.
Li, Y & Sarkar, FH (2002) Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein. Cancer Lett 186, 157164.
Li, Y, Upadhyay, S, Bhuiyan, M & Sarker, F (1999) Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein. Oncogene 18, 31663172.
Lin, X, Switzer, BDemark-Wahnefried, W (2001) Effect of mammalian lignans on the growth of prostate cancer cell lines Anticancer Res 21, 39954000.
Lu, L, Anderson, K, Grady, J, Kohen, F & Nagamani, M (2000) Decreased ovarian hormones during a soya diet: implications for breast cancer prevention Cancer Res 60, 41124121.
McMichael-Phillips, D, Harding, C, Morton, M, Roberts, S, Howell, A, Potten, C, Bundred, N, (1998) Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast. Am J Clin Nutr 68, 1431S1435S.
Maggiolini, M, Bonofiglio, D, Marsico, S, Panno, ML, Cenni, BPicard, D & Ando, S (2001) Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol Pharmacol 60, 595602.
Maggiolini, M, Vivacqua, A, Carpino, A, Bonofiglio, D, Fasanella, G, Salerno, M, Picard, D & Ando, S (2002) The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate cancer cells. Mol Pharmacol 62, 10271035.
Makela, S, Poutanen, M, Lehtimaki, J, Kostian, M, Santti, R & Vihko, R (1995) Estrogen-specific 17beta-hydroxysteroid oxidoreductase type 1 (E.C 1.1.1.62) as a possible target for the action of phytoestrogens. Proc Soc Exp Biol Med 208, 5159.
Markovits, J, Linassier, C, Fosse, P, Couprie, J, Pierre, J, Jacquemin-Sablon, A, Saucier, J, Le Pecq, J & Larsen, A (1989) Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II Cancer Res 49, 51115117.
Maskarinec, G, Williams, A. Inouye, J, Stanczyk, F & Franke, A (2002) A randomized isoflavone intervention among premenopausal women. Cancer Epidemiol Biomarkers Prev 11, 195201.
Mentor-Marcel, R, Lamartiniere, C, Eltoum, I-E, Greenberg, N & Elgavish, A (2001) Genistein in the diet reduces the incidence of poorly differentiated prostatic adenocarcinoma in transgenic mice (TRAMP). Cancer Res 61, 67776782.
Messina, MJ (2003) Emerging evidence on the role of soy in reducing prostate cancer risk. Nutr Rev 61, 117131.
Miksicek, RJ (1995) Estrogenic flavonoids: structural requirements for biological activity. Proc Soc Exp Biol Med 208, 4450.
Mills, P, Beeson, W, Phillips, R & Fraser, G (1989) Cohort study of diet, lifestyle and prostate cancer in Adventist men. Cancer 64, 598604.
Miodini, P, Fioravanti, L, Di Fronzo, G & Cappelletti, V (1999) The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function. Br J Cancer 80, 11501155.
Mitchell, J, Cawood, E, Kinniburgh, D, Provan, A, Collins, A & Irvine, D (2001) Effect of a phytoestrogen food supplement on reproductive health in normal males. Clin Sci 100, 613618.
Mitchell, J, Duthie, S & Collins, A, (2000) Effects of phytoestrogens on growth and DNA integrity in human prostate tumour cell lines: PC-3 and LNCaP. Nutr Cancer 38, 223228.
Monti, E & Sinha, B (1994) Antiproliferative effect of genistein and adriamycin against estrogen-dependent and -independent human breast carcinoma cell lines. Anticancer Res 14, 12211226.
Morton, MS, Chan, PS, Cheng, C, Blacklock, N, Matos-Ferreira, A, branches-Monteiro, L, Correia, R, Lloyd, S & Griffiths, K (1997) Lignans and isoflavonoids in plasma and prostatic fluid in men: samples from Portugal Hong Kong and the United Kingdom. Prostate 32, 122128.
Morton, MS, Wilcox, G, Wahlqvist, ML & Griffiths, K (1994) Determination of lignans and isoflavonoids in human female plasma following dietary supplementation. J Endocrinol 142, 251259.
Mousavi, Y & Adlercreutz, H (1992) Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. J Steroid Biochem Mol Biol 41, 615619.
Mueller, S, Yeh, Y & Chen, W, (1992) Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells. J Cell Biol 119, 13091325.
Murkies, A, Dalais, F, Briganti, E, Burger, H, Healy, D, Wahlqvist, M & Davis, S (2000) Phytoestrogens and breast cancer in postmenopausal women: a case control study. Menopause 7, 289296.
Murrill, W, Brown, N, Zhang, J, Manzolillo, P, Barnes, S & Lamartiniere, C (1996) Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. Carcinogenesis 17, 14511457.
Nagata, C, Inaba, S, Kawakami, N, Kakizoe, T & Shimizu, H (2000) Inverse association of soy product intake with serum androgen and estrogen concentrations in Japanese men. Nutr Cancer 36, 1418.
Nagata, C, Takatsuka, N, Shimizu, H, Hayashi, H, Akamatsu, T & Murase, K (2001) Effect of soymilk consumption on serum estrogen and androgen concentrations in Japanese men. Cancer Epidemiol Biomarkers Prev 10, 179184.
Naik, H, Lehr, J & Pienta, K (1994) An in vitro and in vivo study of antitumour effects of genistein on hormone refractory prostate cancer. Anticancer Res 14, 26172619.
Nakao-Hayashi, J, Ito, H, Kanayasu, T, Morita, I & Murota, S (1992) Stimulatory effects of insulin and insulin-like growth factor 1 on migration and tube formation by vascular cells. Atherosclerosis 92, 141149.
Nomoto, S, Arao, Y, Horiguchi, H, Ikeda, K & Kayama, F (2002) Oestrogen causes G2/M arrest and apoptosis in breast cancer cells MDA-MB-231. Oncol Rep 9, 773776.
Ohta, T, Nakatsugi, S, Watanabe, K, Kawamori, T, Ishikawa, F, Morotomi, M, Sugie, S, Toda, T, Sugimura, T & Wakabayashi, K (2000) Inhibitory effects of bifidobacterium-fermented soy milk on 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine-induced rat mammary carcinogenesis, with a partial contribution of its component isoflavones. Carcinogenesis 21, 937941.
Onozawa, M, Kawamori, T, Baba, M, Fukuda, K, Toda, T, Sato, H, Ohtani, M, Akaza, H, Sugimura, T & Wakabayashi, K (1999) Effects of a soybean isoflavone mixture on carcinogenesis in prostate and seminal vesicles of F344 rats. Jpn J Cancer Res, 90, 393398.
Pagliacci, M, Smacchia, M, Migliorati, G, Grignani, F, Riccardi, C & Nicoletti, I (1994) Growth-inhibitory effects of the natural phyto-oestrogen genistein in MCF-7 human breast cancer cells. Eur J Cancer 30A, 16751682.
Peterson, G & Barnes, S (1991) Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene. Biochem Biophys Res Commun 179, 661667.
Peterson, G & Barnes, S (1993) Genistein and bichanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate 22, 335345.
Petrakis, N, Barnes, S, King, E, Lowenstein, J, Wiencke, J, Lee, M, Miike, R, Krik, M & Coward, L (1996) Stimulatory influence of soy protein isolate on breast secretion in pre and post menopausal women. Cancer Epidemiol Biomarkers Prev 5, 785794.
Phipps, W, Martini, M, Lampe, JW, Slavin, JL & Kurzer, M (1993) Effects of flaxseed ingestion on the menstrual cycle. J Clin Endocrinol Metabol 77, 12151219.
Pietinen, P, Stumpf, K, Mannisto, S, Kataja, V, Uusitupa, M & Adlercreutz, H (2001) Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland. Cancer Epidemiol Biomarkers Prev 10, 339344.
Polascik, T, Oesterling, J & Partin, A (1999) Prostate specific antigen: a decade of discovery - what we have learned and where we are going. J Urol 162, 293306.
Polkowski, K & Mazurek, AP(2000) Biological properties of genistein. A review of in vitro and in vivo data. Acta Pol Pharm 57, 135155.
Pollard, M & Wolter, W (2000) Prevention of spontaneous prostate-related cancer in Lobund-Wistar rats by a soy protein isolate/isoflavone diet. Prostate 45, 101105.
Price, KR & Fenwick, GR (1985) Naturally occurring oestrogens in foods – a review. Food Add Contam 2, 73106.
Prud'homme, J, Jolivet, A, Pichon, M, Savouret, J & Milgrom, E (1990) Monoclonal antibodies against native and denatured forms of estrogen-induced breast cancer protein (BCEI/p52) obtained by expression in Escherichia coli. Cancer Res 50, 23902396.
Reinli, K & Block, G (1996) Phytoestrogen content of foods – a compendium of literature values. Nutr Cancer 26, 123148.
Rice, L, Samedi, V, Medrano, T, Sweeney, C, Baker, H, Stenstrom, A, Furman, J & Shiverick, K (2002) Mechanisms of the growth inhibitory effects of the isoflavonoid biochanin A on LNCaP cells and xenografts. Prostate 52, 201212.
Rochefort, H (1998) Estrogens, cathepsin D and metastasis in breast and ovarian cancer: invasion or proliferation? (in French). C R Seances Soc Biol Fil 192, 241251.
Rokhlin, O & Cohen, M (1995) Differential sensitivity of human prostatic cancer cell lines to the effects of protein kinase and phosphate inhibitors. Cancer Lett 98, 103110.
Rosenberg Zand, RS, Jenkins, DJ, Brown, TJ & Diamandis, EP (2002) Flavonoids can block PSA production by breast and prostate cancer cell lines. Clin Chim Acta 317, 1726.
Rowland, I, Faughan, M, Hoey, L, Wahala, K, Williamson, G & Cassidy, A (2003) Bioavailability of phyto-oestrogens. BrJ Nutr 89, S45S58.
Rowland, I, Wiseman, H, Sanders, T, Adlercreutz, H & Bowey, E (1999) Metabolism of oestrogens and phytoestrogens: role of the gut microflora. Biochem Soc Trans 27, 304308.
Rowland, I, Wiseman, H, Sanders, TABAdlercreutz, H & Bowey, EA (2000) Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr Cancer 36 2732.
Santibanez, J, Navarro, A & Martinez, J (1997) Genistein inhibits proliferation and in vitro invasive potential of human prostatic cancer cell lines. Anticancer Res 17, 11991204.
Sathyamoorthy, N & Wang, T (1997) Differential effects of dietary phyto-oestrogens daidzein and equol on human breast cancer MCF-7 cells. Eur J Cancer 33, 23842389.
Sathyamoorthy, N, Wang, T & Phang, J (1994) Stimulation of pS2 expression by diet-derived compounds. Cancer Res 54, 957961.
Schmitt, E, Dekant, W & Stopper, H (2001) Assaying the estrogenicity of phytoestrogens in cells of different estrogen sensitive tissues. Toxicol In Vitro 15, 433439.
Scholar, E & Toews, M (1994) Inhibition of invasion of murine mammary carcinoma cells by the tyrosine kinase inhibitor genistein. Cancer Lett 87, 159162.
Schuurmans, A, Bolt, J, Veldscholte, J & Mulder, E (1990) Stimulatory effects of antiandrogens on LNCaP human prostate tumor cell growth, EGF-receptor level and acid phosphatase secretion. J Steroid Biochem Mol Biol 37, 849853.
Serraino, M & Thompson, LU (1992) The effect of flaxseed supplementation on the initiation and promotional stages of mammary tumorigenesis. Nutr Cancer 17, 153159.
Setchell, KD, Gosselin, SJ, Welsh, MB, Johnston, JO, Balistreri, WF, Kramer, LW, Dresser, BL & Tarr, MJ (1987) Dietary estrogens – a probable cause of infertility and liver disease in captive cheetahs. Gastroenterology 93, 225233.
Setchell, KD, Zimmer-Nechemias, L, Cai, J & Heubi, JE 1997) Exposure of infants to phyto-oestrogens from soy-based infant formula. Lancet 350, 2327.
Setchell, KDR (2001) Soy isoflavones - benefits and risks from nature's selective estrogen receptor modulators (SERMs). J Am Coll Nutr 20, 354S362S.
Setchell, KDR & Adlercreutz, H (1988) Mammalian lignans and phyto-oestrogens. Recent studies on their formation, metabolism and biological role in health and disease.In Role of the Gut Flora in Toxicity and Cancer 315345 [Rowland, IR, editor] London: Academic Press.
Severson, R, Nomura, A, Grove, J & Stemmermann, G (1989) A prospective study of demographics, diet and prostate cancer among men of Japanese ancestry in Hawaii. Cancer Res 49, 18571860.
Shao, Z, Alpaugh, M, Fontana, J & Barsky, S (1998) Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by P21WAF1/CIP1 induction, G2/M arrest, and apoptosis. J Cell Biochem 69, 4454.
Shao, Z, Wu, J, Shen, Z & Barsky, S (1998) Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res 58, 48514857.
Shao, Z, Wu, J, Shen, Z & Barsky, S (1998) Genistein inhibits both constitutive and EGF-stimulated invasion in ER-negative human breast carcinoma cell lines. Anticancer Res 18, 14351440.
Sharma, O, Adlercreutz, H, Strandberg, J, Zirkin, B, Coffey, D & Ewing, L (1992) Soy of dietary source plays a preventive role against the pathogenesis of prostatitis in rats. J Steroid Biochem Mol Biol 43, 557564.
Shen, J, Klein, R, Wei, Q, Guan, Y, Contois, J, Wang, T, Chang, S & Hursting, S (2000) Low-dose genistein induces cyclin-dependent kinase inhibitors and G1 cell-cycle arrest in human prostate cancer cells. Mol Carcinog 29, 92102.
Shutt, DA (1976) The effects of plant oestrogens on animal reproduction. Endeavour 35, 110113.
Sierens, J, Hartley, JA, Campbell, MJ, Leathem, AJ & Woodside, JV (2001) Effect of phytoestrogen and antioxidant supplementation on oxidative DNA damage assessed using the comet assay. Mutat Res 485, 169176.
Signorello, LB, Brismar, K, Bergstrom, R, Andersson, SO, Wolk, A, Trichopoulos, D & Adami, HO (1999) Insulin-like growth factor-binding protein-1 and prostate cancer. J Natl Cancer Inst 91, 19651967.
Stanford, JL, Just, JJ, Gibbs, M, Wicklund, KG, Neal, CL, Blumenstein, BA & Ostrander, EA (1997) Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk Cancer Res 57, 11941198.
Stattin, P, Adlercreutz, H & Tenkanen, L (2002) Circulating enterolactone and prostate cancer risk: a Nordic nested case-control study. Int J Cancer 99, 124129.
Stephens, F (1997) Phytoestrogens and prostate cancer: possible preventive role. Med J Aust 167, 138140.
Strom, S, Yamamura, Y, Duphorne, C, Spitz, M, Babaian, R, Pillow, P & Hursting, S (1999) Phytoestrogen intake and prostate cancer: a case-control study using a new database. Nutr Cancer 33, 2025.
Sun, X, Plouzek, C, Henry, J, Wang, T & Phang, J (1998) Increased UDP-glucuronosyltransferase activity and decreased prostate specific antigen production by biochanin A in prostate cancer cells. Cancer Res 58, 23792384.
Suzuki, K, Koike, H & Matsui, H (2002) Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC-3. Int J Cancer 99, 846852.
Tham, D, Gardner, C & Haskell, W (1998) Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological and mechanistic evidence. J Clin Endocrinol Metabol 83, 22232235.
Thompson, LU, Robb, P, Serraino, M & Cheung, F (1991) Mammalian lignan production from various foods. Nutr Cancer 16, 4352.
Thompson, LU & Serraino, M (1990) Lignans in flaxseed and breast and colon carcinogenesis Proc Flax Inst USA 3035.
Treolar, A, Boynton, R, Behn, B & Brown, B (1970) Variation of the human menstrual cycle throughout reproductive life. Int J Fertility 12, 77126.
Urban, D, Irwin, W, Kirk, M, Markiewicz, M, Myers, R, Smith, M, Weiss, H, Grizzle, W & Barnes, S (2001) The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen. J Urol 165, 294300.
Wang, C & Kurzer, M (1997) Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells. Nutr Cancer 28, 236247.
Wang, C, Makela, T, Hase, T, Adlercreutz, H & Kurzer, M (1994) Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes. J Steroid Biochem Mol Biol 50, 205212.
Wang, T, Sathyamoorthy, N & Phang, J (1996) Molecular effects of genistein on estrogen receptor mediated pathways. Carcinogenesis 17, 271275.
Weber, K, Setchell, K, Stocco, D & Lephart, E (2001) Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats. J Endocrinol 170, 591599.
Wei, H, Frenkel, K, Bowen, R & Barnes, S (1993) Inhibition of tumour-promoter induced hydrogen peroxide formation by genistein in vitro and in vivo. Nutr Cancer 20, 112.
Welshons, WV, Murphy, CS, Koch, R, Calaf, G & Jordan, VC (1987) Stimulation of breast cancer cells in vitro by the environmental estrogen enterolactone and the phytoestrogen equol. Breast Cancer Res Treat 10, 169175.
Wiseman, H, O'Reilly, J, Adlercreutz, H, Mallet, A, Bowey, E, Rowland, I & Sanders, T (2000) Isoflavone phytoestrogens consumed in soy decrease F2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. Am J Clin Nutr 72, 395400.
Wolk, A, Mantzoros, C, Andersson, S, Bergstrom, R, Signorello, L, Lagiou, P, Adami, H & Trichopoulos, D (1998) Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study. J Natl Cancer Inst 90, 911915.
Wu, A, Ziegler, R, Horn-Ross, P, Nomura, A, West, D, Kolonel, LRosenthal, J & Hoover, RPike, M (1996) Tofu and risk of breast cancer in Asian-Americans. Cancer Epidemiol Biomarkers Prev 5, 901906.
Xu, X, Harris, K, Wang, H, Murphy, P & Hendrich, S (1995) Bioavailability of soybean isoflavones depends on gut microflora in women. J Nutr 125, 23072315.
Xu, X, Wang, H, Murphy, P, Cook, L & Hendrich, S (1994) Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J Nutr 124, 825832.
Yatani, R, Chigusa, I, Akazaki, K, Stemmermann, G, Welsh, R & Correa, P (1982) Geographic pathology of latent prostatic cancer. Int J Cancer 29, 611616.
Yoshiji, H, Gomez, M, Shibuya, M & Thorgeirsson, U (1996) Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer. Cancer Res 56, 20132016.
Yuan, JM, Wang, QS, Ross, RK, Henderson, BE & Yu, MC (1995) Diet and risk of breast cancer in Shanghai and Tianjin, China. Br J Cancer 71, 13531358.
Zaizen, Y, Higuchi, Y, Matsuo, N, Shirabe, K, Tokuda, H & Takeshita, M(2000) Antitumour effects of soybean hypocotyls and soybeans on the mammary tumour induction by N-methyl-n-nitrosourea in F344 rats. Anticancer Res 20, 14391444.
Zava, D & Duwe, G (1997) Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro. Nutr Cancer 27, 3140.
Zhou, JR, Gugger, ET, Tanaka, T, Guo, Y, Blackburn, GL & Clinton, SK (1999) Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumour angiogenesis in mice. J Nutr 129, 16281635.
Zhou, JR, Mukherjee, P, Gugger, ET, Tanaka, T, Blackburn, GL & Clinton, SK (1998) Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis and angiogenesis. Cancer Res 58, 52315238.
Ziegler, R, Hoover, R, Pike, M, Hidesheim, A, Nomura, A, West, D, Wu-Williams, A, Kolonel, L, Horn-Ross, P & Rosenthal, J (1993) Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst 85, 18191827.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
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