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A pilot study of vitamin B12 in the treatment of tiredness

  • F. R. Ellis (a1) and S. Nasser (a1)
Abstract

1. Twenty-eight subjects complaining of tiredness completed a double-blind cross-over trial of injections of hydroxocobalamin (5 mg twice weekly for 2 weeks) followed by a rest period of 2 weeks and then a similar course of matching placebo injections. Symptoms were assessed by a daily self-rating method and included appetite, mood, energy, sleep and general feeling of well-being.

2. Those subjects who received the placebo in the first 2-week period showed a favourable response to hydroxocobalamin in the second period in all measurements made. The response achieved statistical significance (P = 0·006) in respect of general well-being; ‘happiness’ achieved a value of P = 0·032. Subjects who received hydroxocobalamin in the first period showed no difference between responses to active and placebo treatments, which suggests that the effects of the vitamin may persist for a period of at least 4 weeks.

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References
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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