Skip to main content
    • Aa
    • Aa
  • Access
  • Cited by 59
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Andersen, J. M. Rønning, P. O. Herning, H. Bekken, S. D. Haugen, T. B. and Witczak, O. 2016. Fatty acid composition of spermatozoa is associated with BMI and with semen quality. Andrology,

    Hu, Xiaoqian Tao, Ningping Wang, Xichang Xiao, Jianbo and Wang, Mingfu 2016. Marine-derived bioactive compounds with anti-obesity effect: A review. Journal of Functional Foods, Vol. 21, p. 372.

    Khatib, Subreen A. Rossi, Emily L. Bowers, Laura W. and Hursting, Stephen D. 2016. Reducing the burden of obesity-associated cancers with anti-inflammatory long-chain omega-3 polyunsaturated fatty acids. Prostaglandins & Other Lipid Mediators,

    Lin, Chenchen Våge, Villy Mjøs, Svein Are and Kvalheim, Olav Martin 2016. Changes in Serum Fatty Acid Levels During the First Year After Bariatric Surgery. Obesity Surgery, Vol. 26, Issue. 8, p. 1735.

    Lin, C. Andersen, J. R. Våge, V. Rajalahti, T. Mjøs, S. A. and Kvalheim, O. M. 2016. Intensive lifestyle intervention provides rapid reduction of serum fatty acid levels in women with severe obesity without lowering omega-3 to unhealthy levels. Clinical Obesity, Vol. 6, Issue. 4, p. 259.

    Luke, Anna K. Evans, E. Whitney Bond, Dale S. and Thomas, J. Graham 2016. Associations between omega fatty acid consumption and depressive symptoms among individuals seeking behavioural weight loss treatment. Obesity Science & Practice, Vol. 2, Issue. 1, p. 75.

    Mingay, Edwina Veysey, Martin Lucock, Mark Niblett, Suzanne King, Katrina Patterson, Amanda and Garg, Manohar 2016. Sex-dependent association between omega-3 index and body weight status in older Australians. Journal of Nutrition & Intermediary Metabolism, Vol. 5, p. 70.

    Toupchian, Omid Sotoudeh, Gity Mansoori, Anahita Nasli-Esfahani, Ensieh Djalali, Mahmoud Keshavarz, Seyyed Ali and Koohdani, Fariba 2016. Effects of DHA-enriched fish oil on monocyte/macrophage activation marker sCD163, asymmetric dimethyl arginine, and insulin resistance in type 2 diabetic patients. Journal of Clinical Lipidology,

    Fekete, K. Györei, E. Lohner, S. Verduci, E. Agostoni, C. and Decsi, T. 2015. Long-chain polyunsaturated fatty acid status in obesity: a systematic review and meta-analysis. Obesity Reviews, Vol. 16, Issue. 6, p. 488.

    Rose, David Gracheck, Peter and Vona-Davis, Linda 2015. The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer. Cancers, Vol. 7, Issue. 4, p. 2147.

    Ulven, Trond and Christiansen, Elisabeth 2015. Dietary Fatty Acids and Their Potential for Controlling Metabolic Diseases Through Activation of FFA4/GPR120. Annual Review of Nutrition, Vol. 35, Issue. 1, p. 239.

    Vidakovic, Aleksandra Jelena Jaddoe, Vincent W. V. Gishti, Olta Felix, Janine F. Williams, Michelle A. Hofman, Albert Demmelmair, Hans Koletzko, Berthold Tiemeier, Henning and Gaillard, Romy 2015. Body mass index, gestational weight gain and fatty acid concentrations during pregnancy: the Generation R Study. European Journal of Epidemiology, Vol. 30, Issue. 11, p. 1175.

    Albert, Benjamin B. Derraik, José G. B. Brennan, Christine M. Biggs, Janene B. Smith, Greg C. Garg, Manohar L. Cameron-Smith, David Hofman, Paul L. and Cutfield, Wayne S. 2014. Higher omega-3 index is associated with increased insulin sensitivity and more favourable metabolic profile in middle-aged overweight men. Scientific Reports, Vol. 4, p. 6697.

    Arnoldussen, Ilse and Kiliaan, Amanda 2014. Impact of DHA on Metabolic Diseases from Womb to Tomb. Marine Drugs, Vol. 12, Issue. 12, p. 6190.

    Aslan, Mutay Aslan, Ibrahim Özcan, Filiz Eryılmaz, Ramazan Ensari, Cemal and Bilecik, Tuna 2014. A pilot study investigating early postoperative changes of plasma polyunsaturated fatty acids after laparoscopic sleeve gastrectomy. Lipids in Health and Disease, Vol. 13, Issue. 1, p. 62.

    El-Gendy, Ahmed A. and Abbas, Amr M. 2014. Effect of omega-3 fatty acids on haemostatic functions in urocortin-treated obese rats. Journal of Physiology and Biochemistry, Vol. 70, Issue. 3, p. 809.

    Gray, Belinda Steyn, Frederik Davies, Peter Stephen Wynford and Vitetta, Luis 2014. Liver function parameters, cholesterol, and phospholipid α-linoleic acid are associated with adipokine levels in overweight and obese adults. Nutrition Research, Vol. 34, Issue. 5, p. 375.

    Howe, Peter Buckley, Jonathan Murphy, Karen Pettman, Tahna Milte, Catherine and Coates, Alison 2014. Relationship between Erythrocyte Omega-3 Content and Obesity Is Gender Dependent. Nutrients, Vol. 6, Issue. 5, p. 1850.

    Wilkinson, S. J. Downing, J. A. Thomson, P. C. and Newman, R. E. 2014. Dietary fatty acids affect the growth, body composition and performance of post-weaning gilt progeny. Animal Production Science, Vol. 54, Issue. 3, p. 339.

    Wójcik, Cezary Lohe, Kimberly Kuang, Chenzhong Xiao, Yan Jouni, Zeida and Poels, Eduard 2014. Modulation of adipocyte differentiation by omega-3 polyunsaturated fatty acids involves the ubiquitin-proteasome system. Journal of Cellular and Molecular Medicine, Vol. 18, Issue. 4, p. 590.


Plasma n-3 polyunsaturated fatty acids are negatively associated with obesity

  • Michelle Micallef (a1), Irene Munro (a1), Melinda Phang (a1) and Manohar Garg (a1) (a2)
  • DOI:
  • Published online: 19 May 2009

The objective of the present study was to investigate the relationship between plasma n-3 PUFA composition and weight status. A total of 124 adults, stratified by weight status: healthy weight (n 21), overweight (n 40) and obese (n 63) were recruited. Fasting blood samples, anthropometric measures and body composition were collected. Plasma fatty acid composition was determined by GC. BMI, waist circumference and hip circumference were inversely correlated with n-3 PUFA, EPA and DHA (P < 0·05 for all) in the obese group. Obese individuals had significantly lower plasma concentrations of total n-3 PUFA, compared with healthy-weight individuals (4·53 (sd 1·11) v. 5·25 (sd 1·43) %). When subjects were pooled and stratified into quartiles of total n-3 PUFA, a significant inverse trend was found for BMI (P = 0·002), waist circumference and hip circumference (P = 0·01 and P < 0·001 respectively). Higher plasma levels of total n-3 PUFA are associated with a healthier BMI, waist circumference and hip circumference. Our findings suggest that n-3 PUFA may play an important role in weight status and abdominal adiposity.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Plasma n-3 polyunsaturated fatty acids are negatively associated with obesity
      Your Kindle email address
      Available formats
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Plasma n-3 polyunsaturated fatty acids are negatively associated with obesity
      Available formats
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Plasma n-3 polyunsaturated fatty acids are negatively associated with obesity
      Available formats
Corresponding author
*Corresponding author: Professor Manohar Garg, fax +61 02 4921 2028, email
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

4G Blackburn (1995) Effect of degree of weight loss on health benefits. Obes Res 3, Suppl. 2, 211s216s.

5JO Hill , H Thompson & H Wyatt (2005) Weight maintenance: what's missing? J Am Diet Assoc 105, Suppl. 1, S63S66.

6ML Dansinger , JA Gleason , JL Griffith , (2005) Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA 293, 4353.

7PM Kris-Etherton , WS Harris & LJ Appel (2003) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Arterioscler Thromb Vasc Biol 23, e20e30.

8JD Krebs , LM Browning , NK McLean , (2006) Additive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic women. Int J Obes (Lond) 30, 15351544.

10CE Friedberg , MJ Janssen , RJ Heine , (1998) Fish oil and glycemic control in diabetes. A meta-analysis. Diabetes Care 21, 494500.

12GR Hajer , TW van Haeften & FL Visseren (2008) Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 29, 29592971.

14P Flachs , V Mohamed-Ali , O Horakova , (2006) Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. Diabetologia 49, 394397.

16MC Cave , RT Hurt , TH Frazier , (2008) Obesity, inflammation, and the potential application of pharmaconutrition. Nutr Clin Pract 23, 1634.

17M Karlsson , S Marild , J Brandberg , (2006) Serum phospholipid fatty acids, adipose tissue, and metabolic markers in obese adolescents. Obesity (Silver Spring) 14, 19311939.

18G Ailhaud & P Guesnet (2004) Fatty acid composition of fats is an early determinant of childhood obesity: a short review and an opinion. Obes Rev 5, 2126.

19T Decsi , D Molnar & B Koletzko (1996) Long-chain polyunsaturated fatty acids in plasma lipids of obese children. Lipids 31, 305311.

20C Agostoni , E Riva , R Bellu , (1994) Relationships between the fatty acid status and insulinemic indexes in obese children. Prostaglandins Leukot Essent Fatty Acids 51, 317321.

21AP Simopoulos (2002) Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 21, 495505.

23UG Kyle , I Bosaeus , AD De Lorenzo , (2004) Bioelectrical impedance analysis – part I: review of principles and methods. Clin Nutr 23, 12261243.

26S Scaglioni , E Verduci , M Salvioni , (2006) Plasma long-chain fatty acids and the degree of obesity in Italian children. Acta Paediatr 95, 964969.

29S Ikemoto , M Takahashi , N Tsunoda , (1996) High-fat diet-induced hyperglycemia and obesity in mice: differential effects of dietary oils. Metabolism 45, 15391546.

31C Couet , J Delarue , P Ritz , (1997) Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults. Int J Obes Relat Metab Disord 21, 637643.

32I Thorsdottir , H Tomasson , I Gunnarsdottir , (2007) Randomized trial of weight-loss-diets for young adults varying in fish and fish oil content. Int J Obes (Lond) 31, 15601566.

33M Garemo , RA Lenner & B Strandvik (2007) Swedish pre-school children eat too much junk food and sucrose. Acta Paediatr 96, 266272.

35D Parra , A Ramel , N Bandarra , (2008) A diet rich in long chain omega-3 fatty acids modulates satiety in overweight and obese volunteers during weight loss. Appetite 51, 676680.

36JA Nettleton & R Katz (2005) n-3 Long-chain polyunsaturated fatty acids in type 2 diabetes: a review. J Am Diet Assoc 105, 428440.

37SB Haugaard , S Madsbad , CE Hoy , (2006) Dietary intervention increases n-3 long-chain polyunsaturated fatty acids in skeletal muscle membrane phospholipids of obese subjects. Implications for insulin sensitivity. Clin Endocrinol (Oxf) 64, 169178.

38KG Murphy , WS Dhillo & SR Bloom (2006) Gut peptides in the regulation of food intake and energy homeostasis. Endocr Rev 27, 719727.

39DE Cummings & J Overduin (2007) Gastrointestinal regulation of food intake. J Clin Invest 117, 1323.

40M Winnicki , VK Somers , V Accurso , (2002) Fish-rich diet, leptin, and body mass. Circulation 106, 289291.

41P Perez-Matute , A Marti , JA Martinez , (2007) Conjugated linoleic acid inhibits glucose metabolism, leptin and adiponectin secretion in primary cultured rat adipocytes. Mol Cell Endocrinol 268, 5058.

42TA Mori , V Burke , IB Puddey , (2004) Effect of fish diets and weight loss on serum leptin concentration in overweight, treated-hypertensive subjects. J Hypertens 22, 19831990.

44S Furukawa , T Fujita , M Shimabukuro , (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114, 17521761.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *