Skip to main content
    • Aa
    • Aa
  • Access
  • Cited by 20
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Acosta, Monica L. Castro Smith, Leanne Miller, Rosalind J. McCarthy, Danielle I. Farrimond, Jonathan A. and Hall, Wendy L. 2016. Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations. The Journal of Nutritional Biochemistry,

    Afrin, Sadia Gasparrini, Massimiliano Forbes-Hernandez, Tamara Y. Reboredo-Rodriguez, Patricia Mezzetti, Bruno Varela-López, Alfonso Giampieri, Francesca and Battino, Maurizio 2016. Promising Health Benefits of the Strawberry: A Focus on Clinical Studies. Journal of Agricultural and Food Chemistry, Vol. 64, Issue. 22, p. 4435.

    Castro-Acosta, Monica L. Lenihan-Geels, Georgia N. Corpe, Christopher P. and Hall, Wendy L. 2016. Berries and anthocyanins: promising functional food ingredients with postprandial glycaemia-lowering effects. Proceedings of the Nutrition Society, Vol. 75, Issue. 03, p. 342.

    Coe, Shelly and Ryan, Lisa 2016. White bread enriched with polyphenol extracts shows no effect on glycemic response or satiety, yet may increase postprandial insulin economy in healthy participants. Nutrition Research, Vol. 36, Issue. 2, p. 193.

    Forbes-Hernandez, Tamara Y. Gasparrini, Massimiliano Afrin, Sadia Bompadre, Stefano Mezzetti, Bruno Quiles, Josè L. Giampieri, Francesca and Battino, Maurizio 2016. The Healthy Effects of Strawberry Polyphenols: Which Strategy behind Antioxidant Capacity?. Critical Reviews in Food Science and Nutrition, Vol. 56, Issue. sup1, p. S46.

    Moser, Sydney Lim, Jongbin Chegeni, Mohammad Wightman, JoLynne Hamaker, Bruce and Ferruzzi, Mario 2016. Concord and Niagara Grape Juice and Their Phenolics Modify Intestinal Glucose Transport in a Coupled in Vitro Digestion/Caco-2 Human Intestinal Model. Nutrients, Vol. 8, Issue. 7, p. 414.

    Nyambe-Silavwe, H. and Williamson, G. 2016. Polyphenol- and fibre-rich dried fruits with green tea attenuate starch-derived postprandial blood glucose and insulin: a randomised, controlled, single-blind, cross-over intervention. British Journal of Nutrition, Vol. 116, Issue. 03, p. 443.

    Pinent, Montserrat González-Abuín, Noemí Blay, Mayte and Ardévol, Anna 2016. Molecular Nutrition and Diabetes.

    Serrano, Joan Casanova-Martí, Àngela Gil-Cardoso, Katherine Blay, M. Teresa Terra, Ximena Pinent, Montserrat and Ardévol, Anna 2016. Acutely administered grape-seed proanthocyanidin extract acts as a satiating agent. Food Funct., Vol. 7, Issue. 1, p. 483.

    Giampieri, Francesca Forbes-Hernandez, Tamara Y. Gasparrini, Massimiliano Alvarez-Suarez, José M. Afrin, Sadia Bompadre, Stefano Quiles, Josè L. Mezzetti, Bruno and Battino, Maurizio 2015. Strawberry as a health promoter: an evidence based review. Food Funct., Vol. 6, Issue. 5, p. 1386.

    Pinent, Montserrat Blay, Mayte Serrano, Joan and Ardévol, Anna 2015. Effects of Flavanols on the Enteroendocrine System: Repercussions on Food Intake. Critical Reviews in Food Science and Nutrition, p. 00.

    Tsuda, Takanori 2015. Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon-like peptide-1 secretion. Molecular Nutrition & Food Research, Vol. 59, Issue. 7, p. 1264.

    Yang, Kaiyuan Hashemi, Zohre Han, Wei Jin, Alena Yang, Han Ozga, Jocelyn Li, Liang and Chan, Catherine B. 2015. Hydrolysis enhances bioavailability of proanthocyanidin-derived metabolites and improves β-cell function in glucose intolerant rats. The Journal of Nutritional Biochemistry, Vol. 26, Issue. 8, p. 850.

    González-Abuín, Noemi Martínez-Micaelo, Neus Margalef, Maria Blay, Mayte Arola-Arnal, Anna Muguerza, Begoña Ardévol, Anna and Pinent, Montserrat 2014. A grape seed extract increases active glucagon-like peptide-1 levels after an oral glucose load in rats. Food & Function, Vol. 5, Issue. 9, p. 2357.

    González-Abuín, Noemi Martínez-Micaelo, Neus Blay, Mayte Ardévol, Anna and Pinent, Montserrat 2014. Grape-Seed Procyanidins Prevent the Cafeteria-Diet-Induced Decrease of Glucagon-Like Peptide-1 Production. Journal of Agricultural and Food Chemistry, Vol. 62, Issue. 5, p. 1066.

    Miller, Rosalind Putnam, Sophie Edwards, Michael Woodward, Gary and Kay, Colin 2013. Bioactives in Fruit.

    Panickar, Kiran S. 2013. Effects of dietary polyphenols on neuroregulatory factors and pathways that mediate food intake and energy regulation in obesity. Molecular Nutrition & Food Research, Vol. 57, Issue. 1, p. 34.

    Rokka, Susanna Ketoja, Elise Järvenpää, Eila and Tahvonen, Raija 2013. The glycaemic and C-peptide responses of foods rich in dietary fibre from oat, buckwheat and lingonberry. International Journal of Food Sciences and Nutrition, Vol. 64, Issue. 5, p. 528.

    Linderborg, Kaisa M. Järvinen, Riikka Lehtonen, Henna-Maria Viitanen, Matti and Kallio, Heikki P.T. 2012. The fiber and/or polyphenols present in lingonberries null the glycemic effect of the sugars present in the berries when consumed together with added glucose in healthy human volunteers. Nutrition Research, Vol. 32, Issue. 7, p. 471.

    Törrönen, Riitta McDougall, Gordon J. Dobson, Gary Stewart, Derek Hellström, Jarkko Mattila, Pirjo Pihlava, Juha-Matti Koskela, Ali and Karjalainen, Reijo 2012. Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects. Journal of Functional Foods, Vol. 4, Issue. 4, p. 746.


Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects

  • Riitta Törrönen (a1), Essi Sarkkinen (a2), Tarja Niskanen (a2), Niina Tapola (a2), Kyllikki Kilpi (a3) and Leo Niskanen (a4) (a5)
  • DOI:
  • Published online: 20 September 2011

Berries are often consumed with sucrose. They are also rich sources of polyphenols which may modulate glycaemia after carbohydrate ingestion. The present study investigated the postprandial glucose, insulin and glucagon-like peptide 1 (GLP-1) responses to sucrose ingested with berries, in comparison with a similar sucrose load without berries. A total of twelve healthy subjects were recruited to a randomised, single-blind, placebo-controlled crossover study. They participated in two meal tests on separate days. The berry meal was a purée (150 g) made of bilberries, blackcurrants, cranberries and strawberries with 35 g sucrose. The control meal included the same amount of sucrose and available carbohydrates in water. Fingertip capillary and venous blood samples were taken at baseline and at 15, 30, 45, 60, 90 and 120 min after starting to eat the meal. Glucose, insulin and GLP-1 concentrations were determined from the venous samples, and glucose also from the capillary samples. Compared to the control meal, ingestion of the berry meal resulted in lower capillary and venous plasma glucose and serum insulin concentrations at 15 min (P = 0·021, P < 0·007 and P = 0·028, respectively), in higher concentrations at 90 min (P = 0·028, P = 0·021 and P = 0·042, respectively), and in a modest effect on the GLP-1 response (P = 0·05). It also reduced the maximum increases of capillary and venous glucose and insulin concentrations (P = 0·009, P = 0·011 and P = 0·005, respectively), and improved the glycaemic profile (P < 0·001 and P = 0·003 for capillary and venous samples, respectively). These results suggest that the glycaemic control after ingestion of sucrose can be improved by simultaneous consumption of berries.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects
      Available formats
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects
      Available formats
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects
      Available formats
Corresponding author
*Corresponding author: Dr R. Törrönen, fax +358 17 162792, email
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1 NP Seeram (2010) Recent trends and advances in berry health benefits research. J Agric Food Chem 58, 38693870.

2JM Koponen , AM Happonen , PH Mattila , (2007) Contents of anthocyanins and ellagitannins in selected foods consumed in Finland. J Agric Food Chem 55, 16121619.

4JK Hellström , AR Törrönen & PH Mattila (2009) Proanthocyanidins in common food products of plant origin. J Agric Food Chem 57, 78997906.

5K Hanhineva , R Törrönen , I Bondia-Pons , (2010) Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci 11, 13651402.

6 GJ McDougall , F Shpiro , P Dobson , (2005) Different polyphenolic components of soft fruits inhibit α-amylase and α-glucosidase. J Agric Food Chem 53, 27602766.

7M da Silva Pinto , YI Kwon , E Apostolidis , (2008) Functionality of bioactive compounds in Brazilian strawberry (Fragaria × ananassa Duch.) cultivars: evaluation of hyperglycemia and hypertension potential using in vitro models. J Agric Food Chem 56, 43864392.

8 T Wilson , AP Singh , N Vorsa , (2008) Human glycemic response and phenolic content of unsweetened cranberry juice. J Med Food 11, 4654.

9H-M Lehtonen , R Järvinen , K Linderborg , (2010) Postprandial hyperglycemia and insulin response are affected by sea buckthorn (Hippophaë rhamnoides ssp. turkestanica) berry and its ethanol-soluble metabolites. Eur J Clin Nutr 64, 14651471.

10R Törrönen , E Sarkkinen , N Tapola , (2010) Berries modify the postprandial plasma glucose response to sucrose in healthy subjects. Br J Nutr 103, 10941097.

11LAH Rosén , LO Blanco Silva , UK Andersson , (2009) Endosperm and whole grain rye breads are characterized by low post-prandial insulin response and a beneficial blood glucose profile. Nutr J 8, 42.

13KA Hätönen , ME Similä , JR Virtamo , (2006) Methodologic considerations in the measurement of glycemic index: glycemic response to rye bread, oatmeal porridge, and mashed potato. Am J Clin Nutr 84, 10551061.

14DS Ludwig (2002) The glycemic index. Physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. JAMA 287, 24142423.

15P Dandona , A Aljada , A Chaudhuri , (2005) Metabolic syndrome. A comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 111, 14481454.

16JJ Holst (2007) The physiology of glucagon-like peptide 1. Physiol Rev 87, 14091439.

17LJ Karhunen , KR Juvonen , A Huotari , (2008) Effect of protein, fat, carbohydrate and fibre on gastrointestinal peptide release in humans. Regul Pept 149, 7078.

18 DA D'Alessio & TP Vahl (2004) Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetes. Am J Physiol Endocrinol Metab 286, E882E890.

19KL Johnston , MN Clifford & LM Morgan (2002) Possible role for apple juice phenolic compounds in the acute modification of glucose tolerance and gastrointestinal hormone secretion in humans. J Sci Food Agric 82, 18001805.

21J Hlebowicz , A Hlebowicz , S Lindstedt , (2009) Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr 89, 815821.

22L Ranganath , F Norris , L Morgan , (1998) Delayed gastric emptying occurs following acarbose administration and is a further mechanism for its anti-hyperglycaemic effect. Diabet Med 15, 120124.

23C Seifarth , J Bergmann , JJ Holst , (1998) Prolonged and enhanced secretion of glucagon-like peptide 1 (7–36 amide) after oral sucrose due to alpha-glucosidase inhibition (acarbose) in type 2 diabetic patients. Diabet Med 15, 485491.

24M Ulmius , A Johansson & G Önning (2009) The influence of dietary fibre source and gender on the postprandial glucose and lipid response in healthy subjects. Eur J Nutr 48, 395402.

25 AA Moukarzel & MT Sabri (1996) Gastric physiology and function: effects of fruit juices. J Am Coll Nutr 15, Suppl. 5, 18S25S.

27K Teff (2000) Nutritional implications of cephalic phase responses. Appetite 34, 206213.

28 KL Teff (2011) How neural mediation of anticipatory and compensatory insulin release helps us tolerate food. Physiol Behav 103, 4450.

29B Ahrén & JJ Holst (2001) The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes 50, 10301038.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *