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Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial

  • Kirsi Laitinen (a1) (a2), Tuija Poussa (a3) and Erika Isolauri (a4) (a5)
Abstract

Balanced glucose metabolism ensures optimal fetal growth with long-term health implications conferred on both mother and child. We examined whether supplementation of probiotics with dietary counselling affects glucose metabolism in normoglycaemic pregnant women. At the first trimester of pregnancy 256 women were randomised to receive nutrition counselling to modify dietary intake according to current recommendations or as controls; the dietary intervention group was further randomised to receive probiotics (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12; diet/probiotics) or placebo (diet/placebo) in a double-blind manner, whilst the control group received placebo (control/placebo). Blood glucose concentrations were lowest in the diet/probiotics group during pregnancy (baseline-adjusted means 4·45, 4·60 and 4·56 mmol/l in diet/probiotics, diet/placebo and control/placebo, respectively; P = 0·025) and over the 12 months' postpartum period (baseline-adjusted means 4·87, 5·01 and 5·02 mmol/l; P = 0·025). Better glucose tolerance in the diet/probiotics group was confirmed by a reduced risk of elevated glucose concentration compared with the control/placebo group (OR 0·31 (95 % CI 0·12, 0·78); P = 0·013) as well as by the lowest insulin concentration (adjusted means 7·55, 9·32 and 9·27 mU/l; P = 0·032) and homeostasis model assessment (adjusted means 1·49, 1·90 and 1·88; P = 0·028) and the highest quantitative insulin sensitivity check index (adjusted means 0·37, 0·35 and 0·35; P = 0·028) during the last trimester of pregnancy. The effects observed extended over the 12-month postpartum period. The present study demonstrated that improved blood glucose control can be achieved by dietary counselling with probiotics even in a normoglycaemic population and thus may provide potential novel means for the prophylactic and therapeutic management of glucose disorders.

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Corresponding author
*Corresponding author: Dr Kirsi Laitinen, fax +358 2 333 6862, email kirsi.laitinen@utu.fi
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1 A Ben-Haroush , Y Tyogev & M Hod (2004) Epidemiology of gestational diabetes mellitus and its association with type 2 diabetes. Diabet Med 21, 103113.

2 I Östlund , U Hanson , A Björklund , (2003) Maternal and fetal outcomes if gestational impaired glucose tolerance is not treated. Diabetes Care 26, 21072111.

3 A Plagemann , T Harder , R Kohlhoff , (1997) Glucose tolerance and insulin secretion in children of mothers with pregestational IDDM or gestational diabetes. Diabetologia 40, 10941100.

4 T Clausen , TK Burski , N Oyen , (2005) Maternal anthropometric and metabolic factors in the first half of pregnancy and risk of neonatal macrosomia in term pregnancies. A prospective study. Eur J Endocrinol 153, 887894.

6 G Danaei , CMM Lawes , S Vander Hoorn , (2006) Global and regional mortality from ischaemic heart disease and stroke attributable to higher-than-optimum blood glucose concentration: comparative risk assessment. Lancet 368, 16511659.

7 B Ahrén (2007) Insulin secretion and insulin sensitivity in relation to fasting glucose in healthy subjects. Diabetes Care 30, 644648.

8 K Yamaoka & T Tango (2005) Efficacy of lifestyle education to prevent type 2 diabetes. Diabetes Care 28, 27802786.

10 PJ Turnbaugh , RE Ley , MA Mahowald , (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 10271031.

11 F Bäckhed , JK Manchester , CF Semenkovich , . (2007) Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A 104, 979984.

12 SE Goldblum , TW Grann , X Ding , . (1994) Lipopolysaccharide (LPS)-binding protein and soluble CD14 function as accessory molecules for LPS-induced changes in endothelial barrier function, in vitro. J Clin Invest 93, 692702.

13 B Yu , E Hailman & SD Wright (1997) Lipopolysaccharides binding protein and soluble CD14 catalyze exchange of phospholipids. J Clin Invest 99, 315324.

14 K Laitinen , U Hoppu , M Hämäläinen , (2006) Breast milk fatty acids may link innate and adaptive immune regulation: analysis of soluble CD14, prostaglandin E2 and fatty acids. Pediatr Res 59, 723727.

16 A Ouwehand , E Isolauri , PV Kirjavainen , . (2000) The mucus binding of Bifidobacterium lactis Bb12 is enhanced in the presence of Lactobacillus GG and Lact. delbrueckii subsp. bulgaricus. Lett Appl Microbiol 30, 1013.

19 M Kalliomäki , S Salminen , H Arvilommi , . (2001) Probiotics in primary prevention of atopic disease: a randomised, placebo-controlled trial. Lancet 357, 10761079.

21 W Becker , N Lyhne , AN Pedersen , (2004) Nordic nutrition recommendations 2004 – integrating nutrition and physical activity. Scand J Nutr 48, 178187.

23 A Katz , SS Nambi , K Mather , (2000) Quantitative insulin sensitivy check index: a simple accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85, 24022410.

25 CA Crowther , JE Hiller , JR Moss , (2005) Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. New Engl J Med 352, 24772486.

26 K Löbner , A Knopff , A Baumgarten , (2006) Predictors of postpartum diabetes in women with gestational diabetes mellitus. Diabetes 55, 792797.

27 M Tabuchi , M Ozaki , A Tamura , (2003) Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem 67, 14211424.

28 T Matsuzaki , Y Nagata , S Kado , (1997) Effect of oral administration of Lactobacillus casei on alloxan-induced diabetes in mice. APMIS 105, 637642.

29 H Yadav , S Jain & PR Sinha (2007) Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high-fructose fed rats. Nutrition 23, 6268.

30 H Yadav , S Jain & PR Sinha (2006) Effect of dahi containing Lactococcus lactis on the progression of diabetes induced by a high-fructose diet in rats. Biosci Biotechnol Biochem 70, 12551258.

31 M Kalliomäki , T Poussa , S Salminen , . (2007) Probiotics during the first 7 years of life: a cumulative risk reduction of eczema in a randomized, placebo-controlled trial. J Allergy Clin Immunol 119, 10191021.

33 NM Delzenne & PD Cani (2005) A place for dietary fibre in the management of the metabolic syndrome. Micronutrients, neutraceutics and functional foods. Curr Opin Clin Nutr Metab Care 8, 636640.

36 MJ Stampfer , FB Hu , JE Manson , (2000) Primary prevention of coronary heart disease in women through diet and lifestyle. New Engl J Med 343, 1622.

37 R Weiss , J Dziura , TS Burgert , (2004) Obesity and the metabolic syndrome in children and adolescents. New Engl J Med 350, 23622374.

38 RE Ley , PJ Turnbaugh , S Klein , (2006) Human gut microbes associated with obesity. Nature 444, 10221023.

39 PD Cani , AM Neyrinck , F Fava , (2007) Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50, 23742383.

40 SJ Creely , PG McTernan , CM Kusminski , . (2007) Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab 292, E740E747.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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