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The proportion of trans monounsaturated fatty acids in serum triacylglycerols or platelet phospholipids as an objective indicator of their short-term intake in healthy men

  • Ronald P. Mensink (a1) and Gerard Hornstra (a1)
Abstract

Unfavourable effects of trans monounsaturated fatty acid (trans-C18:1) isomers on health variables have been reported. Reports on their actual intake, however, are scarce, because of the absence in many nutrient databases of values for trans-C18:1, and the wide variation in the level of trans fatty acids between different brands of the same product. We therefore examined whether the intake of trans-C18:1 is reflected by trans-C18:1 concentrations in serum triacylglycerols or platelet phospholipids. Thirtyeight men received two diets in random order. During the first experimental period twenty men consumed a Western-type control diet for six weeks, and eighteen men consumed a modified diet in which 70% of the fat was replaced by palm oil. After a wash-out period of 3 weeks, regimens were crossed over (second experimental period). The proportion of total fatty acids from trans-C18:1 in the diet decreased from 4·7 (SEM 0·27) during the control to 2·1 (SEM 0·16) on the modified diet (P < 0·001). Trans-C18:1 in serum triacylglycerols decreased from 3·5 (SEM 0·13) to 2·8 (SEM 0·11)% (P < 0·001), and in platelet phospholipids from 1·0 (SEM 0·06) to 0·7 (SEM 0·4)% (P < 0·001). After the first experimental period trans-C18:1 in the diet correlated with trans-C18:1 in serum triacylglycerols (r 0·41; P = 0·014), and platelet phospholipids (r 0·52; P = 0·001). Also, differences in the intake between the two periods correlated with changes in the proportion of trans-C18:1 in serum triacylglycerols (r 0·56; P= 0·001) and platelet phospholipids (r 0·58; P < 0·001). These results suggest that analyses of blood lipid fractions can be used to estimate the intake, and to monitor changes in the intake, of trans-C18:1.

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References
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British Nutrition Foundation's Task Force on Trans Fatty Acids (1987). Trans Fatty Acids. London: British Nutrition Foundation.
Dayton S., Hashimoto S., Dixon W. & Pearce M. L. (1966). Composition of lipids in human serum and adipose tissue during prolonged feeding of a diet high in unsaturated fat. Journal of Lipid Research 7, 103111.
De Iongh H., Beerthis R. K., den Hartog C., Dalderup L. M. & van der Spek P. A. F. (1965). The influence of some dietary fats on serum lipids in man. Bibliotheca Nutritio et Dieta 7, 137152.
Emken E. A. (1984). Nutrition and biochemistry of trans and positional fatty acid isomers in hydrogenated oils. Annual Review of Nutrition 4, 339376.
Emken E. A, Rohwedder W. K., Dutton H. J., DeJarlais W. J., Adlof R. O., Mackin J., Dougherty R. & Iacono J. M. (1979). Incorporation of deuterium labeled cis- and trans-9-octadecenoic acid in humans: plasma, erythrocyte, and platelet neutral lipids. Metabolism 28, 575583.
Enig M. G., Pallansch L. A., Sampugna J. & Keeney M. (1983). Fatty acid composition of the fat in selected food items with emphasis on trans components. Journal of the American Oil Chemists Society 60, 17881795.
Enig M. G., Keeney M. & Sampugna J. (1990). Isomeric trans fatty acids in the U.S. diet. Journal of the American College of Nutrition 9, 471486.
Gurr M. I. (1986). Trans fatty acids - Metabolic and nutritional significance. Nutrition Bulletin 11, 105122.
Hornstra G., van Houwelingen A. C., Kester A. D. M. & Sundram K. (1991). A palm oil-enriched diet lowers serum lipoprotein(a) in normocholesterolemic volunteers. Atherosclerosis 90, 91–93. Hunter, D. J., Rimm, E. B., Sacks, F. M., Stampfer, M. J., Colditz, G. A., Litin, L. B. & Willett, W. C. (1992). Comparison of measures of fatty acid intake by subcutaneous fat aspirate, food frequency questionnaire, and diet records in a free-living population of US men. American Journal of Epidemiology 135, 418427.
Koletzko B. (1991). Zufuhr, Stoffwechsel und biologische Wirkungen trans-isomerer Fettsäuren bei Säuglingen (Supply, metabolism and biological effects of trans-isomeric fatty acids in infants). Nahrung 35, 229283.
Liu K., Cooper R., McKeever J., McKeever P., Byington R., Soltero I., Stamler R., Gosch F., Stevens E. & Stamler J. (1979). Assessment of the association between habitual salt intake and high blood pressure:methodological problems. American Journal of Epidemiology 110,219226.
London S. J., Sacks F. M., Caesar J., Stampfer M. J., Siguel E. & Willett W. C. (1991). Fatty acid composition of subcutaneous adipose tissue and diet in postmenopausal US women. American Journal of Clinical Nutrition 54, 340345.
Mensink R. P. & Katan M. B. (1990). Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. New England Journal of Medicine 323, 439445.
Mensink R. P., Zock P. L., Katan M. B. & Hornstra G. (1992). Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans. Journal of Lipid Research 33, 14931501.
Rand M. L., Hennissen A. A. H. M. & Hornstra G. (1986). Effects of dietary sunflowerseed oil and marine oil on membrane fluidity, arterial thrombosis and platelet responses in rats. Atherosclerosis 62, 267276.
Sampugna J., Pallansch L. A., Enig M. G. & Keeney M. (1982). Rapid analysis of trans fatty acids on SP-2340 glass capillary columns. Journal of Chromatography 249, 245255.
Siguel E. N. & Lerman R. H. (1993). Trans-fatty acid patterns in patients with angiographically documented coronary artery disease. American Journal of Cardiology 71, 916920.
Slover H. T., Thompson R. H., Davis C. S. & Merola G. V. (1985). Lipids in margarines and margarine-like products. Journal of the American Oil Chemists Society 62, 775786.
Snedecor G. W. & Cochran W. G. (1980). Statistical Methods, 7th ed. Ames: Iowa State University Press.
Sommerfeld M. (1983). Trans unsaturated fatty acids in natural products and processed foods. Progress in Lipid Research 22, 221223.
Statistical Analysis Systems (1985). SAS User's Guide: Statistics. Cary, NC: SAS Institute Inc.
Sundram K., Hornstra G. & Schaap J. E. (1990). Characteristics of palm oil based food products developed for a nutritional intervention programme. Food Sciences and Nutrition 42F, 193202.
Sundram K., Hornstra G., van Houwelingen A. C. & Kester A. D. M. (1992). Replacement of dietary fat with palm oil: effect on human serum lipids, lipoproteins and apolipoproteins. British Journal of Nutrition 68, 677692.
Van den Reek M. M., Craig-Schmidt M. C., Weete J. D. & Clark A. J. (1986). Fat in the diets of adolescent girls with emphasis on isomeric fatty acids. American Journal of Clinical Nutrition 43, 530537.
Van Houwelingen A. C., Kester A. D. M., Kromhout D. & Hornstra G. (1989). Comparison between the habitual intake of polyunsaturated fatty acids from fish and their concentrations in serum lipid fractions European Journal of Clinical Nutrition 43, 1120.
Willett W. C., Stampfer M. J., Manson J. E., Colditz G. A, Speizer F. E., Rosner B. A., Sampson L. A. & Hennekens C. H. (1993). Intake of trans fatty acids and risk of coronary heart disease among women. Lancet 341, 581585.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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