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Pulses and carcinogenesis: potential for the prevention of colon, breast and other cancers

  • John C. Mathers (a1)

Consumption of pulses as components of healthy diets is encouraged because it is believed that this is likely to help in reducing the risk of common non-communicable diseases, including cancers. However, the evidence base for the role of pulses in prevention of cancers is unconvincing because of the difficulties, using conventional epidemiological tools, in ascertaining the quantitative contribution made by pulses to cancer risk. Advances in understanding of the biological basis of cancer and of the mechanisms of action of cancer-preventing compounds offer new insights into the role of food-derived substances and of diet—gene interactions in modulating cancer risk. Pulses contain a rich variety of compounds which, if consumed in sufficient quantities, may help to reduce tumour risk.

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Corresponding author
*Corresponding author: Professor John Mathers, tel +44 0191 222 6912, fax +44 0191 222 8684, email
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Adlercreutz, H, Fotsis, T, Bannwart, C, Wahala, K, Brunow, G & Hase, T (1991) Isotope dilution gas chromatographic—mass spectrometric method for the determination of lignans and iso-flavonoids in human urine, including identification of genistein. Clinica Chimica Acta 199, 263278.
Ambrosone, CB, Freudenheim, JL, Thompson, PA, Bowman, E, Vena, JE, Marshall, JR, Graham, S, Laughlin, R, Nemoto, Y & Shields, PG (1999) Manganese superoxide dismutase (MnSOD ) genetic polymorphisms, dietary antioxidants, and risk of breast cancer. Cancer Research 59, 602606.
Anonymous (2001) Anti-inflammatories inhibit cancer growth–but how? Science 291, 581582.
Armstrong, F & Mathers, JC (2000) Kill and cure: dietary augmentation of immune defences against colon cancer. Proceedings of the Nutrition Society 59, 215220.
Asp, N-G, van amelsvoort, JMM & Hautvast, JGAJ (1996) Nutritional implications of resistant starch. Nutrition Research Reviews 9, 131.
Beazer-barclay, Y, Levy, DB, Moser, AR, Dove, WF, Hamilton, SR, Vogelstein, B & Kinzler, KW (1996) Sulindac suppresses tumori-genesis in the Min mouse. Carcinogenesis 17, 17571760.
Bonnotte, B, Favre, N, Reveneau, S, Micheau, O, Droin, N, Garrido, C, Fontana, A, Chauffert, B, Solary, E & Martin, F (1998) Cancer cell sensitization to fas-mediated apoptosis by sodium butyrate. Cell Death Differentiation 5, 480487.
Botterweck, AA, van den brandt, PA & Goldbohm, RA (1998) A prospective cohort study on vegetable and fruit consumption and stomach cancer risk in The Netherlands. American Journal of Epidemiology 148, 842853.
Burn, J, Chapman, PD, Bishop, DT & Mathers, J (1998) Diet and cancer prevention: the Concerted Action Polyp Prevention (CAPP) Studies. Proceedings of the Nutrition Society 57, 183186.
Cassidy, A, Bingham, SA & Cummings, JH (1994) Starch intake and colorectal cancer risk: an international comparison. British Journal of Cancer 69, 937942.
Collett, GP, Robson, CN, Mathers, JC & Campbell, FC (2001) Curcumin modifies Apcmin apoptosis resistance and inhibits 2- amino 1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) induced tumour formation in Apcmin mice. Carcinogenesis 22, 101104.
D'argenio, G, Cosenza, V, Delle, Cave M, Iovino, P, Delle, valle N, Lombardi, G & Mazzacca, G (1996) Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model. Gastroenterology 110, 17271734.
Department of Health (1998) Nutritional Aspects of the Development of Cancer. Report of Health and Social Subjects 48. London: The Stationery Office.
Department of Health (1999) Saving Lives: Our Healthier Nation. London: The Stationery Office.
Doll, R & Peto, R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. Journal of the National Cancer Institute 66, 11911308.
Elder, DJE & Paraskeva, C (1997) NSAIDs to prevent colorectal cancer: a question of sensitivity. Gastroenterology 113, 19992003.
Fodde, R, Edelmann, W, Yang, K, van leeuwen, C, Carlson, C, Renault, B, Breukel, C, Alt, E, Lipkin, M, Khan, PM & Kucherlapati, R (1994) A targeted chain termination mutation in the mouse Apc gene results in multiple intestinal tumours. Proceedings of the National Academy of Sciences USA 91, 89698973.
Franceschi, S (1999) Nutrients and food groups and large bowel cancer in Europe. European Journal of Cancer Prevention 8, Suppl. 1, S49–S52.
Frazer, GE (1999) Associations between diet and cancer, ischemic heart disease, and all-cause mortality in non-Hispanic white California Seventh-day Adventists. American Journal of Clinical Nutrition 70, 532S538S.
Giovannucci, E, Egan, KM, Hunter, DJ, Stampfer, MJ, Colditz, GA, Willett, WC & Speizer, FE (1995) Aspirin and the risk of color-ectal cancer in women. New England Journal of Medicine 333, 609614.
Goodlad, JS & Mathers, JC (1990) Large bowel fermentation in rats given diets containing raw peas (Pisum sativum ). British Journal of Nutrition 64, 569587.
Hague, A, Butt, AJ & Paraskeva, C (1996) The role of butyrate in human colonic epithelial cells: an energy source or inducer of differentiation and apoptosis? Proceedings of the Nutrition Society 55, 937943.
Hanahan, D & Weinberg, RA (2000) The hallmarks of cancer. Cell 100, 5770.
Huang, MT, Newmark, HL & Frenkel, K (1997) Inhibitory effects of curcumin on tumourigenesis in mice. Journal of Cell Bio- chemistry Suppl. 27, 2634.
Hughes, JS, Ganthavorn, C & Wilson-sanders, S (1997) Dry beans inhibit azoxymethane-induced colon carcinogenesis in F344 rats. Journal of Nutrition 127, 23282333.
Hustad, S, Ueland, PM, Vollset, SE, Zhang, Y, Bjørke-monsen, AL & Schneede, J (2000) Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetra-hydrofolate reductase C677T polymorphism. Clinical Chemistry 46, 10651071.
Ingram, D, Sanders, C, Kolybaba, M & Lopez, D (1997) Case-control study of phyto-oestrogens and breast cancer. Lancet 350, 990994.
Jacoby, RF, Seibert, K, Cole, CE, Kelloff, G & Lubet, RA (2000) The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the Min mouse model of adenomatous polyposis. Cancer Research 60, 50405044.
Jain, MG, Hislop, GT, Howe, GR & Ghadirian, P (1999) Plant foods, antioxidants, and prostate cancer risk; findings from case-control studies in Canada. Nutrition and Cancer 34, 173184.
Kennedy, AR, Beazer-barclay, Y, Kinzler, W & Newberne, PM (1996) Suppression of carcinogenesis in the intestines of Minmice by the soybean-derived Bowman—Birk inhibitor. Cancer Research 56, 679682.
Key, FB & Mathers, JC (1995) Digestive adaptations of rats give white bread and cooked haricot beans (Phaseolus vulgaris): large-bowel fermentation and digestion of complex carbohydrates. British Journal of Nutrition 74, 393406.
Lamartiniere, CA (2000) Protection against breast cancer with genistein: a component of soy. American Journal of Clinical Nutrition 71, Suppl., 1705S1707S.
Lee, HP, Gourley, L, Duffey, SW, Esteve, J, Lee, J & Day, NE (1991) Dietary effects on breast cancer risk in Singapore. Lancet 337, 11971200.
Lippmann, SM, Lee, JJ & Sabichi, AL (1998) Cancer chemopre-vention: progress and promise. Journal of the National Cancer Institute 90, 15141527.
Lu, L-JW, Anderson, KE, Grady, JJ, Kohen, F & Nagamani, M (2000) Decreased ovarian hormones during a soya diet: implications for breast cancer prevention. Cancer Research 60, 41124121.
Ma, J, Stampfer, MJ, Giovannucci, E, Artigas, C, Hunter, DJ, Fuchs, C, Willett, WC, Selhub, J, Hennekens, CH & Rozen, R (1997) Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Research 57, 10981109.
Mcintosh, GH, Wang, YHA & Royle, PJ (1998) A diet containing chickpeas and wheat offers less protection against colon tumours than a casein and wheat diet in dimethylhydrazine-treated rats. Journal of Nutrition 128, 804809.
Mariadason, JM, Corner, GA & Augenlicht, LH (2000) Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: Comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer. Cancer Research 60, 45614572.
Marnett, LJ (1992) Aspirin and the potential role of prostaglandins in colon cancer. Cancer Research 52, 55755589.
Mathers, JC (2000) Food and cancer prevention: human intervention studies. In Dietary Carcinogens and Antimutagens. Chemical and Biological Aspects, pp. 395403 [Johnson, IT and Fenwick, GR, editors]. Cambridge: Royal Society of Chemistry.
Mathers, JC & Dawson, LD (1991) Large bowel fermentation in rats eating processed potatoes. British Journal of Nutrition 66, 313329.
Mathers, JC, Smith, H & Carter, S (1997) Dose:response effects of raw potato starch on small intestinal escape, large-bowel fermentation and gut transit time in the rat. British Journal of Nutrition 78, 10151029.
Moser, AR, Pitot, HC & Dove, WF (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247, 322324.
Polakis, P (1997) The adenomatous polyposis coli (APC) tumor suppressor. Biochimica Biophysica Acta 1332, F127–F147.
Potischman, N, Swanson, CA, Coates, RJ, Gammon, RD, Brogan, DR, Curtin, J & Brinton, LA (1999) Intake of food groups and associated micronutrients in relation to early-stage breast cancer. International Journal of Cancer 82, 315321.
Probert, CS, Emmett, PM & Heaton, KW (1995) Some determinants of whole-gut transit time: a population-based study. Quarterly Journal of Medicine 88, 311315.
Schuurman, AG, Goldbohm, RA, Dorant, E & van den brandt, PA (1998) Vegetable and fruit consumption and prostate cancer risk: a cohort study in The Netherlands. Cancer Epidemiology, Biomarkers and Prevention 7, 873880.
Siavoshian, S, Segain, JP, Kornprobst, M, Bonnet, C, Cherbut, C, Galmiche, JP & Blottiere, HM (2000) Butyrate and trichostatin A effects on the proliferation/ differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. Gut 46, 507514.
Singh, DK & Lippmann, SM (1998 a) Cancer chemoprevention. Part 1: Retinoids and carotenoids and other classic antioxidants. Oncology 12, 16431653, 1657–1658.
Singh, DK & Lippmann, SM (1998 b) Cancer chemoprevention. Part 2: Hormones, nonclassic antioxidant natural agents, NSAIDs and other agents. Oncology 12, 17871800.
Sørensen, IK, Kristiansen, E, Mortensen, A, Nicolaisen, GM, Wijnands, JAH, van kranen, HJ & van kreijl, CF (1998) The effect of soy isoflavones on the development of intestinal neoplasia in the ApcMin mouse. Cancer Letters 130, 217225.
Steinbach, G, Lynch, PM, Phillips, RKS, Wallace, MH, Hawk, E, Gordon, GB, Wakabayashi, N, Saunders, B, Shen, Y, Fujimura, T, Su, L-K, Levin, B, Godio, L, Patterson, S, Rodriguez-bigas, MA, Jester, SL, King, KL, Schumacher, M, Abbruzzese, J, Dubois, RN, Hittelman, WN, Zimmerman, S, Sherman, JW & Kelloff, G (2000) The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. New England Journal of Medicine 342, 19461952.
Stephens, FO (1999) The rising incidence of breast cancer in women and prostate cancer in men: A possible preventive role for nature's sex hormone modifiers – the phytoestrogens (Review). Oncology Reports 6, 865870.
Stumpf, K, Pietinen, P, Puska, P & Adlercreutz, H (2000) Changes in serum enterolactone, genistein, and diadzein in a dietary intervention study in Finland. Cancer Epidemiology, Bio-markers and Prevention 9, 13691372.
Takayama, T, Katsui, S, Takahasi, Y, Ohi, M, Nojiri, S, Sakamaki, S, Kato, J, Kogawa, K, Miyaki, H & Niitsu, Y (1998) Aberrant crypt foci of the colon as precursors of adenoma and cancer. New England Journal of Medicine 339, 12771284.
Takezaki, T, Gao, CM, Ding, JH, Liu, TK, Li, MS & Tajima, K (1999) Comparative study of lifestyles of residents in high and low risk areas for gastric cancer in Jiangsu Province, China; with special reference to allium vegetables. Journal of Epidemiology 9, 297305.
Thun, MJ, Namboodiri, MM & Heath, CW (1991) Aspirin use and reduced risk of fatal colon cancer. New England Journal of Medicine 325, 15931596.
Tuyns, AJ, Kaaks, R & Haelterman, M (1988) Colorectal cancer and the consumption of foods: a case-control study in Belgium. Nutrition and Cancer 11, 189204.
Tzonou, A, Lipwoth, L, Kalandidi, A, Trichopoulou, A, Gamatsi, I, Hsieh, CC, Notara, V & Trichopoulos, D (1996) Dietary factors and the risk of endometrial cancer: a case-control study in Greece. British Journal of Cancer 73, 12841290.
Waddell, WR & Loughry, RW (1983) Sulindac for polyposis of the colon. Journal of Surgical Oncology 24, 8387.
Wasan, HS, Novelli, M, Bee, J & Bodmer, WF (1997) Dietary fat influences on polyp phenotype in multiple intestinal neoplasiamice. Proceedings of the National Academy of Sciences USA 94, 33083313.
Willett, WC (1995) Diet, nutrition and avoidable cancer. Environmental Health Perspectives 103, Suppl. 8a, 165170.
Williamson, SLH, Kartheuser, A, Coaker, J, Dehghan, kooshkghazi M, Fodde, R, Burn, J & Mathers, JC (1999) Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months. Carcinogenesis 20, 805810.
World Cancer Research Fund/American Institute of Cancer Research (1997) Food, Nutrition and the Prevention of Cancer: a global perspective. Washington: World Cancer Research Fund/American Institute of Cancer Research.
World Health Organization (1990) Diet, Nutrition and the Prevention of Chronic Diseases. Report of a WHO study group. Technical Report Series 797. Geneva: World Health Organization.
Wu, JT, Archer, SY, Hinnebusch, B, Meng, S & Hodin, RA (2001) Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. American Journal of Physiology, Gastrointestinal and Liver Physiology 280, G482–G490.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
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