Skip to main content
×
×
Home

Replacement of dietary fat with palm oil: effect on human serum lipids, lipoproteins and apolipoproteins

  • Kalyana Sundram (a1), Gerard Hornstra (a1), Adriana C. v. Houwelingen (a1) and Arnold D. M. Kester (a2)
Abstract

Thirty-eight male volunteers participated in a double-blind cross-over trial evaluating the effect of replacing the usual sources of saturated fat in the Dutch diet (animal fats and hydrogenated oils) by palm oil, which is virtually free of cholesterol and trans-fatty acids, on serum lipids, lipoproteins and apolipoproteins. Maximum (about 70%) replacement had no significant effect on serum total cholesterol or most lipoprotein fractions, but resulted in an 11% increase in serum high-density-lipoprotein (HDL)2-cholesterol relative to the control (P2 = 0.01). The palm-oil diet also caused an 8% decrease in low-density-lipoprotein (LDL):HDL2+HDL3-cholesterol ratio (P2 = 0.02) as well as a 9% decrease in triacylglycerols in the low-density-lipoprotein fractions (P2 = 0.01). Palm oil consumption resulted in a 4% increase in serum apolipoprotein AI (P2 = 0.008) and a 4% decrease in apolipoprotein B (P2 = 0.01) relative to the control diet; the B:AI apolipoprotein ratio was decreased by 8% (P2 < 0.0001). These results were not significantly affected by the different lipoprotein E phenotypes of the volunteers. Although the observed differences were relatively modest, the present study, nonetheless, indicates that dietary palm oil, when replacing a major part of the normal fat content in a Dutch diet, may slightly reduce the lipoprotein- and apolipoprotein-associated cardiovascular risk profiles

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Replacement of dietary fat with palm oil: effect on human serum lipids, lipoproteins and apolipoproteins
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Replacement of dietary fat with palm oil: effect on human serum lipids, lipoproteins and apolipoproteins
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Replacement of dietary fat with palm oil: effect on human serum lipids, lipoproteins and apolipoproteins
      Available formats
      ×
Copyright
References
Hide All
Alvers, J. J., Wahl, P. W., Cabana, V. G., Hazzard, W. R. & Hoover, J. J. (1976). Quantitation of apolipoprotein A1 of human plasma high density lipoprotein. Metabolism 25, 633644.
AMA Council on Scientific Affairs (1983). Dietary and pharmacological therapy for the lipid risk factors: a council statement. Journal of the American Medical Association 250, 18731879.
Anderson, J. T., Grande, F. & Keys, A. (1976). Independence of the effects of cholesterol and degree of saturation of fat in the diet on serum cholesterol in man. American Journal of Clinical Nutrition 29, 17841789.
Anon (1987). New findings on palm oil. Nutrition Review 45, 205207.
Armitage, P. & Berry, G. (1987). Statistical Methods in Medical Research. Oxford: Blackwell.
Baudet, M. F., Dachet, C., Lasserre, M., Esteva, O. & Jacotot, B. (1984). Modification in the composition and metabolic properties of human low density lipoproteins by different dietary fats. Journal of Lipid Research 25, 456468.
Bligh, E. G. & Dyer, W. J. (1959). A rapid method for total lipid extraction and purification. Canadian Journal of Biochemistry and Physiology 37, 911917.
Bonanome, A. & Grundy, S. M. (1988). Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. New England Journal of Medicine 318, 12441248.
Bovenkamp, P. v. d. & Katan, M. B. (1981). Cholesterol content of chicken skin. Journal of Food Science 46, 291.
Denke, M. A. & Breslow, J. L. (1988). Effect of a low fat diet with and without intermittent saturated fat and cholesterol ingestion on plasma lipid, lipoprotein and apolipoprotein levels in normal volunteers. Journal of Lipid Research 29, 963970.
Fisher, E. A., Blum, C. B., Zannis, V. I. & Breslow, J. L. (1983). Independent effects of dietary saturated fat and cholesterol on plasma lipids, lipoproteins and apolipoprotein E. Journal of Lipid Research 24, 10391048.
Ginsberg, H. N., Barr, S. L., Gilbert, A., Karmally, W., Deckelbaum, R., Kaplan, K., Ramakrishnan, R., Holleran, S. & Dell, R. B. (1990). Reduction of plasma cholesterol levels in normal men on an American Heart Association step 1 diet or a step 1 diet with added monounsaturated fat. New England Journal of Medicine 322, 574579.
Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B. & Dawber, T. R. (1977). High density lipoprotein as a protective factor against coronary heart disease. American Journal of Medicine 62, 707714.
Grande, F. (1962). Dog serum lipid responses to dietary fats differing in the chain length of the saturated fatty acids. Journal of Nutrition 76, 255264.
Grundy, S. M. & Vega, G. L. (1988). Plasma cholesterol responsiveness to saturated fatty acids. American Journal of Clinical Nutrition 47, 822824.
Hashim, S. A., Artega, A. & van Itallie, T. B. (1960). Effect of saturated medium chain triglyceride on serum lipids in man. Lancet i, 11051108.
Havekes, L. M., de Knijff, P., Beisiegel, U., Havinga, J., Smit, M. & Klasen, E. (1987). A rapid micromethod for apolipoprotein E phenotyping directly in serum. Journal of Lipid Research 28, 455463.
Havekes, L. M., Hemmink, J. & de Wit, E. (1981). Low-density-lipoprotein apoprotein B in plasma as measured by radial immunodiffusion and rocket immunoelectrophoresis. Clinical Chemistry 27, 18291833.
Hayes, K. C., Pronczuk, A., Lindsay, A. & Diersen-Schade, D. (1991). Dietary saturated fatty acids (12:0, 14:0, 16:0) differ in their impact on plasma cholesterol and lipoproteins in non-human primates. American Journal of Clinical Nutrition 53, 491498.
Hegsted, D. M., McGandy, R. B., Meyers, M. L. & Stare, F. J. (1965). Quantitative effects of dietary fat on serum cholesterol in man. American Journal of Clinical Nutrition 27, 281295.
Keys, A., Anderson, J. T. & Grande, F. (1965 a). Prediction of serum cholesterol responses of man to changes in fats in the diet. Lancet ii, 959966.
Keys, A., Anderson, J. T. & Grande, F. (1965 b). Serum cholesterol responses to changes in diet. IV. Particular saturated fatty acids in the diet. Metabolism 14, 776787.
Laine, C. W., Snodgrass, C. M., Dawson, E. A., Ener, M. A., Kuba, K. & Frantz, I. D. Jr (1982). Lightly hydrogenated soya oil versus other vegetable oils as a lipid-lowering dietary constituent. American Journal of Clinical Nutrition 35, 683690.
(1988). Manual for BECEL® Food Programme. Vlaardingen, The Netherlands: Unilever Research.
Mattson, F. H. & Grundy, S. M. (1985). Comparison of effects of dietary saturated, monounsaturated and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. Journal of Lipid Research 26, 194202.
McNamara, D. J. (1990). Dietary cholesterol: effects on lipid metabolism. Current Opinion in Lipidology 1, 1822.
Mensink, R. P. & Katan, M. B. (1989). Effect of a diet enriched with monounsaturated or polyunsaturated fatty acids on levels of low-density and high-density lipoprotein cholesterol in healthy women and men. New England Journal of Medicine 321, 436441.
Mensink, R. P. & Katan, M. B. (1990). Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. New England Journal of Medicine 323, 439445.
Mielke, S. (1987). The prospects for palm oil up to the year 2000. Oil World 30, 147156.
Miller, N. E., Hammett, F., Saltissi, S., Rao, S., van Zeller, H., Coltart, J. & Lewis, B. (1981). Relation of angiographically defined coronary artery disease to plasma lipoprotein subfractions and apolipoproteins. British Medical Journal 282, 17411744.
Ministry of Welfare, Health and Cultural Affairs and Ministry of Agriculture and Fisheries, The Netherlands (1988). Wat eet Nederland: Results of Food Consumption Survey 1987–1988. Zeist, The Netherlands: TNO CIVO Toxicology and Nutrition Inst.
Naito, H. K. (1985). The association of serum lipids, lipoproteins and apolipoproteins with coronary artery disease assessed by coronary arteriography. In Atherosclerosis [Lee, K. T., editor]. Annals of the New York Academy of Science 454, 230238.
Pownall, H. J., Shepherd, J., Mantulin, W. W., Sklar, L. A. & Gotto, A. M. Jr (1980). Effect of saturated and polyunsaturated fat diets on the composition and structure of human low density lipoproteins. Atherosclerosis 36, 299314.
Qureshi, A. A., Burger, W. C., Peterson, D. M. & Elson, C. E. (1986). The structure of an inhibitor of cholesterol biosynthesis isolated from barley. Journal of Biological Chemistry 261, 1054410550.
Rand, M. L., Hennissen, A. A. H. M. & Hornstra, G. (1986). Effects of dietary sunflowerseed oil and marine oil on membrane fluidity, arterial thrombosis and platelet responses in rats. Atherosclerosis 62, 267276.
Rhoads, G. G., Gulbrandsen, C. L. & Kagan, A. (1976). Serum lipoproteins and coronary heart disease in a population study of Hawaii Japanese men. New England Journal of Medicine 294, 293298.
Schmitz, G. & Assmann, G. (1982). Isolation of human serum HDL1 by zonal ultracentrifugation. Journal of Lipid Research 23, 903910.
Spritz, N. & Mishkel, M. A. (1969). Effects of dietary fats on plasma lipids and lipoproteins: an hypothesis for the lipid-lowering effect of unsaturated fatty acids. Journal of Clinical Investigation 48, 7886.
Sundram, K., Hornstra, G. & Schaap, J. E. (1990 a). Characteristics of palm oil based food products developed for a nutritional intervention programme. Food Science and Nutrition 42F, 193202.
Sundram, K., Khor, H. T. & Ong, A. S. H. (1990 b). Effect of dietary palm oil and its fractions on rat plasma and high density lipoprotein lipids. Lipids 25, 187193.
Tatami, R., Mabuchi, H., Ueda, K., Ueda, R., Haba, T., Kametani, T., Ito., Koizumi, J., Ohta, M., Miyamoto, S., Nakayama, A., Kanaya, H., Oiwake, H., Genda, A. & Takeda, R. (1981). Intermediate-density lipoprotein and cholesterol-rich very low density lipoprotein in angiographically determined coronary artery disease. Circulation 64, 11741184.
Terpstra, A. H. M., Woodward, C. J. H. & Sanchez-Muniz, F. J. (1981). Improved techniques for the separation of serum lipoproteins by density gradient ultracentrifugation: visualization by prestaining and rapid separation of serum lipoproteins from small volumes of serum. Annals of Biochemistry 111, 149157.
Vega, G. L., Groszek, E., Wolf, R. & Grundy, S. M. (1982). Influence of polyunsaturated fats on composition of plasma lipoproteins and apolipoproteins. Journal of Lipid Research 23, 811822.
Zanni, E. E., Zannis, V. I., Blum, C. B., Herbert, P. N. & Breslow, J. L. (1987). Effect of egg cholesterol and dietary fats on plasma lipids, lipoproteins and apolipoproteins of normal women consuming natural diets. Journal of Lipid Research 28, 518527.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed