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Role of dietary fat type in the development of adiposity from dietary obesity-susceptible Sprague–Dawley rats

Published online by Cambridge University Press:  09 March 2007

In Surk Jang ,
Dae Yeon Hwang ,
Kab Ryong Chae ,
Ju Eun Lee ,
Yong Kyu Kim ,
Tae Seok Kang ,
Jin Hee Hwang ,
Chae Hyung Lim  and
Young Bum Huh
In Surk Jang*
Affiliation:
Department of Animal Science &Biotechnology, RAIRC, Jinju National University, Chilam-Dong 150, Jinju, KyeongNam, Korea
Dae Yeon Hwang
Affiliation:
Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA, Nokbun-Dong, Eungpyung-Ku 5, Seoul, Korea
Kab Ryong Chae
Affiliation:
Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA, Nokbun-Dong, Eungpyung-Ku 5, Seoul, Korea
Ju Eun Lee
Affiliation:
Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA, Nokbun-Dong, Eungpyung-Ku 5, Seoul, Korea
Yong Kyu Kim
Affiliation:
Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA, Nokbun-Dong, Eungpyung-Ku 5, Seoul, Korea
Tae Seok Kang
Affiliation:
Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA, Nokbun-Dong, Eungpyung-Ku 5, Seoul, Korea
Jin Hee Hwang
Affiliation:
Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA, Nokbun-Dong, Eungpyung-Ku 5, Seoul, Korea
Chae Hyung Lim
Affiliation:
Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA, Nokbun-Dong, Eungpyung-Ku 5, Seoul, Korea
Young Bum Huh
Affiliation:
Department of Anatomy, College of Medicine, Kyunghee University, Hoeki-Dong 1, Dongdaemum-Ku, Seoul, Korea
*
*Corresponding author: Dr InSurk Jang, fax +82 55 751 3267, email isjang@jinju.ac.kr
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Abstract

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The present study was designed to define how dietary fat type regulates body adiposity in dietary obesity-susceptible (DOS) Sprague–Dawley (SD) rats. Eighty-three SD rats received a purified diet containing 50 g maize oil (MO)/kg for 3 weeks and then thirty-nine of the rats, designated as the DOS rats, were allotted to diets containing 160 g MO (DOS-MO), beef tallow (DOS-BT) or fish oil (DOS-FO)/kg for 9 weeks. As a result of the experiment, the DOS-FO rats had significantly (P<0·05) reduced weight gain and abdominal and epididymal fat-pad mass than the DOS-MO and DOS-BT rats. Serum leptin level was also significantly (P<0·05) lower in the DOS-FO rats; however, hypothalamic leptin receptor (a and b) mRNA and neuropeptide Y expressions were not altered by dietary fat sources. A lower acetyl-CoA carboxylase mRNA expression in the liver was observed in the DOS-FO group, whereas hepatic peroxisome proliferator-activated receptor-γ mRNA and protein expressions were markedly elevated in the DOS-FO group compared with those in the other groups. We did not observe differences in acetyl-CoA carboxylase and peroxisome proliferator-activated receptor-γ expressions in epididymal fat of the DOS rats consuming MO, BT or FO. It is concluded from our present observations that dietary fat type, especially that rich in FO, plays a potential role in down-regulation of adiposity by altering hepatic lipogenic genes, rather than feeding behaviour, in the DOS-SD rats.

Keywords

Fat typeLeptinHypothalamic leptin receptorNeuropeptide YAcetyl carboxylase CoAPeroxisome proliferator-activated receptor-γ
Type
Research Article
Information
British Journal of Nutrition , Volume 89 , Issue 3 , March 2003 , pp. 429 - 437
Copyright
Copyright © The Nutrition Society 2003

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