Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 40
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Bertinato, Jesse Lavergne, Christopher Rahimi, Sophia Rachid, Hiba Vu, Nina Plouffe, Louise and Swist, Eleonora 2016. Moderately Low Magnesium Intake Impairs Growth of Lean Body Mass in Obese-Prone and Obese-Resistant Rats Fed a High-Energy Diet. Nutrients, Vol. 8, Issue. 5, p. 253.


    Fazeli, P. K. and Klibanski, A. 2014. Determinants of GH resistance in malnutrition. Journal of Endocrinology, Vol. 220, Issue. 3, p. R57.


    Alcantara, Ethel H. Shin, Mee Young Feldmann, Jörg Nixon, Graeme F. Beattie, John H. and Kwun, In Sook 2013. Long-term zinc deprivation accelerates rat vascular smooth muscle cell proliferation involving the down-regulation of JNK1/2 expression in MAPK signaling. Atherosclerosis, Vol. 228, Issue. 1, p. 46.


    Maggio, Marcello De Vita, Francesca Lauretani, Fulvio Buttò, Valeria Bondi, Giuliana Cattabiani, Chiara Nouvenne, Antonio Meschi, Tiziana Dall'Aglio, Elisabetta and Ceda, Gian 2013. IGF-1, the Cross Road of the Nutritional, Inflammatory and Hormonal Pathways to Frailty. Nutrients, Vol. 5, Issue. 10, p. 4184.


    Wang, M.Q. ., W.J. Tao ., S.S. Ye ., Y.J. Du ., C. Wang and ., S.X. Shen 2012. Effects of Dietary Pharmacological Zinc on Growth, Liver Metallothionein, Cu, Zn-SOD Concentration and Serum Parameters in Piglets. Journal of Animal and Veterinary Advances, Vol. 11, Issue. 9, p. 1390.


    Prescod, Alexia L. V. Halliday, William C. and Taylor, Carla G. 2011. Protein deficiency, but not zinc deficiency, reduces recovery of type 1 and type 2 muscle fibre diameters in the gastrocnemius muscle of growing rats. British Journal of Nutrition, Vol. 106, Issue. 05, p. 675.


    Ishikawa, Misao Shimoda, Shinji and Nakamura, Yoshiki 2010. Histological Study of the Periodontal Ligament and Alveolar Bone in Magnesium-deficient Rats. Journal of Oral Biosciences, Vol. 52, Issue. 2, p. 170.


    Ishikawa, Misao Shimoda, Shinji and Nakamura, Yoshiki 2010. Histological Study of the Periodontal Ligament and Alveolar Bone in Magnesium-deficient Rats. Journal of Oral Biosciences, Vol. 52, Issue. 2, p. 170.


    Hoppe, C Mølgaard, C Dalum, C Vaag, A and Michaelsen, K F 2009. Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-day supplementation study in prepubertal boys. European Journal of Clinical Nutrition, Vol. 63, Issue. 9, p. 1076.


    Aagaard-Tillery, Kjersti Mitchell, Nicole desRoberts, Clotilde and Lane, Robert H 2008. Gastroenterology and Nutrition: Neonatology Questions and Controversies.


    Rude, Robert K. 2008. Principles of Bone Biology.


    2007. Amino Acids and Proteins for the Athlete.


    Eli, Robert and Fasciano, James A. 2006. An adjunctive preventive treatment for heart disease and a set of diagnostic tests to detect it: Insulin-like growth factor-1 deficiency and cell membrane pathology are an inevitable cause of heart disease. Medical Hypotheses, Vol. 66, Issue. 5, p. 964.


    Rude, R. K. Gruber, H. E. Norton, H. J. Wei, L. Y. Frausto, A. and Kilburn, J. 2006. Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism. Osteoporosis International, Vol. 17, Issue. 7, p. 1022.


    Brand-Miller, Jennie C. and Wolever, Thomas M. S. 2005. The use of glycaemic index tables to predict glycaemic index of breakfast meals. British Journal of Nutrition, Vol. 94, Issue. 01, p. 133.


    Deicher, R. and Horl, W. H. 2005. Hormonal adjuvants for the treatment of renal anaemia. European Journal of Clinical Investigation, Vol. 35, Issue. s3, p. 75.


    Apines-Amar, Mary Jane S. Satoh, Shuichi Caipang, Christopher Marlowe A. Kiron, Viswanath Watanabe, Takeshi and Aoki, Takashi 2004. Amino acid-chelate: a better source of Zn, Mn and Cu for rainbow trout, Oncorhynchus mykiss. Aquaculture, Vol. 240, Issue. 1-4, p. 345.


    Ovesen, J. MØller-Madsen, B. Thomsen, J.S. Danscher, G. and Mosekilde, Li. 2001. The positive effects of zinc on skeletal strength in growing rats. Bone, Vol. 29, Issue. 6, p. 565.


    Rodríguez, J. Pablo and Rosselot, Gastón 2001. Effects of zinc on cell proliferation and proteoglycan characteristics of epiphyseal chondrocytes. Journal of Cellular Biochemistry, Vol. 82, Issue. 3, p. 501.


    Castillo-Durán, C. and Cassorla, F. 1999. Trace Minerals in Human Growth and Development. Journal of Pediatric Endocrinology and Metabolism, Vol. 12, Issue. 5,


    ×

Role of insulin-like growth factor-1 and growth hormone in growth inhibition induced by magnesium and zinc deficiencies

  • Inge Dørup (a1), Allan Flyvbjerg (a1), Maria E. Everts (a1) and Torben Clausen (a1)
  • DOI: http://dx.doi.org/10.1079/BJN19910051
  • Published online: 01 March 2007
Abstract

Nutritional deficiencies of magnesium or zinc lead to a progressive and often marked growth retardation. We have evaluated the effect of Mg and Zn deficiency on growth, serum insulin-like growth factor-1 (s-IGF-1), growth hormone (s-GH) and insulin (s-insulin) in young rats. In 3-week-old rats maintained on Mg-deficient fodder for 12 d the weight gain was reduced by about 34%, compared with pair-fed controls. This was accompanied by a 44% reduction in s-IGF-1, while s-insulin showed no decrease. After 3 weeks on Mg-deficient fodder, growth had ceased while serum Mg (s-Mg) and s-IGF-1 were reduced by 76 and 60% respectively. Following repletion with Mg, s-Mg was completely normalized in 1 week, and s-IGF-1 reached control level after 2 weeks. Growth rate increased, but the rats had failed to catch up fully in weight after 3.5 weeks. Absolute and relative pair-feeding were compared during a Mg repletion experiment. Absolute pair-fed animals were given the same absolute amount of fodder as the Mg-deficient rats had consumed the day before. Relative pair-fed animals were given the same amount of fodder, on a body-weight basis, consumed in the Mg-deficient group the day before. In a repletion experiment the two methods did not differ significantly from each other with respect to body-weight, muscle weight, tibia length and s-IGF-1, although there was a tendency towards higher levels in the relative pair-fed group. The peak in s-GH after growth hormone-releasing factor 40 (GRF 40) was 336 (se 63) μg/l in 5-week-old rats that had been Mg depleted for 14 d, whereas age-matched control animals showed a peak of 363 (se 54) μg/l (not significant).

In 3-week-old rats maintained on Zn-deficient fodder for 14 d weight gain was reduced by 83% compared with pair-fed controls. Serum Zn (s-Zn) and s-IGF-1 were reduced by 80 and 69% respectively, while s-insulin was reduced by 66%. The Zn-deficient animals showed a more pronounced growth inhibition than that seen during Mg deficiency and after 17 d on Zn-deficient fodder s-IGF-1 was reduced by 83%. Following repletion with Zn, s-Zn was normalized and s-IGF-1 had increased by 194% (P <0.05) after 3 d. s-IGF-1, however, was not normalized until after 2.5 weeks of repletion. Growth rate increased but the catch-up in weight was not complete during 6 weeks. The maximum increase in s-GH after GRF 40 was 774 (se 61) μg/l in control animals ν. 657 (se 90) μg/l in 6-week-old rats that had been Zn-depleted for 12 d (not significant). In conclusion, both Mg and Zn deficiency lead to growth inhibition that is accompanied by reduced circulating s-IGF-1, but unchanged s-GH response. Zn deficiency, but not Mg deficiency, caused a reduction in s-insulin. The reduction in s-IGF-1 could not be attributed to reduced energy intake, but seems to be a specific effect of nutritional deficiency of Mg or Zn. It is suggested that the growth retardation seen during these deficiency states may be mediated through reduced s-IGF-1 production.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Role of insulin-like growth factor-1 and growth hormone in growth inhibition induced by magnesium and zinc deficiencies
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Role of insulin-like growth factor-1 and growth hormone in growth inhibition induced by magnesium and zinc deficiencies
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Role of insulin-like growth factor-1 and growth hormone in growth inhibition induced by magnesium and zinc deficiencies
      Available formats
      ×
Copyright
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

J. L. Caddell & D. R. Goddard (1967). Studies in protein-calorie malnutrition. I. Chemical evidence for magnesium deficiency. New England Journal of Medicine 276, 533535.

A. Flyvbjerg , I. Dørup , M. E. Everts & H. Ørskov (1991). Evidence that potassium deficiency induces growth retardation through reduced circulating levels of growth hormone and insulin-like growth factor I. Metabolism 40, 769775.

A. Flyvbjerg , J. Frystyk , O. Thorlacius-Ussing & H. Ørskov (1989). Somatostatin analogue administration prevents increase in kidney somatomedin C and initial renal growth in diabetic and uninephrectomized rats. Diabetologia 32, 261265.

E. R. Froesch , C. Schmid , J. Schwander & J. Zapf (1985). Actions of insulin-like growth factors. Annual Reviews of Physiology 47, 443467.

H. Ørskov , A. G. Thomsen & H. Yde (1968). Wick-chromatography for rapid and reliable immunoassay of insulin, glucagon and growth hormone. Nature 219, 193195.

S. Southon , G. Livesey , J. M. Gee & I. T. Johnson (1985). Intestinal cellular proliferation and protein synthesis in zinc-deficient rats. British Journal of Nutrition 53, 595603.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: