Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 10
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Wang, Sen Duan, Chen Liu, Huan Shao, Wanzhen Wu, Cuiyan Han, Jing and Guo, Xiong 2016. The roles of selenium, insulin-like growth factor binding protein 2 and suppressor of cytokine signaling 3 in the pathogenesis of Kashin–Beck disease. Biomarkers, Vol. 21, Issue. 5, p. 409.


    Wen, Yan Hao, Jingcan Xiao, Xiao Wang, Wenyu Guo, Xiong Lin, Weimin Yang, Tielin Liu, Xiaogang Shen, Hui Tan, Lijun Chen, Xiangding Tian, Qing Deng, Hong-Wen and Zhang, Feng 2016. PPARGC1B gene is associated with Kashin-Beck disease in Han Chinese. Functional & Integrative Genomics, Vol. 16, Issue. 4, p. 459.


    Yang, Lei Zhao, Guang-Hui Liu, Huan Wang, Xi Guo, Xiong and Lammi, Mikko J. 2016. Field synopsis and meta-analyses of genetic epidemiological evidence for Kashin–Beck disease, an endemic osteoarthropathy in China. Molecular Genetics and Genomics,


    Zhang, Feng Dai, Lanlan Lin, Weimin Wang, Wenyu Liu, Xuanzhu Zhang, Jianguo Yang, Tielin Liu, Xiaogang Shen, Hui Chen, Xiangding Tan, Lijun Tian, Qing Deng, Hong-Wen Xu, Xun and Guo, Xiong 2016. Exome sequencing identified FGF12 as a novel candidate gene for Kashin-Beck disease. Functional & Integrative Genomics, Vol. 16, Issue. 1, p. 13.


    Du, X.A. Wang, H.M. Dai, X.X. Kou, Y. Wu, R.P. Chen, Q. Cao, J.L. Mo, X.Y. and Xiong, Y.M. 2015. Role of selenoprotein S (SEPS1) -105G>A polymorphisms and PI3K/Akt signaling pathway in Kashin-Beck disease. Osteoarthritis and Cartilage, Vol. 23, Issue. 2, p. 210.


    Katunga, Lalage A. Gudimella, Preeti Efird, Jimmy T. Abernathy, Scott Mattox, Taylor A. Beatty, Cherese Darden, Timothy M. Thayne, Kathleen A. Alwair, Hazaim Kypson, Alan P. Virag, Jitka A. and Anderson, Ethan J. 2015. Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy. Molecular Metabolism, Vol. 4, Issue. 6, p. 493.


    Méplan, Catherine 2015. Selenium and Chronic Diseases: A Nutritional Genomics Perspective. Nutrients, Vol. 7, Issue. 5, p. 3621.


    Guo, X. Ma, W.-J. Zhang, F. Ren, F.-L. Qu, C.-J. and Lammi, M.J. 2014. Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease. Osteoarthritis and Cartilage, Vol. 22, Issue. 11, p. 1774.


    Yan, Denglu Pei, Fuxing and Song, Yancheng 2014. Serum levels of M-CSF, RANKL and OPG in rats fed with Kashin-Beck disease-affected diet. Journal of Orthopaedic Surgery and Research, Vol. 9, Issue. 1,


    Zhang, Feng Guo, Xiong Zhang, Yinping Wen, Yan Wang, Weizhuo Wang, Sen Yang, Tielin Shen, Hui Chen, Xiangding Tian, Qing Tan, Lijun and Deng, Hong-Wen 2014. Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin–Beck disease. Human Genetics, Vol. 133, Issue. 6, p. 793.


    ×

SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease

  • Xiao Hong Du (a1), Xiao Xia Dai (a1), Rui Xia Song (a1), Xiu Zhen Zou (a1), Wen Yan Sun (a1), Xiao Yan Mo (a2), Guang Lu Bai (a3) and Yong Min Xiong (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114511002704
  • Published online: 23 June 2011
Abstract

Kashin-Beck disease (KBD) is a chronic endemic osteoarthropathy, which mainly occurs in West and Northeast China. Epidemiological studies suggest that Se deficiency is an important environmental factor for the incidence of KBD. Glutathione peroxidase 4 (GPx4) belongs to the glutathione peroxidase family, which is crucial for optimal antioxidant defences. Our purpose is to investigate the putative association between GPx4 polymorphisms and the risk of KBD. Restriction fragment length polymorphism-PCR was used to detect two SNP (rs713041, rs4807542) in 219 cases and 194 controls in Han Chinese subjects, and quantitative analysis for the GPx4 mRNA level was performed by the real-time PCR method. The results revealed that linkage disequilibrium existed in the two SNP. A significant difference was observed in the haplotype A-T (P = 0·0066) of GPx4, which was obviously lower in the KBD cases (0·006 v. 0·032 %). Correlation analysis based on a single locus showed no association between each SNP and KBD risk. Furthermore, the GPx4 mRNA level was dramatically lower in the blood of KBD patients. Overall, our finding indicated GPx4 polymorphisms and decreased mRNA level may be related to the development of KBD in the Chinese population, suggesting GPx4 as a possible candidate susceptibility gene for KBD.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Y. M. Xiong, fax +86 29 82655032, email xiongym2009@yahoo.com.cn
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1R Tomlinson (1999) Beijing conference reviews Kashin-Beck disease. BMJ 318, 485.

4R Moreno-Reyes , C Suetens , F Mathieu , (1998) Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. N Engl J Med 339, 11121120.

12YM Xiong , XY Mo , XZ Zou , (2010) Association study between polymorphisms in selenoprotein genes and susceptibility to Kashin-Beck disease. Osteoarthritis Cartilage 18, 817824.

15H Imai & Y Nakagawa (2003) Biological significance of phospholipid hydroperoxide glutathione peroxidase (phgpx, gpx4) in mammalian cells. Free Radic Biol Med 34, 145169.

16LV Papp , J Lu , A Holmgren , (2007) From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal 9, 775806.

18C Méplan , DJ Hughes , B Pardini , (2010) Genetic variants in selenoprotein genes increase risk of colorectal cancer. Carcinogenesis 31, 10741079.

19G Bermano , V Pagmantidis , N Holloway , (2007) Evidence that a polymorphism within the 3′UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Genes Nutr 2, 225232.

20M Udler , AT Maia , A Cebrian , (2007) Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer. J Clin Oncol 25, 30153023.

21S Villette , A Kyle , KM Brown , (2002) A novel single nucleotide polymorphism in the 3′ untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism. Blood Cells Mol Dis 29, 174178.

22M Maiorino , V Bosello , F Ursini , (2003) Genetic variations of gpx-4 and male infertility in humans. Biol Reprod 68, 11341341.

28RA Sunde & KB Hadley (2010) Phospholipid hydroperoxide glutathione peroxidase (Gpx4) is highly regulated in male turkey poults and can be used to determine dietary selenium requirements. Exp Biol Med (Maywood) 235, 2331.

29KM Brown , K Pickard , F Nicol , (2000) Effects of organic and inorganic selenium supplementation on selenoenzyme activity in blood lymphocytes, granulocytes, platelets and erythrocytes. Clin Sci 98, 593599.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: