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Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease

  • Christine Dalgård (a1), Flemming Nielsen (a2), Jason D. Morrow (a3), Henrik Enghusen-Poulsen (a4), Torbjörn Jonung (a5), Mogens Hørder (a1) and Moniek P. M. de Maat (a6) (a7)
  • DOI: http://dx.doi.org/10.1017/S0007114508995660
  • Published online: 28 May 2008
Abstract

Inflammation and endothelial activation are associated with an increased risk of CVD and epidemiological evidence suggests an association between levels of markers of inflammation or endothelial activation and the intake of fruit. Also, vitamin E, a fat-soluble antioxidant, has anti-inflammatory properties. We performed a randomised 2 × 2 factorial, crossover trial to determine the effect of orange and blackcurrant juice (500 ml/d) and vitamin E (15 mg RRR-α-tocopherol/d) supplementation on markers of inflammation and endothelial activation in forty-eight patients with peripheral arterial disease. Patients were randomly allocated to two dietary supplements from the four possible combinations of juice and vitamin E: juice+vitamin E; juice+placebo; reference beverage (sugar drink)+vitamin E; and reference beverage+placebo. The supplementations were given for 28 d, separated by a 4-week wash-out period. Analysis of main effects showed that juice decreased C-reactive protein (CRP) by 11 % and fibrinogen by 3 % while the reference drink increased CRP by 13 % and fibrinogen by 2 % (P < 0·008 and P < 0·002, respectively). No significant differences were measured for IL-6 and the endothelial activation markers von Willebrand factor, tissue-plasminogen activator and plasmin activator inhibitor-1. Vitamin E supplementation had no significant effects on the various markers. We observed no significant interaction between juice and vitamin E. In this study, orange and blackcurrant juice reduced markers of inflammation, but not markers of endothelial activation, in patients with peripheral arterial disease, relative to sugar drinks.

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*Corresponding author: Dr Christine Dalgård, fax +45 6550 3682, email cdalgaard@health.sdu.dk
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1J Danesh , JG Wheeler , GM Hirschfield , S Eda , G Eiriksdottir , A Rumley , GDO Lowe , MB Pepys & V Gudnason (2004) C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 350, 13871397.

2MP de Maat & A Trion (2004) C-reactive protein as a risk factor versus risk marker. Curr Opin Lipidol 15, 651657.

3MB Pepys , GM Hirschfield , GA Tennent , (2006) Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 440, 12171221.

4KK Ray , CP Cannon , R Cairns , (2005) Relationship between uncontrolled risk factors and C-reactive protein levels in patients receiving standard or intensive statin therapy for acute coronary syndromes in the PROVE IT-TIMI 22 trial. J Am Coll Cardiol 46, 14171424.

5KJ Joshipura , FB Hu , JE Manson , (2001) The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 134, 11061114.

6HC Hung , KJ Joshipura , R Jiang , (2004) Fruit and vegetable intake and risk of major chronic disease. J Natl Cancer Inst 96, 15771584.

7B Voetsch , RC Jin & J Loscalzo (2004) Nitric oxide insufficiency and atherothrombosis. Histochem Cell Biol 122, 353367.

12Heart Protection Study Collaborative Group (2002) MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20, 536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360, 2333.

13NR Cook , CM Albert , JM Gaziano , E Zaharris , J MacFadyen , E Danielson , JE Buring & JE Manson (2007) A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch Intern Med 167, 16101618.

15BG Brown , XQ Zhao , A Chait , (2001) Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 345, 15831592.

17U Justesen , P Knuthsen & T Leth (1997) Determination of plant polyphenols in Danish foodstuffs by HPLC–UV and LC–MS detection. Cancer Lett 114, 165167.

18C Dalgård , L Christiansen , T Jonung , MI Mackness , MPM de Maat & M Hørder (2007) No influence of increased intake of orange and blackcurrant juices and dietary amounts of vitamin E on paraoxonase-1 activity in patients with peripheral arterial disease. Eur J Nutr 46, 354363.

19B Frei & MG Trabe (2001) The new US Dietary Reference Intakes for vitamins C and E. Redox Rep 6, 59.

22M Levine , Y Wang , SJ Padayatty & J Morrow (2001) A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci U S A 98, 98429846.

23KT Khaw , S Bingham , A Welch , R Luben , N Wareham , S Oakes & N Day (2001) Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. Lancet 357, 657663.

24A Tjonneland , K Overvad , J Haraldsdottir , S Bang , M Ewertz & OM Jensen (1991) Validation of a semiquantitative food frequency questionnaire developed in Denmark. Int J Epidemiol 20, 906912.

25MP de Maat , EM Bladbjerg , T Drivsholm , K Borch-Johnsen , L Moller & J Jespersen (2003) Inflammation, thrombosis and atherosclerosis: results of the Glostrup study. J Thromb Haemost 1, 950957.

28J Lykkesfeldt , S Loft & HE Poulsen (1995) Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection – are they reliable biomarkers of oxidative stress? Anal Biochem 229, 329335.

30S Mehta & JA Farmer (2007) Obesity and inflammation: a new look at an old problem. Curr Atheroscler Rep 9, 134138.

31AM Wilson , JD Swan , H Ding , (2007) Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy. Atherosclerosis 191, 175181.

32PM Ridker , CP Cannon , D Morrow , N Rifai , LM Rose , CH McCabe , MA Pfeffer & E Braunwald (2005) C-reactive protein levels and outcomes after statin therapy. N Engl J Med 352, 2028.

33MPJ de Winther , E Kanters , G Kraal & MH Hofker (2005) Nuclear factor κB signaling in atherogenesis. Arterioscler Thromb Vasc Biol 25, 904914.

35K Esposito , F Nappo , R Marfella , G Giugliano , F Giugliano , M Ciotola , L Quagliaro , A Ceriello & D Giugliano (2002) Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 106, 20672072.

36M Yano , G Hasegawa , M Ishii , M Yamasaki , M Fukui , N Nakamura & T Yoshikawa (2004) Short-term exposure of high glucose concentration induces generation of reactive oxygen species in endothelial cells: implication for the oxidative stress associated with postprandial hyperglycemia. Redox Rep 9, 111116.

38VM Breinholt , SE Nielsen , P Knuthsen , ST Lauridsen , B Daneshvar & A Sorensen (2003) Effects of commonly consumed fruit juices and carbohydrates on redox status and anticancer biomarkers in female rats. Nutr Cancer 45, 4652.

41B Weinhold & U Rüther (1997) Interleukin-6-dependent and -independent regulation of the human C-reactive protein gene. Biochem J 327, 425429.

42JV Castell , T Geiger , V Gross , T Andus , E Walter , T Hirano , T Kishimoto & PC Heinrich (1988) Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat. Eur J Biochem 177, 357361.

43Z Dibbs , J Thornby , BG White & DL Mann (1999) Natural variability of circulating levels of cytokines and cytokine receptors in patients with heart failure: implications for clinical trials. J Am Coll Cardiol 33, 19351942.

44S Rose-John , J Scheller , G Elson & SA Jones (2006) Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol 80, 227236.

46A Azzi , R Gysin , P Kempna , A Munteanu , L Villacorta , T Visarius & JM Zingg (2004) Regulation of gene expression by alpha-tocopherol. Biol Chem 385, 585591.

47EA Bermudez & PM Ridker (2002) C-reactive protein, statins, and the primary prevention of atherosclerotic cardiovascular disease. Prev Cardiol 5, 4246.

48U Landmesser , F Bahlmann , M Mueller , (2005) Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans. Circulation 111, 23562363.

49RS Rosenson (2004) Statins in atherosclerosis: lipid-lowering agents with antioxidant capabilities. Atherosclerosis 173, 112.

50R De Caterina , F Cipollone , FP Filardo , (2002) Low-density lipoprotein level reduction by the 3-hydroxy-3-methylglutaryl coenzyme-A inhibitor simvastatin is accompanied by a related reduction of F2-isoprostane formation in hypercholesterolemic subjects: no further effect of vitamin E. Circulation 106, 25432549.

51W Palmas , S Ma , B Psaty , J Goff , C Darwin & RG Barr (2007) Antihypertensive medications and C-reactive protein in the multi-ethnic study of atherosclerosis. Am J Hypertens 20, 233241.

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