Skip to main content
    • Aa
    • Aa
  • Access
  • Cited by 15
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Trivedi, Ruchir and Salvo, Marissa C. 2016. Utilization and Safety of Common Over-the-Counter Dietary/Nutritional Supplements, Herbal Agents, and Homeopathic Compounds for Disease Prevention. Medical Clinics of North America, Vol. 100, Issue. 5, p. 1089.

    Vidlar, Ales Student, Vladimir Vostalova, Jitka Fromentin, Emilie Roller, Marc Simanek, Vilím and Student, Vladimir 2016. Cranberry fruit powder (Flowens™) improves lower urinary tract symptoms in men: a double-blind, randomized, placebo-controlled study. World Journal of Urology, Vol. 34, Issue. 3, p. 419.

    Asare, George Awuku Afriyie, Daniel Ngala, Robert A. Appiah, Alfred A. Anang, Yvonne Musah, Iddi Adjei, Samuel Bamfo-Quaicoe, Kwabena Sule, Derick Gyan, Ben A. Arhin, Peter and Edoh, Dominic A. 2015. Shrinkage of Prostate and Improved Quality of Life: Management of BPH Patients withCroton membranaceusEthanolic Root Extract. Evidence-Based Complementary and Alternative Medicine, Vol. 2015, p. 1.

    Bharti, Singh Deepmala, Katiyar Ragini, Tilak and Ratan, Kumar Srivastava 2015. In vitro assessment of antimicrobial potency and synergistic effects of three medicinal plants (Mentha arvensis, Carissa carandas and Calendula officinalis) extract against pathogenic bacteria. African Journal of Microbiology Research, Vol. 9, Issue. 5, p. 286.

    Duffey, Kiyah J. and Sutherland, Lisa A. 2015. Adult consumers of cranberry juice cocktail have lower C-reactive protein levels compared with nonconsumers. Nutrition Research, Vol. 35, Issue. 2, p. 118.

    Gordon, Lynne 2014. Cranberry in radiotherapy: dispelling the myths. A review of the literature. Journal of Radiotherapy in Practice, Vol. 13, Issue. 01, p. 98.

    Joseph, Shama V. Edirisinghe, Indika and Burton-Freeman, Britt M. 2014. Berries: Anti-inflammatory Effects in Humans. Journal of Agricultural and Food Chemistry, Vol. 62, Issue. 18, p. 3886.

    Riso, Patrizia Vendrame, Stefano Del Bo', Cristian Martini, Daniela Martinetti, Antonia Seregni, Ettore Visioli, Francesco Parolini, Marina and Porrini, Marisa 2014. Effect of 10-day broccoli consumption on inflammatory status of young healthy smokers. International Journal of Food Sciences and Nutrition, Vol. 65, Issue. 1, p. 106.

    Dorren, Rhonda Torkos, Sherry and Murray, Michael T. 2013. Textbook of Natural Medicine.


    Vasileiou, Ioanna Katsargyris, Athanasios Theocharis, Stamatios and Giaginis, Constantinos 2013. Current clinical status on the preventive effects of cranberry consumption against urinary tract infections. Nutrition Research, Vol. 33, Issue. 8, p. 595.

    Jepson, Ruth G Williams, Gabrielle Craig, Jonathan C and Jepson, Ruth G 2012. Cochrane Database of Systematic Reviews.

    Challem, Jack 2011. Medical Journal Watch: Context and Applications. Alternative and Complementary Therapies, Vol. 17, Issue. 1, p. 57.

    Sengupta, Gairik Hazra, Avijit Kundu, Anup and Ghosh, Anirban 2011. Comparison of Murraya koenigii– and Tribulus terrestris–Based Oral Formulation Versus Tamsulosin in the Treatment of Benign Prostatic Hyperplasia in Men Aged >50 Years: A Double-Blind, Double-Dummy, Randomized Controlled Trial. Clinical Therapeutics, Vol. 33, Issue. 12, p. 1943.

    Vidlar, Ales Vostalova, Jitka Ulrichova, Jitka Student, Vladimir Krajicek, Milan Vrbkova, Jana and Simanek, Vilim 2010. The safety and efficacy of a silymarin and selenium combination in men after radical prostatectomy - a six month placebo-controlled double-blind clinical trial. Biomedical Papers, Vol. 154, Issue. 3, p. 239.


The effectiveness of dried cranberries (Vaccinium macrocarpon) in men with lower urinary tract symptoms

  • Ales Vidlar (a1), Jitka Vostalova (a2), Jitka Ulrichova (a2), Vladimir Student (a1), David Stejskal (a3), Richard Reichenbach (a4), Jana Vrbkova (a5), Filip Ruzicka (a6) and Vilim Simanek (a1)
  • DOI:
  • Published online: 31 August 2010

Lower urinary tract symptoms (LUTS) are a common condition in older men. The objective of the present study was to evaluate the efficacy and tolerability of cranberry (Vaccinium macrocarpon) powder in men at risk of prostate disease with LUTS, elevated prostate-specific antigen (PSA), negative prostate biopsy and clinically confirmed chronic non-bacterial prostatitis. Forty-two participants received either 1500 mg of the dried powdered cranberries per d for 6 months (cranberry group; n 21) or no cranberry treatment (control group; n 21). Physical examination, International Prostate Symptom Score, quality of life (QoL), five-item version of the International Index of Erectile Function (IIEF-5), basic clinical chemistry parameters, haematology, Se, testosterone, PSA (free and total), C-reactive protein (CRP), antioxidant status, transrectal ultrasound prostate volume, urinary flow rate, ultrasound-estimated post-void residual urine volume at baseline, and at 3 and 6 months, and urine ex vivo anti-adherence activity were determined in all subjects. In contrast to the control group, patients in the cranberry group had statistically significant improvement in International Prostate Symptom Score, QoL, urination parameters including voiding parameters (rate of urine flow, average flow, total volume and post-void residual urine volume), and lower total PSA level on day 180 of the study. There was no influence on blood testosterone or serum CRP levels. There was no statistically significant improvement in the control group. The results of the present trial are the first firm evidence that cranberries may ameliorate LUTS, independent of benign prostatic hyperplasia or C-reactive protein level.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The effectiveness of dried cranberries (Vaccinium macrocarpon) in men with lower urinary tract symptoms
      Available formats
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      The effectiveness of dried cranberries (Vaccinium macrocarpon) in men with lower urinary tract symptoms
      Available formats
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      The effectiveness of dried cranberries (Vaccinium macrocarpon) in men with lower urinary tract symptoms
      Available formats
Corresponding author
*Corresponding author: Dr Jitka Vostalova, fax +420 585 632 302, email
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1V Kupelian , KT McVary , MJ Barry , (2009) Association of C-reactive protein and lower urinary tract symptoms in men and women: results from Boston Area community health survey. J Urol 73, 950957.

2JC Nickel , CG Roehrborn , MP O'Leary , (2008) The relationship between prostate inflammation and lower urinary tract symptoms: examination of baseline data from the REDUCE trial. Eur Urol 54, 13791384.

3JL St Sauver , AV Sarma , DJ Jacobson , (2009) Associations between C-reactive protein and benign prostatic hyperplasia/lower urinary tract symptom outcomes in a population-based cohort. Am J Epidemiol 169, 12811290.

4CR Chapple (2004) Pharmacological therapy of benign prostatic hyperplasia/lower urinary tract symptoms: an overview for the practicing clinician. BJU Int 94, 738744.

5EA Klein (2005) Can prostate cancer be prevented? Nat Clin Pract Urol 2, 2431.

6SC Thomasset , DP Berry , G Garcea , (2006) Dietary polyphenolic phytochemicals – promising cancer chemopreventive agents in humans? A review of their clinical properties. Int J Cancer 120, 451458.

7CL Van Patten , JG de Boer & ES Tomlinson Guns (2008) Diet and dietary supplements intervention trials for the prevention of prostate recurrence: a review of randomized controlled trial evidence. J Urol 180, 23142322.

9CC Neto (2007) Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases. Mol Nutr Food Res 51, 652664.

10DR Guay (2009) Cranberry and urinary tract infections. Drugs 69, 775807.

11AB Howell (2007) Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Mol Nutr Food Res 51, 732737.

12H Shmuely , J Yahav , Z Samra , (2007) Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics and a proton pump inhibitor. Mol Nutr Food Res 51, 746751.

13A Yamanaka , R Kimizuka , T Kato , (2004) Inhibitory effects of cranberry juice on attachment of oral streptococci and biofilm formation. Oral Microbiol Immunol 19, 150154.

15R Narayansingh & RAR Hurta (2008) Cranberry extract and quercetin modulate the expression of cyclooxygenase-2 (COX-2) and IκBα in human colon cancer cells. J Sci Food Agric 89, 542547.

17JN Krieger , LJ Nyberg & JC Nickel (1999) NIH consensus definition and classification of prostatitis. JAMA 282, 236237.

18K Valentova , D Stejskal , P Bednar , (2007) Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial. J Agric Food Chem 55, 32173224.

19RC Rosen , JC Cappelleri , MD Smith , (1999) Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 11, 319326.

23RC Dedhia & KT McVary (2008) Phytotherapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Urol 179, 21192125.

24MET McMurdo , I Argo , G Phillips , (2009) Cranberry or trimethoprim for the prevention of recurrent urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 63, 389395.

26S Vasto , G Carruba , G Candore , (2008) Inflammation and prostate cancer. Future Oncol 4, 637645.

27I Palikova , J Vostalova , A Zdarilova , (2010) Long-term effects of three commercial cranberry products on the antioxidative status in rats: a pilot study. J Agric Food Chem 58, 16721678.

28DJ Tindall & RS Rittmaster (2008) The rationale for inhibiting 5-α-reductase isoenzymes in the prevention and treatment of prostate cancer. J Urol 179, 12351242.

29F Giuliano (2006) Impact of medical treatments for benign prostatic hyperplasia on sexual function. BJU Int 97, 3438, discussion 44–45.

30JA Duke , MJ Bogenschutz-Godwin , J DuCellier , (2002) Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *